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Ravichandran Ramasamy
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Meeting Abstracts

207-LB: Aldose Reductase Inhibition by AT-001 Limits Diastolic Dysfunction and Adverse Remodelling in Diabetic Cardiomyopathy

QUTUBA G. KARWI, KESHAV GOPAL, SEYED AMIRHOSSEIN TABATABAEI DAKHILI, CORY S. WAGG, LIYAN ZHANG, QIUYU SUN, CHRISTINA T. SAED, SAI PANIDARAPU, RICCARDO PERFETTI, RAVICHANDRAN RAMASAMY, JOHN R. USSHER, GARY LOPASCHUK
Journal: Diabetes
Diabetes 2022;71(Supplement_1):207-LB
https://doi.org/10.2337/db22-207-LB
Published: 01 June 2022
View article titled, 207-LB: Aldose Reductase Inhibition by AT-001 Limits Diastolic Dysfunction and Adverse Remodelling in Diabetic Cardiomyopathy
Meeting Abstracts

379-P: Aldose Reductase Inhibition by AT-001 Prevents Diabetic Cardiomyopathy via Reducing Myocardial Fatty Acid Oxidation Rates

KESHAV GOPAL, QUTUBA G. KARWI, SEYED AMIRHOSSEIN TABATABAEI DAKHILI, CORY S. WAGG, RICCARDO PERFETTI, RAVICHANDRAN RAMASAMY, JOHN R. USSHER, GARY LOPASCHUK
Journal: Diabetes
Diabetes 2021;70(Supplement_1):379-P
https://doi.org/10.2337/db21-379-P
Published: 01 June 2021
View article titled, 379-P: Aldose Reductase Inhibition by AT-001 Prevents Diabetic Cardiomyopathy via Reducing Myocardial Fatty Acid Oxidation Rates
Meeting Abstracts

1080-P: Addressing the Safety Challenges of Aldose Reductase Inhibition: Development of AT-001 for Diabetic Cardiomyopathy, a Potent and Selective Next Generation Aldose Reductase Inhibitor

RICCARDO PERFETTI, GAUTHAM YEPURI, NOSIRUDEEN A. QUADRI, AMEEN F. GHANNAM, RAVICHANDRAN RAMASAMY, SHOSHANA SHENDELMAN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1080-P
https://doi.org/10.2337/db20-1080-P
Published: 01 June 2020
View article titled, 1080-P: Addressing the Safety Challenges of Aldose Reductase Inhibition: Development of AT-001 for Diabetic Cardiomyopathy, a Potent and Selective Next Generation Aldose Reductase Inhibitor
Meeting Abstracts

462-P: AT-001, a Next Generation Aldose Reductase Inhibitor with Improved Selectivity and Specificity, Protects from Cellular Damage Associated with Hyperglycemia

RICCARDO PERFETTI, GAUTHAM YEPURI, NOSIRUDEEN A. QUADRI, RAVICHANDRAN RAMASAMY, AMEEN F. GHANNAM, SHOSHANA SHENDELMAN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):462-P
https://doi.org/10.2337/db20-462-P
Published: 01 June 2020
View article titled, 462-P: AT-001, a Next Generation Aldose Reductase Inhibitor with Improved Selectivity and Specificity, Protects from Cellular Damage Associated with Hyperglycemia
Journal Articles

Human Aldose Reductase Expression Prevents Atherosclerosis Regression in Diabetic Mice

Chujun Yuan, Jiyuan Hu, Saj Parathath, Lisa Grauer, Courtney Blachford Cassella, Svetlana Bagdasarov, Ira J. Goldberg, Ravichandran Ramasamy, Edward A. Fisher
Journal: Diabetes
Diabetes 2018;67(9):1880–1891
https://doi.org/10.2337/db18-0156
Published: 11 June 2018
View article titled, Human Aldose Reductase Expression Prevents Atherosclerosis Regression in Diabetic Mice
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Includes: Supplementary data
Journal Articles

RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes

Gurdip Daffu, Xiaoping Shen, Laura Senatus, Devi Thiagarajan, Andisheh Abedini, Carmen Hurtado del Pozo, Rosa Rosario, Fei Song, Richard A. Friedman, Ravichandran Ramasamy, Ann Marie Schmidt
Journal: Diabetes
Diabetes 2015;64(12):4046–4060
https://doi.org/10.2337/db15-0575
Published: 07 August 2015
View article titled, RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes
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Includes: Supplementary data
Journal Articles

RAGE Regulates the Metabolic and Inflammatory Response to High-Fat Feeding in Mice

Fei Song, Carmen Hurtado del Pozo, Rosa Rosario, Yu Shan Zou, Radha Ananthakrishnan, Xiaoyuan Xu, Payal R. Patel, Vivian M. Benoit, Shi Fang Yan, Huilin Li, Richard A. Friedman, Jason K. Kim, Ravichandran Ramasamy, Anthony W. Ferrante, Jr., Ann Marie Schmidt
Journal: Diabetes
Diabetes 2014;63(6):1948–1965
https://doi.org/10.2337/db13-1636
Published: 15 May 2014
View article titled, RAGE Regulates the Metabolic and Inflammatory Response to High-Fat Feeding in Mice
Open the PDF for RAGE Regulates the Metabolic and Inflammatory Response to High-Fat Feeding in Mice in another window
Includes: Supplementary data
Journal Articles

Aldose Reductase Drives Hyperacetylation of Egr-1 in Hyperglycemia and Consequent Upregulation of Proinflammatory and Prothrombotic Signals

Srinivasan Vedantham, Devi Thiagarajan, Radha Ananthakrishnan, Lingjie Wang, Rosa Rosario, Yu Shan Zou, Ira Goldberg, Shi Fang Yan, Ann Marie Schmidt, Ravichandran Ramasamy
Journal: Diabetes
Diabetes 2014;63(2):761–774
https://doi.org/10.2337/db13-0032
Published: 16 January 2014
View article titled, Aldose Reductase Drives Hyperacetylation of Egr-1 in Hyperglycemia and Consequent Upregulation of Proinflammatory and Prothrombotic Signals
Open the PDF for Aldose Reductase Drives Hyperacetylation of Egr-1 in Hyperglycemia and Consequent Upregulation of Proinflammatory and Prothrombotic Signals in another window
Includes: Supplementary data
Journal Articles

Deletion of the Receptor for Advanced Glycation End Products Reduces Glomerulosclerosis and Preserves Renal Function in the Diabetic OVE26 Mouse

Nina Reiniger, Kai Lau, Daren McCalla, Bonnie Eby, Bin Cheng, Yan Lu, Wu Qu, Nosirudeen Quadri, Radha Ananthakrishnan, Maryana Furmansky, Rosa Rosario, Fei Song, Vivek Rai, Alan Weinberg, Richard Friedman, Ravichandran Ramasamy, Vivette D'Agati, Ann Marie Schmidt
Journal: Diabetes
Diabetes 2010;59(8):2043–2054
https://doi.org/10.2337/db09-1766
Published: 01 August 2010
View article titled, Deletion of the Receptor for Advanced Glycation End Products Reduces Glomerulosclerosis and Preserves Renal Function in the Diabetic OVE26 Mouse
Open the PDF for Deletion of the Receptor for Advanced Glycation End Products Reduces Glomerulosclerosis and Preserves Renal Function in the Diabetic OVE26 Mouse in another window
Includes: Supplementary data
Journal Articles

RAGE and Modulation of Ischemic Injury in the Diabetic Myocardium

Loredana G. Bucciarelli, Radha Ananthakrishnan, Yuying C. Hwang, Michiyo Kaneko, Fei Song, David R. Sell, Christopher Strauch, Vincent M. Monnier, Shi Fang Yan, Ann Marie Schmidt, Ravichandran Ramasamy
Journal: Diabetes
Diabetes 2008;57(7):1941–1951
https://doi.org/10.2337/db07-0326
Published: 01 July 2008
View article titled, RAGE and Modulation of Ischemic Injury in the Diabetic Myocardium
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Journal Articles

Aldose Reductase Inhibition Protects Diabetic and Nondiabetic Rat Hearts from Ischemic Injury

Ravichandran Ramasamy, Peter J Oates, Saul Schaefer
Journal: Diabetes
Diabetes 1997;46(2):292–300
https://doi.org/10.2337/diab.46.2.292
Published: 01 February 1997
View article titled, Aldose Reductase Inhibition Protects Diabetic and Nondiabetic Rat Hearts from Ischemic Injury
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