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Renée de Mutsert
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Journal Articles

Association Between Low Sex Hormone–Binding Globulin and Increased Risk of Type 2 Diabetes Is Mediated by Increased Visceral and Liver Fat: Results From Observational and Mendelian Randomization Analyses

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Theresa A. Stangl, Chantal M. Wiepjes, Roelof A.J. Smit, Astrid van Hylckama Vlieg, Hildo J. Lamb, Jeroen H.P.M. van der Velde, Esther Winters-van Eekelen, Sebastiaan C. Boone, Martijn C.G.J. Brouwers, Frits R. Rosendaal, Martin den Heijer, Annemieke C. Heijboer, Renée de Mutsert
Journal: Diabetes
Diabetes 2024;73(11):1793–1804
https://doi.org/10.2337/db23-0982
Published: 06 August 2024
View article titled, Association Between Low Sex Hormone–Binding Globulin and Increased Risk of Type 2 Diabetes Is Mediated by Increased Visceral and Liver Fat: Results From Observational and Mendelian Randomization Analyses
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Journal Articles

Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism

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Ruifang Li-Gao, David A. Hughes, Jan B. van Klinken, Renée de Mutsert, Frits R. Rosendaal, Dennis O. Mook-Kanamori, Nicholas J. Timpson, Ko Willems van Dijk
Journal: Diabetes
Diabetes 2021;70(12):2932–2946
https://doi.org/10.2337/db21-0397
Published: 05 October 2021
View article titled, Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism
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Journal Articles

Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity

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Hanieh Yaghootkar, Yiying Zhang, Cassandra N. Spracklen, Tugce Karaderi, Lam Opal Huang, Jonathan Bradfield, Claudia Schurmann, Rebecca S. Fine, Michael H. Preuss, Zoltan Kutalik, Laura B.L. Wittemans, Yingchang Lu, Sophia Metz, Sara M. Willems, Ruifang Li-Gao, Niels Grarup, Shuai Wang, Sophie Molnos, América A. Sandoval-Zárate, Mike A. Nalls, Leslie A. Lange, Jeffrey Haesser, Xiuqing Guo, Leo-Pekka Lyytikäinen, Mary F. Feitosa, Colleen M. Sitlani, Cristina Venturini, Anubha Mahajan, Tim Kacprowski, Carol A. Wang, Daniel I. Chasman, Najaf Amin, Linda Broer, Neil Robertson, Kristin L. Young, Matthew Allison, Paul L. Auer, Matthias Blüher, Judith B. Borja, Jette Bork-Jensen, Germán D. Carrasquilla, Paraskevi Christofidou, Ayse Demirkan, Claudia A. Doege, Melissa E. Garcia, Mariaelisa Graff, Kaiying Guo, Hakon Hakonarson, Jaeyoung Hong, Yii-Der Ida Chen, Rebecca Jackson, Hermina Jakupović, Pekka Jousilahti, Anne E. Justice, Mika Kähönen, Jorge R. Kizer, Jennifer Kriebel, Charles A. LeDuc, Jin Li, Lars Lind, Jian’an Luan, David A. Mackey, Massimo Mangino, Satu Männistö, Jayne F. Martin Carli, Carolina Medina-Gomez, Dennis O. Mook-Kanamori, Andrew P. Morris, Renée de Mutsert, Matthias Nauck, Ivana Prokic, Craig E. Pennell, Arund D. Pradhan, Bruce M. Psaty, Olli T. Raitakari, Robert A. Scott, Tea Skaaby, Konstantin Strauch, Kent D. Taylor, Alexander Teumer, Andre G. Uitterlinden, Ying Wu, Jie Yao, Mark Walker, Kari E. North, Peter Kovacs, M. Arfan Ikram, Cornelia M. van Duijn, Paul M. Ridker, Stephen Lye, Georg Homuth, Erik Ingelsson, Tim D. Spector, Barbara McKnight, Michael A. Province, Terho Lehtimäki, Linda S. Adair, Jerome I. Rotter, Alexander P. Reiner, James G. Wilson, Tamara B. Harris, Samuli Ripatti, Harald Grallert, James B. Meigs, Veikko Salomaa, Torben Hansen, Ko Willems van Dijk, Nicholas J. Wareham, Struan F.A. Grant, Claudia Langenberg, Timothy M. Frayling, Cecilia M. Lindgren, Karen L. Mohlke, Rudolph L. Leibel, Ruth J.F. Loos, Tuomas O. Kilpeläinen
Journal: Diabetes
Diabetes 2020;69(12):2806–2818
https://doi.org/10.2337/db20-0070
Published: 11 September 2020
View article titled, Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity
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Journal Articles

Genome-Wide Association Study on the Early-Phase Insulin Response to a Liquid Mixed Meal: Results From the NEO Study

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Ruifang Li-Gao, Françoise Carlotti, Renée de Mutsert, Astrid van Hylckama Vlieg, Eelco J.P. de Koning, J. Wouter Jukema, Frits R. Rosendaal, Ko Willems van Dijk, Dennis O. Mook-Kanamori
Journal: Diabetes
Diabetes 2019;68(12):2327–2336
https://doi.org/10.2337/db19-0378
Published: 19 September 2019
View article titled, Genome-Wide Association Study on the Early-Phase Insulin Response to a Liquid Mixed Meal: Results From the NEO Study
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Includes: Supplementary data
Journal Articles

Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension

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Yingjie Ji, Andrianos M. Yiorkas, Francesca Frau, Dennis Mook-Kanamori, Harald Staiger, E. Louise Thomas, Naeimeh Atabaki-Pasdar, Archie Campbell, Jessica Tyrrell, Samuel E. Jones, Robin N. Beaumont, Andrew R. Wood, Marcus A. Tuke, Katherine S. Ruth, Anubha Mahajan, Anna Murray, Rachel M. Freathy, Michael N. Weedon, Andrew T. Hattersley, Caroline Hayward, Jürgen Machann, Hans-Ulrich Häring, Paul Franks, Renée de Mutsert, Ewan Pearson, Norbert Stefan, Timothy M. Frayling, Karla V. Allebrandt, Jimmy D. Bell, Alexandra I. Blakemore, Hanieh Yaghootkar
Journal: Diabetes
Diabetes 2019;68(1):207–219
https://doi.org/10.2337/db18-0708
Published: 23 October 2018
View article titled, Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension
Open the PDF for Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension in another window
Includes: Supplementary data
Meeting Abstracts

Genome-Wide and Abdominal Imaging Data Characterizes Common Alleles Associated with Higher BMI and Subcutaneous Fat but Less Liver Fat and Lower Risk of Type 2 Diabetes

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HANIEH YAGHOOTKAR, YINGJIE JI, ANDRIANOS M. YIORKAS, FRANCESCA FRAU, DENNIS MOOK-KANAMORI, RENÉE DE MUTSERT, JESSICA TYRRELL, SAMUEL E. JONES, ROBERT BEAUMONT, ANDREW R. WOOD, LOUISE THOMAS, KARLA V. ALLEBRANDT, NORBERT STEFAN, HARALD STAIGER, EWAN PEARSON, ALEX I. BLAKEMORE, JIMMY D. BELL, TIMOTHY M. FRAYLING
Journal: Diabetes
Diabetes 2018;67(Supplement_1):20-OR
https://doi.org/10.2337/db18-20-OR
Published: 01 July 2018
View article titled, Genome-Wide and Abdominal Imaging Data Characterizes Common Alleles Associated with Higher BMI and Subcutaneous Fat but Less Liver Fat and Lower Risk of Type 2 Diabetes