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Meeting Abstracts

1607-P: FGF1 Induces Glucokinase Upregulation and Increased Lactate Export in Mouse Hepatocytes

MORVARID KABIR, MARILYN ADER, NAREG THOMAS, EKIHIRO SEKI, RICHARD N. BERGMAN

Diabetes 2023;72(Supplement_1):1607-P

https://doi.org/10.2337/db23-1607-P

Published: 20 June 2023

View article titled, 1607-P: FGF1 Induces Glucokinase Upregulation and Increased Lactate Export in Mouse Hepatocytes

Meeting Abstracts

365-OR: A Machine-Learning Approach to Estimate Insulin Resistance from Untargeted Metabolomics Data

NICHOLETTE ALLRED, FANG-CHI HSU, SHYH-HUEI CHEN, MAGGIE NG, MARK O. GOODARZI, JEROME I. ROTTER, LYNNE E. WAGENKNECHT, MICHAEL BANCKS, RICHARD N. BERGMAN, DONALD W. BOWDEN

Diabetes 2023;72(Supplement_1):365-OR

https://doi.org/10.2337/db23-365-OR

Published: 20 June 2023

View article titled, 365-OR: A Machine-Learning Approach to Estimate Insulin Resistance from Untargeted Metabolomics Data

Meeting Abstracts

123-LB: Extended Fasting Reveals Effect of Canagliflozin to Mobilize Ketones in Canines

MARILYN ADER, RASHIN SEDIGHI, MORVARID KABIR, RICHARD N. BERGMAN

Diabetes 2022;71(Supplement_1):123-LB

https://doi.org/10.2337/db22-123-LB

Published: 01 June 2022

View article titled, 123-LB: Extended Fasting Reveals Effect of Canagliflozin to Mobilize Ketones in Canines

Meeting Abstracts

1342-P: Reduction of Glucokinase and Glucokinase Regulatory Protein Expression by siRNA Is Associated with the Reduction of Lactate and Pyruvate Export from Canine Hepatocytes

MORVARID KABIR, MARILYN ADER, RICHARD N. BERGMAN

Diabetes 2022;71(Supplement_1):1342-P

https://doi.org/10.2337/db22-1342-P

Published: 01 June 2022

View article titled, 1342-P: Reduction of Glucokinase and Glucokinase Regulatory Protein Expression by siRNA Is Associated with the Reduction of Lactate and Pyruvate Export from Canine Hepatocytes

Meeting Abstracts

1300-P: Novel Insulin Modified Oral Glucose Tolerance Test Improves the Estimation of Insulin Sensitivity and Glucose Effectiveness

DARKO STEFANOVSKI, FRANCESCA PICCININI, MARILYN ADER, MORVARID KABIR, RICHARD N. BERGMAN

Diabetes 2022;71(Supplement_1):1300-P

https://doi.org/10.2337/db22-1300-P

Published: 01 June 2022

View article titled, 1300-P: Novel Insulin Modified Oral Glucose Tolerance Test Improves the Estimation of Insulin Sensitivity and Glucose Effectiveness

Meeting Abstracts

120-OR: Dapagliflozin Increases Adiponectin and Its Receptors, and Reduces Inflammation and Ceramide Synthesis Enzymes in the Obese Prediabetic Dog

MORVARID KABIR, RICHARD N. BERGMAN, V. SASHI GOPAUL, HSIUCHIUNG YANG, CATHRYN M. KOLKA

Diabetes 2021;70(Supplement_1):120-OR

https://doi.org/10.2337/db21-120-OR

Published: 01 June 2021

View article titled, 120-OR: Dapagliflozin Increases Adiponectin and Its Receptors, and Reduces Inflammation and Ceramide Synthesis Enzymes in the Obese Prediabetic Dog

Meeting Abstracts

202-LB: Reduced Glucose Effectiveness Exacerbates Impaired Glucose Tolerance in Prediabetic Dogs

CATHRYN M. KOLKA, JAY PORTER, MARILYN ADER, RICHARD N. BERGMAN

Diabetes 2021;70(Supplement_1):202-LB

https://doi.org/10.2337/db21-202-LB

Published: 01 June 2021

View article titled, 202-LB: Reduced Glucose Effectiveness Exacerbates Impaired Glucose Tolerance in Prediabetic Dogs

Meeting Abstracts

1711-P: Dapagliflozin Promotes Adipose Beiging and Lipolysis and Reduces Adipocyte Size in the Obese Prediabetic Dog

MORVARID KABIR, RICHARD N. BERGMAN, FRANCESCA PICCININI, DARKO STEFANOVSKI, V. SASHI GOPAUL, HSIU-CHIUNG YANG, CATHRYN M. KOLKA

Diabetes 2020;69(Supplement_1):1711-P

https://doi.org/10.2337/db20-1711-P

Published: 01 June 2020

View article titled, 1711-P: Dapagliflozin Promotes Adipose Beiging and Lipolysis and Reduces Adipocyte Size in the Obese Prediabetic Dog

Meeting Abstracts

1951-P: Glucose Effectiveness Fails to Compensate for Insulin Resistance after Fat Feeding in Dogs

MARILYN ADER, CATHRYN M. KOLKA, RICHARD N. BERGMAN

Diabetes 2020;69(Supplement_1):1951-P

https://doi.org/10.2337/db20-1951-P

Published: 01 June 2020

View article titled, 1951-P: Glucose Effectiveness Fails to Compensate for Insulin Resistance after Fat Feeding in Dogs

Journal Articles

Erratum. Hypothesis: Role of Reduced Hepatic Insulin Clearance in the Pathogenesis of Type 2 Diabetes. Diabetes 2019;68: 1709–1716

Richard N. Bergman, Francesca Piccinini, Morvarid Kabir, Cathryn M. Kolka, Marilyn Ader

Diabetes 2019;68(12):2350

https://doi.org/10.2337/db19-er12a

Published: 09 October 2019

View article titled, Erratum. Hypothesis: Role of Reduced Hepatic Insulin Clearance in the Pathogenesis of Type 2 Diabetes. Diabetes 2019;68: 1709–1716

Journal Articles

Hypothesis: Role of Reduced Hepatic Insulin Clearance in the Pathogenesis of Type 2 Diabetes

Richard N. Bergman, Francesca Piccinini, Morvarid Kabir, Cathryn M. Kolka, Marilyn Ader

Diabetes 2019;68(9):1709–1716

https://doi.org/10.2337/db19-0098

Published: 14 August 2019

View article titled, Hypothesis: Role of Reduced Hepatic Insulin Clearance in the Pathogenesis of Type 2 Diabetes

Meeting Abstracts

149-LB: The MetAP2 Inhibitor, ZGN-1061, Improves Insulin Sensitivity and Beta-Cell Function in Patients with Type 2 Diabetes

ROSALIND FABUNMI, RICHARD N. BERGMAN, FRANCESCA PICCININI, TERRI KIM, DONGLIANG ZHUANG, KRISTIN TAYLOR, DENNIS D. KIM

Diabetes 2019;68(Supplement_1):149-LB

https://doi.org/10.2337/db19-149-LB

Published: 01 June 2019

View article titled, 149-LB: The MetAP2 Inhibitor, ZGN-1061, Improves Insulin Sensitivity and Beta-Cell Function in Patients with Type 2 Diabetes

Meeting Abstracts

1761-P: Brain-Restricted CB1-Receptor Antagonists Increase Oxygen Consumption Rate and Promote Beiging in 3T3-L1 Adipocytes Similar to Rimonabant Suggesting that Central Effects Can Be Avoided

REBECCA K. PASZKIEWICZ, RICHARD N. BERGMAN, AARON FRANK, ORISON O. WOOLCOTT, ROBERTA DE SOUZA SANTOS, MALINI S. IYER, DEBORAH CLEGG, MORVARID KABIR

Diabetes 2019;68(Supplement_1):1761-P

https://doi.org/10.2337/db19-1761-P

Published: 01 June 2019

View article titled, 1761-P: Brain-Restricted CB1-Receptor Antagonists Increase Oxygen Consumption Rate and Promote Beiging in 3T3-L1 Adipocytes Similar to Rimonabant Suggesting that Central Effects Can Be Avoided

Meeting Abstracts

1330-P: Ethnic Differences in Insulin Clearance: Relationship with Admixture Scores, Diet, and Physical Activity

FRANCESCA PICCININI, BARBARA GOWER, JOSE R. FERNANDEZ, RICHARD N. BERGMAN

Diabetes 2019;68(Supplement_1):1330-P

https://doi.org/10.2337/db19-1330-P

Published: 01 June 2019

View article titled, 1330-P: Ethnic Differences in Insulin Clearance: Relationship with Admixture Scores, Diet, and Physical Activity

Meeting Abstracts

1843-P: Reduced Sampling for the Estimation of Hepatic and Extrahepatic Insulin Clearance in Children of Different Ethnicities

FRANCESCA PICCININI, BARBARA GOWER, JOSE R. FERNANDEZ, RICHARD N. BERGMAN

Diabetes 2019;68(Supplement_1):1843-P

https://doi.org/10.2337/db19-1843-P

Published: 01 June 2019

View article titled, 1843-P: Reduced Sampling for the Estimation of Hepatic and Extrahepatic Insulin Clearance in Children of Different Ethnicities

Journal Articles

Peripheral Mechanisms Mediating the Sustained Antidiabetic Action of FGF1 in the Brain

Jarrad M. Scarlett, Kenjiro Muta, Jenny M. Brown, Jennifer M. Rojas, Miles E. Matsen, Nikhil K. Acharya, Anna Secher, Camilla Ingvorsen, Rasmus Jorgensen, Thomas Høeg-Jensen, Darko Stefanovski, Richard N. Bergman, Francesca Piccinini, Karl J. Kaiyala, Masakazu Shiota, Gregory J. Morton, Michael W. Schwartz

Diabetes 2019;68(3):654–664

https://doi.org/10.2337/db18-0498

Published: 06 December 2018

View article titled, Peripheral Mechanisms Mediating the Sustained Antidiabetic Action of FGF1 in the Brain

Includes: Supplementary data

Meeting Abstracts

Metabolic Clearance Rate of Insulin Is Not Saturable within the Physiological Range

ISAAC ASARE BEDIAKO, REBECCA L. PASZKIEWICZ, ORISON O. WOOLCOTT, RICHARD N. BERGMAN

Diabetes 2018;67(Supplement_1):1828-P

https://doi.org/10.2337/db18-1828-P

Published: 01 July 2018

View article titled, Metabolic Clearance Rate of Insulin Is Not Saturable within the Physiological Range

Meeting Abstracts

Ethnic Differences in Hepatic Insulin Clearance Seen since Childhood Suggest a Genetic Basis

FRANCESCA PICCININI, DAVID POLIDORI, BARBARA GOWER, JOSE R. FERNANDEZ, RICHARD N. BERGMAN

Diabetes 2018;67(Supplement_1):1844-P

https://doi.org/10.2337/db18-1844-P

Published: 01 July 2018

View article titled, Ethnic Differences in Hepatic Insulin Clearance Seen since Childhood Suggest a Genetic Basis

Meeting Abstracts

Metabolic Differences among Children of Different Ethnicities Are Magnified when Hepatic Insulin Extraction Is Included

FRANCESCA PICCININI, BARBARA GOWER, JOSE R. FERNANDEZ, RICHARD N. BERGMAN

Diabetes 2018;67(Supplement_1):1336-P

https://doi.org/10.2337/db18-1336-P

Published: 01 July 2018

View article titled, Metabolic Differences among Children of Different Ethnicities Are Magnified when Hepatic Insulin Extraction Is Included

Meeting Abstracts

Dapagliflozin Improves Insulin Sensitivity in the Obese Prediabetic Canine

REBECCA L. PASZKIEWICZ, RICHARD N. BERGMAN, ISAAC ASARE BEDIAKO, HASMIK J. MKRTCHYAN, V. SASHI GOPAUL, HSIU-CHIUNG YANG, EVA LUNDBORG, STELLA KIM, IVAN FORMENTINI, CATHRYN M. KOLKA

Diabetes 2018;67(Supplement_1):113-LB

https://doi.org/10.2337/db18-113-LB

Published: 01 July 2018

View article titled, Dapagliflozin Improves Insulin Sensitivity in the Obese Prediabetic Canine

NARROW

1607-P: FGF1 Induces Glucokinase Upregulation and Increased Lactate Export in Mouse Hepatocytes

365-OR: A Machine-Learning Approach to Estimate Insulin Resistance from Untargeted Metabolomics Data

123-LB: Extended Fasting Reveals Effect of Canagliflozin to Mobilize Ketones in Canines

1342-P: Reduction of Glucokinase and Glucokinase Regulatory Protein Expression by siRNA Is Associated with the Reduction of Lactate and Pyruvate Export from Canine Hepatocytes

1300-P: Novel Insulin Modified Oral Glucose Tolerance Test Improves the Estimation of Insulin Sensitivity and Glucose Effectiveness

120-OR: Dapagliflozin Increases Adiponectin and Its Receptors, and Reduces Inflammation and Ceramide Synthesis Enzymes in the Obese Prediabetic Dog

202-LB: Reduced Glucose Effectiveness Exacerbates Impaired Glucose Tolerance in Prediabetic Dogs

1711-P: Dapagliflozin Promotes Adipose Beiging and Lipolysis and Reduces Adipocyte Size in the Obese Prediabetic Dog

1951-P: Glucose Effectiveness Fails to Compensate for Insulin Resistance after Fat Feeding in Dogs

Erratum. Hypothesis: Role of Reduced Hepatic Insulin Clearance in the Pathogenesis of Type 2 Diabetes. Diabetes 2019;68: 1709–1716

Hypothesis: Role of Reduced Hepatic Insulin Clearance in the Pathogenesis of Type 2 Diabetes

149-LB: The MetAP2 Inhibitor, ZGN-1061, Improves Insulin Sensitivity and Beta-Cell Function in Patients with Type 2 Diabetes

1761-P: Brain-Restricted CB1-Receptor Antagonists Increase Oxygen Consumption Rate and Promote Beiging in 3T3-L1 Adipocytes Similar to Rimonabant Suggesting that Central Effects Can Be Avoided

1330-P: Ethnic Differences in Insulin Clearance: Relationship with Admixture Scores, Diet, and Physical Activity

1843-P: Reduced Sampling for the Estimation of Hepatic and Extrahepatic Insulin Clearance in Children of Different Ethnicities

Peripheral Mechanisms Mediating the Sustained Antidiabetic Action of FGF1 in the Brain

Metabolic Clearance Rate of Insulin Is Not Saturable within the Physiological Range

Ethnic Differences in Hepatic Insulin Clearance Seen since Childhood Suggest a Genetic Basis

Metabolic Differences among Children of Different Ethnicities Are Magnified when Hepatic Insulin Extraction Is Included

Dapagliflozin Improves Insulin Sensitivity in the Obese Prediabetic Canine

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