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Meeting Abstracts

78-OR: LRH-1/NR5A2 Agonism Triggers an Anti-Inflammatory Phenotypic Switch of Immune Cells from Patients with Type 1 Diabetes and Improves Islet Engraftment/Function

NADIA COBO-VUILLEUMIER, SILVIA RODRIGUEZ-FERNANDEZ, PETRA I. LORENZO, LIVIA LOPEZ, AKAITZ DORRONSORO, CHRISTIAN C. LACHAUD, LIDIA ALMENARA-FUENTES, MIREIA RAMOS-RODRÍGUEZ, ISABEL MERIDA, MANUEL AGUILAR-DIOSDADO, RITA NANO, SR., LORENZO PIEMONTI, LORENZO PASQUALI, FRANZ MARTIN, ISABEL GARCIA-SANCHEZ, MARIA ASUNCION MARTINEZ-BROCCA, MARTA VIVES-PI, BENOIT R. GAUTHIER
Journal: Diabetes
Diabetes 2022;71(Supplement_1):78-OR
https://doi.org/10.2337/db22-78-OR
Published: 01 June 2022
View articletitled, 78-OR: LRH-1/NR5A2 Agonism Triggers an Anti-Inflammatory Phenotypic Switch of Immune Cells from Patients with Type 1 Diabetes and Improves Islet Engraftment/Function
Journal Articles

Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes

Andrea Vecchione, Tatiana Jofra, Jolanda Gerosa, Kimberly Shankwitz, Roberta Di Fonte, Giuseppe Galvani, Elio Ippolito, Maria Pia Cicalese, Andrew R. Schultz, Howie R. Seay, Mariagrazia Favellato, Giulia Milardi, Angela Stabilini, Francesca Ragogna, Pauline Grogan, Eleonora Bianconi, Andrea Laurenzi, Amelia Caretto, Rita Nano, Raffaela Melzi, Nichole Danzl, Emanuele Bosi, Lorenzo Piemonti, Alessandro Aiuti, Todd Brusko, Constantinos Petrovas, Manuela Battaglia, Georgia Fousteri
Journal: Diabetes
Diabetes 2021;70(12):2892–2902
https://doi.org/10.2337/db21-0091
Published: 07 October 2021
View articletitled, Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes
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Journal Articles

Islets for Research: Nothing Is Perfect, but We Can Do Better

Rita Nano, Julie A. Kerr-Conte, Domenico Bosco, Marie Karlsson, Vanessa Lavallard, Raffaella Melzi, Valery Gmyr, Alessia Mercalli, Thierry Berney, François Pattou, Olle Korsgren, Lorenzo Piemonti
Journal: Diabetes
Diabetes 2019;68(8):1541–1543
https://doi.org/10.2337/db19-0367
Published: 15 July 2019
View articletitled, Islets for Research: Nothing Is Perfect, but We Can Do Better
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Journal Articles

Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion

Nicholas H.F. Fine, Craig L. Doig, Yasir S. Elhassan, Nicholas C. Vierra, Piero Marchetti, Marco Bugliani, Rita Nano, Lorenzo Piemonti, Guy A. Rutter, David A. Jacobson, Gareth G. Lavery, David J. Hodson
Journal: Diabetes
Diabetes 2018;67(2):278–290
https://doi.org/10.2337/db16-1356
Published: 04 December 2017
View articletitled, Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion
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Includes: Supplementary data
Journal Articles

Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity

Edward A. Phelps, Chiara Cianciaruso, Iacovos P. Michael, Miriella Pasquier, Jamil Kanaani, Rita Nano, Vanessa Lavallard, Nils Billestrup, Jeffrey A. Hubbell, Steinunn Baekkeskov
Journal: Diabetes
Diabetes 2016;65(9):2686–2699
https://doi.org/10.2337/db16-0180
Published: 09 June 2016
View articletitled, Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity
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Includes: Supplementary data
Journal Articles

RFamide Peptides 43RFa and 26RFa Both Promote Survival of Pancreatic β-Cells and Human Pancreatic Islets but Exert Opposite Effects on Insulin Secretion

Riccarda Granata, Fabio Settanni, Letizia Trovato, Davide Gallo, Iacopo Gesmundo, Rita Nano, Maria Pia Gallo, Loredana Bergandi, Marco Volante, Giuseppe Alloatti, Lorenzo Piemonti, Jérôme Leprince, Mauro Papotti, Hubert Vaudry, Huy Ong, Ezio Ghigo
Journal: Diabetes
Diabetes 2014;63(7):2380–2393
https://doi.org/10.2337/db13-1522
Published: 14 June 2014
View articletitled, RFamide Peptides 43RFa and 26RFa Both Promote Survival of Pancreatic β-Cells and Human Pancreatic Islets but Exert Opposite Effects on Insulin Secretion
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Journal Articles

Autologous Pancreatic Islet Transplantation in Human Bone Marrow. Diabetes 2013;62: 3523–3531

Paola Maffi, Gianpaolo Balzano, Maurilio Ponzoni, Rita Nano, Valeria Sordi, Raffaella Melzi, Alessia Mercalli, Marina Scavini, Antonio Esposito, Jacopo Peccatori, Elisa Cantarelli, Carlo Messina, Massimo Bernardi, Alessandro Del Maschio, Carlo Staudacher, Claudio Doglioni, Fabio Ciceri, Antonio Secchi, Lorenzo Piemonti
Journal: Diabetes
Diabetes 2014;63(1):377
https://doi.org/10.2337/db14-er01
Published: 13 December 2013
View articletitled, Autologous Pancreatic Islet Transplantation in Human Bone Marrow. Diabetes 2013;62: 3523–3531
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Journal Articles

Autologous Pancreatic Islet Transplantation in Human Bone Marrow

Paola Maffi, Gianpaolo Balzano, Maurilio Ponzoni, Rita Nano, Valeria Sordi, Raffaella Melzi, Alessia Mercalli, Marina Scavini, Antonio Esposito, Jacopo Peccatori, Elisa Cantarelli, Carlo Messina, Massimo Bernardi, Alessandro Del Maschio, Carlo Staudacher, Claudio Doglioni, Fabio Ciceri, Antonio Secchi, Lorenzo Piemonti
Journal: Diabetes
Diabetes 2013;62(10):3523–3531
https://doi.org/10.2337/db13-0465
Published: 17 September 2013
View articletitled, Autologous Pancreatic Islet Transplantation in Human Bone Marrow
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Includes: Supplementary data
Journal Articles

Alloantibody and Autoantibody Monitoring Predicts Islet Transplantation Outcome in Human Type 1 Diabetes

Lorenzo Piemonti, Matthew J. Everly, Paola Maffi, Marina Scavini, Francesca Poli, Rita Nano, Massimo Cardillo, Raffaella Melzi, Alessia Mercalli, Valeria Sordi, Vito Lampasona, Alejandro Espadas de Arias, Mario Scalamogna, Emanuele Bosi, Ezio Bonifacio, Antonio Secchi, Paul I. Terasaki
Journal: Diabetes
Diabetes 2013;62(5):1656–1664
https://doi.org/10.2337/db12-1258
Published: 16 April 2013
View articletitled, Alloantibody and Autoantibody Monitoring Predicts Islet Transplantation Outcome in Human Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients With Type 1 Diabetes

Alessandra Ferraro, Carlo Socci, Angela Stabilini, Andrea Valle, Paolo Monti, Lorenzo Piemonti, Rita Nano, Sven Olek, Paola Maffi, Marina Scavini, Antonio Secchi, Carlo Staudacher, Ezio Bonifacio, Manuela Battaglia
Journal: Diabetes
Diabetes 2011;60(11):2903–2913
https://doi.org/10.2337/db11-0090
Published: 17 October 2011
View articletitled, Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients With Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Obestatin Promotes Survival of Pancreatic β-Cells and Human Islets and Induces Expression of Genes Involved in the Regulation of β-Cell Mass and Function

Riccarda Granata, Fabio Settanni, Davide Gallo, Letizia Trovato, Luigi Biancone, Vincenzo Cantaluppi, Rita Nano, Marta Annunziata, Pietro Campiglia, Elisa Arnoletti, Corrado Ghè, Marco Volante, Mauro Papotti, Giampiero Muccioli, Ezio Ghigo
Journal: Diabetes
Diabetes 2008;57(4):967–979
https://doi.org/10.2337/db07-1104
Published: 01 April 2008
View articletitled, Obestatin Promotes Survival of Pancreatic β-Cells and Human Islets and Induces Expression of Genes Involved in the Regulation of β-Cell Mass and Function
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Journal Articles

Human Pancreatic Islets Produce and Secrete MCP-1/CCL2: Relevance in Human Islet Transplantation

Lorenzo Piemonti, Biagio Eugenio Leone, Rita Nano, Alessandra Saccani, Paolo Monti, Paola Maffi, Giancarlo Bianchi, Antonio Sica, Giuseppe Peri, Raffaella Melzi, Luca Aldrighetti, Antonio Secchi, Valerio Di Carlo, Paola Allavena, Federico Bertuzzi
Journal: Diabetes
Diabetes 2002;51(1):55–65
https://doi.org/10.2337/diabetes.51.1.55
Published: 01 January 2002
View articletitled, Human Pancreatic Islets Produce and Secrete MCP-1/CCL2: Relevance in Human Islet Transplantation
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Journal Articles

High Glucose Causes Apoptosis in Cultured Human Pancreatic Islets of Langerhans: A Potential Role for Regulation of Specific Bcl Family Genes Toward an Apoptotic Cell Death Program

Massimo Federici, Marta Hribal, Lucia Perego, Marco Ranalli, Zaira Caradonna, Carla Perego, Luciana Usellini, Rita Nano, Paolo Bonini, Federico Bertuzzi, Lionel N.J.L. Marlier, Alberto M. Davalli, Orazio Carandente, Antonio E. Pontiroli, Gerry Melino, Piero Marchetti, Renato Lauro, Giorgio Sesti, Franco Folli
Journal: Diabetes
Diabetes 2001;50(6):1290–1301
https://doi.org/10.2337/diabetes.50.6.1290
Published: 01 June 2001
View articletitled, High Glucose Causes Apoptosis in Cultured Human Pancreatic Islets of Langerhans: A Potential Role for Regulation of Specific Bcl Family Genes Toward an Apoptotic Cell Death Program
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