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Journal Articles

Loss of Glomerular Permselectivity in Type 2 Diabetes Associates With Progression to Kidney Failure

Pierre J. Saulnier, Helen C. Looker, Anita Layton, Kevin V. Lemley, Robert G. Nelson, Petter Bjornstad

Diabetes 2023;72(11):1682–1691

https://doi.org/10.2337/db23-0310

Published: 16 August 2023

View article titled, Loss of Glomerular Permselectivity in Type 2 Diabetes Associates With Progression to Kidney Failure

Meeting Abstracts

406-P: Spatial Metabolomics of Human Kidney Tissues Reveal Impaired Tricarboxylic Acid (TCA) Cycle Turnover in Type 1 Diabetes (T1D)

Diabetes 2023;72(Supplement_1):406-P

https://doi.org/10.2337/db23-406-P

Published: 20 June 2023

View article titled, 406-P: Spatial Metabolomics of Human Kidney Tissues Reveal Impaired Tricarboxylic Acid (TCA) Cycle Turnover in Type 1 Diabetes (T1D)

Meeting Abstracts

1148-P: Glycoprotein Acetyls (GlycA) Associate with Intraglomerular Hemodynamic Dysfunction, Albuminuria, Central Adiposity, and Insulin Resistance (IR) in Youth with Type 1 Diabetes (T1D)

TRENTON REINICKE, ALYSSA CALDWELL-MCGEE, CARISSA BIRZNIEKS, DIEGO CARRASCO, M. LOREDANA MARCOVECCHIO, KRISTEN J. NADEAU, KALIE L. TOMMERDAHL, MEGHAN E. PAULEY, JANET K. SNELL-BERGEON, SUSAN GROSS, DAVID CHERNEY, TIMOTHY B. VIGERS, LAURA PYLE, LYNETTE DRISCOLL, FARID H. MAHMUD, ALLISON DART, MEDA E. PAVKOV, ROBERT G. NELSON, PETTER BJORNSTAD

Diabetes 2023;72(Supplement_1):1148-P

https://doi.org/10.2337/db23-1148-P

Published: 20 June 2023

View article titled, 1148-P: Glycoprotein Acetyls (GlycA) Associate with Intraglomerular Hemodynamic Dysfunction, Albuminuria, Central Adiposity, and Insulin Resistance (IR) in Youth with Type 1 Diabetes (T1D)

Meeting Abstracts

1159-P: Impaired Insulin Sensitivity Relates to Preclinical Biomarkers of Neurodegenerative Disease in Young Adults With and Without Type 1 Diabetes (T1D)

ALLISON SHAPIRO, CHRISTINA COUGHLAN, CARISSA VINOVSKIS, TIMOTHY B. VIGERS, MEGHAN E. PAULEY, JANET K. SNELL-BERGEON, ALEXIS A. MACDONALD, KALIE L. TOMMERDAHL, DANIËL VAN RAALTE, IAN DE BOER, ROBERT G. NELSON, LAURA PYLE, KRISTEN J. NADEAU, PETTER BJORNSTAD

Diabetes 2023;72(Supplement_1):1159-P

https://doi.org/10.2337/db23-1159-P

Published: 20 June 2023

View article titled, 1159-P: Impaired Insulin Sensitivity Relates to Preclinical Biomarkers of Neurodegenerative Disease in Young Adults With and Without Type 1 Diabetes (T1D)

Meeting Abstracts

9-OR: Insulin Resistance (IR) and Kidney Oxidative Metabolism in People with Type 1 Diabetes (T1D)

Diabetes 2023;72(Supplement_1):9-OR

https://doi.org/10.2337/db23-9-OR

Published: 20 June 2023

View article titled, 9-OR: Insulin Resistance (IR) and Kidney Oxidative Metabolism in People with Type 1 Diabetes (T1D)

Meeting Abstracts

319-OR: Effect of Vertical Sleeve Gastrectomy (VSG) on the Kidney Transcriptome of Youth with Type 2 Diabetes (T2D)

Diabetes 2023;72(Supplement_1):319-OR

https://doi.org/10.2337/db23-319-OR

Published: 20 June 2023

View article titled, 319-OR: Effect of Vertical Sleeve Gastrectomy (VSG) on the Kidney Transcriptome of Youth with Type 2 Diabetes (T2D)

Meeting Abstracts

317-OR: Metabolomic Analyses Identify Novel Predictors of Diabetic Kidney Disease in Youth-Onset Type 2 Diabetes

LAURA PYLE, TIMOTHY B. VIGERS, LAURE EL GHORMLI, IAN DE BOER, ROBERT G. NELSON, SUSHRUT WAIKAR, HIDDO L. HEERSPINK, NEIL WHITE, KALIE L. TOMMERDAHL, LORI M. LAFFEL, AMY S. SHAH, KIMBERLY DREWS, JUSTIN R. RYDER, ROSE GUBITOSI-KLUG, KUMAR SHARMA, PETTER BJORNSTAD

Diabetes 2023;72(Supplement_1):317-OR

https://doi.org/10.2337/db23-317-OR

Published: 20 June 2023

View article titled, 317-OR: Metabolomic Analyses Identify Novel Predictors of Diabetic Kidney Disease in Youth-Onset Type 2 Diabetes

Meeting Abstracts

316-OR: ADA Presidents' Select Abstract: Structural Lesions on Kidney Biopsy in Youth-Onset Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D)

VIJI NAIR, ABHIJIT NAIK, FADHL ALAKWAA, JENNIFER A. SCHAUB, TIMOTHY B. VIGERS, MARKUS BITZER, LAURA PYLE, FRANK C. BROSIUS, III, PATRICIA E. LADD, VIRAL SHAH, KALIE L. TOMMERDAHL, KUMAR SHARMA, IAN DE BOER, PIERRE-JEAN SAULNIER, HELEN C. LOOKER, ROBERT G. NELSON, JEFFREY B. HODGIN, PETTER BJORNSTAD

Diabetes 2023;72(Supplement_1):316-OR

https://doi.org/10.2337/db23-316-OR

Published: 20 June 2023

View article titled, 316-OR: ADA Presidents' Select Abstract: Structural Lesions on Kidney Biopsy in Youth-Onset Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D)

Meeting Abstracts

1095-P: Proteomic Analyses Identify Novel Predictors of Loss of Glycemic Control in Youth-Onset Type 2 Diabetes

TIMOTHY B. VIGERS, LAURE EL GHORMLI, IAN DE BOER, ROBERT G. NELSON, KUMAR SHARMA, SUSHRUT WAIKAR, HIDDO L. HEERSPINK, NEIL WHITE, KALIE L. TOMMERDAHL, LORI M. LAFFEL, AMY S. SHAH, KIMBERLY DREWS, JUSTIN R. RYDER, ROSE GUBITOSI-KLUG, PETTER BJORNSTAD, LAURA PYLE

Diabetes 2023;72(Supplement_1):1095-P

https://doi.org/10.2337/db23-1095-P

Published: 20 June 2023

View article titled, 1095-P: Proteomic Analyses Identify Novel Predictors of Loss of Glycemic Control in Youth-Onset Type 2 Diabetes

Meeting Abstracts

194-OR: Lower Insulin Sensitivity before the Onset of Type 2 Diabetes Is Associated with Increased Risk of Albuminuria after Diabetes Onset

MEEAH R. WILLIG, EMMA J. STINSON, HELEN C. LOOKER, CASSIE M. MITCHELL, ROBERT L. HANSON, ROBERT G. NELSON, JONATHAN KRAKOFF, DOUGLAS C. CHANG

Diabetes 2023;72(Supplement_1):194-OR

https://doi.org/10.2337/db23-194-OR

Published: 20 June 2023

View article titled, 194-OR: Lower Insulin Sensitivity before the Onset of Type 2 Diabetes Is Associated with Increased Risk of Albuminuria after Diabetes Onset

Meeting Abstracts

286-OR: Using iPSC-Derived Islets to Model the Effect of an ABCC8 Arg1420His Mutation in Fetal and Adult Islets

ANUP K. NAIR, KATIYA BARKHO, MICHAEL TRAURIG, ROBERT G. NELSON, CLIFTON BOGARDUS, III, LESLIE BAIER

Diabetes 2023;72(Supplement_1):286-OR

https://doi.org/10.2337/db23-286-OR

Published: 20 June 2023

View article titled, 286-OR: Using iPSC-Derived Islets to Model the Effect of an ABCC8 Arg1420His Mutation in Fetal and Adult Islets

Meeting Abstracts

390-P: Adipose Insulin Resistance Relates to Perturbed Renal Hemodynamics in Obese Youth with and without Type 2 Diabetes

CARSON PLATNICK, POTTUMARTHI V. PRASAD, LU-PING LI, LAURA PYLE, ROBERT G. NELSON, DANIËL VAN RAALTE, KRISTEN J. NADEAU, PETTER BJORNSTAD

Diabetes 2022;71(Supplement_1):390-P

https://doi.org/10.2337/db22-390-P

Published: 01 June 2022

View article titled, 390-P: Adipose Insulin Resistance Relates to Perturbed Renal Hemodynamics in Obese Youth with and without Type 2 Diabetes

Meeting Abstracts

404-P: Relationships among Triglyceride (TG) Concentrations across Lipoprotein Subclasses, Intraglomerular Hemodynamics, and Kidney Oxygen Availability in Adolescents with Type 1 Diabetes (T1D)

MEGHAN E. PAULEY, KALIE L. TOMMERDAHL, CARISSA VINOVSKIS, LAURA PYLE, R. PAUL WADWA, ROBERT G. NELSON, KRISTEN J. NADEAU, PETTER BJORNSTAD

Diabetes 2022;71(Supplement_1):404-P

https://doi.org/10.2337/db22-404-P

Published: 01 June 2022

View article titled, 404-P: Relationships among Triglyceride (TG) Concentrations across Lipoprotein Subclasses, Intraglomerular Hemodynamics, and Kidney Oxygen Availability in Adolescents with Type 1 Diabetes (T1D)

Meeting Abstracts

301-OR: Modeling the Type 2 Diabetes–Associated ABCC8 Arg1420 His Mutation using iPSC–Derived Pancreatic Islet-Like Cells

ANUP K. NAIR, MICHAEL TRAURIG, JEFF SUTHERLAND, ROBERT G. NELSON, CLIFTON BOGARDUS, III, LESLIE BAIER

Diabetes 2022;71(Supplement_1):301-OR

https://doi.org/10.2337/db22-301-OR

Published: 01 June 2022

View article titled, 301-OR: Modeling the Type 2 Diabetes–Associated ABCC8 Arg1420 His Mutation using iPSC–Derived Pancreatic Islet-Like Cells

Journal Articles

Pima Indian Contributions to Our Understanding of Diabetic Kidney Disease

Robert G. Nelson, William C. Knowler, Matthias Kretzler, Kevin V. Lemley, Helen C. Looker, Michael Mauer, William E. Mitch, Behzad Najafian, Peter H. Bennett

Diabetes 2021;70(8):1603–1616

https://doi.org/10.2337/dbi20-0043

Published: 13 August 2021

View article titled, Pima Indian Contributions to Our Understanding of Diabetic Kidney Disease

Journal Articles

Intraglomerular Dysfunction Predicts Kidney Failure in Type 2 Diabetes

Pierre J. Saulnier, Helen C. Looker, Michael Mauer, Behzad Najafian, Elise Gand, Stephanie Ragot, Robert G. Nelson, Petter Bjornstad

Diabetes 2021;70(10):2344–2352

https://doi.org/10.2337/db21-0154

Published: 13 July 2021

View article titled, Intraglomerular Dysfunction Predicts Kidney Failure in Type 2 Diabetes

Meeting Abstracts

184-OR: Youth-Onset (YO) Type 2 Diabetes (T2D) Is Associated with More Severe Structural Lesions on Kidney Biopsy than Adult-Onset (AO) T2D

HELEN C. LOOKER, CAMERON SEVERN, TIMOTHY B. VIGERS, LAURA PYLE, PIERRE-JEAN SAULNIER, BEHZAD NAJAFIAN, MICHAEL MAUER, ROBERT G. NELSON, PETTER BJORNSTAD

Diabetes 2021;70(Supplement_1):184-OR

https://doi.org/10.2337/db21-184-OR

Published: 01 June 2021

View article titled, 184-OR: Youth-Onset (YO) Type 2 Diabetes (T2D) Is Associated with More Severe Structural Lesions on Kidney Biopsy than Adult-Onset (AO) T2D

Journal Articles

Relative Hypoxia and Early Diabetic Kidney Disease in Type 1 Diabetes

Carissa Vinovskis, Lu-Ping Li, Pottumarthi Prasad, Kalie Tommerdahl, Laura Pyle, Robert G. Nelson, Meda E. Pavkov, Daniel van Raalte, Marian Rewers, Marlon Pragnell, Farid H. Mahmud, David Z. Cherney, Richard J. Johnson, Kristen J. Nadeau, Petter Bjornstad

Diabetes 2020;69(12):2700–2708

https://doi.org/10.2337/db20-0457

Published: 31 July 2020

View article titled, Relative Hypoxia and Early Diabetic Kidney Disease in Type 1 Diabetes

Meeting Abstracts

302-OR: ADA Presidents’ Select Abstract: The Balance of Vascular Tone in the Afferent (RA) and Efferent (RE) Arterioles Associates with Diabetic Kidney Lesions and Predicts Progression to End Stage Kidney Disease (ESKD) in Type 2 Diabetes (T2D)

PIERRE-JEAN SAULNIER, HELEN C. LOOKER, MICHAEL MAUER, ROBERT G. NELSON, PETTER BJORNSTAD

Diabetes 2020;69(Supplement_1):302-OR

https://doi.org/10.2337/db20-302-OR

Published: 01 June 2020

View article titled, 302-OR: ADA Presidents’ Select Abstract: The Balance of Vascular Tone in the Afferent (RA) and Efferent (RE) Arterioles Associates with Diabetic Kidney Lesions and Predicts Progression to End Stage Kidney Disease (ESKD) in Type 2 Diabetes (T2D)

Meeting Abstracts

1653-P: Association between Genetic Admixture Estimates for Five Ancestral Populations and Diabetes-Related Traits in Pacific Islanders

WEN-CHI HSUEH, PANKAJ KUMAR, SAIED SAFABAKHSH, LOIS JONES, JOANNE CURRAN, WILLIAM C. KNOWLER, ROBERT G. NELSON, ROBERT L. HANSON

Diabetes 2020;69(Supplement_1):1653-P

https://doi.org/10.2337/db20-1653-P

Published: 01 June 2020

View article titled, 1653-P: Association between Genetic Admixture Estimates for Five Ancestral Populations and Diabetes-Related Traits in Pacific Islanders

NARROW

Loss of Glomerular Permselectivity in Type 2 Diabetes Associates With Progression to Kidney Failure

406-P: Spatial Metabolomics of Human Kidney Tissues Reveal Impaired Tricarboxylic Acid (TCA) Cycle Turnover in Type 1 Diabetes (T1D)

1148-P: Glycoprotein Acetyls (GlycA) Associate with Intraglomerular Hemodynamic Dysfunction, Albuminuria, Central Adiposity, and Insulin Resistance (IR) in Youth with Type 1 Diabetes (T1D)

1159-P: Impaired Insulin Sensitivity Relates to Preclinical Biomarkers of Neurodegenerative Disease in Young Adults With and Without Type 1 Diabetes (T1D)

9-OR: Insulin Resistance (IR) and Kidney Oxidative Metabolism in People with Type 1 Diabetes (T1D)

319-OR: Effect of Vertical Sleeve Gastrectomy (VSG) on the Kidney Transcriptome of Youth with Type 2 Diabetes (T2D)

317-OR: Metabolomic Analyses Identify Novel Predictors of Diabetic Kidney Disease in Youth-Onset Type 2 Diabetes

316-OR: ADA Presidents' Select Abstract: Structural Lesions on Kidney Biopsy in Youth-Onset Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D)

1095-P: Proteomic Analyses Identify Novel Predictors of Loss of Glycemic Control in Youth-Onset Type 2 Diabetes

194-OR: Lower Insulin Sensitivity before the Onset of Type 2 Diabetes Is Associated with Increased Risk of Albuminuria after Diabetes Onset

286-OR: Using iPSC-Derived Islets to Model the Effect of an ABCC8 Arg1420His Mutation in Fetal and Adult Islets

390-P: Adipose Insulin Resistance Relates to Perturbed Renal Hemodynamics in Obese Youth with and without Type 2 Diabetes

404-P: Relationships among Triglyceride (TG) Concentrations across Lipoprotein Subclasses, Intraglomerular Hemodynamics, and Kidney Oxygen Availability in Adolescents with Type 1 Diabetes (T1D)

301-OR: Modeling the Type 2 Diabetes–Associated ABCC8 Arg1420 His Mutation using iPSC–Derived Pancreatic Islet-Like Cells

Pima Indian Contributions to Our Understanding of Diabetic Kidney Disease

Intraglomerular Dysfunction Predicts Kidney Failure in Type 2 Diabetes

184-OR: Youth-Onset (YO) Type 2 Diabetes (T2D) Is Associated with More Severe Structural Lesions on Kidney Biopsy than Adult-Onset (AO) T2D

Relative Hypoxia and Early Diabetic Kidney Disease in Type 1 Diabetes

302-OR: ADA Presidents’ Select Abstract: The Balance of Vascular Tone in the Afferent (RA) and Efferent (RE) Arterioles Associates with Diabetic Kidney Lesions and Predicts Progression to End Stage Kidney Disease (ESKD) in Type 2 Diabetes (T2D)

1653-P: Association between Genetic Admixture Estimates for Five Ancestral Populations and Diabetes-Related Traits in Pacific Islanders

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