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Robert K. Semple
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Journal Articles

Anti-Insulin Receptor Antibodies Improve Hyperglycemia in a Mouse Model of Human Insulin Receptoropathy

Free
Gemma V. Brierley, Hannah Webber, Eerika Rasijeff, Sarah Grocott, Kenneth Siddle, Robert K. Semple
Journal: Diabetes
Diabetes 2020;69(11):2481–2489
https://doi.org/10.2337/db20-0345
Published: 17 August 2020
View article titled, Anti-Insulin Receptor Antibodies Improve Hyperglycemia in a Mouse Model of Human Insulin Receptoropathy
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Journal Articles

A Pharmacogenetic Approach to the Treatment of Patients With PPARG Mutations

Free
Maura Agostini, Erik Schoenmakers, Junaid Beig, Louise Fairall, Istvan Szatmari, Odelia Rajanayagam, Frederick W. Muskett, Claire Adams, A. David Marais, Stephen O’Rahilly, Robert K. Semple, Laszlo Nagy, Amit R. Majithia, John W.R. Schwabe, Dirk J. Blom, Rinki Murphy, Krishna Chatterjee, David B. Savage
Journal: Diabetes
Diabetes 2018;67(6):1086–1092
https://doi.org/10.2337/db17-1236
Published: 05 April 2018
View article titled, A Pharmacogenetic Approach to the Treatment of Patients With PPARG Mutations
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Includes: Supplementary data
Journal Articles

Genetic Evidence for a Normal-Weight “Metabolically Obese” Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes

Free
Hanieh Yaghootkar, Robert A. Scott, Charles C. White, Weihua Zhang, Elizabeth Speliotes, Patricia B. Munroe, Georg B. Ehret, Joshua C. Bis, Caroline S. Fox, Mark Walker, Ingrid B. Borecki, Joshua W. Knowles, Laura Yerges-Armstrong, Claes Ohlsson, John R.B. Perry, John C. Chambers, Jaspal S. Kooner, Nora Franceschini, Claudia Langenberg, Marie-France Hivert, Zari Dastani, J. Brent Richards, Robert K. Semple, Timothy M. Frayling
Journal: Diabetes
Diabetes 2014;63(12):4369–4377
https://doi.org/10.2337/db14-0318
Published: 13 November 2014
View article titled, Genetic Evidence for a Normal-Weight “Metabolically Obese” Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes
Open the PDF for Genetic Evidence for a Normal-Weight “Metabolically Obese” Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes in another window
Includes: Supplementary data
Journal Articles

Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity

Free
Robert A. Scott, Tove Fall, Dorota Pasko, Adam Barker, Stephen J. Sharp, Larraitz Arriola, Beverley Balkau, Aurelio Barricarte, Inês Barroso, Heiner Boeing, Françoise Clavel-Chapelon, Francesca L. Crowe, Jacqueline M. Dekker, Guy Fagherazzi, Ele Ferrannini, Nita G. Forouhi, Paul W. Franks, Diana Gavrila, Vilmantas Giedraitis, Sara Grioni, Leif C. Groop, Rudolf Kaaks, Timothy J. Key, Tilman Kühn, Luca A. Lotta, Peter M. Nilsson, Kim Overvad, Domenico Palli, Salvatore Panico, J. Ramón Quirós, Olov Rolandsson, Nina Roswall, Carlotta Sacerdote, Núria Sala, María-José Sánchez, Matthias B. Schulze, Afshan Siddiq, Nadia Slimani, Ivonne Sluijs, Annemieke M.W. Spijkerman, Anne Tjonneland, Rosario Tumino, Daphne L. van der A, Hanieh Yaghootkar, The RISC Study Group, The EPIC-InterAct Consortium, Mark I. McCarthy, Robert K. Semple, Elio Riboli, Mark Walker, Erik Ingelsson, Tim M. Frayling, David B. Savage, Claudia Langenberg, Nicholas J. Wareham
Journal: Diabetes
Diabetes 2014;63(12):4378–4387
https://doi.org/10.2337/db14-0319
Published: 13 November 2014
View article titled, Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity
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Includes: Supplementary data
Journal Articles

Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes

Open Access
Hanieh Yaghootkar, Claudia Lamina, Robert A. Scott, Zari Dastani, Marie-France Hivert, Liling L. Warren, Alena Stancáková, Sarah G. Buxbaum, Leo-Pekka Lyytikäinen, Peter Henneman, Ying Wu, Chloe Y.Y. Cheung, James S. Pankow, Anne U. Jackson, Stefan Gustafsson, Jing Hua Zhao, Christie M. Ballantyne, Weijia Xie, Richard N. Bergman, Michael Boehnke, Fatiha el Bouazzaoui, Francis S. Collins, Sandra H. Dunn, Josee Dupuis, Nita G. Forouhi, Christopher Gillson, Andrew T. Hattersley, Jaeyoung Hong, Mika Kähönen, Johanna Kuusisto, Lyudmyla Kedenko, Florian Kronenberg, Alessandro Doria, Themistocles L. Assimes, Ele Ferrannini, Torben Hansen, Ke Hao, Hans Häring, Joshua W. Knowles, Cecilia M. Lindgren, John J. Nolan, Jussi Paananen, Oluf Pedersen, Thomas Quertermous, Ulf Smith, the GENESIS Consortium, the RISC Consortium, Terho Lehtimäki, Ching-Ti Liu, Ruth J.F. Loos, Mark I. McCarthy, Andrew D. Morris, Ramachandran S. Vasan, Tim D. Spector, Tanya M. Teslovich, Jaakko Tuomilehto, Ko Willems van Dijk, Jorma S. Viikari, Na Zhu, Claudia Langenberg, Erik Ingelsson, Robert K. Semple, Alan R. Sinaiko, Colin N.A. Palmer, Mark Walker, Karen S.L. Lam, Bernhard Paulweber, Karen L. Mohlke, Cornelia van Duijn, Olli T. Raitakari, Aurelian Bidulescu, Nick J. Wareham, Markku Laakso, Dawn M. Waterworth, Debbie A. Lawlor, James B. Meigs, J. Brent Richards, Timothy M. Frayling
Journal: Diabetes
Diabetes 2013;62(10):3589–3598
https://doi.org/10.2337/db13-0128
Published: 17 September 2013
View article titled, Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes
Open the PDF for Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes in another window
Includes: Supplementary data
Journal Articles

Genetic Defects in Human Pericentrin Are Associated With Severe Insulin Resistance and Diabetes

Open Access
Isabel Huang-Doran, Louise S. Bicknell, Francis M. Finucane, Nuno Rocha, Keith M. Porter, Y.C. Loraine Tung, Ferenc Szekeres, Anna Krook, John J. Nolan, Mark O’Driscoll, Michael Bober, Stephen O’Rahilly, Andrew P. Jackson, Robert K. Semple, for the Majewski Osteodysplastic Primordial Dwarfism Study Group
Journal: Diabetes
Diabetes 2011;60(3):925–935
https://doi.org/10.2337/db10-1334
Published: 21 February 2011
View article titled, Genetic Defects in Human Pericentrin Are Associated With Severe Insulin Resistance and Diabetes
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Includes: Supplementary data
Journal Articles

The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation

Free
Victoria A. Payne, Neil Grimsey, Antoinette Tuthill, Sam Virtue, Sarah L. Gray, Edoardo Dalla Nora, Robert K. Semple, Stephen O'Rahilly, Justin J. Rochford
Journal: Diabetes
Diabetes 2008;57(8):2055–2060
https://doi.org/10.2337/db08-0184
Published: 01 August 2008
View article titled, The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation
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Includes: Supplementary data
Journal Articles

Paradoxical Elevation of High–Molecular Weight Adiponectin in Acquired Extreme Insulin Resistance Due to Insulin Receptor Antibodies

Free
Robert K. Semple, Nils H. Halberg, Keith Burling, Maria A. Soos, Todd Schraw, Jian'an Luan, Elaine K. Cochran, David B. Dunger, Nicholas J. Wareham, Philipp E. Scherer, Phillip Gorden, Stephen O'Rahilly
Journal: Diabetes
Diabetes 2007;56(6):1712–1717
https://doi.org/10.2337/db06-1665
Published: 01 June 2007
View article titled, Paradoxical Elevation of High–Molecular Weight Adiponectin in Acquired Extreme Insulin Resistance Due to Insulin Receptor Antibodies
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Journal Articles

Analysis of Genetic Variation in Akt2/PKB-β in Severe Insulin Resistance, Lipodystrophy, Type 2 Diabetes, and Related Metabolic Phenotypes

Free
Karen Tan, Wendy A. Kimber, Jian’an Luan, Maria A. Soos, Robert K. Semple, Nicholas J. Wareham, Stephen O’Rahilly, Inês Barroso
Journal: Diabetes
Diabetes 2007;56(3):714–719
https://doi.org/10.2337/db06-0921
Published: 01 March 2007
View article titled, Analysis of Genetic Variation in Akt2/PKB-β in Severe Insulin Resistance, Lipodystrophy, Type 2 Diabetes, and Related Metabolic Phenotypes
Open the PDF for Analysis of Genetic Variation in Akt2/PKB-β in Severe Insulin Resistance, Lipodystrophy, Type 2 Diabetes, and Related Metabolic Phenotypes in another window
Includes: Supplementary data