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Journal Articles

Atf4 Protects Islet β-Cell Identity and Function Under Acute Glucose-Induced Stress but Promotes β-Cell Failure in the Presence of Free Fatty Acid

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Mahircan Yagan, Sadia Najam, Ruiying Hu, Yu Wang, Mathew T. Dickerson, Prasanna K. Dadi, Yanwen Xu, Alan J. Simmons, Roland Stein, Christopher M. Adams, David A. Jacobson, Ken S. Lau, Qi Liu, Guoqiang Gu
Journal: Diabetes
Diabetes 2025;74(5):838–849
https://doi.org/10.2337/db24-0360
Published: 03 February 2025
View articletitled, Atf4 Protects Islet β-Cell Identity and Function Under Acute Glucose-Induced Stress but Promotes β-Cell Failure in the Presence of Free Fatty Acid
Open the PDF for Atf4 Protects Islet β-Cell Identity and Function Under Acute Glucose-Induced Stress but Promotes β-Cell Failure in the Presence of Free Fatty Acid in another window
Meeting Abstracts

1767-P: A Modifying Effect of Genetic Background on S64F MAFA-Induced Dysglycemia

Free
ZACHARY LOYD, DONGSOO LEE, MIN GUO, ROLAND STEIN, JEEYEON CHA
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1767-P
https://doi.org/10.2337/db24-1767-P
Published: 14 June 2024
View articletitled, 1767-P: A Modifying Effect of Genetic Background on S64F MAFA-Induced Dysglycemia
Meeting Abstracts

290-OR: Acetylation Induces a SUMOylation–Phosphorylation Switch to Enhance MafA Transactivation

Free
MARGOT CHIRIKJIAN, JIANI Z. LIANG, ALBERTO BARTOLOMÉ, RAJESH SONI, ROLAND STEIN, UPTAL PAJVANI
Journal: Diabetes
Diabetes 2024;73(Supplement_1):290-OR
https://doi.org/10.2337/db24-290-OR
Published: 14 June 2024
View articletitled, 290-OR: Acetylation Induces a SUMOylation–Phosphorylation Switch to Enhance MafA Transactivation
Meeting Abstracts

1742-P: Loss of MAFB Compromises a-Cell Identity and Glucagon Secretion in Adult Human Islets

Free
KATIE C. COATE, XIN TONG, JIN-HUA LIU, REGINA JENKINS, RADHIKA ARAMANDLA, NANDITA DEY, SEUNG KIM, MARCELA BRISSOVA, ALVIN C. POWERS, ROLAND STEIN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1742-P
https://doi.org/10.2337/db23-1742-P
Published: 20 June 2023
View articletitled, 1742-P: Loss of MAFB Compromises a-Cell Identity and Glucagon Secretion in Adult Human Islets
Journal Articles

Lipid Droplets Protect Human β-Cells From Lipotoxicity-Induced Stress and Cell Identity Changes

Free
Xin Tong, Roland Stein
Journal: Diabetes
Diabetes 2021;70(11):2595–2607
https://doi.org/10.2337/db21-0261
Published: 25 August 2021
View articletitled, Lipid Droplets Protect Human β-Cells From Lipotoxicity-Induced Stress and Cell Identity Changes
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Journal Articles

Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health

Free
Xin Tong, Chunhua Dai, John T. Walker, Gopika G. Nair, Arion Kennedy, Rotonya M. Carr, Matthias Hebrok, Alvin C. Powers, Roland Stein
Journal: Diabetes
Diabetes 2020;69(3):342–354
https://doi.org/10.2337/db19-0281
Published: 13 December 2020
View articletitled, Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health
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Includes: Supplementary data
Meeting Abstracts

2116-P: MAFA S64F Missense Mutation Causes Islet Beta-Cell Aging and Senescence

Free
JEEYEON CHA, EMILY M. WALKER, XIN TONG, MIN GUO, JIN HUA LIU, SOPHIA YU, DONATO IACOVAZZO, FRANCK MAUVAIS-JARVIS, SARAH E. FLANAGAN, MARTA KORBONITS, JOHN M. STAFFORD, ROLAND STEIN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):2116-P
https://doi.org/10.2337/db20-2116-P
Published: 01 June 2020
View articletitled, 2116-P: MAFA S64F Missense Mutation Causes Islet Beta-Cell Aging and Senescence
Journal Articles

The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function

Free
Jason M. Spaeth, Jin-Hua Liu, Daniel Peters, Min Guo, Anna B. Osipovich, Fardin Mohammadi, Nilotpal Roy, Anil Bhushan, Mark A. Magnuson, Matthias Hebrok, Christopher V.E. Wright, Roland Stein
Journal: Diabetes
Diabetes 2019;68(9):1806–1818
https://doi.org/10.2337/db19-0349
Published: 14 June 2019
View articletitled, The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function
Open the PDF for The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function in another window
Includes: Supplementary data
Journal Articles

Examining How the MAFB Transcription Factor Affects Islet β-Cell Function Postnatally

Free
Holly A. Cyphert, Emily M. Walker, Yan Hang, Sangeeta Dhawan, Rachana Haliyur, Lauren Bonatakis, Dana Avrahami, Marcela Brissova, Klaus H. Kaestner, Anil Bhushan, Alvin C. Powers, Roland Stein
Journal: Diabetes
Diabetes 2019;68(2):337–348
https://doi.org/10.2337/db18-0903
Published: 13 November 2018
View articletitled, Examining How the MAFB Transcription Factor Affects Islet β-Cell Function Postnatally
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Includes: Supplementary data
Journal Articles

Defining a Novel Role for the Pdx1 Transcription Factor in Islet β-Cell Maturation and Proliferation During Weaning

Free
Jason M. Spaeth, Manisha Gupte, Mark Perelis, Yu-Ping Yang, Holly Cyphert, Shuangli Guo, Jin-Hua Liu, Min Guo, Joseph Bass, Mark A. Magnuson, Christopher Wright, Roland Stein
Journal: Diabetes
Diabetes 2017;66(11):2830–2839
https://doi.org/10.2337/db16-1516
Published: 13 July 2017
View articletitled, Defining a Novel Role for the Pdx1 Transcription Factor in Islet β-Cell Maturation and Proliferation During Weaning
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Includes: Supplementary data
Journal Articles

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo

Free
Taka-aki Matsuoka, Satoshi Kawashima, Takeshi Miyatsuka, Shugo Sasaki, Naoki Shimo, Naoto Katakami, Dan Kawamori, Satomi Takebe, Pedro L. Herrera, Hideaki Kaneto, Roland Stein, Iichiro Shimomura
Journal: Diabetes
Diabetes 2017;66(5):1293–1300
https://doi.org/10.2337/db16-0887
Published: 21 February 2017
View articletitled, Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo
Open the PDF for Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo in another window
Includes: Supplementary data
Journal Articles

Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells

Free
Leena Paul, Emily M. Walker, Yiannis Drosos, Holly A. Cyphert, Geoffrey Neale, Roland Stein, Jack South, Gerard Grosveld, Pedro L. Herrera, Beatriz Sosa-Pineda
Journal: Diabetes
Diabetes 2016;65(3):687–698
https://doi.org/10.2337/db15-0713
Published: 02 December 2015
View articletitled, Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells
Open the PDF for Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells in another window
Includes: Supplementary data
Journal Articles

MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function

Free
David W. Scoville, Holly A. Cyphert, Lan Liao, Jianming Xu, Al Reynolds, Shuangli Guo, Roland Stein
Journal: Diabetes
Diabetes 2015;64(11):3772–3783
https://doi.org/10.2337/db15-0281
Published: 15 July 2015
View articletitled, MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function
Open the PDF for MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function in another window
Includes: Supplementary data
Journal Articles

Islet-1 Is Essential for Pancreatic β-Cell Function

Free
Benjamin N. Ediger, Aiping Du, Jingxuan Liu, Chad S. Hunter, Erik R. Walp, Jonathan Schug, Klaus H. Kaestner, Roland Stein, Doris A. Stoffers, Catherine L. May
Journal: Diabetes
Diabetes 2014;63(12):4206–4217
https://doi.org/10.2337/db14-0096
Published: 13 November 2014
View articletitled, Islet-1 Is Essential for Pancreatic β-Cell Function
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Includes: Supplementary data
Journal Articles

The MafA Transcription Factor Becomes Essential to Islet β-Cells Soon After Birth

Open Access
Yan Hang, Tsunehiko Yamamoto, Richard K.P. Benninger, Marcela Brissova, Min Guo, Will Bush, David W. Piston, Alvin C. Powers, Mark Magnuson, Debbie C. Thurmond, Roland Stein
Journal: Diabetes
Diabetes 2014;63(6):1994–2005
https://doi.org/10.2337/db13-1001
Published: 15 May 2014
View articletitled, The MafA Transcription Factor Becomes Essential to Islet β-Cells Soon After Birth
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Includes: Supplementary data
Journal Articles

Islet α-, β-, and δ-Cell Development Is Controlled by the Ldb1 Coregulator, Acting Primarily With the Islet-1 Transcription Factor

Open Access
Chad S. Hunter, Shilpy Dixit, Tsadok Cohen, Benjamin Ediger, Crystal Wilcox, Mark Ferreira, Heiner Westphal, Roland Stein, Catherine Lee May
Journal: Diabetes
Diabetes 2013;62(3):875–886
https://doi.org/10.2337/db12-0952
Published: 14 February 2013
View articletitled, Islet α-, β-, and δ-Cell Development Is Controlled by the Ldb1 Coregulator, Acting Primarily With the Islet-1 Transcription Factor
Open the PDF for Islet α-, β-, and δ-Cell Development Is Controlled by the Ldb1 Coregulator, Acting Primarily With the Islet-1 Transcription Factor in another window
Includes: Supplementary data
Journal Articles

FoxO Feedback Control of Basal IRS-2 Expression in Pancreatic β-Cells Is Distinct From That in Hepatocytes

Open Access
Shin Tsunekawa, Damien Demozay, Isabelle Briaud, Jill McCuaig, Domenico Accili, Roland Stein, Christopher J. Rhodes
Journal: Diabetes
Diabetes 2011;60(11):2883–2891
https://doi.org/10.2337/db11-0340
Published: 17 October 2011
View articletitled, FoxO Feedback Control of Basal IRS-2 Expression in Pancreatic β-Cells Is Distinct From That in Hepatocytes
Open the PDF for FoxO Feedback Control of Basal IRS-2 Expression in Pancreatic β-Cells Is Distinct From That in Hepatocytes in another window
Includes: Supplementary data
Journal Articles

MafA and MafB Regulate Genes Critical to β-Cells in a Unique Temporal Manner

Open Access
Isabella Artner, Yan Hang, Magdalena Mazur, Tsunehiko Yamamoto, Min Guo, Jill Lindner, Mark A. Magnuson, Roland Stein
Journal: Diabetes
Diabetes 2010;59(10):2530–2539
https://doi.org/10.2337/db10-0190
Published: 13 July 2010
View articletitled, MafA and MafB Regulate Genes Critical to β-Cells in a Unique Temporal Manner
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Includes: Supplementary data
Journal Articles

Regulation of MafA Expression in Pancreatic β-Cells in db/db Mice With Diabetes

Open Access
Taka-aki Matsuoka, Hideaki Kaneto, Takeshi Miyatsuka, Tsunehiko Yamamoto, Kaoru Yamamoto, Ken Kato, Iichiro Shimomura, Roland Stein, Munehide Matsuhisa
Journal: Diabetes
Diabetes 2010;59(7):1709–1720
https://doi.org/10.2337/db08-0693
Published: 27 April 2010
View articletitled, Regulation of MafA Expression in Pancreatic β-Cells in db/db Mice With Diabetes
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Includes: Supplementary data
Journal Articles

Islet-1 is Required for the Maturation, Proliferation, and Survival of the Endocrine Pancreas

Open Access
Aiping Du, Chad S. Hunter, Johanna Murray, Daniel Noble, Chen-Leng Cai, Sylvia M. Evans, Roland Stein, Catherine Lee May
Journal: Diabetes
Diabetes 2009;58(9):2059–2069
https://doi.org/10.2337/db08-0987
Published: 05 June 2009
View articletitled, Islet-1 is Required for the Maturation, Proliferation, and Survival of the Endocrine Pancreas
Open the PDF for Islet-1 is Required for the Maturation, Proliferation, and Survival of the Endocrine Pancreas in another window