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Romy Kursawe
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Meeting Abstracts

211-OR: Massively Parallel Characterization of Thousands of Type 2 Diabetes–Associated Variants in Multiple Cell Types Nominates Candidate Causal Regulatory Alleles and Mechanisms

MADHAV KOTHARI, REDWAN M. BHUIYAN, JACOB C. ULIRSCH, HANNAH DEWEY, NIKETA NERURKAR, ROMY KURSAWE, SUSAN KALES, DANIEL BERENZY, RYAN TEWHEY, MICHAEL L. STITZEL
Journal: Diabetes
Diabetes 2024;73(Supplement_1):211-OR
https://doi.org/10.2337/db24-211-OR
Published: 14 June 2024
View articletitled, 211-OR: Massively Parallel Characterization of Thousands of Type 2 Diabetes–Associated Variants in Multiple Cell Types Nominates Candidate Causal Regulatory Alleles and Mechanisms
Journal Articles

Alterations in Adipose Tissue Distribution, Cell Morphology, and Function Mark Primary Insulin Hypersecretion in Youth With Obesity

Domenico Tricò, Martina Chiriacò, Jessica Nouws, Alla Vash-Margita, Romy Kursawe, Elena Tarabra, Alfonso Galderisi, Andrea Natali, Cosimo Giannini, Marc Hellerstein, Ele Ferrannini, Sonia Caprio
Journal: Diabetes
Diabetes 2024;73(6):941–952
https://doi.org/10.2337/db23-0450
Published: 23 October 2023
View articletitled, Alterations in Adipose Tissue Distribution, Cell Morphology, and Function Mark Primary Insulin Hypersecretion in Youth With Obesity
Open the PDF for Alterations in Adipose Tissue Distribution, Cell Morphology, and Function Mark Primary Insulin Hypersecretion in Youth With Obesity in another window
Meeting Abstracts

285-OR: Surveying Specific and Shared Responses of Human Islets to T2D-Associated Stressors

EISHANI K. SOKOLOWSKI, REDWAN M. BHUIYAN, ROMY KURSAWE, MICHAEL L. STITZEL, DUYGU UCAR
Journal: Diabetes
Diabetes 2023;72(Supplement_1):285-OR
https://doi.org/10.2337/db23-285-OR
Published: 20 June 2023
View articletitled, 285-OR: Surveying Specific and Shared Responses of Human Islets to T2D-Associated Stressors
Meeting Abstracts

2061-P: Islet Single Cell Transcriptomes Reveal Cellular and Gene Regulatory Alterations in Type 2 Diabetes Pathogenesis

NATHAN LAWLOR, ROMY KURSAWE, MICHAEL L. STITZEL
Journal: Diabetes
Diabetes 2020;69(Supplement_1):2061-P
https://doi.org/10.2337/db20-2061-P
Published: 01 June 2020
View articletitled, 2061-P: Islet Single Cell Transcriptomes Reveal Cellular and Gene Regulatory Alterations in Type 2 Diabetes Pathogenesis
Journal Articles

Altered In Vivo Lipid Fluxes and Cell Dynamics in Subcutaneous Adipose Tissues Are Associated With the Unfavorable Pattern of Fat Distribution in Obese Adolescent Girls

Jessica Nouws, Mark Fitch, Mariana Mata, Nicola Santoro, Brittany Galuppo, Romy Kursawe, Deepak Narayan, Alla Vash-Margita, Bridget Pierpont, Gerald I. Shulman, Marc Hellerstein, Sonia Caprio
Journal: Diabetes
Diabetes 2019;68(6):1168–1177
https://doi.org/10.2337/db18-1162
Published: 01 April 2019
View articletitled, Altered In Vivo Lipid Fluxes and Cell Dynamics in Subcutaneous Adipose Tissues Are Associated With the Unfavorable Pattern of Fat Distribution in Obese Adolescent Girls
Open the PDF for Altered In Vivo Lipid Fluxes and Cell Dynamics in Subcutaneous Adipose Tissues Are Associated With the Unfavorable Pattern of Fat Distribution in Obese Adolescent Girls in another window
Includes: Supplementary data
Journal Articles

Type 2 Diabetes–Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets

Shubham Khetan, Romy Kursawe, Ahrim Youn, Nathan Lawlor, Alexandria Jillette, Eladio J. Marquez, Duygu Ucar, Michael L. Stitzel
Journal: Diabetes
Diabetes 2018;67(11):2466–2477
https://doi.org/10.2337/db18-0393
Published: 04 September 2018
View articletitled, Type 2 Diabetes–Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets
Open the PDF for Type 2 Diabetes–Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets in another window
Includes: Supplementary data
Journal Articles

A Type 2 Diabetes–Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus

Tamara S. Roman, Maren E. Cannon, Swarooparani Vadlamudi, Martin L. Buchkovich, Brooke N. Wolford, Ryan P. Welch, Mario A. Morken, Grace J. Kwon, Arushi Varshney, Romy Kursawe, Ying Wu, Anne U. Jackson, National Institutes of Health Intramural Sequencing Center (NISC) Comparative Sequencing Program, Michael R. Erdos, Johanna Kuusisto, Markku Laakso, Laura J. Scott, Michael Boehnke, Francis S. Collins, Stephen C.J. Parker, Michael L. Stitzel, Karen L. Mohlke
Journal: Diabetes
Diabetes 2017;66(9):2521–2530
https://doi.org/10.2337/db17-0464
Published: 06 July 2017
View articletitled, A Type 2 Diabetes–Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus
Open the PDF for A Type 2 Diabetes–Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus in another window
Includes: Supplementary data
Journal Articles

A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents

Romy Kursawe, Vishwa D. Dixit, Philipp E. Scherer, Nicola Santoro, Deepak Narayan, Ruth Gordillo, Cosimo Giannini, Ximena Lopez, Bridget Pierpont, Jessica Nouws, Gerald I. Shulman, Sonia Caprio
Journal: Diabetes
Diabetes 2016;65(3):610–618
https://doi.org/10.2337/db15-1478
Published: 30 December 2015
View articletitled, A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents
Open the PDF for A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents in another window
Includes: Supplementary data
Journal Articles

Decreased Transcription of ChREBP-α/β Isoforms in Abdominal Subcutaneous Adipose Tissue of Obese Adolescents With Prediabetes or Early Type 2 Diabetes: Associations With Insulin Resistance and Hyperglycemia

Romy Kursawe, Sonia Caprio, Cosimo Giannini, Deepak Narayan, Aiping Lin, Ebe D’Adamo, Melissa Shaw, Bridget Pierpont, Samuel W. Cushman, Gerald I. Shulman
Journal: Diabetes
Diabetes 2013;62(3):837–844
https://doi.org/10.2337/db12-0889
Published: 14 February 2013
View articletitled, Decreased Transcription of ChREBP-α/β Isoforms in Abdominal Subcutaneous Adipose Tissue of Obese Adolescents With Prediabetes or Early Type 2 Diabetes: Associations With Insulin Resistance and Hyperglycemia
Open the PDF for Decreased Transcription of ChREBP-α/β Isoforms in Abdominal Subcutaneous Adipose Tissue of Obese Adolescents With Prediabetes or Early Type 2 Diabetes: Associations With Insulin Resistance and Hyperglycemia in another window
Includes: Supplementary data
Journal Articles

SirT1 Regulates Adipose Tissue Inflammation

Matthew P. Gillum, Maya E. Kotas, Derek M. Erion, Romy Kursawe, Paula Chatterjee, Kevin T. Nead, Eric S. Muise, Jennifer J. Hsiao, David W. Frederick, Shin Yonemitsu, Alexander S. Banks, Li Qiang, Sanjay Bhanot, Jerrold M. Olefsky, Dorothy D. Sears, Sonia Caprio, Gerald I. Shulman
Journal: Diabetes
Diabetes 2011;60(12):3235–3245
https://doi.org/10.2337/db11-0616
Published: 13 November 2011
View articletitled, SirT1 Regulates Adipose Tissue Inflammation
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Includes: Supplementary data
Journal Articles

Cellularity and Adipogenic Profile of the Abdominal Subcutaneous Adipose Tissue From Obese Adolescents: Association With Insulin Resistance and Hepatic Steatosis

Romy Kursawe, Markus Eszlinger, Deepak Narayan, Teresa Liu, Merlijn Bazuine, Anna M.G. Cali, Ebe D'Adamo, Melissa Shaw, Bridget Pierpont, Gerald I. Shulman, Samuel W. Cushman, Arthur Sherman, Sonia Caprio
Journal: Diabetes
Diabetes 2010;59(9):2288–2296
https://doi.org/10.2337/db10-0113
Published: 01 September 2010
View articletitled, Cellularity and Adipogenic Profile of the Abdominal Subcutaneous Adipose Tissue From Obese Adolescents: Association With Insulin Resistance and Hepatic Steatosis
Open the PDF for Cellularity and Adipogenic Profile of the Abdominal Subcutaneous Adipose Tissue From Obese Adolescents: Association With Insulin Resistance and Hepatic Steatosis in another window
Includes: Supplementary data
Journal Articles

Deletion of the α-Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity

William A. Chutkow, Andreas L. Birkenfeld, Jonathan D. Brown, Hui-Young Lee, David W. Frederick, Jun Yoshioka, Parth Patwari, Romy Kursawe, Samuel W. Cushman, Jorge Plutzky, Gerald I. Shulman, Varman T. Samuel, Richard T. Lee
Journal: Diabetes
Diabetes 2010;59(6):1424–1434
https://doi.org/10.2337/db09-1212
Published: 18 March 2010
View articletitled, Deletion of the α-Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity
Open the PDF for Deletion of the α-Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity in another window
Includes: Supplementary data