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Meeting Abstracts

1-LB: Advancing Therapy in Basal Insulin Users with Type 2 Diabetes (T2D): Hypoglycemia as a Function of HbA1c in the SoliMix Trial

RORY J. MCCRIMMON, PHILIP HOME, ALICE Y. CHENG, FRANCESCO GIORGINO, VIVIAN FONSECA, ELISABETH SOUHAMI, AGUSTINA ALVAREZ, ANDERS H. BOSS, LYDIE MELAS-MELT, JULIO ROSENSTOCK

Diabetes 2021;70(Supplement_1):1-LB

DOI: https://doi.org/10.2337/db21-1-LB

Published: 01 June 2021

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Meeting Abstracts

234-OR: Advancing Therapy in Uncontrolled Basal Insulin-Treated Type 2 Diabetes (T2D): Better Clinical Outcomes with IGlarLixi vs. Premix 70/30 in the SoliMix Trial

JULIO ROSENSTOCK, RIFAT EMRAL, LEOBARDO SAUQUE-REYNA, VISWANATHAN MOHAN, CARLOS TRESCOLI, SAUD N. AL SIFRI, NEBOJSA LALIC, AGUSTINA ALVAREZ, PASCALINE PICARD, NACIMA DEMIL, MIREILLE BONNEMAIRE, RORY J. MCCRIMMON

Diabetes 2021;70(Supplement_1):234-OR

DOI: https://doi.org/10.2337/db21-234-OR

Published: 01 June 2021

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Meeting Abstracts

748-P: Advancing Therapy in Uncontrolled Basal Insulin (BI)-Treated Type 2 Diabetes (T2D): Subanalysis of the SoliMix Trial in Participants in Europe

ALICE Y. CHENG, RORY J. MCCRIMMON, VIVIAN FONSECA, CARLOS TRESCOLI, MARTIN HALUZIK, JOCHEN SEUFERT, AGUSTINA ALVAREZ, ELISABETH SOUHAMI, PASCALINE PICARD, MIREILLE BONNEMAIRE, JULIO ROSENSTOCK

Diabetes 2021;70(Supplement_1):748-P

DOI: https://doi.org/10.2337/db21-748-P

Published: 01 June 2021

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Meeting Abstracts

749-P: Advancing Therapy in Uncontrolled Basal Insulin (BI)-Treated Type 2 Diabetes (T2D): Subanalysis of the SoliMix Trial Outside Europe

VIVIAN FONSECA, JULIO ROSENSTOCK, ALICE Y. CHENG, RIFAT EMRAL, LEOBARDO SAUQUE-REYNA, VISWANATHAN MOHAN, SAUD N. AL SIFRI, AGUSTINA ALVAREZ, KHIER DJABALLAH, PASCALINE PICARD, ELISABETH SOUHAMI, RORY J. MCCRIMMON

Diabetes 2021;70(Supplement_1):749-P

DOI: https://doi.org/10.2337/db21-749-P

Published: 01 June 2021

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Meeting Abstracts

747-P: Improved Treatment Perceptions with IGlarLixi vs. Premix Insulin in Type 2 Diabetes (T2D) Uncontrolled on Basal Insulin (BI) + Oral Antihyperglycemic Drugs (OADs): Patient-Reported Outcomes (PROs) of the SoliMix Trial

WILLIAM H. POLONSKY, RORY J. MCCRIMMON, KATHERINE H. WHITMIRE, FRANCESCO GIORGINO, JUNG-FU CHEN, CHARLIE NICHOLLS, ELISHEVA LEW, AGUSTINA ALVAREZ, MATHIEU COUDERT, JULIO ROSENSTOCK

Diabetes 2021;70(Supplement_1):747-P

DOI: https://doi.org/10.2337/db21-747-P

Published: 01 June 2021

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Meeting Abstracts

746-P: Advancing Therapy in Uncontrolled Basal Insulin-Treated Type 2 Diabetes (T2D): Nocturnal Hypoglycemia in the SoliMix Trial

RORY J. MCCRIMMON, ALICE Y. CHENG, VIVIAN FONSECA, RICARDO CHOZA, THAMER ALESSA, AGUSTINA ALVAREZ, ELISABETH SOUHAMI, ANDERS H. BOSS, PASCALINE PICARD, JULIO ROSENSTOCK

Diabetes 2021;70(Supplement_1):746-P

DOI: https://doi.org/10.2337/db21-746-P

Published: 01 June 2021

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Meeting Abstracts

674-P: Efficacy and Safety of Cotadutide, a Dual GLP-1 and Glucagon Receptor Agonist in Patients with T2DM and DKD

VICTORIA E. PARKER, THUONG HOANG, HEIKE SCHLICHTHAAR, FRASER W. GIBB, BARBARA WENZEL, MAXIMILIAN G. POSCH, YI-TING CHANG, MARCELLA PETRONE, LARS HANSEN, PHILIP AMBERY, HIDDO L. HEERSPINK, RORY J. MCCRIMMON, LUTZ JERMUTUS

Diabetes 2021;70(Supplement_1):674-P

DOI: https://doi.org/10.2337/db21-674-P

Published: 01 June 2021

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Journal Articles

Inhibition of NFAT Signaling Restores Microvascular Endothelial Function in Diabetic Mice

Eliana Garcia-Vaz, Alison D. McNeilly, Lisa M. Berglund, Abrar Ahmad, Jennifer R. Gallagher, Anna-Maria Dutius Andersson, Rory J. McCrimmon, Anna V. Zetterqvist, Maria F. Gomez, Faisel Khan

Diabetes 2020;69(3):424–435

DOI: https://doi.org/10.2337/db18-0870

Published: 05 December 2020

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Includes: Supplementary data

Meeting Abstracts

960-P: Characteristics of U.S. Patients with Type 2 Diabetes Prescribed GLP-1RA+SGLT2i in Combination during 2018

RORY J. MCCRIMMON, HELENE N. CHRISTENSEN, INGRID HOLST, ADAM LENART, BERNHARD LUDVIK, RIKKE S. BRANDT, JOHANNE S. PILTOFT, ATHENA PHILIS-TSIMIKAS

Diabetes 2020;69(Supplement_1):960-P

DOI: https://doi.org/10.2337/db20-960-P

Published: 01 June 2020

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Meeting Abstracts

1837-P: Central IL-6 Receptor Deficiency Impairs Pancreatic Insulin Secretion

ALISON D. MCNEILLY, JENNIFER GALLAGHER, RORY J. MCCRIMMON

Diabetes 2019;68(Supplement_1):1837-P

DOI: https://doi.org/10.2337/db19-1837-P

Published: 01 June 2019

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Meeting Abstracts

113-OR: ADA Presidents' Select Abstract: Dishabituation with High Intensity Exercise Improves Epinephrine Response and Symptomatic Awareness to Hypoglycemia in People with Type 1 Diabetes and Impaired Awareness of Hypoglycemia

CATRIONA M. FARRELL, DANIEL J. WEST, SIMONA M. HAPCA, TIMOTHY JONES, ALISON D. MCNEILLY, RORY J. MCCRIMMON

Diabetes 2019;68(Supplement_1):113-OR

DOI: https://doi.org/10.2337/db19-113-OR

Published: 01 June 2019

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Meeting Abstracts

383-P: The Potential Role of Il-6 in Defective Glucose Sensing following Recurrent Hypoglycaemia

ALISON D. MCNEILLY, JENNIFER GALLAGHER, RORY J. MCCRIMMON

Diabetes 2019;68(Supplement_1):383-P

DOI: https://doi.org/10.2337/db19-383-P

Published: 01 June 2019

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Meeting Abstracts

372-P: Activation of the Nrf2 Pathway Provides Protection against Hypoglycaemia-Induced Cognitive Impairment in a Rodent Model of Type 1 Diabetes

ALISON D. MCNEILLY, JENNIFER GALLAGHER, ALBENA T. DINKOVA-KOSTOVA, RORY J. MCCRIMMON

Diabetes 2019;68(Supplement_1):372-P

DOI: https://doi.org/10.2337/db19-372-P

Published: 01 June 2019

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Meeting Abstracts

373-P: Recurrent Insulin-Induced Hypoglycaemia Leads to Weight Gain in Association with Increased Adiposity and Reduced Basal Metabolic Rate

ALISON D. MCNEILLY, JENNIFER GALLAGHER, RORY J. MCCRIMMON

Diabetes 2019;68(Supplement_1):373-P

DOI: https://doi.org/10.2337/db19-373-P

Published: 01 June 2019

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Meeting Abstracts

Sotagliflozin in Combination with Optimized Insulin Therapy Reduced HbA1c Levels with a Decreased Daily Insulin Requirement after 52 Weeks in Adults with T1D

JEREMY PETTUS, STUART A. WEINZIMER, RORY J. MCCRIMMON, FRANCISCO JAVIER AMPUDIA BLASCO, JOHN A. STEWART, PAUL STRUMPH, JULIANA H. OLIVEIRA, PABLO LAPUERTA, RITA CASTRO

Diabetes 2018;67(Supplement_1):5-LB

DOI: https://doi.org/10.2337/db18-5-LB

Published: 01 July 2018

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Journal Articles

High-Intensity Exercise as a Dishabituating Stimulus Restores Counterregulatory Responses in Recurrently Hypoglycemic Rodents

Alison D. McNeilly, Jennifer R. Gallagher, Jeffrey T.-J. Huang, Michael L.J. Ashford, Rory J. McCrimmon

Diabetes 2017;66(6):1696–1702

DOI: https://doi.org/10.2337/db16-1533

Published: 07 March 2017

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Includes: Supplementary data

Journal Articles

Nrf2-Mediated Neuroprotection Against Recurrent Hypoglycemia Is Insufficient to Prevent Cognitive Impairment in a Rodent Model of Type 1 Diabetes

Alison D. McNeilly, Jennifer R. Gallagher, Albena T. Dinkova-Kostova, John D. Hayes, John Sharkey, Michael L.J. Ashford, Rory J. McCrimmon

Diabetes 2016;65(10):3151–3160

DOI: https://doi.org/10.2337/db15-1653

Published: 13 July 2016

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Includes: Supplementary data

Journal Articles

Diazoxide Improves Hormonal Counterregulatory Responses to Acute Hypoglycemia in Long-standing Type 1 Diabetes

Priya S. George, Roger Tavendale, Colin N.A. Palmer, Rory J. McCrimmon

Diabetes 2015;64(6):2234–2241

DOI: https://doi.org/10.2337/db14-1539

Published: 15 January 2015

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Includes: Supplementary data

Journal Articles

Hypoglycemia in Type 1 Diabetes

Rory J. McCrimmon, Robert S. Sherwin

Diabetes 2010;59(10):2333–2339

DOI: https://doi.org/10.2337/db10-0103

Published: 01 October 2010

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Journal Articles

The Medial Amygdalar Nucleus: A Novel Glucose-Sensing Region That Modulates the Counterregulatory Response to Hypoglycemia

Ligang Zhou, Nina Podolsky, Zhen Sang, Yuyan Ding, Xiaoning Fan, Qingchun Tong, Barry E. Levin, Rory J. McCrimmon

Diabetes 2010;59(10):2646–2652

DOI: https://doi.org/10.2337/db09-0995

Published: 13 July 2010

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Includes: Supplementary data

NARROW

1-LB: Advancing Therapy in Basal Insulin Users with Type 2 Diabetes (T2D): Hypoglycemia as a Function of HbA1c in the SoliMix Trial

234-OR: Advancing Therapy in Uncontrolled Basal Insulin-Treated Type 2 Diabetes (T2D): Better Clinical Outcomes with IGlarLixi vs. Premix 70/30 in the SoliMix Trial

748-P: Advancing Therapy in Uncontrolled Basal Insulin (BI)-Treated Type 2 Diabetes (T2D): Subanalysis of the SoliMix Trial in Participants in Europe

749-P: Advancing Therapy in Uncontrolled Basal Insulin (BI)-Treated Type 2 Diabetes (T2D): Subanalysis of the SoliMix Trial Outside Europe

747-P: Improved Treatment Perceptions with IGlarLixi vs. Premix Insulin in Type 2 Diabetes (T2D) Uncontrolled on Basal Insulin (BI) + Oral Antihyperglycemic Drugs (OADs): Patient-Reported Outcomes (PROs) of the SoliMix Trial

746-P: Advancing Therapy in Uncontrolled Basal Insulin-Treated Type 2 Diabetes (T2D): Nocturnal Hypoglycemia in the SoliMix Trial

674-P: Efficacy and Safety of Cotadutide, a Dual GLP-1 and Glucagon Receptor Agonist in Patients with T2DM and DKD

Inhibition of NFAT Signaling Restores Microvascular Endothelial Function in Diabetic Mice

960-P: Characteristics of U.S. Patients with Type 2 Diabetes Prescribed GLP-1RA+SGLT2i in Combination during 2018

1837-P: Central IL-6 Receptor Deficiency Impairs Pancreatic Insulin Secretion

113-OR: ADA Presidents' Select Abstract: Dishabituation with High Intensity Exercise Improves Epinephrine Response and Symptomatic Awareness to Hypoglycemia in People with Type 1 Diabetes and Impaired Awareness of Hypoglycemia

383-P: The Potential Role of Il-6 in Defective Glucose Sensing following Recurrent Hypoglycaemia

372-P: Activation of the Nrf2 Pathway Provides Protection against Hypoglycaemia-Induced Cognitive Impairment in a Rodent Model of Type 1 Diabetes

373-P: Recurrent Insulin-Induced Hypoglycaemia Leads to Weight Gain in Association with Increased Adiposity and Reduced Basal Metabolic Rate

Sotagliflozin in Combination with Optimized Insulin Therapy Reduced HbA1c Levels with a Decreased Daily Insulin Requirement after 52 Weeks in Adults with T1D

High-Intensity Exercise as a Dishabituating Stimulus Restores Counterregulatory Responses in Recurrently Hypoglycemic Rodents

Nrf2-Mediated Neuroprotection Against Recurrent Hypoglycemia Is Insufficient to Prevent Cognitive Impairment in a Rodent Model of Type 1 Diabetes

Diazoxide Improves Hormonal Counterregulatory Responses to Acute Hypoglycemia in Long-standing Type 1 Diabetes

Hypoglycemia in Type 1 Diabetes

The Medial Amygdalar Nucleus: A Novel Glucose-Sensing Region That Modulates the Counterregulatory Response to Hypoglycemia

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