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Rudolph L. Leibel
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Journal Articles

Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity

Free
Hanieh Yaghootkar, Yiying Zhang, Cassandra N. Spracklen, Tugce Karaderi, Lam Opal Huang, Jonathan Bradfield, Claudia Schurmann, Rebecca S. Fine, Michael H. Preuss, Zoltan Kutalik, Laura B.L. Wittemans, Yingchang Lu, Sophia Metz, Sara M. Willems, Ruifang Li-Gao, Niels Grarup, Shuai Wang, Sophie Molnos, América A. Sandoval-Zárate, Mike A. Nalls, Leslie A. Lange, Jeffrey Haesser, Xiuqing Guo, Leo-Pekka Lyytikäinen, Mary F. Feitosa, Colleen M. Sitlani, Cristina Venturini, Anubha Mahajan, Tim Kacprowski, Carol A. Wang, Daniel I. Chasman, Najaf Amin, Linda Broer, Neil Robertson, Kristin L. Young, Matthew Allison, Paul L. Auer, Matthias Blüher, Judith B. Borja, Jette Bork-Jensen, Germán D. Carrasquilla, Paraskevi Christofidou, Ayse Demirkan, Claudia A. Doege, Melissa E. Garcia, Mariaelisa Graff, Kaiying Guo, Hakon Hakonarson, Jaeyoung Hong, Yii-Der Ida Chen, Rebecca Jackson, Hermina Jakupović, Pekka Jousilahti, Anne E. Justice, Mika Kähönen, Jorge R. Kizer, Jennifer Kriebel, Charles A. LeDuc, Jin Li, Lars Lind, Jian’an Luan, David A. Mackey, Massimo Mangino, Satu Männistö, Jayne F. Martin Carli, Carolina Medina-Gomez, Dennis O. Mook-Kanamori, Andrew P. Morris, Renée de Mutsert, Matthias Nauck, Ivana Prokic, Craig E. Pennell, Arund D. Pradhan, Bruce M. Psaty, Olli T. Raitakari, Robert A. Scott, Tea Skaaby, Konstantin Strauch, Kent D. Taylor, Alexander Teumer, Andre G. Uitterlinden, Ying Wu, Jie Yao, Mark Walker, Kari E. North, Peter Kovacs, M. Arfan Ikram, Cornelia M. van Duijn, Paul M. Ridker, Stephen Lye, Georg Homuth, Erik Ingelsson, Tim D. Spector, Barbara McKnight, Michael A. Province, Terho Lehtimäki, Linda S. Adair, Jerome I. Rotter, Alexander P. Reiner, James G. Wilson, Tamara B. Harris, Samuli Ripatti, Harald Grallert, James B. Meigs, Veikko Salomaa, Torben Hansen, Ko Willems van Dijk, Nicholas J. Wareham, Struan F.A. Grant, Claudia Langenberg, Timothy M. Frayling, Cecilia M. Lindgren, Karen L. Mohlke, Rudolph L. Leibel, Ruth J.F. Loos, Tuomas O. Kilpeläinen
Journal: Diabetes
Diabetes 2020;69(12):2806–2818
https://doi.org/10.2337/db20-0070
Published: 11 September 2020
View article titled, Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity
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Journal Articles

β-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells

Free
Lina Sui, Nichole Danzl, Sean R. Campbell, Ryan Viola, Damian Williams, Yuan Xing, Yong Wang, Neil Phillips, Greg Poffenberger, Bjarki Johannesson, Jose Oberholzer, Alvin C. Powers, Rudolph L. Leibel, Xiaojuan Chen, Megan Sykes, Dieter Egli
Journal: Diabetes
Diabetes 2018;67(1):26–35
https://doi.org/10.2337/db17-0120
Published: 20 September 2017
View article titled, β-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells
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Includes: Supplementary data
Journal Articles

Biologic Responses to Weight Loss and Weight Regain: Report From an American Diabetes Association Research Symposium

Free
Rudolph L. Leibel, Randy J. Seeley, Tamara Darsow, Erika Gebel Berg, Steven R. Smith, Robert Ratner
Journal: Diabetes
Diabetes 2015;64(7):2299–2309
https://doi.org/10.2337/db15-0004
Published: 17 June 2015
View article titled, Biologic Responses to Weight Loss and Weight Regain: Report From an American Diabetes Association Research Symposium
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Journal Articles

β-Cell Dysfunction Due to Increased ER Stress in a Stem Cell Model of Wolfram Syndrome

Open Access
Linshan Shang, Haiqing Hua, Kylie Foo, Hector Martinez, Kazuhisa Watanabe, Matthew Zimmer, David J. Kahler, Matthew Freeby, Wendy Chung, Charles LeDuc, Robin Goland, Rudolph L. Leibel, Dieter Egli
Journal: Diabetes
Diabetes 2014;63(3):923–933
https://doi.org/10.2337/db13-0717
Published: 13 February 2014
View article titled, β-Cell Dysfunction Due to Increased ER Stress in a Stem Cell Model of Wolfram Syndrome
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Includes: Supplementary data
Journal Articles

An Apparent Role for Alox15 in the Pathogenesis of Diabetes in the NOD Mouse : Parsing the Supporting Genetic Data

Free
Stuart P. Weisberg, Rudolph L. Leibel
Journal: Diabetes
Diabetes 2008;57(1):1–2
https://doi.org/10.2337/db07-1592
Published: 01 January 2008
View article titled, An Apparent Role for Alox15 in the Pathogenesis of Diabetes in the NOD Mouse : Parsing the Supporting Genetic Data
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Journal Articles

Is the Energy Homeostasis System Inherently Biased Toward Weight Gain?

Free
Michael W. Schwartz, Stephen C. Woods, Randy J. Seeley, Gregory S. Barsh, Denis G. Baskin, Rudolph L. Leibel
Journal: Diabetes
Diabetes 2003;52(2):232–238
https://doi.org/10.2337/diabetes.52.2.232
Published: 01 February 2003
View article titled, Is the Energy Homeostasis System Inherently Biased Toward Weight Gain?
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Journal Articles

Effects of Leptin Deficiency and Short-Term Repletion on Hepatic Gene Expression in Genetically Obese Mice

Free
Anthony W. Ferrante, Jr.,, Marie Thearle, Ted Liao, Rudolph L. Leibel
Journal: Diabetes
Diabetes 2001;50(10):2268–2278
https://doi.org/10.2337/diabetes.50.10.2268
Published: 01 October 2001
View article titled, Effects of Leptin Deficiency and Short-Term Repletion on Hepatic Gene Expression in Genetically Obese Mice
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Journal Articles

Transgenic Complementation of Leptin-Receptor Deficiency: I. Rescue of the Obesity/Diabetes Phenotype of LEPR-Null Mice Expressing a LEPR-B Transgene

Free
Timothy J. Kowalski, Shun-Mei Liu, Rudolph L. Leibel, Streamson C. Chua, Jr.
Journal: Diabetes
Diabetes 2001;50(2):425–435
https://doi.org/10.2337/diabetes.50.2.425
Published: 01 February 2001
View article titled, Transgenic Complementation of Leptin-Receptor Deficiency: I. Rescue of the Obesity/Diabetes Phenotype of LEPR-Null Mice Expressing a LEPR-B Transgene
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Journal Articles

The Gln223 Arg and Lys656 Asn Polymorphisms in the Human Leptin Receptor Do Not Associate With Traits Related to Obesity

Free
Kristi Silver, Jeremy Walston, Wendy K Chung, Flora Yao, Vipul V Parikh, Ross Andersen, Lawrence J Cheskin, Dariush Elahi, Denis Muller, Rudolph L Leibel, Alan R Shuldiner
Journal: Diabetes
Diabetes 1997;46(11):1898–1900
https://doi.org/10.2337/diab.46.11.1898
Published: 01 November 1997
View article titled, The Gln223 Arg and Lys656 Asn Polymorphisms in the Human Leptin Receptor Do Not Associate With Traits Related to Obesity
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Journal Articles

Exonic and Intronic Sequence Variation in the Human Leptin Receptor Gene (LEPR)

Free
Wendy K Chung, Loraine Power-Kehoe, Melvin Chua, Florence Chu, Louis Aronne, Zilla Huma, Melinda Sothern, John N Udall, Bowie Kahle, Rudolph L Leibel
Journal: Diabetes
Diabetes 1997;46(9):1509–1511
https://doi.org/10.2337/diab.46.9.1509
Published: 01 September 1997
View article titled, Exonic and Intronic Sequence Variation in the Human Leptin Receptor Gene (LEPR)
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Journal Articles

Phenotype of the Obese Koletsky (f) Rat Due to Tyr763Stop Mutation in the Extracellular Domain of the Leptin Receptor (Lepr): Evidence for Deficient Plasma-to-CSF Transport of Leptin in Both the Zucker and Koletsky Obese Rat

Free
X Sharon Wu-Peng, Streamson C Chua, Jr, Norichika Okada, Shun-Mei Liu, Margery Nicolson, Rudolph L Leibel
Journal: Diabetes
Diabetes 1997;46(3):513–518
https://doi.org/10.2337/diab.46.3.513
Published: 01 March 1997
View article titled, Phenotype of the Obese Koletsky (f) Rat Due to Tyr763Stop Mutation in the Extracellular Domain of the Leptin Receptor (Lepr): Evidence for Deficient Plasma-to-CSF Transport of Leptin in Both the Zucker and Koletsky Obese Rat
Open the PDF for Phenotype of the Obese Koletsky (f) Rat Due to Tyr763Stop Mutation in the Extracellular Domain of the Leptin Receptor (Lepr): Evidence for Deficient Plasma-to-CSF Transport of Leptin in Both the Zucker and Koletsky Obese Rat in another window
Journal Articles

Absence of Linkage of Obesity and Energy Metabolism to Markers Flanking Homologues of Rodent Obesity Genes in Pima Indians

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Rod A Norman, Rudolph L Leibel, Wendy K Chung, Loraine Power-Kehoe, Streamson C Chua, Jr, William C Knowler, D Bruce Thompson, Clifton Bogardus, Eric Ravussin
Journal: Diabetes
Diabetes 1996;45(9):1229–1232
https://doi.org/10.2337/diab.45.9.1229
Published: 01 September 1996
View article titled, Absence of Linkage of Obesity and Energy Metabolism to Markers Flanking Homologues of Rodent Obesity Genes in Pima Indians
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Journal Articles

Phenotype of fatty Due to Gln269Pro Mutation in the Leptin Receptor (Lepr)

Free
Streamson C Chua, Jr, David W White, X Sharon Wu-Peng, Shun-Mei Liu, Norichika Okada, Erin E Kershaw, Wendy K Chung, Loraine Power-Kehoe, Melvin Chua, Louis A Tartaglia, Rudolph L Leibel
Journal: Diabetes
Diabetes 1996;45(8):1141–1143
https://doi.org/10.2337/diab.45.8.1141
Published: 01 August 1996
View article titled, Phenotype of fatty Due to Gln269Pro Mutation in the Leptin Receptor (Lepr)
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