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Journal Articles

The Science of Diabetes and a Life of Trials: The 2024 Banting Medal for Scientific Achievement Award Lecture

Rury R. Holman
Journal: Diabetes
Diabetes 2025;74(2):164–174
https://doi.org/10.2337/db24-0719
Published: 21 January 2025
View article titled, The Science of Diabetes and a Life of Trials: The 2024 Banting Medal for Scientific Achievement Award Lecture
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Meeting Abstracts

181-OR: Declining eGFR over Time Predicts the Risk of a Composite of Primary or Secondary Major Adverse Cardiovascular Events or Heart Failure Hospitalization, in People with Type 2 Diabetes—EXSCEL Post Hoc analysis

ABDERRAHIM OULHAJ, ABUBAKER E. SULIMAN, KATHRIN ELLER, FAISAL AZIZ, RUTH L. COLEMAN, RACHID BENTOUMI, DIRK VON LEWINSKI, RURY R. HOLMAN, HARALD SOURIJ
Journal: Diabetes
Diabetes 2024;73(Supplement_1):181-OR
https://doi.org/10.2337/db24-181-OR
Published: 14 June 2024
View article titled, 181-OR: Declining eGFR over Time Predicts the Risk of a Composite of Primary or Secondary Major Adverse Cardiovascular Events or Heart Failure Hospitalization, in People with Type 2 Diabetes—EXSCEL Post Hoc analysis
Meeting Abstracts

1332-P: Young-Onset Type 2 Diabetes—UK Prospective Diabetes Trial (UKPDS) 30-Year Follow-up

BERYL LIN, RUTH L. COLEMAN, FIONA BRAGG, ERNESTO MADDALONI, RURY R. HOLMAN, AMANDA I. ADLER
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1332-P
https://doi.org/10.2337/db24-1332-P
Published: 14 June 2024
View article titled, 1332-P: Young-Onset Type 2 Diabetes—UK Prospective Diabetes Trial (UKPDS) 30-Year Follow-up
Meeting Abstracts

218-LB: Remission of Type 2 Diabetes after Weight Loss in "Normal" Weight People—The ReTUNE Study

ROY TAYLOR, KEATON M. IRVINE, ALISON C. BARNES, TARA L. KELLY, LUCY G. CLARK, KIEREN G. HOLLINGSWORTH, AHMAD AL-MRABEH, RURY R. HOLMAN, DAVIDE ROMERES, CLAUDIO COBELLI
Journal: Diabetes
Diabetes 2022;71(Supplement_1):218-LB
https://doi.org/10.2337/db22-218-LB
Published: 01 June 2022
View article titled, 218-LB: Remission of Type 2 Diabetes after Weight Loss in "Normal" Weight People—The ReTUNE Study
Meeting Abstracts

958-P: Once-Weekly Exenatide Effects on EGFR Slope and UACR as a Function of Baseline UACR: An EXSCEL Trial Post Hoc Analysis

LINDSAY E. CLEGG, ANNEMARIE VAN DER AART, ROBERT C. PENLAND, DAVID W. BOULTON, C. DAVID SJÖSTRÖM, ROBERT J. MENTZ, RURY R. HOLMAN, HIDDO L. HEERSPINK
Journal: Diabetes
Diabetes 2020;69(Supplement_1):958-P
https://doi.org/10.2337/db20-958-P
Published: 01 June 2020
View article titled, 958-P: Once-Weekly Exenatide Effects on EGFR Slope and UACR as a Function of Baseline UACR: An EXSCEL Trial Post Hoc Analysis
Meeting Abstracts

570-P: Osteoprotegerin Induces Endothelial Dysfunction and Is Associated with Vascular Complications In Type 2 Diabetes

ERNESTO MADDALONI, KYOUNGMIN PARK, MICHELA DI GUIDA, LUCIA CORAGGIO, CECILIA LUORDI, LUCA D’ONOFRIO, MARCO G. BARONI, MARIA G. CAVALLO, PAOLA D’ANGELO, SALVATORE DE COSMO, FRIDA LEONETTI, SUSANNA MORANO, LELIO MORVIDUCCI, PAOLO POZZILLI, SABRINA PRUDENTE, GIUSEPPE PUGLIESE, VINCENZO TRISCHITTA, RURY R. HOLMAN, GEORGE L. KING, RAFFAELLA BUZZETTI, OMNIPOD HORIZON STUDY GROUP
Journal: Diabetes
Diabetes 2020;69(Supplement_1):570-P
https://doi.org/10.2337/db20-570-P
Published: 01 June 2020
View article titled, 570-P: Osteoprotegerin Induces Endothelial Dysfunction and Is Associated with Vascular Complications In Type 2 Diabetes
Meeting Abstracts

1418-P: Increased Risk of Incident Heart Failure and All-Cause Mortality in Insulin-Resistant People with Type 2 Diabetes in the United Kingdom Prospective Diabetes Study (UKPDS)

MALGORZATA WAMIL, RUTH L. COLEMAN, AMANDA ADLER, JOHN J. MCMURRAY, RURY R. HOLMAN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1418-P
https://doi.org/10.2337/db20-1418-P
Published: 01 June 2020
View article titled, 1418-P: Increased Risk of Incident Heart Failure and All-Cause Mortality in Insulin-Resistant People with Type 2 Diabetes in the United Kingdom Prospective Diabetes Study (UKPDS)
Meeting Abstracts

6-LB: Effect of Open-Label SGLT2 Inhibitor Treatment When Combined with Exenatide on Cardiovascular and Renal Outcomes in EXSCEL

LINDSAY E. CLEGG, ROBERT C. PENLAND, DAVID W. BOULTON, SRINIVAS BACHINA, MARCUS THURESSON, HIDDO L. HEERSPINK, STEPHANIE GUSTAVSON, C. DAVID SJöSTRöM, JAMES A. RUGGLES, ADRIAN F. HERNANDEZ, JOHN B. BUSE, ROBERT J. MENTZ, RURY R. HOLMAN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):6-LB
https://doi.org/10.2337/db19-6-LB
Published: 01 June 2019
View article titled, 6-LB: Effect of Open-Label SGLT2 Inhibitor Treatment When Combined with Exenatide on Cardiovascular and Renal Outcomes in EXSCEL
Meeting Abstracts

2436-PUB: Predicting Risk for New-Onset Type 2 Diabetes in Chinese People with Coronary Heart Disease and Impaired Glucose Tolerance

SHISHI XU, CHARLES A. SCOTT, RUTH L. COLEMAN, JAAKKO TUOMILEHTO, RURY R. HOLMAN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):2436-PUB
https://doi.org/10.2337/db19-2436-PUB
Published: 01 June 2019
View article titled, 2436-PUB: Predicting Risk for New-Onset Type 2 Diabetes in Chinese People with Coronary Heart Disease and Impaired Glucose Tolerance
Meeting Abstracts

1479-P: Predictors of Incident Hospitalization for Heart Failure in the ACE Trial Population

CHARLES A.B. SCOTT, JOHN J. MCMURRAY, LARS RYDÉN, YIHONG SUN, MICHAL TENDERA, RUTH L. COLEMAN, RURY R. HOLMAN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1479-P
https://doi.org/10.2337/db19-1479-P
Published: 01 June 2019
View article titled, 1479-P: Predictors of Incident Hospitalization for Heart Failure in the ACE Trial Population
Meeting Abstracts

1466-P: Estimating Cardiovascular Risk in People with Type 2 Diabetes and Cardiovascular Disease: UKPDS Outcomes Model

RUTH L. COLEMAN, ALASTAIR M. GRAY, DARREN K. MCGUIRE, RURY R. HOLMAN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1466-P
https://doi.org/10.2337/db19-1466-P
Published: 01 June 2019
View article titled, 1466-P: Estimating Cardiovascular Risk in People with Type 2 Diabetes and Cardiovascular Disease: UKPDS Outcomes Model
Meeting Abstracts

253-OR: Microvascular Complications in Latent Autoimmune Diabetes of Adults: Results from the UKPDS

ERNESTO MADDALONI, RUTH L. COLEMAN, RURY R. HOLMAN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):253-OR
https://doi.org/10.2337/db19-253-OR
Published: 01 June 2019
View article titled, 253-OR: Microvascular Complications in Latent Autoimmune Diabetes of Adults: Results from the UKPDS
Meeting Abstracts

Cardiovascular Event Hazards over Time in TECOS

M. ANGELYN BETHEL, HARALD SOURIJ, SUSANNA R. STEVENS, YULIYA LOKHNYGINA, RENATO D. LOPES, AMANDA ADLER, DARREN K. MCGUIRE, ERIC PETERSON, RURY R. HOLMAN
Journal: Diabetes
Diabetes 2018;67(Supplement_1):452-P
https://doi.org/10.2337/db18-452-P
Published: 01 July 2018
View article titled, Cardiovascular Event Hazards over Time in TECOS
Meeting Abstracts

Impact of SGLT2 Inhibitors (SGLT2i) on Cardiovascular (CV) Risk and Estimated Glomerular Filtration Rate (eGFR) in the EXSCEL Placebo Group

LINDSAY CLEGG, HIDDO L. HEERSPINK, ROBERT C. PENLAND, WEIFENG TANG, DAVID W. BOULTON, SRINIVAS BACHINA, ROBERT D. FOX, PETER FENICI, MARCUS THURESSON, ROBERT J. MENTZ, ADRIAN F. HERNANDEZ, M. ANGELYN BETHEL, RURY R. HOLMAN
Journal: Diabetes
Diabetes 2018;67(Supplement_1):130-LB
https://doi.org/10.2337/db18-130-LB
Published: 01 July 2018
View article titled, Impact of SGLT2 Inhibitors (SGLT2i) on Cardiovascular (CV) Risk and Estimated Glomerular Filtration Rate (eGFR) in the EXSCEL Placebo Group
Meeting Abstracts

Renal Outcomes in the EXenatide Study of Cardiovascular Event Lowering (EXSCEL)

M. ANGELYN BETHEL, ROBERT J. MENTZ, PETER MERRILL, JOHN B. BUSE, JULIANA C. CHAN, SHAUN G. GOODMAN, NAYYAR IQBAL, NELI JAKUBONIENE, BRIAN G. KATONA, YULIYA LOKHNYGINA, RENATO D. LOPES, ALDO P. MAGGIONI, PETER K. OHMAN, NEIL R. POULTER, AMBADY RAMACHANDRAN, TSVETALINA TANKOVA, BERNARD ZINMAN, ADRIAN F. HERNANDEZ, RURY R. HOLMAN
Journal: Diabetes
Diabetes 2018;67(Supplement_1):522-P
https://doi.org/10.2337/db18-522-P
Published: 01 July 2018
View article titled, Renal Outcomes in the EXenatide Study of Cardiovascular Event Lowering (EXSCEL)
Meeting Abstracts

EXSCEL—Once-Weekly Exenatide Reduces Medical Resource Utilization in Patients with Type 2 Diabetes Mellitus

SHELBY D. REED, YANHONG LI, HELEN A. DAKIN, FRAUKE BECKER, JOSE LEAL, STEPHANIE GUSTAVSON, BERNT KARTMAN, ERIC T. WITTBRODT, ROBERT J. MENTZ, NEHA PAGIDIPATI, M. ANGELYN BETHEL, ALASTAIR M. GRAY, RURY R. HOLMAN, ADRIAN F. HERNANDEZ
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1319-P
https://doi.org/10.2337/db18-1319-P
Published: 01 July 2018
View article titled, EXSCEL—Once-Weekly Exenatide Reduces Medical Resource Utilization in Patients with Type 2 Diabetes Mellitus
Meeting Abstracts

Regional Variations in Case Fatality following a Major Coronary or Cerebrovascular Event in People with Type 2 Diabetes—Evidence from the ADVANCE Trial and TECOS Trial

PHILIP M. CLARKE, XINYANG HUA, JOHN CHALMERS, MARK WOODWARD, ESQ., RUTH L. COLEMAN, JENNIFER B. GREEN, DARREN K. MCGUIRE, RURY R. HOLMAN
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1299-P
https://doi.org/10.2337/db18-1299-P
Published: 01 July 2018
View article titled, Regional Variations in Case Fatality following a Major Coronary or Cerebrovascular Event in People with Type 2 Diabetes—Evidence from the ADVANCE Trial and TECOS Trial
Journal Articles

Effects of Rosiglitazone, Glyburide, and Metformin on β-Cell Function and Insulin Sensitivity in ADOPT

Steven E. Kahn, John M. Lachin, Bernard Zinman, Steven M. Haffner, R. Paul Aftring, Gitanjali Paul, Barbara G. Kravitz, William H. Herman, Giancarlo Viberti, Rury R. Holman, and the ADOPT Study Group
Journal: Diabetes
Diabetes 2011;60(5):1552–1560
https://doi.org/10.2337/db10-1392
Published: 23 April 2011
View article titled, Effects of Rosiglitazone, Glyburide, and Metformin on β-Cell Function and Insulin Sensitivity in ADOPT
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Journal Articles

Obesity Is a Major Determinant of the Association of C-Reactive Protein Levels and the Metabolic Syndrome in Type 2 Diabetes

Steven E. Kahn, Bernard Zinman, Steven M. Haffner, M. Colleen O’Neill, Barbara G. Kravitz, Dahong Yu, Martin I. Freed, William H. Herman, Rury R. Holman, Nigel P. Jones, John M. Lachin, Giancarlo C. Viberti, the ADOPT Study Group
Journal: Diabetes
Diabetes 2006;55(8):2357–2364
https://doi.org/10.2337/db06-0116
Published: 01 August 2006
View article titled, Obesity Is a Major Determinant of the Association of C-Reactive Protein Levels and the Metabolic Syndrome in Type 2 Diabetes
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Journal Articles

Risk Factors for Renal Dysfunction in Type 2 Diabetes: U.K. Prospective Diabetes Study 74

Ravi Retnakaran, Carole A. Cull, Kerensa I. Thorne, Amanda I. Adler, Rury R. Holman, for the UKPDS Study Group
Journal: Diabetes
Diabetes 2006;55(6):1832–1839
https://doi.org/10.2337/db05-1620
Published: 01 June 2006
View article titled, Risk Factors for Renal Dysfunction in Type 2 Diabetes: <subtitle>U.K. Prospective Diabetes Study 74</subtitle>
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