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Meeting Abstracts

1132-P: Genetic Relationships between Birth Weight and Type 2 Diabetes

LAUREN E. WEDEKIND, WEN-CHI HSUEH, MUIDEEN OLAIYA, SAYUKO KOBES, LESLIE BAIER, WILLIAM C. KNOWLER, ANUBHA MAHAJAN, MARK MCCARTHY, ROBERT L. HANSON

Diabetes 2021;70(Supplement_1):1132-P

DOI: https://doi.org/10.2337/db21-1132-P

Published: 01 June 2021

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Meeting Abstracts

160-OR: Increased Adiposity and Low Height-for-Age in Early Childhood Is Associated with Later Metabolic Risk in American Indian Children and Adolescents

MARIA J. RAMIREZ-LUZURIAGA, SAYUKO KOBES, MADHUMITA SINHA, WILLIAM C. KNOWLER, ROBERT L. HANSON

Diabetes 2021;70(Supplement_1):160-OR

DOI: https://doi.org/10.2337/db21-160-OR

Published: 01 June 2021

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Meeting Abstracts

1642-P: Colocalization Analyses of Genetic Associations of Type 2 Diabetes with DNA Methylation on Chromosome 11p in American Indians

ROBERT L. HANSON, SAYUKO KOBES, WEN-CHI HSUEH, YUNHUA L. MULLER, WILLIAM C. KNOWLER, LESLIE BAIER

Diabetes 2020;69(Supplement_1):1642-P

DOI: https://doi.org/10.2337/db20-1642-P

Published: 01 June 2020

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Meeting Abstracts

1460-P: Type 2 Diabetes Polygenic Score in Addition to Clinical Factors for Prediction of Diabetes Incidence in an Indigenous American Population

LAUREN E. WEDEKIND, SAYUKO KOBES, WEN-CHI HSUEH, LESLIE BAIER, WILLIAM C. KNOWLER, ANUBHA MAHAJAN, MARK I. MCCARTHY, ROBERT L. HANSON

Diabetes 2020;69(Supplement_1):1460-P

DOI: https://doi.org/10.2337/db20-1460-P

Published: 01 June 2020

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Meeting Abstracts

1977-P: Whole-Exome Sequencing Followed by Functional Analysis to Identify Variants That May Influence Body Mass Index (BMI) via a Role in Adipogenesis

YUNHUA L. MULLER, SAMANTHA E. DAY, CIGDEM KOROGLU, SAYUKO KOBES, ROBERT L. HANSON, WILLIAM C. KNOWLER, HYE IN KIM, CRISTOPHER VAN HOUT, NEHAL GOSALIA, ALAN R. SHULDINER, CLIFTON BOGARDUS, III, LESLIE BAIER

Diabetes 2020;69(Supplement_1):1977-P

DOI: https://doi.org/10.2337/db20-1977-P

Published: 01 June 2020

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Meeting Abstracts

2018-P: Whole-Genome Sequence Identifies Potentially Functional Variants in Cytochrome B5 Type A (CYB5A) that Associate with Obesity in Southwest American Indians

SAMANTHA E. DAY, MICHAEL TRAURIG, PAOLO PIAGGI, PANKAJ KUMAR, SAYUKO KOBES, ROBERT L. HANSON, CLIFTON BOGARDUS, III, LESLIE BAIER

Diabetes 2020;69(Supplement_1):2018-P

DOI: https://doi.org/10.2337/db20-2018-P

Published: 01 June 2020

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Meeting Abstracts

271-OR: Whole-Exome Sequence Identifies Potentially Functional Rare Variants in Bardet-Biedl Syndrome (BBS) Genes that Associate with Obesity in American Indians

SAMANTHA E. DAY, YUNHUA L. MULLER, SAYUKO KOBES, HYE IN KIM, CRISTOPHER V. VAN HOUT, NEHAL GOSALIA, BIN YE, ALAN R. SHULDINER, ROBERT L. HANSON, CIGDEM KOROGLU ALTOK, CLIFTON BOGARDUS, III, LESLIE J. BAIER

Diabetes 2019;68(Supplement_1):271-OR

DOI: https://doi.org/10.2337/db19-271-OR

Published: 01 June 2019

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Meeting Abstracts

1715-P: Identifying Potentially Functional Variants in Regulatory Regions in KCNQ1 that Associate with Type 2 Diabetes in American Indians

YUNHUA L. MULLER, SAMANTHA E. DAY, SAYUKO KOBES, WILLIAM C. KNOWLER, ROBERT L. HANSON, CLIFTON BOGARDUS, III, LESLIE J. BAIER

Diabetes 2019;68(Supplement_1):1715-P

DOI: https://doi.org/10.2337/db19-1715-P

Published: 01 June 2019

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Meeting Abstracts

1701-P: Genome-Wide Association Study Identifies Novel Potential Associations with Birth Weight in a Southwestern American Indian Population

LAUREN E. WEDEKIND, WEN-CHI HSUEH, SAYUKO KOBES, MUIDEEN T. OLAIYA, WILLIAM C. KNOWLER, LESLIE J. BAIER, ROBERT L. HANSON

Diabetes 2019;68(Supplement_1):1701-P

DOI: https://doi.org/10.2337/db19-1701-P

Published: 01 June 2019

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Meeting Abstracts

1709-P: Assessing the Role of 211 “Established” Type 2 Diabetes Variants in American Indians

ROBERT L. HANSON, LAUREN E. WEDEKIND, WEN-CHI HSUEH, SAYUKO KOBES, LESLIE J. BAIER, CLIFTON BOGARDUS, III, WILLIAM C. KNOWLER

Diabetes 2019;68(Supplement_1):1709-P

DOI: https://doi.org/10.2337/db19-1709-P

Published: 01 June 2019

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Meeting Abstracts

1597-P: Incidence of Diabetes in Young Adult South Asians Compared with Pima Indians

K.M. VENKAT NARAYAN, DIMPLE KONDAL, SAYUKO KOBES, MOHAN DEEPA, NATALIE R. DAYA, SHIVANI A. PATEL, RANJIT MOHAN ANJANA, LISA R. STAIMEZ, MOHAMMED K. ALI, UNJALI GUJRAL, DORAIRAJ PRABHAKARAN, ROOPA SHIVASHANKAR, MASOOD KADIR, ELIZABETH SELVIN, VISWANATHAN MOHAN, ROBERT L. HANSON, NIKHIL TANDON

Diabetes 2019;68(Supplement_1):1597-P

DOI: https://doi.org/10.2337/db19-1597-P

Published: 01 June 2019

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Meeting Abstracts

1598-P: Incidence of Diabetes in South Asian Adults in Urban India/Pakistan Compared with Blacks and Whites in U.S.

K.M. VENKAT NARAYAN, DIMPLE KONDAL, NATALIE R. DAYA, SHIVANI A. PATEL, MOHAN DEEPA, RANJIT MOHAN ANJANA, LISA R. STAIMEZ, UNJALI GUJRAL, SAYUKO KOBES, ROOPA SHIVASHANKAR, MOHAMMED K. ALI, MASOOD KADIR, DORAIRAJ PRABHAKARAN, ROBERT L. HANSON, VISWANATHAN MOHAN, ELIZABETH SELVIN, NIKHIL TANDON

Diabetes 2019;68(Supplement_1):1598-P

DOI: https://doi.org/10.2337/db19-1598-P

Published: 01 June 2019

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Meeting Abstracts

125-OR: Child Growth Tracking and Type 2 Diabetes Risk: A Life Course Analysis

MUIDEEN T. OLAIYA, WILLIAM C. KNOWLER, ROBERT L. HANSON, SAYUKO KOBES, ROBERT NELSON, MADHUMITA SINHA

Diabetes 2019;68(Supplement_1):125-OR

DOI: https://doi.org/10.2337/db19-125-OR

Published: 01 June 2019

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Meeting Abstracts

Differential Effects of Birth Weight on Early-Onset Type 2 Diabetes in Adolescents and Young Adults

MUIDEEN T. OLAIYA, MADHUMITA SINHA, ROBERT L. HANSON, SAYUKO KOBES, ROBERT NELSON, WILLIAM C. KNOWLER

Diabetes 2018;67(Supplement_1):153-LB

DOI: https://doi.org/10.2337/db18-153-LB

Published: 01 July 2018

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Meeting Abstracts

A Low-Frequency Amerindian Specific Variant in PALD1, a Negative Regulator of Insulin Signaling, Associates with Type 2 Diabetes

ANUP K. NAIR, JEFF R. SUTHERLAND, GREGORY R. ELSON, PAOLO PIAGGI, SAYUKO KOBES, ROBERT L. HANSON, CLIFTON BOGARDUS, III, LESLIE BAIER

Diabetes 2018;67(Supplement_1):213-LB

DOI: https://doi.org/10.2337/db18-213-LB

Published: 01 July 2018

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Meeting Abstracts

Genome-Wide Association Study of Inflammatory Cytokines in Southwestern Native Americans Identifies Novel Association between WWOX and Serum TNF-? Levels

LAUREN E. WEDEKIND, MARY WALTER, SAYUKO KOBES, PENG CHEN, WEN-CHI HSUEH, ROBERT NELSON, LESLIE BAIER, WILLIAM C. KNOWLER, ROBERT L. HANSON

Diabetes 2018;67(Supplement_1):1713-P

DOI: https://doi.org/10.2337/db18-1713-P

Published: 01 July 2018

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Journal Articles

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

Andrew R. Wood, Anna Jonsson, Anne U. Jackson, Nan Wang, Nienke van Leewen, Nicholette D. Palmer, Sayuko Kobes, Joris Deelen, Lorena Boquete-Vilarino, Jussi Paananen, Alena Stančáková, Dorret I. Boomsma, Eco J.C. de Geus, Elisabeth M.W. Eekhoff, Andreas Fritsche, Mark Kramer, Giel Nijpels, Annemarie Simonis-Bik, Timon W. van Haeften, Anubha Mahajan, Michael Boehnke, Richard N. Bergman, Jaakko Tuomilehto, Francis S. Collins, Karen L. Mohlke, Karina Banasik, Christopher J. Groves, Mark I. McCarthy, Diabetes Research on Patient Stratification (DIRECT), Ewan R. Pearson, Andrea Natali, Andrea Mari, Thomas A. Buchanan, Kent D. Taylor, Anny H. Xiang, Anette P. Gjesing, Niels Grarup, Hans Eiberg, Oluf Pedersen, Yii-Derr Chen, Markku Laakso, Jill M. Norris, Ulf Smith, Lynne E. Wagenknecht, Leslie Baier, Donald W. Bowden, Torben Hansen, Mark Walker, Richard M. Watanabe, Leen M. ‘t Hart, Robert L. Hanson, Timothy M. Frayling

Diabetes 2017;66(8):2296–2309

DOI: https://doi.org/10.2337/db16-1452

Published: 10 May 2017

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Includes: Supplementary data

Journal Articles

A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants in GPR158 Associated With Reduced Energy Expenditure in American Indians

Paolo Piaggi, Ivica Masindova, Yunhua L. Muller, Josep Mercader, Gregory B. Wiessner, Peng Chen, SIGMA Type 2 Diabetes Consortium, Sayuko Kobes, Wen-Chi Hsueh, Milliejoan Mongalo, William C. Knowler, Jonathan Krakoff, Robert L. Hanson, Clifton Bogardus, Leslie J. Baier

Diabetes 2017;66(8):2284–2295

DOI: https://doi.org/10.2337/db16-1565

Published: 05 May 2017

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Includes: Supplementary data

Journal Articles

Analysis of SLC16A11 Variants in 12,811 American Indians: Genotype-Obesity Interaction for Type 2 Diabetes and an Association With RNASEK Expression

Michael Traurig, Robert L. Hanson, Alejandra Marinelarena, Sayuko Kobes, Paolo Piaggi, Shelley Cole, Joanne E. Curran, John Blangero, Harald Göring, Satish Kumar, Robert G. Nelson, Barbara V. Howard, William C. Knowler, Leslie J. Baier, Clifton Bogardus

Diabetes 2016;65(2):510–519

DOI: https://doi.org/10.2337/db15-0571

Published: 20 October 2015

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Includes: Supplementary data

Journal Articles

ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes

Leslie J. Baier, Yunhua Li Muller, Maria Sara Remedi, Michael Traurig, Paolo Piaggi, Gregory Wiessner, Ke Huang, Alyssa Stacy, Sayuko Kobes, Jonathan Krakoff, Peter H. Bennett, Robert G. Nelson, William C. Knowler, Robert L. Hanson, Colin G. Nichols, Clifton Bogardus

Diabetes 2015;64(12):4322–4332

DOI: https://doi.org/10.2337/db15-0459

Published: 05 August 2015

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Includes: Supplementary data

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NARROW

1132-P: Genetic Relationships between Birth Weight and Type 2 Diabetes

160-OR: Increased Adiposity and Low Height-for-Age in Early Childhood Is Associated with Later Metabolic Risk in American Indian Children and Adolescents

1642-P: Colocalization Analyses of Genetic Associations of Type 2 Diabetes with DNA Methylation on Chromosome 11p in American Indians

1460-P: Type 2 Diabetes Polygenic Score in Addition to Clinical Factors for Prediction of Diabetes Incidence in an Indigenous American Population

1977-P: Whole-Exome Sequencing Followed by Functional Analysis to Identify Variants That May Influence Body Mass Index (BMI) via a Role in Adipogenesis

2018-P: Whole-Genome Sequence Identifies Potentially Functional Variants in Cytochrome B5 Type A (CYB5A) that Associate with Obesity in Southwest American Indians

271-OR: Whole-Exome Sequence Identifies Potentially Functional Rare Variants in Bardet-Biedl Syndrome (BBS) Genes that Associate with Obesity in American Indians

1715-P: Identifying Potentially Functional Variants in Regulatory Regions in KCNQ1 that Associate with Type 2 Diabetes in American Indians

1701-P: Genome-Wide Association Study Identifies Novel Potential Associations with Birth Weight in a Southwestern American Indian Population

1709-P: Assessing the Role of 211 “Established” Type 2 Diabetes Variants in American Indians

1597-P: Incidence of Diabetes in Young Adult South Asians Compared with Pima Indians

1598-P: Incidence of Diabetes in South Asian Adults in Urban India/Pakistan Compared with Blacks and Whites in U.S.

125-OR: Child Growth Tracking and Type 2 Diabetes Risk: A Life Course Analysis

Differential Effects of Birth Weight on Early-Onset Type 2 Diabetes in Adolescents and Young Adults

A Low-Frequency Amerindian Specific Variant in PALD1, a Negative Regulator of Insulin Signaling, Associates with Type 2 Diabetes

Genome-Wide Association Study of Inflammatory Cytokines in Southwestern Native Americans Identifies Novel Association between WWOX and Serum TNF-? Levels

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants in GPR158 Associated With Reduced Energy Expenditure in American Indians

Analysis of SLC16A11 Variants in 12,811 American Indians: Genotype-Obesity Interaction for Type 2 Diabetes and an Association With RNASEK Expression

ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes

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