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Meeting Abstracts

292-LB: Cholesterol Accumulation in Islets Exacerbates Insulin Secretory Defects in a Model of Mild ß-Cell Dysfunction

REHANA AKTER, BREANNE BARROW, REBECCA L. HULL-MEICHLE, SAKENEH ZRAIKA, STEVEN E. KAHN

Diabetes 2023;72(Supplement_1):292-LB

https://doi.org/10.2337/db23-292-LB

Published: 20 June 2023

View articletitled, 292-LB: Cholesterol Accumulation in Islets Exacerbates Insulin Secretory Defects in a Model of Mild ß-Cell Dysfunction

Meeting Abstracts

1753-P: Islet GLP-1R Protein Expression Is Reduced in Humans with Cystic Fibrosis–Related Diabetes

RACHNA VEMIREDDY, JOSEPH J. CASTILLO, BRENDY S. FOUNTAINE, THEO K. BAMMLER, JAMES MACDONALD, REBECCA L. HULL-MEICHLE, SINA GHARIB, SAKENEH ZRAIKA

Diabetes 2023;72(Supplement_1):1753-P

https://doi.org/10.2337/db23-1753-P

Published: 20 June 2023

View articletitled, 1753-P: Islet GLP-1R Protein Expression Is Reduced in Humans with Cystic Fibrosis–Related Diabetes

Meeting Abstracts

1546-P: Gut-Specific Neprilysin Deletion Increases Insulin Secretion in High-Fat–Fed Mice

NATHALIE ESSER, STEVE M. MONGOVIN, BREANNE BARROW, SAKENEH ZRAIKA

Diabetes 2023;72(Supplement_1):1546-P

https://doi.org/10.2337/db23-1546-P

Published: 20 June 2023

View articletitled, 1546-P: Gut-Specific Neprilysin Deletion Increases Insulin Secretion in High-Fat–Fed Mice

Meeting Abstracts

1765-P: Direct ß-Cell Effects of miR-6727-3p, an miRNA Related to Improved ß-Cell Function in Humans

SAKENEH ZRAIKA, BREANNE BARROW, DANIEL ENQUOBAHRIE, THEO K. BAMMLER, JAMES MACDONALD, SENGKEO SRINOUANPRACHANH, KWUN CHUEN GARY CHAN, EDWARD J. BOYKO, STEVEN E. KAHN, PANDORA WANDER

Diabetes 2023;72(Supplement_1):1765-P

https://doi.org/10.2337/db23-1765-P

Published: 20 June 2023

View articletitled, 1765-P: Direct ß-Cell Effects of miR-6727-3p, an miRNA Related to Improved ß-Cell Function in Humans

Meeting Abstracts

1457-P: Cholesterol Accumulation in Islets Increases Steroidogenic Acute Regulatory (StAR) Protein Expression and Decreases Islet Cell Viability and ß-Cell Function

REHANA AKTER, MEGHAN F. HOGAN, NATHALIE ESSER, JOSEPH J. CASTILLO, REBECCA L. HULL-MEICHLE, SAKENEH ZRAIKA, STEVEN E. KAHN

Diabetes 2022;71(Supplement_1):1457-P

https://doi.org/10.2337/db22-1457-P

Published: 01 June 2022

View articletitled, 1457-P: Cholesterol Accumulation in Islets Increases Steroidogenic Acute Regulatory (StAR) Protein Expression and Decreases Islet Cell Viability and ß-Cell Function

Meeting Abstracts

130-OR: Statin Exposure Increases Star (Steroidogenic Acute Regulatory Protein) Expression in Islets: A Novel Mechanism for ß-Cell Dysfunction and Increased Diabetes Risk?

MEGHAN F. HOGAN, NATHALIE ESSER, ANDREW T. TEMPLIN, JOSEPH J. CASTILLO, REHANA AKTER, REBECCA L. HULL, STEVEN E. KAHN, SAKENEH ZRAIKA

Diabetes 2021;70(Supplement_1):130-OR

https://doi.org/10.2337/db21-130-OR

Published: 01 June 2021

View articletitled, 130-OR: Statin Exposure Increases Star (Steroidogenic Acute Regulatory Protein) Expression in Islets: A Novel Mechanism for ß-Cell Dysfunction and Increased Diabetes Risk?

Meeting Abstracts

1797-P: Effect of LCZ696 and Its Components Sacubitril and Valsartan on Insulin Secretion and Glucose Homeostasis in Mice

NATHALIE ESSER, CHRISTINE R. SCHMIDT, BREANNE BARROW, LAURA CRONIC, DARYL J. HACKNEY, STEVE M. MONGOVIN, REBECCA L. HULL, SAKENEH ZRAIKA

Diabetes 2020;69(Supplement_1):1797-P

https://doi.org/10.2337/db20-1797-P

Published: 01 June 2020

View articletitled, 1797-P: Effect of LCZ696 and Its Components Sacubitril and Valsartan on Insulin Secretion and Glucose Homeostasis in Mice

Meeting Abstracts

2039-P: Plasmin-Mediated Cleavage of Human Islet Amyloid Polypeptide (hIAPP) Protects ß-Cells from Amyloid-Induced Toxicity

NATHALIE ESSER, MEGHAN F. HOGAN, ANDREW T. TEMPLIN, JOSEPH J. CASTILLO, DANIEL RALEIGH, JOHN S. EDGAR, SAKENEH ZRAIKA, REBECCA L. HULL, STEVEN E. KAHN

Diabetes 2020;69(Supplement_1):2039-P

https://doi.org/10.2337/db20-2039-P

Published: 01 June 2020

View articletitled, 2039-P: Plasmin-Mediated Cleavage of Human Islet Amyloid Polypeptide (hIAPP) Protects ß-Cells from Amyloid-Induced Toxicity

Meeting Abstracts

2042-P: Loss of Apoptosis Repressor with Caspase Recruitment Domain Promotes High-Fat Diet Induced Hyperglycemia In Vivo

ANDREW T. TEMPLIN, CHRISTINE R. SCHMIDT, MEGHAN F. HOGAN, NATHALIE ESSER, RICHARD N. KITSIS, REBECCA L. HULL, SAKENEH ZRAIKA, STEVEN E. KAHN

Diabetes 2020;69(Supplement_1):2042-P

https://doi.org/10.2337/db20-2042-P

Published: 01 June 2020

View articletitled, 2042-P: Loss of Apoptosis Repressor with Caspase Recruitment Domain Promotes High-Fat Diet Induced Hyperglycemia In Vivo

Meeting Abstracts

2040-P: Chronic Activation of CREB by Islet Amyloid Increases Star (Steroidogenic Acute Regulatory Protein) Expression in Islets

MEGHAN F. HOGAN, NATHALIE ESSER, ANDREW T. TEMPLIN, JOSEPH J. CASTILLO, SAKENEH ZRAIKA, REBECCA L. HULL, STEVEN E. KAHN

Diabetes 2020;69(Supplement_1):2040-P

https://doi.org/10.2337/db20-2040-P

Published: 01 June 2020

View articletitled, 2040-P: Chronic Activation of CREB by Islet Amyloid Increases Star (Steroidogenic Acute Regulatory Protein) Expression in Islets

Meeting Abstracts

154-OR: Neprilysin Inhibition Increases Glucagon Levels with Possible Implications for Hepatic Amino Acid Metabolism

SASHA KJELDSEN, SAKENEH ZRAIKA, STEVE M. MONGOVIN, LASSE H. HANSEN, DIJANA TERZIC, PETER D. MARK, JR., PETER PLOMGAARD, JENS P. GØTZE, MARIE WINTHER-SOERENSEN, JENNA HUNT, KATRINE D. GALSGAARD, METTE M. ROSENKILDE, GIJS H. GOOSSENS, ELLEN E. BLAAK, JENS J. HOLST, NICOLAI J. WEWER ALBRECHTSEN

Diabetes 2020;69(Supplement_1):154-OR

https://doi.org/10.2337/db20-154-OR

Published: 01 June 2020

View articletitled, 154-OR: Neprilysin Inhibition Increases Glucagon Levels with Possible Implications for Hepatic Amino Acid Metabolism

Meeting Abstracts

1829-P: Acute Inhibition of Intestinal Neprilysin Enhances Glucose-Stimulated Insulin Secretion in Mice

NATHALIE ESSER, THOMAS O. MUNDINGER, BREANNE BARROW, STEVE M. MONGOVIN, SAKENEH ZRAIKA

Diabetes 2019;68(Supplement_1):1829-P

https://doi.org/10.2337/db19-1829-P

Published: 01 June 2019

View articletitled, 1829-P: Acute Inhibition of Intestinal Neprilysin Enhances Glucose-Stimulated Insulin Secretion in Mice

Meeting Abstracts

2126-P: Physiological Concentrations of IL-1 Beta Promote Islet Amyloid Deposition by Increasing Beta-Cell Secretion of Human Islet Amyloid Polypeptide

ANDREW T. TEMPLIN, MAHNAZ MELLATI, DANIEL ZEMAN-MEIER, MEGHAN F. HOGAN, NATHALIE ESSER, SAKENEH ZRAIKA, REBECCA L. HULL, STEVEN E. KAHN

Diabetes 2019;68(Supplement_1):2126-P

https://doi.org/10.2337/db19-2126-P

Published: 01 June 2019

View articletitled, 2126-P: Physiological Concentrations of IL-1 Beta Promote Islet Amyloid Deposition by Increasing Beta-Cell Secretion of Human Islet Amyloid Polypeptide

Meeting Abstracts

2125-P: Increased StAR (Steroidogenic Acute Regulatory Protein) Is Detrimental to ß Cells and Promotes Mitochondrial Dysfunction

MEGHAN F. HOGAN, NATHALIE ESSER, ANDREW T. TEMPLIN, SAKENEH ZRAIKA, REBECCA L. HULL, SAM EL-OSTA, STEVEN E. KAHN

Diabetes 2019;68(Supplement_1):2125-P

https://doi.org/10.2337/db19-2125-P

Published: 01 June 2019

View articletitled, 2125-P: Increased StAR (Steroidogenic Acute Regulatory Protein) Is Detrimental to ß Cells and Promotes Mitochondrial Dysfunction

Meeting Abstracts

2124-P: The Tissue Plasminogen Activator (tPA)/Plasmin System Reduces Amyloid Formation by Cleaving Human Islet Amyloid Polypeptide (hIAPP)

NATHALIE ESSER, MEGHAN F. HOGAN, ALFRED APLIN, ANDREW T. TEMPLIN, SAM EL-OSTA, DANIEL RALEIGH, JOHN S. EDGAR, SAKENEH ZRAIKA, REBECCA L. HULL, STEVEN E. KAHN

Diabetes 2019;68(Supplement_1):2124-P

https://doi.org/10.2337/db19-2124-P

Published: 01 June 2019

View articletitled, 2124-P: The Tissue Plasminogen Activator (tPA)/Plasmin System Reduces Amyloid Formation by Cleaving Human Islet Amyloid Polypeptide (hIAPP)

Meeting Abstracts

Treatment of Hyperglycemia with Empagliflozin, With or Without Metformin, Improves Islet Endothelial Cell Health and Insulin Secretion in db/db Diabetic Mice

MEGHAN F. HOGAN, DARYL J. HACKNEY, ALFRED APLIN, THOMAS O. MUNDINGER, SAKENEH ZRAIKA, REBECCA L. HULL

Diabetes 2018;67(Supplement_1):1815-P

https://doi.org/10.2337/db18-1815-P

Published: 01 July 2018

View articletitled, Treatment of Hyperglycemia with Empagliflozin, With or Without Metformin, Improves Islet Endothelial Cell Health and Insulin Secretion in db/db Diabetic Mice

Meeting Abstracts

Evidence for Necroptosis as a Mechanism of Islet Amyloid–Induced Beta-Cell Death

ANDREW T. TEMPLIN, MEGHAN F. HOGAN, NATHALIE ESSER, SAKENEH ZRAIKA, REBECCA L. HULL, STEVEN E. KAHN

Diabetes 2018;67(Supplement_1):82-OR

https://doi.org/10.2337/db18-82-OR

Published: 01 July 2018

View articletitled, Evidence for Necroptosis as a Mechanism of Islet Amyloid–Induced Beta-Cell Death

Meeting Abstracts

Pharmacological Neprilysin Inhibition Improves Glucose Homeostasis in a Mouse Model of Type 2 Diabetes

JACQUELINE H. PARILLA, STEVE MONGOVIN, BREANNE BARROW, NATHALIE ESSER, SAKENEH ZRAIKA

Diabetes 2018;67(Supplement_1):1825-P

https://doi.org/10.2337/db18-1825-P

Published: 01 July 2018

View articletitled, Pharmacological Neprilysin Inhibition Improves Glucose Homeostasis in a Mouse Model of Type 2 Diabetes

Meeting Abstracts

Tissue Plasminogen Activator (tPA) Expression Is Increased by Islet Amyloid Formation In Vitro

NATHALIE ESSER, MEGHAN F. HOGAN, ANDREW T. TEMPLIN, MARK ZIEMANN, ASSAM EL-OSTA, SAKENEH ZRAIKA, REBECCA L. HULL, STEVEN E. KAHN

Diabetes 2018;67(Supplement_1):2107-P

https://doi.org/10.2337/db18-2107-P

Published: 01 July 2018

View articletitled, Tissue Plasminogen Activator (tPA) Expression Is Increased by Islet Amyloid Formation In Vitro

Journal Articles

Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation

Andrew T. Templin, Tanya Samarasekera, Daniel T. Meier, Meghan F. Hogan, Mahnaz Mellati, Michael T. Crow, Richard N. Kitsis, Sakeneh Zraika, Rebecca L. Hull, Steven E. Kahn

Diabetes 2017;66(10):2636–2645

https://doi.org/10.2337/db16-1352

Published: 20 July 2017

View articletitled, Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation

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292-LB: Cholesterol Accumulation in Islets Exacerbates Insulin Secretory Defects in a Model of Mild ß-Cell Dysfunction

1753-P: Islet GLP-1R Protein Expression Is Reduced in Humans with Cystic Fibrosis–Related Diabetes

1546-P: Gut-Specific Neprilysin Deletion Increases Insulin Secretion in High-Fat–Fed Mice

1765-P: Direct ß-Cell Effects of miR-6727-3p, an miRNA Related to Improved ß-Cell Function in Humans

1457-P: Cholesterol Accumulation in Islets Increases Steroidogenic Acute Regulatory (StAR) Protein Expression and Decreases Islet Cell Viability and ß-Cell Function

130-OR: Statin Exposure Increases Star (Steroidogenic Acute Regulatory Protein) Expression in Islets: A Novel Mechanism for ß-Cell Dysfunction and Increased Diabetes Risk?

1797-P: Effect of LCZ696 and Its Components Sacubitril and Valsartan on Insulin Secretion and Glucose Homeostasis in Mice

2039-P: Plasmin-Mediated Cleavage of Human Islet Amyloid Polypeptide (hIAPP) Protects ß-Cells from Amyloid-Induced Toxicity

2042-P: Loss of Apoptosis Repressor with Caspase Recruitment Domain Promotes High-Fat Diet Induced Hyperglycemia In Vivo

2040-P: Chronic Activation of CREB by Islet Amyloid Increases Star (Steroidogenic Acute Regulatory Protein) Expression in Islets

154-OR: Neprilysin Inhibition Increases Glucagon Levels with Possible Implications for Hepatic Amino Acid Metabolism

1829-P: Acute Inhibition of Intestinal Neprilysin Enhances Glucose-Stimulated Insulin Secretion in Mice

2126-P: Physiological Concentrations of IL-1 Beta Promote Islet Amyloid Deposition by Increasing Beta-Cell Secretion of Human Islet Amyloid Polypeptide

2125-P: Increased StAR (Steroidogenic Acute Regulatory Protein) Is Detrimental to ß Cells and Promotes Mitochondrial Dysfunction

2124-P: The Tissue Plasminogen Activator (tPA)/Plasmin System Reduces Amyloid Formation by Cleaving Human Islet Amyloid Polypeptide (hIAPP)

Treatment of Hyperglycemia with Empagliflozin, With or Without Metformin, Improves Islet Endothelial Cell Health and Insulin Secretion in db/db Diabetic Mice

Evidence for Necroptosis as a Mechanism of Islet Amyloid–Induced Beta-Cell Death

Pharmacological Neprilysin Inhibition Improves Glucose Homeostasis in a Mouse Model of Type 2 Diabetes

Tissue Plasminogen Activator (tPA) Expression Is Increased by Islet Amyloid Formation In Vitro

Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation

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