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Journal Articles

Adipose tissue biology and effect of weight loss in women with lipedema

Vincenza Cifarelli, Gordon I. Smith, Silvia Gonzalez-Nieves, Dmitri Samovski, Hector H. Palacios, Jun Yoshino, Richard I. Stein, Anja Fuchs, Thomas F. Wright, Samuel Klein

Diabetes db240890

https://doi.org/10.2337/db24-0890

Published: 09 December 2024

View article titled, Adipose tissue biology and effect of weight loss in women with lipedema

Journal Articles

Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People With Obesity and Type 2 Diabetes

Max C. Petersen, Mihoko Yoshino, Gordon I. Smith, Rafael C. Gaspar, Mario Kahn, Dmitri Samovski, Gerald I. Shulman, Samuel Klein

Diabetes 2024;73(12):2055–2064

https://doi.org/10.2337/db24-0083

Published: 12 September 2024

View article titled, Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People With Obesity and Type 2 Diabetes

Meeting Abstracts

347-OR: Plasma Lipidome in People with Insulin-Sensitive and Insulin-Resistant Obesity

MAX C. PETERSEN, GORDON I. SMITH, AARON ARMANDO, OSWALD QUEHENBERGER, EDWARD A. DENNIS, SAMUEL KLEIN

Diabetes 2024;73(Supplement_1):347-OR

https://doi.org/10.2337/db24-347-OR

Published: 14 June 2024

View article titled, 347-OR: Plasma Lipidome in People with Insulin-Sensitive and Insulin-Resistant Obesity

Journal Articles

Critical Evaluation of Indices Used to Assess β-Cell Function

Chao Cao, Han-Chow E. Koh, Dominic N. Reeds, Bruce W. Patterson, Samuel Klein, Bettina Mittendorfer

Diabetes 2024;73(3):391–400

https://doi.org/10.2337/db23-0613

Published: 28 November 2023

View article titled, Critical Evaluation of Indices Used to Assess β-Cell Function

Meeting Abstracts

334-OR: Pemvidutide (ALT-801) , a Balanced (1:1) GLP-1/Glucagon Dual Receptor Agonist, Induces Rapid and Marked Weight Loss without the Need for Dose Titration in People with Overweight/Obesity

SAMUEL KLEIN, JOHN J. NESTOR, JR., M. SCOTT HARRIS, ANVAR SUYUNDIKOV, ROB CASPER, STACI M. STEELE, JACQUES D. PAYNE, VYJAYANTHI KRISHNAN, M. SCOT ROBERTS, SARAH K. BROWNE

Diabetes 2022;71(Supplement_1):334-OR

https://doi.org/10.2337/db22-334-OR

Published: 01 June 2022

View article titled, 334-OR: Pemvidutide (ALT-801) , a Balanced (1:1) GLP-1/Glucagon Dual Receptor Agonist, Induces Rapid and Marked Weight Loss without the Need for Dose Titration in People with Overweight/Obesity

Meeting Abstracts

1411-P: Increased 24-Hour Plasma Free Fatty Acids in People with Obesity and Prediabetes

MAX C. PETERSEN, SARAH S. FARABI, GORDON SMITH, SAMUEL KLEIN

Diabetes 2022;71(Supplement_1):1411-P

https://doi.org/10.2337/db22-1411-P

Published: 01 June 2022

View article titled, 1411-P: Increased 24-Hour Plasma Free Fatty Acids in People with Obesity and Prediabetes

Meeting Abstracts

236-OR: Volagidemab, a Human Glucagon Receptor Antagonist, Improves Glycemic Control in Subjects with Type 1 Diabetes (T1D): A 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial

JEREMY PETTUS, SCHAFER C. BOEDER, MARK P. CHRISTIANSEN, DOUGLAS S. DENHAM, TIMOTHY S. BAILEY, HALIS K. AKTURK, LESLIE J. KLAFF, JULIO ROSENSTOCK, MICKIE H.M. CHENG, BRUCE W. BODE, EDGAR D. BAUTISTA, HAI YAN, DUNG THAI, SATISH K. GARG, SAMUEL KLEIN

Diabetes 2021;70(Supplement_1):236-OR

https://doi.org/10.2337/db21-236-OR

Published: 01 June 2021

View article titled, 236-OR: Volagidemab, a Human Glucagon Receptor Antagonist, Improves Glycemic Control in Subjects with Type 1 Diabetes (T1D): A 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial

Meeting Abstracts

30-LB: Effect of Intense Lifestyle Therapy in People with Obesity and Type 2 Diabetes

MIHOKO YOSHINO, JUN YOSHINO, ADAM J. BITTEL, DANIEL BITTEL, DOMINIC REEDS, RICHARD STEIN, DAVID R. SINACORE, WILLIAM T. CADE, ADEWOLE L. OKUNADE, BRUCE W. PATTERSON, SAMUEL KLEIN

Diabetes 2021;70(Supplement_1):30-LB

https://doi.org/10.2337/db21-30-LB

Published: 01 June 2021

View article titled, 30-LB: Effect of Intense Lifestyle Therapy in People with Obesity and Type 2 Diabetes

Journal Articles

Obesity Is Associated With Increased Basal and Postprandial β-Cell Insulin Secretion Even in the Absence of Insulin Resistance

Stephan van Vliet, Han-Chow E. Koh, Bruce W. Patterson, Mihoko Yoshino, Richard LaForest, Robert J. Gropler, Samuel Klein, Bettina Mittendorfer

Diabetes 2020;69(10):2112–2119

https://doi.org/10.2337/db20-0377

Published: 10 July 2020

View article titled, Obesity Is Associated With Increased Basal and Postprandial β-Cell Insulin Secretion Even in the Absence of Insulin Resistance

Meeting Abstracts

2031-P: Obesity and Insulin Resistance Alter the Biodistribution of Whole Body Insulin-Stimulated Glucose Disposal

HAN-CHOW KOH, STEPHAN VAN VLIET, RICHARD LAFOREST, ROBERT GROPLER, SAMUEL KLEIN, BETTINA MITTENDORFER

Diabetes 2020;69(Supplement_1):2031-P

https://doi.org/10.2337/db20-2031-P

Published: 01 June 2020

View article titled, 2031-P: Obesity and Insulin Resistance Alter the Biodistribution of Whole Body Insulin-Stimulated Glucose Disposal

Meeting Abstracts

1472-P: Clinical Profile of Nonalcoholic Fatty Liver Disease in Adults with Type 2 Diabetes Mellitus

KENNETH CUSI, MICHAEL RODEN, ALFRED S. BARRITT, IV, ROBERTO J. FIRPI, VIRGINIA CLARK, SAMUEL KLEIN, ANNA LOK, PHILIP NEWSOME, KAREN CORBIN, MIRIAM B. VOS, RAJENDER REDDY, CHERYL SCHOEN, ANDREA R. MOSPAN, JAWAHAR L. TAUNK, KATHLEEN WYNE, BRENT NEUSCHWANDER-TETRI, ARUN SANYAL

Diabetes 2020;69(Supplement_1):1472-P

https://doi.org/10.2337/db20-1472-P

Published: 01 June 2020

View article titled, 1472-P: Clinical Profile of Nonalcoholic Fatty Liver Disease in Adults with Type 2 Diabetes Mellitus

Meeting Abstracts

Clinical Profile of Adults with Nonalcoholic Steatohepatitis (NASH) With and Without Type 2 Diabetes Mellitus (T2DM)

KENNETH CUSI, ALFRED S. BARRITT, IV, VIRGINIA CLARK, ROBERTO J. FIRPI, SAMUEL KLEIN, ANNA LOK, ROHIT LOOMBA, LAURA MALAHIAS, BRENT NEUSCHWANDER-TETRI, CHERYL SCHOEN, K. RAJENDER REDDY, JAWAHAR L. TAUNK, KATHLEEN WYNE, ARUN J. SANYAL

Diabetes 2018;67(Supplement_1):1640-P

https://doi.org/10.2337/db18-1640-P

Published: 01 July 2018

View article titled, Clinical Profile of Adults with Nonalcoholic Steatohepatitis (NASH) With and Without Type 2 Diabetes Mellitus (T2DM)

Meeting Abstracts

Changing Glucose Tolerance during Pregnancy—Implications for Diagnosis of Gestational Diabetes Mellitus (GDM)

WILLIAM C. KNOWLER, KIMBERLY DREWS, LEANNE REDMAN, KAUMUDI J. JOSHIPURA, S. SONIA ARTEAGA, XAVIER PI-SUNYER, LINDA VAN HORN, RENA R. WING, SAMUEL KLEIN, LIFE-MOMS RESEARCH GROUP

Diabetes 2018;67(Supplement_1):119-OR

https://doi.org/10.2337/db18-119-OR

Published: 01 July 2018

View article titled, Changing Glucose Tolerance during Pregnancy—Implications for Diagnosis of Gestational Diabetes Mellitus (GDM)

Meeting Abstracts

Fasting-Induced Changes in Glucagon Secretion Are Dysregulated in Obesity

JENNIFER H. STERN, GORDON I. SMITH, ROGER H. UNGER, SAMUEL KLEIN, PHILIPP E. SCHERER

Diabetes 2018;67(Supplement_1):271-LB

https://doi.org/10.2337/db18-271-LB

Published: 01 July 2018

View article titled, Fasting-Induced Changes in Glucagon Secretion Are Dysregulated in Obesity

Journal Articles

Alterations in 3-Hydroxyisobutyrate and FGF21 Metabolism Are Associated With Protein Ingestion–Induced Insulin Resistance

Lydia-Ann L.S. Harris, Gordon I. Smith, Bruce W. Patterson, Raja S. Ramaswamy, Adewole L. Okunade, Shannon C. Kelly, Lane C. Porter, Samuel Klein, Jun Yoshino, Bettina Mittendorfer

Diabetes 2017;66(7):1871–1878

https://doi.org/10.2337/db16-1475

Published: 04 May 2017

View article titled, Alterations in 3-Hydroxyisobutyrate and FGF21 Metabolism Are Associated With Protein Ingestion–Induced Insulin Resistance

Includes: Supplementary data

Journal Articles

Sweet Dopamine: Sucrose Preferences Relate Differentially to Striatal D₂ Receptor Binding and Age in Obesity

Marta Y. Pepino, Sarah A. Eisenstein, Allison N. Bischoff, Samuel Klein, Stephen M. Moerlein, Joel S. Perlmutter, Kevin J. Black, Tamara Hershey

Diabetes 2016;65(9):2618–2623

https://doi.org/10.2337/db16-0407

Published: 15 June 2016

View article titled, Sweet Dopamine: Sucrose Preferences Relate Differentially to Striatal D<sub>2</sub> Receptor Binding and Age in Obesity

Journal Articles

Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function

Katsuhiko Funai, Irfan J. Lodhi, Larry D. Spears, Li Yin, Haowei Song, Samuel Klein, Clay F. Semenkovich

Diabetes 2016;65(2):358–370

https://doi.org/10.2337/db15-0659

Published: 28 October 2015

View article titled, Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function

Includes: Supplementary data

Journal Articles

Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation

Gordon I. Smith, Jun Yoshino, Kelly L. Stromsdorfer, Seth J. Klein, Faidon Magkos, Dominic N. Reeds, Samuel Klein, Bettina Mittendorfer

Diabetes 2015;64(5):1555–1563

https://doi.org/10.2337/db14-1279

Published: 04 December 2014

View article titled, Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation

Journal Articles

Response to Comment on Fabbrini et al. Effect of Plasma Uric Acid on Antioxidant Capacity, Oxidative Stress, and Insulin Sensitivity in Obese Subjects. Diabetes 2014;63:976−981

Elisa Fabbrini, Mauro Serafini, Samuel Klein

Diabetes 2014;63(9):e19

https://doi.org/10.2337/db14-0885

Published: 16 August 2014

View article titled, Response to Comment on Fabbrini et al. Effect of Plasma Uric Acid on Antioxidant Capacity, Oxidative Stress, and Insulin Sensitivity in Obese Subjects. Diabetes 2014;63:976−981

Journal Articles

The Extracellular Matrix Protein MAGP1 Supports Thermogenesis and Protects Against Obesity and Diabetes Through Regulation of TGF-β

Clarissa S. Craft, Terri A. Pietka, Timothy Schappe, Trey Coleman, Michelle D. Combs, Samuel Klein, Nada A. Abumrad, Robert P. Mecham

Diabetes 2014;63(6):1920–1932

https://doi.org/10.2337/db13-1604

Published: 15 May 2014

View article titled, The Extracellular Matrix Protein MAGP1 Supports Thermogenesis and Protects Against Obesity and Diabetes Through Regulation of TGF-β

Includes: Supplementary data

NARROW

Adipose tissue biology and effect of weight loss in women with lipedema

Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People With Obesity and Type 2 Diabetes

347-OR: Plasma Lipidome in People with Insulin-Sensitive and Insulin-Resistant Obesity

Critical Evaluation of Indices Used to Assess β-Cell Function

334-OR: Pemvidutide (ALT-801) , a Balanced (1:1) GLP-1/Glucagon Dual Receptor Agonist, Induces Rapid and Marked Weight Loss without the Need for Dose Titration in People with Overweight/Obesity

1411-P: Increased 24-Hour Plasma Free Fatty Acids in People with Obesity and Prediabetes

236-OR: Volagidemab, a Human Glucagon Receptor Antagonist, Improves Glycemic Control in Subjects with Type 1 Diabetes (T1D): A 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial

30-LB: Effect of Intense Lifestyle Therapy in People with Obesity and Type 2 Diabetes

Obesity Is Associated With Increased Basal and Postprandial β-Cell Insulin Secretion Even in the Absence of Insulin Resistance

2031-P: Obesity and Insulin Resistance Alter the Biodistribution of Whole Body Insulin-Stimulated Glucose Disposal

1472-P: Clinical Profile of Nonalcoholic Fatty Liver Disease in Adults with Type 2 Diabetes Mellitus

Clinical Profile of Adults with Nonalcoholic Steatohepatitis (NASH) With and Without Type 2 Diabetes Mellitus (T2DM)

Changing Glucose Tolerance during Pregnancy—Implications for Diagnosis of Gestational Diabetes Mellitus (GDM)

Fasting-Induced Changes in Glucagon Secretion Are Dysregulated in Obesity

Alterations in 3-Hydroxyisobutyrate and FGF21 Metabolism Are Associated With Protein Ingestion–Induced Insulin Resistance

Sweet Dopamine: Sucrose Preferences Relate Differentially to Striatal D₂ Receptor Binding and Age in Obesity

Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function

Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation

Response to Comment on Fabbrini et al. Effect of Plasma Uric Acid on Antioxidant Capacity, Oxidative Stress, and Insulin Sensitivity in Obese Subjects. Diabetes 2014;63:976−981

The Extracellular Matrix Protein MAGP1 Supports Thermogenesis and Protects Against Obesity and Diabetes Through Regulation of TGF-β

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