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Meeting Abstracts

466-P: Changes in Oral and Intestinal Bacterial Flora Associated with Pain Thresholds

KAZUHIRO KUDOH, YUKI TAKEUCHI, SHO OSONOI, TAKANORI SASAKI, SAORI OGASAWARA, SOROKU YAGIHASHI, HIROKI MIZUKAMI

Diabetes 2022;71(Supplement_1):466-P

DOI: https://doi.org/10.2337/db22-466-P

Published: 01 June 2022

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Meeting Abstracts

80-OR: Proinflammatory Macrophage Impairs Retrograde Axonal Transport via Inflammation and Insulin Resistance in Sensory Neurons

SHO OSONOI, HIROKI MIZUKAMI, SAORI OGASAWARA, KAZUHIRO KUDOH, MAKOTO DAIMON, SOROKU YAGIHASHI

Diabetes 2022;71(Supplement_1):80-OR

DOI: https://doi.org/10.2337/db22-80-OR

Published: 01 June 2022

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Meeting Abstracts

1448-P: Partial Pancreatectomy Increased α-Cell Volume Density, but Not Compensated ß-Cell Volume in Japanese Subjects

YUKI TAKEUCHI, HIROKI MIZUKAMI, SHO OSONOI, KAZUHIRO KUDOH, TAKANORI SASAKI, SOROKU YAGIHASHI

Diabetes 2022;71(Supplement_1):1448-P

DOI: https://doi.org/10.2337/db22-1448-P

Published: 01 June 2022

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Meeting Abstracts

206-OR: RAGE-Dependent Macrophage Activation Aggravates Retrograde Axonal Transport via Attenuated Insulin Signaling of Peripheral Nerves in Experimental Diabetic Polyneuropathy

SHO OSONOI, HIROKI MIZUKAMI, KAZUHIRO KUDO, YASUHIKO YAMAMOTO

Diabetes 2021;70(Supplement_1):206-OR

DOI: https://doi.org/10.2337/db21-206-OR

Published: 01 June 2021

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Journal Articles

MEK/ERK Signaling in β-Cells Bifunctionally Regulates β-Cell Mass and Glucose-Stimulated Insulin Secretion Response to Maintain Glucose Homeostasis

Yoshiko Matsumoto Ikushima, Motoharu Awazawa, Naoki Kobayashi, Sho Osonoi, Seiichi Takemiya, Hiroshi Kobayashi, Hirotsugu Suwanai, Yuichi Morimoto, Kotaro Soeda, Jun Adachi, Masafumi Muratani, Jean Charron, Hiroki Mizukami, Noriko Takahashi, Kohjiro Ueki

Diabetes 2021;70(7):1519–1535

DOI: https://doi.org/10.2337/db20-1295

Published: 27 April 2021

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Meeting Abstracts

2047-P: Possible Implication of Cyclin D2 in Beta-Cell Proliferation of Human Perinatal Islet

SHO OSONOI, HIROSHI ICHINOHE, KAZUHIRO KUDO, SOROKU YAGIHASHI, HIROKI MIZUKAMI

Diabetes 2020;69(Supplement_1):2047-P

DOI: https://doi.org/10.2337/db20-2047-P

Published: 01 June 2020

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Meeting Abstracts

561-P: Activated Xanthine Oxidase in Serum Is a Potent Therapeutic Target for Experimental Diabetic Polyneuropathy

HIROSHI ICHINOHE, HIROKI MIZUKAMI, SHO OSONOI, KAZUHIRO KUDO, SOROKU YAGIHASHI

Diabetes 2020;69(Supplement_1):561-P

DOI: https://doi.org/10.2337/db20-561-P

Published: 01 June 2020

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Meeting Abstracts

1575-P: Health-Related Quality of Life in Patients with Type 2 Diabetes: A Case-Control Study

HIROSHI MURAKAMI, TOMOYUKI FUJITA, MASAYA MURABAYASHI, SATORU MIZUSHIRI, SHO OSONOI, YUKI MATSUHASHI, MAKOTO DAIMON

Diabetes 2020;69(Supplement_1):1575-P

DOI: https://doi.org/10.2337/db20-1575-P

Published: 01 June 2020

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Journal Articles

Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation

Joon Ho Moon, Yeong Gi Kim, Kyuho Kim, Sho Osonoi, Shuang Wang, Diane C. Saunders, Juehu Wang, Katherine Yang, Hyeongseok Kim, Junguee Lee, Ji-Seon Jeong, Ronadip R. Banerjee, Seung K. Kim, Yingjie Wu, Hiroki Mizukami, Alvin C. Powers, Michael S. German, Hail Kim

Diabetes 2020;69(2):205–214

DOI: https://doi.org/10.2337/db19-0546

Published: 05 December 2019

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Includes: Supplementary data

Meeting Abstracts

319-OR: Deficit of Retrograde Axonal Transportation Was Mediated via Activation of Macrophage RAGE Signaling in Experimental Diabetic Polyneuropathy

SHO OSONOI, HIROKI MIZUKAMI, KAZUHISA TAKAHASHI, KAZUHIRO KUDO, KAZUNORI SANGO, SOROKU YAGIHASHI

Diabetes 2019;68(Supplement_1):319-OR

DOI: https://doi.org/10.2337/db19-319-OR

Published: 01 June 2019

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Meeting Abstracts

1452-P: Association between Aging and Insulin Resistance and Secretion in a General Nondiabetic Population

TOMOYUKI FUJITA, MAKOTO DAIMON, HIROSHI MURAKAMI, SATORU MIZUSHIRI, YUKI MATSUHASHI, SHO OSONOI, MASAYA MURABAYASHI, KAZUHISA TAKAHASHI, YUKI NISHIYA

Diabetes 2019;68(Supplement_1):1452-P

DOI: https://doi.org/10.2337/db19-1452-P

Published: 01 June 2019

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Meeting Abstracts

2148-P: Islet Endocrine Cells Shows a Unique Pattern on Development and Growth of Each Cell Type in Human Subjects

SHO OSONOI, HIROKI MIZUKAMI, KAZUHISA TAKAHASHI, KAZUHIRO KUDO, SOROKU YAGIHASHI

Diabetes 2019;68(Supplement_1):2148-P

DOI: https://doi.org/10.2337/db19-2148-P

Published: 01 June 2019

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Meeting Abstracts

2127-P: Reduced Islet Parasympathetic Nerve Density Correlates with Decrease in Beta-Cell Volume of Islet in Lean Type 2 Diabetic Goto-Kakizaki Rat

HIROKI MIZUKAMI, DANYANG GUO, KAZUHISA TAKAHASHI, SHO OSONOI, KAZUHIRO KUDO, SOROKU YAGIHASHI

Diabetes 2019;68(Supplement_1):2127-P

DOI: https://doi.org/10.2337/db19-2127-P

Published: 01 June 2019

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Meeting Abstracts

566-P: Mild Increase of Proinflammatory Macrophages Correlates with Reduction of Nerve Fiber Density in Sural Nerve of Human Type 2 Diabetic Subjects

HIROKI MIZUKAMI, SHO OSONOI, KAZUHISA TAKAHASHI, KAZUHIRO KUDO, CHIEKO ITABASHI, SOROKU YAGIHASHI

Diabetes 2019;68(Supplement_1):566-P

DOI: https://doi.org/10.2337/db19-566-P

Published: 01 June 2019

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Meeting Abstracts

The Postprandial C-peptide–to–Glucose Ratio Correlated with Beta-Cell Function in Japanese Patients with Type 2 Diabetes Mellitus

YUKI MATSUHASHI, SHINJI CHIKAZAWA, HIROFUMI NAKAYAMA, MASAYA MURABAYASHI, SATORU MIZUSHIRI, SHO OSONOI, KAZUHISA TAKAHASHI, HIDEYUKI OTAKA, MIYUKI YANAGIMACHI, HIROSHI MURAKAMI, MAKOTO DAIMON

Diabetes 2018;67(Supplement_1):1831-P

DOI: https://doi.org/10.2337/db18-1831-P

Published: 01 July 2018

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Meeting Abstracts

Synergistic Effects of Long-Term Combination Therapy of DPP-4 Inhibitor and SGLT2 Inhibitor on the Preservation of Beta-Cell Volume in Rats with Type 2 Diabetes

HIROKI MIZUKAMI, DANYANG GUO, KAZUHISA TAKAHASHI, SHO OSONOI, SAORI OGASAWARA, WATARU INABA, SOROKU YAGIHASHI

Diabetes 2018;67(Supplement_1):2132-P

DOI: https://doi.org/10.2337/db18-2132-P

Published: 01 July 2018

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Meeting Abstracts

Beneficial Effects of Xanthine Oxidase Inhibitor, Topiloxostat, on Experimental Diabetic Neuropathy in Mice

HIROKI MIZUKAMI, REMINA KOYAMA, KAZUHISA TAKAHASHI, SHO OSONOI, SAORI OGASAWARA, SOROKU YAGIHASHI

Diabetes 2018;67(Supplement_1):549-P

DOI: https://doi.org/10.2337/db18-549-P

Published: 01 July 2018

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Meeting Abstracts

Suppression of Neuropathy Development in Diabetic Rage-Deficient Mice Is Associated with Absence of M1/M2 Macrophage Skewing in the Sciatic Nerve

SHO OSONOI, HIROKI MIZUKAMI, SAORI OGASAWARA, KAZUHISA TAKAHASHI, KAZUNORI SANGO, SOROKU YAGIHASHI

Diabetes 2018;67(Supplement_1):575-P

DOI: https://doi.org/10.2337/db18-575-P

Published: 01 July 2018

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NARROW

466-P: Changes in Oral and Intestinal Bacterial Flora Associated with Pain Thresholds

80-OR: Proinflammatory Macrophage Impairs Retrograde Axonal Transport via Inflammation and Insulin Resistance in Sensory Neurons

1448-P: Partial Pancreatectomy Increased α-Cell Volume Density, but Not Compensated ß-Cell Volume in Japanese Subjects

206-OR: RAGE-Dependent Macrophage Activation Aggravates Retrograde Axonal Transport via Attenuated Insulin Signaling of Peripheral Nerves in Experimental Diabetic Polyneuropathy

MEK/ERK Signaling in β-Cells Bifunctionally Regulates β-Cell Mass and Glucose-Stimulated Insulin Secretion Response to Maintain Glucose Homeostasis

2047-P: Possible Implication of Cyclin D2 in Beta-Cell Proliferation of Human Perinatal Islet

561-P: Activated Xanthine Oxidase in Serum Is a Potent Therapeutic Target for Experimental Diabetic Polyneuropathy

1575-P: Health-Related Quality of Life in Patients with Type 2 Diabetes: A Case-Control Study

Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation

319-OR: Deficit of Retrograde Axonal Transportation Was Mediated via Activation of Macrophage RAGE Signaling in Experimental Diabetic Polyneuropathy

1452-P: Association between Aging and Insulin Resistance and Secretion in a General Nondiabetic Population

2148-P: Islet Endocrine Cells Shows a Unique Pattern on Development and Growth of Each Cell Type in Human Subjects

2127-P: Reduced Islet Parasympathetic Nerve Density Correlates with Decrease in Beta-Cell Volume of Islet in Lean Type 2 Diabetic Goto-Kakizaki Rat

566-P: Mild Increase of Proinflammatory Macrophages Correlates with Reduction of Nerve Fiber Density in Sural Nerve of Human Type 2 Diabetic Subjects

The Postprandial C-peptide–to–Glucose Ratio Correlated with Beta-Cell Function in Japanese Patients with Type 2 Diabetes Mellitus

Synergistic Effects of Long-Term Combination Therapy of DPP-4 Inhibitor and SGLT2 Inhibitor on the Preservation of Beta-Cell Volume in Rats with Type 2 Diabetes

Beneficial Effects of Xanthine Oxidase Inhibitor, Topiloxostat, on Experimental Diabetic Neuropathy in Mice

Suppression of Neuropathy Development in Diabetic Rage-Deficient Mice Is Associated with Absence of M1/M2 Macrophage Skewing in the Sciatic Nerve

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