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Thomas A Buchanan
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Meeting Abstracts

140-OR: Machine Learning for Metabolite Estimation to Examine Contributors to Glucose Homeostasis and Adiposity: The GUARDIAN Consortium

NICHOLETTE ALLRED, HANNAH C. AINSWORTH, XIUQING GUO, ADRIENNE W. MACKAY, FESTUS NYASIMI, OWEN MELIA, YANYU LIANG, DONALD W. BOWDEN, KENT TAYLOR, LESLIE J. RAFFEL, THOMAS A. BUCHANAN, RICHARD M. WATANABE, JEROME I. ROTTER, LYNNE E. WAGENKNECHT, CARL D. LANGEFELD, IV, HAE K. IM
Journal: Diabetes
Diabetes 2022;71(Supplement_1):140-OR
https://doi.org/10.2337/db22-140-OR
Published: 01 June 2022
View article titled, 140-OR: Machine Learning for Metabolite Estimation to Examine Contributors to Glucose Homeostasis and Adiposity: The GUARDIAN Consortium
Meeting Abstracts

1792-P: Measures of ß-Cell Function from Two-Step Hyperglycemic Clamps: Relation to Glycemia

ANNY XIANG, TAMARA S. HANNON, KIEREN J. MATHER, ELENA BARENGOLTS, MELANIE CREE-GREEN, KRISTEN J. NADEAU, SUSAN SAM, STEVEN E. KAHN, THOMAS A. BUCHANAN, THE RISE CONSORTIUM
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1792-P
https://doi.org/10.2337/db20-1792-P
Published: 01 June 2020
View article titled, 1792-P: Measures of ß-Cell Function from Two-Step Hyperglycemic Clamps: Relation to Glycemia
Meeting Abstracts

1794-P: Successful Standardization of a Hyperglycemic Clamp Method across Multiple Clinical Centers in the Restoring Insulin Secretion (RISE) Study

KIEREN J. MATHER, ASHLEY H. TJADEN, SILVA A. ARSLANIAN, KRISTINA UTZSCHNEIDER, SONIA CAPRIO, KRISTINA UTZSCHNEIDER, KAREN M. ATKINSON, MELANIE CREE-GREEN, KRISTEN J. NADEAU, THOMAS A. BUCHANAN, STEVEN E. KAHN, THE RISE CONSORTIUM
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1794-P
https://doi.org/10.2337/db20-1794-P
Published: 01 June 2020
View article titled, 1794-P: Successful Standardization of a Hyperglycemic Clamp Method across Multiple Clinical Centers in the Restoring Insulin Secretion (RISE) Study
Meeting Abstracts

1782-P: Impact of Treatment with Medication vs. Laparoscopic Gastric Banding (GB) on ß-Cell Function in Adults with Impaired Glucose Tolerance (IGT) or Type 2 Diabetes (T2D) in the Restoring Insulin Secretion (RISE) Study

DAVID A. EHRMANN, SHARON EDELSTEIN, ANNY XIANG, THOMAS A. BUCHANAN, SILVA A. ARSLANIAN, SONIA CAPRIO, KIEREN J. MATHER, KRISTEN J. NADEAU, STEVEN E. KAHN, THE RISE CONSORTIUM
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1782-P
https://doi.org/10.2337/db20-1782-P
Published: 01 June 2020
View article titled, 1782-P: Impact of Treatment with Medication vs. Laparoscopic Gastric Banding (GB) on ß-Cell Function in Adults with Impaired Glucose Tolerance (IGT) or Type 2 Diabetes (T2D) in the Restoring Insulin Secretion (RISE) Study
Meeting Abstracts

1679-P: Islet Autoimmunity in Adults with Impaired Glucose Tolerance (IGT) and Newly Diagnosed, Treatment-Naïve Type 2 Diabetes (NDX T2D) in the Restoring Insulin Secretion (RISE) Study

BARBARA BROOKS-WORRELL, ASHLEY H. TJADEN, SHARON EDELSTEIN, BRENDA M. PALOMINO, KRISTINA UTZSCHNEIDER, SILVA A. ARSLANIAN, KIEREN J. MATHER, THOMAS A. BUCHANAN, KRISTEN J. NADEAU, KAREN M. ATKINSON, ELENA BARENGOLTS, STEVEN E. KAHN, JERRY P. PALMER, RISE CONSORTIUM
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1679-P
https://doi.org/10.2337/db20-1679-P
Published: 01 June 2020
View article titled, 1679-P: Islet Autoimmunity in Adults with Impaired Glucose Tolerance (IGT) and Newly Diagnosed, Treatment-Naïve Type 2 Diabetes (NDX T2D) in the Restoring Insulin Secretion (RISE) Study
Meeting Abstracts

1342-P: BMI from Birth to Age 10 Years by Types of Maternal Diabetes during Pregnancy

MARGO A. SIDELL, TING CHOW, MAYRA P. MARTINEZ, CORINNA KOEBNICK, KATHLEEN A. PAGE, THOMAS A. BUCHANAN, ANNY XIANG
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1342-P
https://doi.org/10.2337/db20-1342-P
Published: 01 June 2020
View article titled, 1342-P: BMI from Birth to Age 10 Years by Types of Maternal Diabetes during Pregnancy
Meeting Abstracts

149-OR: In Utero Exposure to Gestational Diabetes Mellitus Is Associated with Increased Food Intake and Orbital Frontal Cortex Responses to Food Cues

SHAN H. LUO, BRENDAN C. ANGELO, TING CHOW, JASMIN ALVES, THOMAS A. BUCHANAN, ANNY XIANG, KATHLEEN A. PAGE
Journal: Diabetes
Diabetes 2020;69(Supplement_1):149-OR
https://doi.org/10.2337/db20-149-OR
Published: 01 June 2020
View article titled, 149-OR: In Utero Exposure to Gestational Diabetes Mellitus Is Associated with Increased Food Intake and Orbital Frontal Cortex Responses to Food Cues
Journal Articles

Effects of Treatment of Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes With Metformin Alone or in Combination With Insulin Glargine on β-Cell Function: Comparison of Responses In Youth And Adults

RISE Consortium Investigators, David A. Ehrmann, Karla A. Temple, Abby Rue, Elena Barengolts, Babak Mokhlesi, Eve Van Cauter, Susan Sam, M. Annette Miller, Steven E. Kahn, Karen M. Atkinson, Jerry P. Palmer, Kristina M. Utzschneider, Tsige Gebremedhin, Abigail Kernan-Schloss, Alexandra Kozedub, Brenda K. Montgomery, Emily J. Morse, Kieren J. Mather, Tammy Garrett, Tamara S. Hannon, Amale Lteif, Aniket Patel, Robin Chisholm, Karen Moore, Vivian Pirics, Linda Pratt, Kristen J. Nadeau, Susan Gross, Philip S. Zeitler, Jayne Williams, Melanie Cree-Green, Yesenia Garcia Reyes, Krista Vissat, Silva A. Arslanian, Kathleen Brown, Nancy Guerra, Kristin Porter, Sonia Caprio, Mary Savoye, Bridget Pierpont, Thomas A. Buchanan, Anny H. Xiang, Enrique Trigo, Elizabeth Beale, Ting Chow, Fadi N. Hendee, Namir Katkhouda, Krishan Nayak, Mayra Martinez, Cortney Montgomery, Xinhui Wang, Jun Wu, Sharon L. Edelstein, John M. Lachin, Ashley Hogan Tjaden, Mark T. Tripputi, Santica Marcovina, Jessica Harting, John Albers, Dave Hill, Peter J. Savage, Ellen W. Leschek
Journal: Diabetes
Diabetes 2019;68(8):1670–1680
https://doi.org/10.2337/db19-0299
Published: 09 June 2019
View article titled, Effects of Treatment of Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes With Metformin Alone or in Combination With Insulin Glargine on β-Cell Function: Comparison of Responses In Youth And Adults
Open the PDF for Effects of Treatment of Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes With Metformin Alone or in Combination With Insulin Glargine on β-Cell Function: Comparison of Responses In Youth And Adults in another window
Includes: Supplementary data
Meeting Abstracts

124-OR: Comparison of OGTT Model-Derived Measures of ß-Cell Function between Youth and Adults

KRISTINA UTZSCHNEIDER, ANDREA MARI, MARK TRIPPUTI, KIEREN J. MATHER, KRISTEN J. NADEAU, SHARON EDELSTEIN, TAMARA S. HANNON, SILVA A. ARSLANIAN, MELANIE CREE-GREEN, THOMAS A. BUCHANAN, SONIA CAPRIO, STEVEN E. KAHN, RISE CONSORTIUM
Journal: Diabetes
Diabetes 2019;68(Supplement_1):124-OR
https://doi.org/10.2337/db19-124-OR
Published: 01 June 2019
View article titled, 124-OR: Comparison of OGTT Model-Derived Measures of ß-Cell Function between Youth and Adults
Meeting Abstracts

122-OR: Impact of Withdrawal of Interventions in the Restoring Insulin Secretion (RISE) Pediatric Medication Study

TAMARA S. HANNON, SHARON EDELSTEIN, SILVA A. ARSLANIAN, SONIA CAPRIO, PHILIP ZEITLER, THOMAS A. BUCHANAN, DAVID A. EHRMANN, KIEREN J. MATHER, ELLEN LESCHEK, MARK TRIPPUTI, STEVEN E. KAHN, KRISTEN J. NADEAU, RISE CONSORTIUM
Journal: Diabetes
Diabetes 2019;68(Supplement_1):122-OR
https://doi.org/10.2337/db19-122-OR
Published: 01 June 2019
View article titled, 122-OR: Impact of Withdrawal of Interventions in the Restoring Insulin Secretion (RISE) Pediatric Medication Study
Meeting Abstracts

1826-P: Comparison of OGTT-Model Measures with the Hyperglycemic Clamp in Youth and Adults with IGT or Early Type 2 Diabetes (DM)

KRISTINA UTZSCHNEIDER, ANDREA MARI, MARK TRIPPUTI, KIEREN J. MATHER, KRISTEN J. NADEAU, SHARON EDELSTEIN, TAMARA S. HANNON, SILVA A. ARSLANIAN, MELANIE CREE-GREEN, THOMAS A. BUCHANAN, SONIA CAPRIO, STEVEN E. KAHN, RISE CONSORTIUM
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1826-P
https://doi.org/10.2337/db19-1826-P
Published: 01 June 2019
View article titled, 1826-P: Comparison of OGTT-Model Measures with the Hyperglycemic Clamp in Youth and Adults with IGT or Early Type 2 Diabetes (DM)
Meeting Abstracts

1411-P: Glycated Hemoglobin A1c Levels during Pregnancy and Risk of Autism in Offspring

ANNY XIANG, TING CHOW, MAYRA P. MARTINEZ, DARIOS GETAHUN, KATHLEEN A. PAGE, THOMAS A. BUCHANAN, R. KLARA FELDMAN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1411-P
https://doi.org/10.2337/db19-1411-P
Published: 01 June 2019
View article titled, 1411-P: Glycated Hemoglobin A1c Levels during Pregnancy and Risk of Autism in Offspring
Meeting Abstracts

1320-P: Baseline Predictors of Change in Glycemia in the Restoring Insulin Secretion (RISE) Pediatric Medication Study

KRISTEN J. NADEAU, SHARON EDELSTEIN, SILVA A. ARSLANIAN, SONIA CAPRIO, PHILIP ZEITLER, THOMAS A. BUCHANAN, DAVID A. EHRMANN, KIEREN J. MATHER, ELLEN LESCHEK, MARK TRIPPUTI, STEVEN E. KAHN, TAMARA S. HANNON, RISE CONSORTIUM
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1320-P
https://doi.org/10.2337/db19-1320-P
Published: 01 June 2019
View article titled, 1320-P: Baseline Predictors of Change in Glycemia in the Restoring Insulin Secretion (RISE) Pediatric Medication Study
Meeting Abstracts

185-OR: Effects of Exposure to Maternal Obesity In Utero on White Matter Connections between the Hypothalamus and Hippocampus in Children

KATHLEEN A. PAGE, SHAN LUO, TING CHOW, RYAN PAYNE CABEEN, KRISTI CLARK, JASMIN ALVES, MAYRA P. MARTINEZ, THOMAS A. BUCHANAN, ANNY XIANG
Journal: Diabetes
Diabetes 2019;68(Supplement_1):185-OR
https://doi.org/10.2337/db19-185-OR
Published: 01 June 2019
View article titled, 185-OR: Effects of Exposure to Maternal Obesity In Utero on White Matter Connections between the Hypothalamus and Hippocampus in Children
Meeting Abstracts

1854-P: Reduced Liver Fat Is Associated with Improved Insulin Sensitivity and Reduced ß-Cell Secretory Demand following Gastric Banding

ANNY XIANG, JUN WU, TING CHOW, MAYRA P. MARTINEZ, DARRYL H. HWANG, ENRIQUE TRIGO, NAMIR KATKHOUDA, ELIZABETH BEALE, KRISHNA S. NAYAK, THOMAS A. BUCHANAN, THE RISE CONSORTIUM
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1854-P
https://doi.org/10.2337/db19-1854-P
Published: 01 June 2019
View article titled, 1854-P: Reduced Liver Fat Is Associated with Improved Insulin Sensitivity and Reduced ß-Cell Secretory Demand following Gastric Banding
Meeting Abstracts

Maternal Type 1 Diabetes and Risk of Autism in Offspring

ANNY XIANG, XINHUI WANG, MAYRA P. MARTINEZ, KATHLEEN A. PAGE, THOMAS A. BUCHANAN
Journal: Diabetes
Diabetes 2018;67(Supplement_1):117-OR
https://doi.org/10.2337/db18-117-OR
Published: 01 July 2018
View article titled, Maternal Type 1 Diabetes and Risk of Autism in Offspring
Journal Articles

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

Andrew R. Wood, Anna Jonsson, Anne U. Jackson, Nan Wang, Nienke van Leewen, Nicholette D. Palmer, Sayuko Kobes, Joris Deelen, Lorena Boquete-Vilarino, Jussi Paananen, Alena Stančáková, Dorret I. Boomsma, Eco J.C. de Geus, Elisabeth M.W. Eekhoff, Andreas Fritsche, Mark Kramer, Giel Nijpels, Annemarie Simonis-Bik, Timon W. van Haeften, Anubha Mahajan, Michael Boehnke, Richard N. Bergman, Jaakko Tuomilehto, Francis S. Collins, Karen L. Mohlke, Karina Banasik, Christopher J. Groves, Mark I. McCarthy, Diabetes Research on Patient Stratification (DIRECT), Ewan R. Pearson, Andrea Natali, Andrea Mari, Thomas A. Buchanan, Kent D. Taylor, Anny H. Xiang, Anette P. Gjesing, Niels Grarup, Hans Eiberg, Oluf Pedersen, Yii-Derr Chen, Markku Laakso, Jill M. Norris, Ulf Smith, Lynne E. Wagenknecht, Leslie Baier, Donald W. Bowden, Torben Hansen, Mark Walker, Richard M. Watanabe, Leen M. ‘t Hart, Robert L. Hanson, Timothy M. Frayling
Journal: Diabetes
Diabetes 2017;66(8):2296–2309
https://doi.org/10.2337/db16-1452
Published: 10 May 2017
View article titled, A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants
Open the PDF for A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants in another window
Includes: Supplementary data
Journal Articles

Improved Performance of Dynamic Measures of Insulin Response Over Surrogate Indices to Identify Genetic Contributors of Type 2 Diabetes: The GUARDIAN Consortium

Nicholette D. Palmer, Lynne E. Wagenknecht, Carl D. Langefeld, Nan Wang, Thomas A. Buchanan, Anny H. Xiang, Hooman Allayee, Richard N. Bergman, Leslie J. Raffel, Yii-Der Ida Chen, Talin Haritunians, Tasha Fingerlin, Mark O. Goodarzi, Kent D. Taylor, Jerome I. Rotter, Richard M. Watanabe, Donald W. Bowden
Journal: Diabetes
Diabetes 2016;65(7):2072–2080
https://doi.org/10.2337/db15-1543
Published: 03 May 2016
View article titled, Improved Performance of Dynamic Measures of Insulin Response Over Surrogate Indices to Identify Genetic Contributors of Type 2 Diabetes: The GUARDIAN Consortium
Open the PDF for Improved Performance of Dynamic Measures of Insulin Response Over Surrogate Indices to Identify Genetic Contributors of Type 2 Diabetes: The GUARDIAN Consortium in another window
Includes: Supplementary data
Journal Articles

Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium

Nicholette D. Palmer, Mark O. Goodarzi, Carl D. Langefeld, Nan Wang, Xiuqing Guo, Kent D. Taylor, Tasha E. Fingerlin, Jill M. Norris, Thomas A. Buchanan, Anny H. Xiang, Talin Haritunians, Julie T. Ziegler, Adrienne H. Williams, Darko Stefanovski, Jinrui Cui, Adrienne W. Mackay, Leora F. Henkin, Richard N. Bergman, Xiaoyi Gao, James Gauderman, Rohit Varma, Craig L. Hanis, Nancy J. Cox, Heather M. Highland, Jennifer E. Below, Amy L. Williams, Noel P. Burtt, Carlos A. Aguilar-Salinas, Alicia Huerta-Chagoya, Clicerio Gonzalez-Villalpando, Lorena Orozco, Christopher A. Haiman, Michael Y. Tsai, W. Craig Johnson, Jie Yao, Laura Rasmussen-Torvik, James Pankow, Beverly Snively, Rebecca D. Jackson, Simin Liu, Jerry L. Nadler, Fouad Kandeel, Yii-Der I. Chen, Donald W. Bowden, Stephen S. Rich, Leslie J. Raffel, Jerome I. Rotter, Richard M. Watanabe, Lynne E. Wagenknecht
Journal: Diabetes
Diabetes 2015;64(5):1853–1866
https://doi.org/10.2337/db14-0732
Published: 18 December 2014
View article titled, Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium
Open the PDF for Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium in another window
Includes: Supplementary data
Journal Articles

Prevention of Diabetes With Pioglitazone in ACT NOW: Physiologic Correlates

Ralph A. DeFronzo, Devjit Tripathy, Dawn C. Schwenke, MaryAnn Banerji, George A. Bray, Thomas A. Buchanan, Stephen C. Clement, Amalia Gastaldelli, Robert R. Henry, Abbas E. Kitabchi, Sunder Mudaliar, Robert E. Ratner, Frankie B. Stentz, Nicolas Musi, Peter D. Reaven, for the ACT NOW Study
Journal: Diabetes
Diabetes 2013;62(11):3920–3926
https://doi.org/10.2337/db13-0265
Published: 18 October 2013
View article titled, Prevention of Diabetes With Pioglitazone in ACT NOW: <subtitle>Physiologic Correlates</subtitle>
Open the PDF for Prevention of Diabetes With Pioglitazone in ACT NOW: <subtitle>Physiologic Correlates</subtitle> in another window
Includes: Supplementary data