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Thomas C. Brodnicki
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Journal Articles

T-Cell–Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities

Florian Wiede, Thomas C. Brodnicki, Pei Kee Goh, Yew A. Leong, Gareth W. Jones, Di Yu, Alan G. Baxter, Simon A. Jones, Thomas W.H. Kay, Tony Tiganis
Journal: Diabetes
Diabetes 2019;68(6):1251–1266
https://doi.org/10.2337/db18-1362
Published: 01 April 2019
View article titled, T-Cell–Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities
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Includes: Supplementary data
Journal Articles

Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon–Dependent Pathway

Zia U.A. Mollah, Hong Sheng Quah, Kate L. Graham, Gaurang Jhala, Balasubramanian Krishnamurthy, Joanna Francisca M. Dharma, Jonathan Chee, Prerak M. Trivedi, Evan G. Pappas, Leanne Mackin, Edward P.F. Chu, Satoru Akazawa, Stacey Fynch, Charlotte Hodson, Andrew J. Deans, Joseph A. Trapani, Mark M.W. Chong, Phillip I. Bird, Thomas C. Brodnicki, Helen E. Thomas, Thomas W.H. Kay
Journal: Diabetes
Diabetes 2017;66(12):3041–3050
https://doi.org/10.2337/db17-0517
Published: 21 July 2017
View article titled, Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon–Dependent Pathway
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Includes: Supplementary data
Journal Articles

Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice

Prerak M. Trivedi, Kate L. Graham, Nicholas A. Scott, Misty R. Jenkins, Suktilang Majaw, Robyn M. Sutherland, Stacey Fynch, Andrew M. Lew, Christopher J. Burns, Balasubramanian Krishnamurthy, Thomas C. Brodnicki, Stuart I. Mannering, Thomas W. Kay, Helen E. Thomas
Journal: Diabetes
Diabetes 2017;66(6):1650–1660
https://doi.org/10.2337/db16-1250
Published: 14 March 2017
View article titled, Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice
Open the PDF for Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice in another window
Includes: Multimedia, Supplementary data
Journal Articles

How to Make Mice Tell the Truth

Helen E. Thomas, Thomas C. Brodnicki, Thomas W.H. Kay
Journal: Diabetes
Diabetes 2016;65(5):1161–1163
https://doi.org/10.2337/dbi16-0001
Published: 15 April 2016
View article titled, How to Make Mice Tell the Truth
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Journal Articles

BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells

Balasubramanian Krishnamurthy, Jonathan Chee, Gaurang Jhala, Prerak Trivedi, Tara Catterall, Claudia Selck, Esteban N. Gurzov, Thomas C. Brodnicki, Kate L. Graham, Jibran A. Wali, Yifan Zhan, Daniel Gray, Andreas Strasser, Janette Allison, Helen E. Thomas, Thomas W.H. Kay
Journal: Diabetes
Diabetes 2015;64(9):3229–3238
https://doi.org/10.2337/db14-1851
Published: 06 May 2015
View article titled, BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells
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Includes: Supplementary data
Journal Articles

Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4+ T Cells Infiltrate Islets in Type 1 Diabetes

Vimukthi Pathiraja, Janine P. Kuehlich, Peter D. Campbell, Balasubramanian Krishnamurthy, Thomas Loudovaris, P. Toby H. Coates, Thomas C. Brodnicki, Philip J. O’Connell, Katherine Kedzierska, Christine Rodda, Philip Bergman, Erin Hill, Anthony W. Purcell, Nadine L. Dudek, Helen E. Thomas, Thomas W.H. Kay, Stuart I. Mannering
Journal: Diabetes
Diabetes 2015;64(1):172–182
https://doi.org/10.2337/db14-0858
Published: 25 August 2014
View article titled, Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4<sup>+</sup> T Cells Infiltrate Islets in Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Deficiency in Type I Interferon Signaling Prevents the Early Interferon–Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice

Hong Sheng Quah, Socorro Miranda-Hernandez, Aimee Khoo, Ashley Harding, Stacey Fynch, Lorraine Elkerbout, Thomas C. Brodnicki, Alan G. Baxter, Thomas W.H. Kay, Helen E. Thomas, Kate L. Graham
Journal: Diabetes
Diabetes 2014;63(3):1032–1040
https://doi.org/10.2337/db13-1210
Published: 13 February 2014
View article titled, Deficiency in Type I Interferon Signaling Prevents the Early Interferon–Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice
Open the PDF for Deficiency in Type I Interferon Signaling Prevents the Early Interferon–Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice in another window
Includes: Supplementary data
Journal Articles

Generation of Stable Pluripotent Stem Cells From NOD Mouse Tail-Tip Fibroblasts

Jun Liu, Michelle P. Ashton, Huseyin Sumer, Moira K. O’Bryan, Thomas C. Brodnicki, Paul J. Verma
Journal: Diabetes
Diabetes 2011;60(5):1393–1398
https://doi.org/10.2337/db10-1540
Published: 23 April 2011
View article titled, Generation of Stable Pluripotent Stem Cells From NOD Mouse Tail-Tip Fibroblasts
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Includes: Supplementary data
Journal Articles

Localization of Idd11 Is Not Associated With Thymus and NKT Cell Abnormalities in NOD Mice

Thomas C. Brodnicki, Anne L. Fletcher, Daniel G. Pellicci, Stuart P. Berzins, Peter McClive, Fiona Quirk, Kylie E. Webster, Hamish S. Scott, Richard L. Boyd, Dale I. Godfrey, Grant Morahan
Journal: Diabetes
Diabetes 2005;54(12):3453–3457
https://doi.org/10.2337/diabetes.54.12.3453
Published: 01 December 2005
View article titled, Localization of <em>Idd11</em> Is Not Associated With Thymus and NKT Cell Abnormalities in NOD Mice
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Includes: Supplementary data
Journal Articles

IL-1 Receptor Deficiency Slows Progression to Diabetes in the NOD Mouse

Helen E. Thomas, Windy Irawaty, Rima Darwiche, Thomas C. Brodnicki, Pere Santamaria, Janette Allison, Thomas W.H. Kay
Journal: Diabetes
Diabetes 2004;53(1):113–121
https://doi.org/10.2337/diabetes.53.1.113
Published: 01 January 2004
View article titled, IL-1 Receptor Deficiency Slows Progression to Diabetes in the NOD Mouse
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Journal Articles

A Susceptibility Allele From a Non-Diabetes-Prone Mouse Strain Accelerates Diabetes in NOD Congenic Mice

Thomas C. Brodnicki, Fiona Quirk, Grant Morahan
Journal: Diabetes
Diabetes 2003;52(1):218–222
https://doi.org/10.2337/diabetes.52.1.218
Published: 01 January 2003
View article titled, A Susceptibility Allele From a Non-Diabetes-Prone Mouse Strain Accelerates Diabetes in NOD Congenic Mice
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