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Journal Articles

Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling

Diabetes 2019;68(4):747–760

https://doi.org/10.2337/db18-0671

Published: 22 January 2019

View article titled, Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling

Includes: Multimedia, Supplementary data

Journal Articles

The No-Go and Nonsense-Mediated RNA Decay Pathways Are Regulated by Inflammatory Cytokines in Insulin-Producing Cells and Human Islets and Determine β-Cell Insulin Biosynthesis and Survival

Seyed Mojtaba Ghiasi, Nicolai Krogh, Björn Tyrberg, Thomas Mandrup-Poulsen

Diabetes 2018;67(10):2019–2037

https://doi.org/10.2337/db18-0073

Published: 31 July 2018

View article titled, The No-Go and Nonsense-Mediated RNA Decay Pathways Are Regulated by Inflammatory Cytokines in Insulin-Producing Cells and Human Islets and Determine β-Cell Insulin Biosynthesis and Survival

Includes: Supplementary data

Journal Articles

Granzyme A in the Pathogenesis of Type 1 Diabetes: The Yes and the No

Thomas Mandrup-Poulsen

Diabetes 2017;66(12):2937–2939

https://doi.org/10.2337/dbi17-0037

Published: 14 November 2017

View article titled, Granzyme A in the Pathogenesis of Type 1 Diabetes: The Yes and the No

Journal Articles

Interleukin-1 Antagonism: A Sturdy Companion for Immune Tolerance Induction in Type 1 Diabetes?

Thomas Mandrup-Poulsen

Diabetes 2014;63(6):1833–1835

https://doi.org/10.2337/db14-0371

Published: 15 May 2014

View article titled, Interleukin-1 Antagonism: A Sturdy Companion for Immune Tolerance Induction in Type 1 Diabetes?

Journal Articles

Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleukin-1 Blockade: Evidence of Improved Immune Regulation

Vitaly Ablamunits, Octavian Henegariu, Jakob Bondo Hansen, Lynn Opare-Addo, Paula Preston-Hurlburt, Pere Santamaria, Thomas Mandrup-Poulsen, Kevan C. Herold

Diabetes 2012;61(1):145–154

https://doi.org/10.2337/db11-1033

Published: 12 December 2011

View article titled, Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleukin-1 Blockade: <subtitle>Evidence of Improved Immune Regulation</subtitle>

Includes: Supplementary data

Journal Articles

Cytokines and Type 1 Diabetes: A Numbers Game

Lars Groth Grunnet, Thomas Mandrup-Poulsen

Diabetes 2011;60(3):697–699

https://doi.org/10.2337/db10-1782

Published: 21 February 2011

View article titled, Cytokines and Type 1 Diabetes: A Numbers Game

Journal Articles

Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in β-Cells

Lars G. Grunnet, Reid Aikin, Morten F. Tonnesen, Steven Paraskevas, Lykke Blaabjerg, Joachim Størling, Lawrence Rosenberg, Nils Billestrup, Dusica Maysinger, Thomas Mandrup-Poulsen

Diabetes 2009;58(8):1807–1815

https://doi.org/10.2337/db08-0178

Published: 26 May 2009

View article titled, Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in β-Cells

Journal Articles

Diabetes and Suppressors of Cytokine Signaling Proteins

Sif G. Rønn, Nils Billestrup, Thomas Mandrup-Poulsen

Diabetes 2007;56(2):541–548

https://doi.org/10.2337/db06-1068

Published: 01 February 2007

View article titled, Diabetes and Suppressors of Cytokine Signaling Proteins

Journal Articles

Interleukin-6 and Diabetes: The Good, the Bad, or the Indifferent?

Ole P. Kristiansen, Thomas Mandrup-Poulsen

Diabetes 2005;54(suppl_2):S114–S124

https://doi.org/10.2337/diabetes.54.suppl_2.S114

Published: 01 December 2005

View article titled, Interleukin-6 and Diabetes: <subtitle>The Good, the Bad, or the Indifferent?</subtitle>

Journal Articles

Is Puberty an Accelerator of Type 1 Diabetes in IL6-174CC Females?

Kathleen M. Gillespie, Runa Nolsøe, Virginie M. Betin, Ole P. Kristiansen, Polly J. Bingley, Thomas Mandrup-Poulsen, Edwin A.M. Gale

Diabetes 2005;54(4):1245–1248

https://doi.org/10.2337/diabetes.54.4.1245

Published: 01 April 2005

View article titled, Is Puberty an Accelerator of Type 1 Diabetes in IL6-174CC Females?

Journal Articles

Cytokines Downregulate the Sarcoendoplasmic Reticulum Pump Ca²⁺ ATPase 2b and Deplete Endoplasmic Reticulum Ca²⁺, Leading to Induction of Endoplasmic Reticulum Stress in Pancreatic β-Cells

Alessandra K. Cardozo, Fernanda Ortis, Joachim Storling, Ying-Mei Feng, Joanne Rasschaert, Morten Tonnesen, Françoise Van Eylen, Thomas Mandrup-Poulsen, André Herchuelz, Décio L. Eizirik

Diabetes 2005;54(2):452–461

https://doi.org/10.2337/diabetes.54.2.452

Published: 01 February 2005

View article titled, Cytokines Downregulate the Sarcoendoplasmic Reticulum Pump Ca2+ ATPase 2b and Deplete Endoplasmic Reticulum Ca2+, Leading to Induction of Endoplasmic Reticulum Stress in Pancreatic β-Cells

Journal Articles

Glucose- and Interleukin-1β-Induced β-Cell Apoptosis Requires Ca²⁺ Influx and Extracellular Signal-Regulated Kinase (ERK) 1/2 Activation and Is Prevented by a Sulfonylurea Receptor 1/Inwardly Rectifying K⁺ Channel 6.2 (SUR/Kir6.2) Selective Potassium Channel Opener in Human Islets

Kathrin Maedler, Joachim Størling, Jeppe Sturis, Richard A. Zuellig, Giatgen A. Spinas, Per O.G. Arkhammar, Thomas Mandrup-Poulsen, Marc Y. Donath

Diabetes 2004;53(7):1706–1713

https://doi.org/10.2337/diabetes.53.7.1706

Published: 01 July 2004

View article titled, Glucose- and Interleukin-1β-Induced β-Cell Apoptosis Requires Ca2+ Influx and Extracellular Signal-Regulated Kinase (ERK) 1/2 Activation and Is Prevented by a Sulfonylurea Receptor 1/Inwardly Rectifying K+ Channel 6.2 (SUR/Kir6.2) Selective Potassium Channel Opener in Human Islets

Journal Articles

Linkage and Association Between a CD4 Gene Polymorphism and IDDM in Danish IDDM Patients

Ole Peter Kristiansen, Mahdi Zamani, Jesper Johannesen, Thomas Mandrup-Poulsen, Jean-Jacques Cassiman, Jørn Nerup, Flemming Pociot, The Danish IDDM Epidemiology and Genetics Group, and The Danish Study Group of Diabetes in Childhood

Diabetes 1998;47(2):281–283

https://doi.org/10.2337/diab.47.2.281

Published: 01 February 1998

View article titled, Linkage and Association Between a CD4 Gene Polymorphism and IDDM in Danish IDDM Patients

Journal Articles

Strain-Dependent Differences in Sensitivity of Rat β-Cells to Interleukin 1β In Vitro and In Vivo

Jesper I Reimers, Herik U Anderson, Dídac Mauricio, Flemming Pociot, Allan Karlsen, Jacob S Peterson, Thomas Mandrup-Poulsen, Jørn Nerup

Diabetes 1996;45(6):771–778

https://doi.org/10.2337/diab.45.6.771

Published: 01 June 1996

View article titled, Strain-Dependent Differences in Sensitivity of Rat β-Cells to Interleukin 1β In Vitro and In Vivo

Journal Articles

Cloning and Expression of Cytokine-Inducible Nitric Oxide Synthase cDNA From Rat Islets of Langerhans

Allan E Karlsen, Henrik U Andersen, Henrik Vissing, Peter Mose Larsen, Stephen J Fey, Beatriz Cuartero, Ole D Madsen, Jacob S Petersen, Steen B Mortensen, Thomas Mandrup-Poulsen, Esper Boel, Jørn Nerup

Diabetes 1995;44(7):753–758

https://doi.org/10.2337/diab.44.7.753

Published: 01 July 1995

View article titled, Cloning and Expression of Cytokine-Inducible Nitric Oxide Synthase cDNA From Rat Islets of Langerhans

Journal Articles

Two-Dimensional Gel Electrophoresis of Rat Islet Proteins: Interleukin 1β-Induced Changes in Protein Expression are Reduced by L-Arginine Depletion and Nicotinamide

Henrik U Andersen, Peter Mose Larsen, Stephen J Fey, Allan E Karlsen, Thomas Mandrup-Poulsen, Jørn Nerup

Diabetes 1995;44(4):400–407

https://doi.org/10.2337/diab.44.4.400

Published: 01 April 1995

View article titled, Two-Dimensional Gel Electrophoresis of Rat Islet Proteins: Interleukin 1β-Induced Changes in Protein Expression are Reduced by <sc>L</sc>-Arginine Depletion and Nicotinamide

Journal Articles

Glutamic Acid Decarboxylase (GAD₆₅) Autoantibodies in Prediction of β-Cell Function and Remission in Recent-Onset IDDM After Cyclosporin Treatment

Jacob Sten Petersen, Thomas Dyrberg, Allan E Karlsen, Jens Mølvig, Birgitte Michelsen, Jørn Nerup, Thomas Mandrup-Poulsen, Canadian-European Randomized Control Trial Group

Diabetes 1994;43(11):1291–1296

https://doi.org/10.2337/diab.43.11.1291

Published: 01 November 1994

View article titled, Glutamic Acid Decarboxylase (GAD65) Autoantibodies in Prediction of β-Cell Function and Remission in Recent-Onset IDDM After Cyclosporin Treatment

Journal Articles

Monokine Antagonism Is Reduced in Patients With IDDM

Thomas Mandrup-Poulsen, Flemming Pociot, Jens Mølvig, Leland Shapiro, Povl Nilsson, Torkil Emdal, Michael Røder, Lisa L Kjems, Charles A Dinarello, Jørn Nerup

Diabetes 1994;43(10):1242–1247

https://doi.org/10.2337/diab.43.10.1242

Published: 01 October 1994

View article titled, Monokine Antagonism Is Reduced in Patients With IDDM

Journal Articles

Nicotinamide Prevents Interleukin-1 Effects on Accumulated Insulin Release and Nitric Oxide Production in Rat Islets of Langerhans

Henrik U Andersen, Klavs H Jørgensen, Jørn Egeberg, Thomas Mandrup-Poulsen, Jørn Nerup

Diabetes 1994;43(6):770–777

https://doi.org/10.2337/diab.43.6.770

Published: 01 June 1994

View article titled, Nicotinamide Prevents Interleukin-1 Effects on Accumulated Insulin Release and Nitric Oxide Production in Rat Islets of Langerhans

Journal Articles

Lack of Predictive Value of Islet Cell Antibodies, Insulin Antibodies, and HLA-DR Phenotype for Remission in Cyclosporin-Treated IDDM Patients

Thomas Mandrup-Poulsen, Jens Mølvig, Henrik U Andersen, Steffen Helqvist, Giatgen A Spinas, Marianne Munck, Canadian-European Randomized Control Trial Group

Diabetes 1990;39(2):204–210

https://doi.org/10.2337/diab.39.2.204

Published: 01 February 1990

View article titled, Lack of Predictive Value of Islet Cell Antibodies, Insulin Antibodies, and HLA-DR Phenotype for Remission in Cyclosporin-Treated IDDM Patients

NARROW

Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling

The No-Go and Nonsense-Mediated RNA Decay Pathways Are Regulated by Inflammatory Cytokines in Insulin-Producing Cells and Human Islets and Determine β-Cell Insulin Biosynthesis and Survival

Granzyme A in the Pathogenesis of Type 1 Diabetes: The Yes and the No

Interleukin-1 Antagonism: A Sturdy Companion for Immune Tolerance Induction in Type 1 Diabetes?

Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleukin-1 Blockade: Evidence of Improved Immune Regulation

Cytokines and Type 1 Diabetes: A Numbers Game

Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in β-Cells

Diabetes and Suppressors of Cytokine Signaling Proteins

Interleukin-6 and Diabetes: The Good, the Bad, or the Indifferent?

Is Puberty an Accelerator of Type 1 Diabetes in IL6-174CC Females?

Cytokines Downregulate the Sarcoendoplasmic Reticulum Pump Ca²⁺ ATPase 2b and Deplete Endoplasmic Reticulum Ca²⁺, Leading to Induction of Endoplasmic Reticulum Stress in Pancreatic β-Cells

Glucose- and Interleukin-1β-Induced β-Cell Apoptosis Requires Ca²⁺ Influx and Extracellular Signal-Regulated Kinase (ERK) 1/2 Activation and Is Prevented by a Sulfonylurea Receptor 1/Inwardly Rectifying K⁺ Channel 6.2 (SUR/Kir6.2) Selective Potassium Channel Opener in Human Islets

Linkage and Association Between a CD4 Gene Polymorphism and IDDM in Danish IDDM Patients

Strain-Dependent Differences in Sensitivity of Rat β-Cells to Interleukin 1β In Vitro and In Vivo

Cloning and Expression of Cytokine-Inducible Nitric Oxide Synthase cDNA From Rat Islets of Langerhans

Two-Dimensional Gel Electrophoresis of Rat Islet Proteins: Interleukin 1β-Induced Changes in Protein Expression are Reduced by L-Arginine Depletion and Nicotinamide

Glutamic Acid Decarboxylase (GAD₆₅) Autoantibodies in Prediction of β-Cell Function and Remission in Recent-Onset IDDM After Cyclosporin Treatment

Monokine Antagonism Is Reduced in Patients With IDDM

Nicotinamide Prevents Interleukin-1 Effects on Accumulated Insulin Release and Nitric Oxide Production in Rat Islets of Langerhans

Lack of Predictive Value of Islet Cell Antibodies, Insulin Antibodies, and HLA-DR Phenotype for Remission in Cyclosporin-Treated IDDM Patients

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