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Thomas W.H. Kay
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Journal Articles

T-Cell–Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities

Florian Wiede, Thomas C. Brodnicki, Pei Kee Goh, Yew A. Leong, Gareth W. Jones, Di Yu, Alan G. Baxter, Simon A. Jones, Thomas W.H. Kay, Tony Tiganis
Journal: Diabetes
Diabetes 2019;68(6):1251–1266
https://doi.org/10.2337/db18-1362
Published: 01 April 2019
View articletitled, T-Cell–Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities
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Includes: Supplementary data
Journal Articles

Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon–Dependent Pathway

Zia U.A. Mollah, Hong Sheng Quah, Kate L. Graham, Gaurang Jhala, Balasubramanian Krishnamurthy, Joanna Francisca M. Dharma, Jonathan Chee, Prerak M. Trivedi, Evan G. Pappas, Leanne Mackin, Edward P.F. Chu, Satoru Akazawa, Stacey Fynch, Charlotte Hodson, Andrew J. Deans, Joseph A. Trapani, Mark M.W. Chong, Phillip I. Bird, Thomas C. Brodnicki, Helen E. Thomas, Thomas W.H. Kay
Journal: Diabetes
Diabetes 2017;66(12):3041–3050
https://doi.org/10.2337/db17-0517
Published: 21 July 2017
View articletitled, Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon–Dependent Pathway
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Includes: Supplementary data
Journal Articles

How to Make Mice Tell the Truth

Helen E. Thomas, Thomas C. Brodnicki, Thomas W.H. Kay
Journal: Diabetes
Diabetes 2016;65(5):1161–1163
https://doi.org/10.2337/dbi16-0001
Published: 15 April 2016
View articletitled, How to Make Mice Tell the Truth
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Journal Articles

Coxsackievirus B5 Infection Induces Dysregulation of microRNAs Predicted to Target Known Type 1 Diabetes Risk Genes in Human Pancreatic Islets

Ki Wook Kim, Andy Ho, Ammira Alshabee-Akil, Anandwardhan A. Hardikar, Thomas W.H. Kay, William D. Rawlinson, Maria E. Craig
Journal: Diabetes
Diabetes 2016;65(4):996–1003
https://doi.org/10.2337/db15-0956
Published: 11 November 2015
View articletitled, Coxsackievirus B5 Infection Induces Dysregulation of microRNAs Predicted to Target Known Type 1 Diabetes Risk Genes in Human Pancreatic Islets
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Journal Articles

BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells

Balasubramanian Krishnamurthy, Jonathan Chee, Gaurang Jhala, Prerak Trivedi, Tara Catterall, Claudia Selck, Esteban N. Gurzov, Thomas C. Brodnicki, Kate L. Graham, Jibran A. Wali, Yifan Zhan, Daniel Gray, Andreas Strasser, Janette Allison, Helen E. Thomas, Thomas W.H. Kay
Journal: Diabetes
Diabetes 2015;64(9):3229–3238
https://doi.org/10.2337/db14-1851
Published: 06 May 2015
View articletitled, BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells
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Includes: Supplementary data
Journal Articles

Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets

William J. Stanley, Sara A. Litwak, Hong Sheng Quah, Sih Min Tan, Thomas W.H. Kay, Tony Tiganis, Judy B. de Haan, Helen E. Thomas, Esteban N. Gurzov
Journal: Diabetes
Diabetes 2015;64(7):2489–2496
https://doi.org/10.2337/db14-1575
Published: 02 March 2015
View articletitled, Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets
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Includes: Supplementary data
Journal Articles

Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4+ T Cells Infiltrate Islets in Type 1 Diabetes

Vimukthi Pathiraja, Janine P. Kuehlich, Peter D. Campbell, Balasubramanian Krishnamurthy, Thomas Loudovaris, P. Toby H. Coates, Thomas C. Brodnicki, Philip J. O’Connell, Katherine Kedzierska, Christine Rodda, Philip Bergman, Erin Hill, Anthony W. Purcell, Nadine L. Dudek, Helen E. Thomas, Thomas W.H. Kay, Stuart I. Mannering
Journal: Diabetes
Diabetes 2015;64(1):172–182
https://doi.org/10.2337/db14-0858
Published: 25 August 2014
View articletitled, Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4+ T Cells Infiltrate Islets in Type 1 Diabetes
Open the PDF for Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4+ T Cells Infiltrate Islets in Type 1 Diabetes in another window
Includes: Supplementary data
Journal Articles

Deficiency in Type I Interferon Signaling Prevents the Early Interferon–Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice

Hong Sheng Quah, Socorro Miranda-Hernandez, Aimee Khoo, Ashley Harding, Stacey Fynch, Lorraine Elkerbout, Thomas C. Brodnicki, Alan G. Baxter, Thomas W.H. Kay, Helen E. Thomas, Kate L. Graham
Journal: Diabetes
Diabetes 2014;63(3):1032–1040
https://doi.org/10.2337/db13-1210
Published: 13 February 2014
View articletitled, Deficiency in Type I Interferon Signaling Prevents the Early Interferon–Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice
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Includes: Supplementary data
Journal Articles

Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells

Balasubramanian Krishnamurthy, Jonathan Chee, Gaurang Jhala, Stacey Fynch, Kate L. Graham, Pere Santamaria, Grant Morahan, Janette Allison, David Izon, Helen E. Thomas, Thomas W.H. Kay
Journal: Diabetes
Diabetes 2012;61(2):425–435
https://doi.org/10.2337/db11-0948
Published: 17 January 2012
View articletitled, Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells
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Includes: Supplementary data
Journal Articles

Prevention of “Humanized” Diabetogenic CD8 T-Cell Responses in HLA-Transgenic NOD Mice by a Multipeptide Coupled-Cell Approach

Marijke Niens, Alexandra E. Grier, Michele Marron, Thomas W.H. Kay, Dale L. Greiner, David V. Serreze
Journal: Diabetes
Diabetes 2011;60(4):1229–1236
https://doi.org/10.2337/db10-1523
Published: 22 March 2011
View articletitled, Prevention of “Humanized” Diabetogenic CD8 T-Cell Responses in HLA-Transgenic NOD Mice by a Multipeptide Coupled-Cell Approach
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Journal Articles

Interleukin-1β Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells: Implications for the Timing of Tolerizing Immunotherapy

Sebastien Bertin-Maghit, Dimeng Pang, Brendan O'Sullivan, Shannon Best, Emily Duggan, Sanjoy Paul, Helen Thomas, Thomas W.H. Kay, Leonard C. Harrison, Raymond Steptoe, Ranjeny Thomas
Journal: Diabetes
Diabetes 2011;60(1):248–257
https://doi.org/10.2337/db10-0104
Published: 27 October 2010
View articletitled, Interleukin-1β Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells: Implications for the Timing of Tolerizing Immunotherapy
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Includes: Supplementary data
Journal Articles

Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax

Mark D. McKenzie, Emma Jamieson, Elisa S. Jansen, Clare L. Scott, David C.S. Huang, Philippe Bouillet, Janette Allison, Thomas W.H. Kay, Andreas Strasser, Helen E. Thomas
Journal: Diabetes
Diabetes 2010;59(3):644–652
https://doi.org/10.2337/db09-1151
Published: 03 December 2009
View articletitled, Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax
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Journal Articles

Proapoptotic BH3-Only Protein Bid Is Essential For Death Receptor–Induced Apoptosis of Pancreatic β-Cells

Mark D. McKenzie, Emma M. Carrington, Thomas Kaufmann, Andreas Strasser, David C.S. Huang, Thomas W.H. Kay, Janette Allison, Helen E. Thomas
Journal: Diabetes
Diabetes 2008;57(5):1284–1292
https://doi.org/10.2337/db07-1692
Published: 01 May 2008
View articletitled, Proapoptotic BH3-Only Protein Bid Is Essential For Death Receptor–Induced Apoptosis of Pancreatic β-Cells
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Includes: Supplementary data
Journal Articles

Cytotoxic T-Cells From T-Cell Receptor Transgenic NOD8.3 Mice Destroy β-Cells via the Perforin and Fas Pathways

Nadine L. Dudek, Helen E. Thomas, Lina Mariana, Robyn M. Sutherland, Janette Allison, Eugene Estella, Eveline Angstetra, Joseph A. Trapani, Pere Santamaria, Andrew M. Lew, Thomas W.H. Kay
Journal: Diabetes
Diabetes 2006;55(9):2412–2418
https://doi.org/10.2337/db06-0109
Published: 01 September 2006
View articletitled, Cytotoxic T-Cells From T-Cell Receptor Transgenic NOD8.3 Mice Destroy β-Cells via the Perforin and Fas Pathways
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Journal Articles

IL-1 Receptor Deficiency Slows Progression to Diabetes in the NOD Mouse

Helen E. Thomas, Windy Irawaty, Rima Darwiche, Thomas C. Brodnicki, Pere Santamaria, Janette Allison, Thomas W.H. Kay
Journal: Diabetes
Diabetes 2004;53(1):113–121
https://doi.org/10.2337/diabetes.53.1.113
Published: 01 January 2004
View articletitled, IL-1 Receptor Deficiency Slows Progression to Diabetes in the NOD Mouse
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Journal Articles

Interleukin-1 Plus γ-Interferon-Induced Pancreatic β-Cell Dysfunction Is Mediated by β-Cell Nitric Oxide Production

Helen E. Thomas, Rima Darwiche, John A. Corbett, Thomas W.H. Kay
Journal: Diabetes
Diabetes 2002;51(2):311–316
https://doi.org/10.2337/diabetes.51.2.311
Published: 01 February 2002
View articletitled, Interleukin-1 Plus γ-Interferon-Induced Pancreatic β-Cell Dysfunction Is Mediated by β-Cell Nitric Oxide Production
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Journal Articles

γ-Interferon Signaling in Pancreatic β-Cells Is Persistent but Can Be Terminated by Overexpression of Suppressor of Cytokine Signaling-1

Mark M.W. Chong, Helen E. Thomas, Thomas W.H. Kay
Journal: Diabetes
Diabetes 2001;50(12):2744–2751
https://doi.org/10.2337/diabetes.50.12.2744
Published: 01 December 2001
View articletitled, γ-Interferon Signaling in Pancreatic β-Cells Is Persistent but Can Be Terminated by Overexpression of Suppressor of Cytokine Signaling-1
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Journal Articles

International Workshop on Lessons From Animal Models for Human Type 1 Diabetes: Identification of Insulin but Not Glutamic Acid Decarboxylase or IA-2 as Specific Autoantigens of Humoral Autoimmunity in Nonobese Diabetic Mice

Ezio Bonifacio, Mark Atkinson, George Eisenbarth, David Serreze, Thomas W.H. Kay, Edwin Lee-Chan, Bhagirath Singh
Journal: Diabetes
Diabetes 2001;50(11):2451–2458
https://doi.org/10.2337/diabetes.50.11.2451
Published: 01 November 2001
View articletitled, International Workshop on Lessons From Animal Models for Human Type 1 Diabetes: Identification of Insulin but Not Glutamic Acid Decarboxylase or IA-2 as Specific Autoantigens of Humoral Autoimmunity in Nonobese Diabetic Mice
Open the PDF for International Workshop on Lessons From Animal Models for Human Type 1 Diabetes: Identification of Insulin but Not Glutamic Acid Decarboxylase or IA-2 as Specific Autoantigens of Humoral Autoimmunity in Nonobese Diabetic Mice in another window