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Journal Articles

IER3IP1 Mutations Cause Neonatal Diabetes Due to Impaired Proinsulin Trafficking

Hossam Montaser, Sonja Leppänen, Eliisa Vähäkangas, Nils Bäck, Alicia Grace, Solja Eurola, Hazem Ibrahim, Väinö Lithovius, Samuel B. Stephens, Tom Barsby, Diego Balboa, Jonna Saarimäki-Vire, Timo Otonkoski

Diabetes 2025;74(4):514–527

https://doi.org/10.2337/db24-0119

Published: 23 October 2024

View article titled, IER3IP1 Mutations Cause Neonatal Diabetes Due to Impaired Proinsulin Trafficking

Journal Articles

Efficient Vascular and Neural Engraftment of Stem Cell–Derived Islets

Julia Thorngren, Anja Brboric, Svitlana Vasylovska, Daisy Hjelmqvist, Gunilla T. Westermark, Jonna Saarimäki-Vire, Jouni Kvist, Diego Balboa, Timo Otonkoski, Per-Ola Carlsson, Joey Lau

Diabetes 2024;73(7):1127–1139

https://doi.org/10.2337/db23-0123

Published: 11 April 2024

View article titled, Efficient Vascular and Neural Engraftment of Stem Cell–Derived Islets

Journal Articles

Increased Frequency of the HLA-DRB104:04-DQA103-DQB103:02 Haplotype Among HLA-DQB106:02–Positive Children With Type 1 Diabetes

Diabetes 2024;73(2):306–311

https://doi.org/10.2337/db23-0387

Published: 07 November 2023

View article titled, Increased Frequency of the HLA-DRB1*04:04-DQA1*03-DQB1*03:02 Haplotype Among HLA-DQB1*06:02–Positive Children With Type 1 Diabetes

Journal Articles

PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes

Bernat Elvira, Valerie Vandenbempt, Julia Bauzá-Martinez, Raphaël Crutzen, Javier Negueruela, Hazem Ibrahim, Matthew L. Winder, Manoja K. Brahma, Beata Vekeriotaite, Pieter-Jan Martens, Sumeet Pal Singh, Fernando Rossello, Pascale Lybaert, Timo Otonkoski, Conny Gysemans, Wei Wu, Esteban N. Gurzov

Diabetes 2022;71(4):653–668

https://doi.org/10.2337/db21-0443

Published: 19 January 2022

View article titled, PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes

Journal Articles

Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress

Hossam Montaser, Kashyap A. Patel, Diego Balboa, Hazem Ibrahim, Väinö Lithovius, Anna Näätänen, Vikash Chandra, Korcan Demir, Sezer Acar, Tawfeg Ben-Omran, Kevin Colclough, Jonathan M. Locke, Matthew Wakeling, Maria Lindahl, Andrew T. Hattersley, Jonna Saarimäki-Vire, Timo Otonkoski

Diabetes 2021;70(4):1006–1018

https://doi.org/10.2337/db20-1174

Published: 26 January 2021

View article titled, Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress

Journal Articles

Early Detection of Peripheral Blood Cell Signature in Children Developing β-Cell Autoimmunity at a Young Age

Diabetes 2019;68(10):2024–2034

https://doi.org/10.2337/db19-0287

Published: 16 July 2019

View article titled, Early Detection of Peripheral Blood Cell Signature in Children Developing β-Cell Autoimmunity at a Young Age

Includes: Supplementary data

Meeting Abstracts

112-OR: Critical Role of Tyrosine Kinase 2 (TYK2) in Human Pancreatic Differentiation

VIKASH CHANDRA, HAZEM IBRAHIM, DIEGO BALBOA, TIMO OTONKOSKI

Diabetes 2019;68(Supplement_1):112-OR

https://doi.org/10.2337/db19-112-OR

Published: 01 June 2019

View article titled, 112-OR: Critical Role of Tyrosine Kinase 2 (TYK2) in Human Pancreatic Differentiation

Journal Articles

MANF Is Required for the Postnatal Expansion and Maintenance of Pancreatic β-Cell Mass in Mice

Tatiana Danilova, Ilya Belevich, Huini Li, Erik Palm, Eija Jokitalo, Timo Otonkoski, Maria Lindahl

Diabetes 2019;68(1):66–80

https://doi.org/10.2337/db17-1149

Published: 10 October 2018

View article titled, MANF Is Required for the Postnatal Expansion and Maintenance of Pancreatic β-Cell Mass in Mice

Includes: Multimedia, Supplementary data

Journal Articles

A Mouse Model of Human Hyperinsulinism Produced by the E1506K Mutation in the Sulphonylurea Receptor SUR1

Kenju Shimomura, Maija Tusa, Michaela Iberl, Melissa F. Brereton, Stephan Kaizik, Peter Proks, Carolina Lahmann, Nagendra Yaluri, Shalem Modi, Hanna Huopio, Jarkko Ustinov, Timo Otonkoski, Markku Laakso, Frances M. Ashcroft

Diabetes 2013;62(11):3797–3806

https://doi.org/10.2337/db12-1611

Published: 18 October 2013

View article titled, A Mouse Model of Human Hyperinsulinism Produced by the E1506K Mutation in the Sulphonylurea Receptor SUR1

Includes: Supplementary data

Journal Articles

Dedifferentiation for Replication of Human β-Cells: A Division Between Mice and Men?

Nils Billestrup, Timo Otonkoski

Diabetes 2008;57(6):1457–1458

https://doi.org/10.2337/db08-0364

Published: 01 June 2008

View article titled, Dedifferentiation for Replication of Human β-Cells: <subtitle>A Division Between Mice and Men?</subtitle>

Journal Articles

Downregulation of EGF Receptor Signaling in Pancreatic Islets Causes Diabetes Due to Impaired Postnatal β-Cell Growth

Päivi J. Miettinen, Jarkko Ustinov, Päivi Ormio, Ru Gao, Jaan Palgi, Elina Hakonen, Lisa Juntti-Berggren, Per-Olof Berggren, Timo Otonkoski

Diabetes 2006;55(12):3299–3308

https://doi.org/10.2337/db06-0413

Published: 01 December 2006

View article titled, Downregulation of EGF Receptor Signaling in Pancreatic Islets Causes Diabetes Due to Impaired Postnatal β-Cell Growth

Journal Articles

Noninvasive Diagnosis of Focal Hyperinsulinism of Infancy With [¹⁸F]-DOPA Positron Emission Tomography

Timo Otonkoski, Kirsti Näntö-Salonen, Marko Seppänen, Riitta Veijola, Hanna Huopio, Khalid Hussain, Päivi Tapanainen, Olli Eskola, Riitta Parkkola, Klas Ekström, Yves Guiot, Jacques Rahier, Markku Laakso, Risto Rintala, Pirjo Nuutila, Heikki Minn

Diabetes 2006;55(1):13–18

https://doi.org/10.2337/diabetes.55.01.06.db05-1128

Published: 01 January 2006

View article titled, Noninvasive Diagnosis of Focal Hyperinsulinism of Infancy With [18F]-DOPA Positron Emission Tomography

Journal Articles

Lack of Association of PAX4 Gene With Type 1 Diabetes in the Finnish and Hungarian Populations

Robert Hermann, Jussi Mantere, Kati Lipponen, Riitta Veijola, Gyula Soltesz, Timo Otonkoski, Olli Simell, Mikael Knip, Jorma Ilonen

Diabetes 2005;54(9):2816–2819

https://doi.org/10.2337/diabetes.54.9.2816

Published: 01 September 2005

View article titled, Lack of Association of PAX4 Gene With Type 1 Diabetes in the Finnish and Hungarian Populations

Journal Articles

Severe Persistent Hyperinsulinemic Hypoglycemia due to a De Novo Glucokinase Mutation

Antonio L. Cuesta-Muñoz, Hanna Huopio, Timo Otonkoski, Juan M. Gomez-Zumaquero, Kirsti Näntö-Salonen, Jacques Rahier, Soledad López-Enriquez, Maria A. García-Gimeno, Pascual Sanz, Federico C. Soriguer, Markku Laakso

Diabetes 2004;53(8):2164–2168

https://doi.org/10.2337/diabetes.53.8.2164

Published: 01 August 2004

View article titled, Severe Persistent Hyperinsulinemic Hypoglycemia due to a De Novo Glucokinase Mutation

Journal Articles

Characterization of Endocrine Progenitor Cells and Critical Factors for Their Differentiation in Human Adult Pancreatic Cell Culture

Ru Gao, Jarkko Ustinov, Mari-Anne Pulkkinen, Karolina Lundin, Olle Korsgren, Timo Otonkoski

Diabetes 2003;52(8):2007–2015

https://doi.org/10.2337/diabetes.52.8.2007

Published: 01 August 2003

View article titled, Characterization of Endocrine Progenitor Cells and Critical Factors for Their Differentiation in Human Adult Pancreatic Cell Culture

Journal Articles

Physical Exercise-Induced Hyperinsulinemic Hypoglycemia Is an Autosomal-Dominant Trait Characterized by Abnormal Pyruvate-Induced Insulin Release

Timo Otonkoski, Nina Kaminen, Jarkko Ustinov, Risto Lapatto, Thomas Meissner, Ertan Mayatepek, Juha Kere, Ilkka Sipilä

Diabetes 2003;52(1):199–204

https://doi.org/10.2337/diabetes.52.1.199

Published: 01 January 2003

View article titled, Physical Exercise-Induced Hyperinsulinemic Hypoglycemia Is an Autosomal-Dominant Trait Characterized by Abnormal Pyruvate-Induced Insulin Release

Journal Articles

Stimulated Endocrine Cell Proliferation and Differentiation in Transplanted Human Pancreatic Islets: Effects of the ob Gene and Compensatory Growth of the Implantation Organ

Björn Tyrberg, Jarkko Ustinov, Timo Otonkoski, Arne Andersson

Diabetes 2001;50(2):301–307

https://doi.org/10.2337/diabetes.50.2.301

Published: 01 February 2001

View article titled, Stimulated Endocrine Cell Proliferation and Differentiation in Transplanted Human Pancreatic Islets: <subtitle>Effects of the ob Gene and Compensatory Growth of the Implantation Organ</subtitle>

Journal Articles

Culture of Adult Human Islet Preparations With Hepatocyte Growth Factor and 804G Matrix Is Mitogenic for Duct Cells but Not for β-Cells

Veronique H Lefebvre, Timo Otonkoski, Jarkko Ustinov, Mari-Anne Huotari, Daniel G Pipeleers, Luc Bouwens

Diabetes 1998;47(1):134–137

https://doi.org/10.2337/diab.47.1.134

Published: 01 January 1998

View article titled, Culture of Adult Human Islet Preparations With Hepatocyte Growth Factor and 804G Matrix Is Mitogenic for Duct Cells but Not for β-Cells

Journal Articles

Functional β-Cell Mass After Transplantation of Human Fetal Pancreatic Cells: Differentiation or Proliferation?

Gillian M Beattie, Timo Otonkoski, Ana D Lopez, Hayek Alberto

Diabetes 1997;46(2):244–248

https://doi.org/10.2337/diab.46.2.244

Published: 01 February 1997

View article titled, Functional β-Cell Mass After Transplantation of Human Fetal Pancreatic Cells: Differentiation or Proliferation?

Journal Articles

Regulation of Proliferation and Differentiation of Human Fetal Pancreatic Islet Cells by Extracellular Matrix, Hepatocyte Growth Factor, and Cell-Cell Contact

Gillian M Beattie, Jeffrey S Rubin, Martin I Mally, Timo Otonkoski, Alberto Hayek

Diabetes 1996;45(9):1223–1228

https://doi.org/10.2337/diab.45.9.1223

Published: 01 September 1996

View article titled, Regulation of Proliferation and Differentiation of Human Fetal Pancreatic Islet Cells by Extracellular Matrix, Hepatocyte Growth Factor, and Cell-Cell Contact

NARROW

IER3IP1 Mutations Cause Neonatal Diabetes Due to Impaired Proinsulin Trafficking

Efficient Vascular and Neural Engraftment of Stem Cell–Derived Islets

Increased Frequency of the HLA-DRB104:04-DQA103-DQB103:02 Haplotype Among HLA-DQB106:02–Positive Children With Type 1 Diabetes

PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes

Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress

Early Detection of Peripheral Blood Cell Signature in Children Developing β-Cell Autoimmunity at a Young Age

112-OR: Critical Role of Tyrosine Kinase 2 (TYK2) in Human Pancreatic Differentiation

MANF Is Required for the Postnatal Expansion and Maintenance of Pancreatic β-Cell Mass in Mice

A Mouse Model of Human Hyperinsulinism Produced by the E1506K Mutation in the Sulphonylurea Receptor SUR1

Dedifferentiation for Replication of Human β-Cells: A Division Between Mice and Men?

Downregulation of EGF Receptor Signaling in Pancreatic Islets Causes Diabetes Due to Impaired Postnatal β-Cell Growth

Noninvasive Diagnosis of Focal Hyperinsulinism of Infancy With [¹⁸F]-DOPA Positron Emission Tomography

Lack of Association of PAX4 Gene With Type 1 Diabetes in the Finnish and Hungarian Populations

Severe Persistent Hyperinsulinemic Hypoglycemia due to a De Novo Glucokinase Mutation

Characterization of Endocrine Progenitor Cells and Critical Factors for Their Differentiation in Human Adult Pancreatic Cell Culture

Physical Exercise-Induced Hyperinsulinemic Hypoglycemia Is an Autosomal-Dominant Trait Characterized by Abnormal Pyruvate-Induced Insulin Release

Stimulated Endocrine Cell Proliferation and Differentiation in Transplanted Human Pancreatic Islets: Effects of the ob Gene and Compensatory Growth of the Implantation Organ

Culture of Adult Human Islet Preparations With Hepatocyte Growth Factor and 804G Matrix Is Mitogenic for Duct Cells but Not for β-Cells

Functional β-Cell Mass After Transplantation of Human Fetal Pancreatic Cells: Differentiation or Proliferation?

Regulation of Proliferation and Differentiation of Human Fetal Pancreatic Islet Cells by Extracellular Matrix, Hepatocyte Growth Factor, and Cell-Cell Contact

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