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Meeting Abstracts

261-OR: ADA Presidents' Select Abstract: Single-Dose GLP-1-Based Pancreatic Gene Therapy Durably Maintains Body Composition and Glycemia after Semaglutide Withdrawal in a Murine Model of Obesity

ALICE L. FITZPATRICK, SUYA WANG, REBECCA REESE, NICOLE PICARD, EMILY COZZI, TIMOTHY J. KIEFFER, JAY CAPLAN, HARITH RAJAGOPALAN

Diabetes 2024;73(Supplement_1):261-OR

https://doi.org/10.2337/db24-261-OR

Published: 14 June 2024

View article titled, 261-OR: ADA Presidents' Select Abstract: Single-Dose GLP-1-Based Pancreatic Gene Therapy Durably Maintains Body Composition and Glycemia after Semaglutide Withdrawal in a Murine Model of Obesity

Journal Articles

The Impact of Different Implantation Sites and Sex on the Differentiation of Human Pancreatic Endoderm Cells Into Insulin-Secreting Cells In Vivo

Nelly Saber, Cara E. Ellis, Diepiriye G. Iworima, Robert K. Baker, Alireza Rezania, Timothy J. Kieffer

Diabetes 2023;72(5):590–598

https://doi.org/10.2337/db22-0692

Published: 06 February 2023

View article titled, The Impact of Different Implantation Sites and Sex on the Differentiation of Human Pancreatic Endoderm Cells Into Insulin-Secreting Cells In Vivo

Journal Articles

Dynamic Ins2 Gene Activity Defines β-Cell Maturity States

Chieh Min Jamie Chu, Honey Modi, Cara Ellis, Nicole A.J. Krentz, Søs Skovsø, Yiwei Bernie Zhao, Haoning Cen, Nilou Noursadeghi, Evgeniy Panzhinskiy, Xiaoke Hu, Derek A. Dionne, Yi Han Xia, Shouhong Xuan, Mark O. Huising, Timothy J. Kieffer, Francis C. Lynn, James D. Johnson

Diabetes 2022;71(12):2612–2631

https://doi.org/10.2337/db21-1065

Published: 28 September 2022

View article titled, Dynamic <em>Ins2</em> Gene Activity Defines β-Cell Maturity States

Meeting Abstracts

816-P: Bioprinted Allogeneic Islet–Containing Implants Normalize Blood Glucose Control in Diabetic Rat Models without Immune Suppression

VALERIO RUSSO, REZA JALILI, YANG YU, RISHIMA AGARWAL, SHENG PAN, NAVID HAKIMI, KAUSHAR JAHAN, EMILY M. WILTS, SHOGO IDA, SPIRO GETSIOS, TIMOTHY J. KIEFFER, SAM WADSWORTH

Diabetes 2022;71(Supplement_1):816-P

https://doi.org/10.2337/db22-816-P

Published: 01 June 2022

View article titled, 816-P: Bioprinted Allogeneic Islet–Containing Implants Normalize Blood Glucose Control in Diabetic Rat Models without Immune Suppression

Journal Articles

Developmental Timing of High-Fat Diet Exposure Impacts Glucose Homeostasis in Mice in a Sex-Specific Manner

Maria M. Glavas, Ann Y. Lee, Ian Miao, Fan Yang, Majid Mojibian, Shannon M. O’Dwyer, Timothy J. Kieffer

Diabetes 2021;70(12):2771–2784

https://doi.org/10.2337/db21-0310

Published: 20 September 2021

View article titled, Developmental Timing of High-Fat Diet Exposure Impacts Glucose Homeostasis in Mice in a Sex-Specific Manner

Journal Articles

Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 but Not PC2

Adam Ramzy, Ali Asadi, Timothy J. Kieffer

Diabetes 2020;69(7):1451–1462

https://doi.org/10.2337/db19-0276

Published: 14 April 2020

View article titled, Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 but Not PC2

Journal Articles

Heparanase Overexpression Induces Glucagon Resistance and Protects Animals From Chemically Induced Diabetes

Dahai Zhang, Fulong Wang, Nathaniel Lal, Amy Pei-Ling Chiu, Andrea Wan, Jocelyn Jia, Denise Bierende, Stephane Flibotte, Sunita Sinha, Ali Asadi, Xiaoke Hu, Farnaz Taghizadeh, Thomas Pulinilkunnil, Corey Nislow, Israel Vlodavsky, James D. Johnson, Timothy J. Kieffer, Bahira Hussein, Brian Rodrigues

Diabetes 2017;66(1):45–57

https://doi.org/10.2337/db16-0761

Published: 07 October 2016

View article titled, Heparanase Overexpression Induces Glucagon Resistance and Protects Animals From Chemically Induced Diabetes

Includes: Supplementary data

Journal Articles

Hypothyroidism Impairs Human Stem Cell–Derived Pancreatic Progenitor Cell Maturation in Mice

Jennifer E. Bruin, Nelly Saber, Shannon O’Dwyer, Jessica K. Fox, Majid Mojibian, Payal Arora, Alireza Rezania, Timothy J. Kieffer

Diabetes 2016;65(5):1297–1309

https://doi.org/10.2337/db15-1439

Published: 06 January 2016

View article titled, Hypothyroidism Impairs Human Stem Cell–Derived Pancreatic Progenitor Cell Maturation in Mice

Includes: Supplementary data

Journal Articles

Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB

Diabetes 2016;65(1):239–254

https://doi.org/10.2337/db15-0122

Published: 22 September 2015

View article titled, Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB

Includes: Supplementary data

Journal Articles

Leptin Administration Enhances Islet Transplant Performance in Diabetic Mice

Heather C. Denroche, Whitney L. Quong, Jennifer E. Bruin, Eva Tudurí, Ali Asadi, Maria M. Glavas, Jessica K. Fox, Timothy J. Kieffer

Diabetes 2013;62(8):2738–2746

https://doi.org/10.2337/db12-1684

Published: 17 July 2013

View article titled, Leptin Administration Enhances Islet Transplant Performance in Diabetic Mice

Journal Articles

Link Between GIP and Osteopontin in Adipose Tissue and Insulin Resistance

Diabetes 2013;62(6):2088–2094

https://doi.org/10.2337/db12-0976

Published: 17 May 2013

View article titled, Link Between GIP and Osteopontin in Adipose Tissue and Insulin Resistance

Includes: Supplementary data

Journal Articles

Maturation of Human Embryonic Stem Cell–Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

Alireza Rezania, Jennifer E. Bruin, Michael J. Riedel, Majid Mojibian, Ali Asadi, Jean Xu, Rebecca Gauvin, Kavitha Narayan, Francis Karanu, John J. O’Neil, Ziliang Ao, Garth L. Warnock, Timothy J. Kieffer

Diabetes 2012;61(8):2016–2029

https://doi.org/10.2337/db11-1711

Published: 17 July 2012

View article titled, Maturation of Human Embryonic Stem Cell–Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

Includes: Supplementary data

Journal Articles

Maintenance of β-Cell Maturity and Plasticity in the Adult Pancreas: Developmental Biology Concepts in Adult Physiology

Marta Szabat, Francis C. Lynn, Brad G. Hoffman, Timothy J. Kieffer, Douglas W. Allan, James D. Johnson

Diabetes 2012;61(6):1365–1371

https://doi.org/10.2337/db11-1361

Published: 14 May 2012

View article titled, Maintenance of β-Cell Maturity and Plasticity in the Adult Pancreas: <subtitle>Developmental Biology Concepts in Adult Physiology</subtitle>

Journal Articles

Pleiotropic Effects of GIP on Islet Function Involve Osteopontin

Diabetes 2011;60(9):2424–2433

https://doi.org/10.2337/db10-1532

Published: 20 August 2011

View article titled, Pleiotropic Effects of GIP on Islet Function Involve Osteopontin

Includes: Supplementary data

Journal Articles

Leptin Therapy Reverses Hyperglycemia in Mice With Streptozotocin-Induced Diabetes, Independent of Hepatic Leptin Signaling

Heather C. Denroche, Jasna Levi, Rhonda D. Wideman, Roveena M. Sequeira, Frank K. Huynh, Scott D. Covey, Timothy J. Kieffer

Diabetes 2011;60(5):1414–1423

https://doi.org/10.2337/db10-0958

Published: 23 April 2011

View article titled, Leptin Therapy Reverses Hyperglycemia in Mice With Streptozotocin-Induced Diabetes, Independent of Hepatic Leptin Signaling

Journal Articles

Production of Functional Glucagon-Secreting α-Cells From Human Embryonic Stem Cells

Alireza Rezania, Michael J. Riedel, Rhonda D. Wideman, Francis Karanu, Ziliang Ao, Garth L. Warnock, Timothy J. Kieffer

Diabetes 2011;60(1):239–247

https://doi.org/10.2337/db10-0573

Published: 22 October 2010

View article titled, Production of Functional Glucagon-Secreting α-Cells From Human Embryonic Stem Cells

Includes: Supplementary data

Journal Articles

Disruption of Hepatic Leptin Signaling Protects Mice From Age- and Diet-Related Glucose Intolerance

Frank K. Huynh, Jasna Levi, Heather C. Denroche, Sarah L. Gray, Peter J. Voshol, Ursula H. Neumann, Madeleine Speck, Streamson C. Chua, Scott D. Covey, Timothy J. Kieffer

Diabetes 2010;59(12):3032–3040

https://doi.org/10.2337/db10-0074

Published: 28 September 2010

View article titled, Disruption of Hepatic Leptin Signaling Protects Mice From Age- and Diet-Related Glucose Intolerance

Includes: Supplementary data

Journal Articles

In Vivo Expression of HGF/NK1 and GLP-1 From dsAAV Vectors Enhances Pancreatic β-Cell Proliferation and Improves Pathology in the db/db Mouse Model of Diabetes

Daniel F. Gaddy, Michael J. Riedel, Sharmila Pejawar-Gaddy, Timothy J. Kieffer, Paul D. Robbins

Diabetes 2010;59(12):3108–3116

https://doi.org/10.2337/db09-1886

Published: 14 September 2010

View article titled, In Vivo Expression of HGF/NK1 and GLP-1 From dsAAV Vectors Enhances Pancreatic β-Cell Proliferation and Improves Pathology in the <em>db/db</em> Mouse Model of Diabetes

Journal Articles

Cleavage of Protein Kinase D After Acute Hypoinsulinemia Prevents Excessive Lipoprotein Lipase–Mediated Cardiac Triglyceride Accumulation

Min Suk Kim, Fang Wang, Prasanth Puthanveetil, Girish Kewalramani, Sheila Innis, Lucy Marzban, Susan F. Steinberg, Travis D. Webber, Timothy J. Kieffer, Ashraf Abrahani, Brian Rodrigues

Diabetes 2009;58(11):2464–2475

https://doi.org/10.2337/db09-0681

Published: 01 November 2009

View article titled, Cleavage of Protein Kinase D After Acute Hypoinsulinemia Prevents Excessive Lipoprotein Lipase–Mediated Cardiac Triglyceride Accumulation

Includes: Supplementary data

Journal Articles

A Switch From Prohormone Convertase (PC)-2 to PC1/3 Expression in Transplanted α-Cells Is Accompanied by Differential Processing of Proglucagon and Improved Glucose Homeostasis in Mice

Rhonda D. Wideman, Scott D. Covey, Gene C. Webb, Daniel J. Drucker, Timothy J. Kieffer

Diabetes 2007;56(11):2744–2752

https://doi.org/10.2337/db07-0563

Published: 01 November 2007

View article titled, A Switch From Prohormone Convertase (PC)-2 to PC1/3 Expression in Transplanted α-Cells Is Accompanied by Differential Processing of Proglucagon and Improved Glucose Homeostasis in Mice

NARROW

261-OR: ADA Presidents' Select Abstract: Single-Dose GLP-1-Based Pancreatic Gene Therapy Durably Maintains Body Composition and Glycemia after Semaglutide Withdrawal in a Murine Model of Obesity

The Impact of Different Implantation Sites and Sex on the Differentiation of Human Pancreatic Endoderm Cells Into Insulin-Secreting Cells In Vivo

Dynamic Ins2 Gene Activity Defines β-Cell Maturity States

816-P: Bioprinted Allogeneic Islet–Containing Implants Normalize Blood Glucose Control in Diabetic Rat Models without Immune Suppression

Developmental Timing of High-Fat Diet Exposure Impacts Glucose Homeostasis in Mice in a Sex-Specific Manner

Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 but Not PC2

Heparanase Overexpression Induces Glucagon Resistance and Protects Animals From Chemically Induced Diabetes

Hypothyroidism Impairs Human Stem Cell–Derived Pancreatic Progenitor Cell Maturation in Mice

Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB

Leptin Administration Enhances Islet Transplant Performance in Diabetic Mice

Link Between GIP and Osteopontin in Adipose Tissue and Insulin Resistance

Maturation of Human Embryonic Stem Cell–Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

Maintenance of β-Cell Maturity and Plasticity in the Adult Pancreas: Developmental Biology Concepts in Adult Physiology

Pleiotropic Effects of GIP on Islet Function Involve Osteopontin

Leptin Therapy Reverses Hyperglycemia in Mice With Streptozotocin-Induced Diabetes, Independent of Hepatic Leptin Signaling

Production of Functional Glucagon-Secreting α-Cells From Human Embryonic Stem Cells

Disruption of Hepatic Leptin Signaling Protects Mice From Age- and Diet-Related Glucose Intolerance

In Vivo Expression of HGF/NK1 and GLP-1 From dsAAV Vectors Enhances Pancreatic β-Cell Proliferation and Improves Pathology in the db/db Mouse Model of Diabetes

Cleavage of Protein Kinase D After Acute Hypoinsulinemia Prevents Excessive Lipoprotein Lipase–Mediated Cardiac Triglyceride Accumulation

A Switch From Prohormone Convertase (PC)-2 to PC1/3 Expression in Transplanted α-Cells Is Accompanied by Differential Processing of Proglucagon and Improved Glucose Homeostasis in Mice

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