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Timothy S Kern
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Journal Articles

Subendothelial matrix stiffening by lysyl oxidase enhances RAGE-mediated retinal endothelial activation in diabetes

Sathishkumar Chandrakumar, Irene Santiago Tierno, Mahesh Agarwal, Nikolaos Matisioudis, Timothy S. Kern, Kaustabh Ghosh
Journal: Diabetes
Diabetes db220761
DOI: https://doi.org/10.2337/db22-0761
Published: 14 April 2023
View article titled, Subendothelial matrix stiffening by lysyl oxidase enhances RAGE-mediated retinal endothelial activation in diabetes
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Journal Articles

Photobiomodulation Inhibits Long-term Structural and Functional Lesions of Diabetic Retinopathy

Yan Cheng, Yunpeng Du, Haitao Liu, Jie Tang, Alex Veenstra, Timothy S. Kern
Journal: Diabetes
Diabetes 2018;67(2):291–298
DOI: https://doi.org/10.2337/db17-0803
Published: 21 November 2017
View article titled, Photobiomodulation Inhibits Long-term Structural and Functional Lesions of Diabetic Retinopathy
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Includes: Supplementary data
Journal Articles

CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy

Jose-Andres C. Portillo, Yalitza Lopez Corcino, Yanling Miao, Jie Tang, Nader Sheibani, Timothy S. Kern, George R. Dubyak, Carlos S. Subauste
Journal: Diabetes
Diabetes 2017;66(2):483–493
DOI: https://doi.org/10.2337/db16-0051
Published: 29 July 2016
View article titled, CD40 in Retinal Müller Cells Induces P2X<sub>7</sub>-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy
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Includes: Supplementary data
Journal Articles

Marrow-Derived Cells Regulate the Development of Early Diabetic Retinopathy and Tactile Allodynia in Mice

Guangyuan Li, Alexander A. Veenstra, Ramaprasad R. Talahalli, Xiaoqi Wang, Rose A. Gubitosi-Klug, Nader Sheibani, Timothy S. Kern
Journal: Diabetes
Diabetes 2012;61(12):3294–3303
DOI: https://doi.org/10.2337/db11-1249
Published: 15 November 2012
View article titled, Marrow-Derived Cells Regulate the Development of Early Diabetic Retinopathy and Tactile Allodynia in Mice
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Includes: Supplementary data
Journal Articles

Oxidation of Fatty Acids Is the Source of Increased Mitochondrial Reactive Oxygen Species Production in Kidney Cortical Tubules in Early Diabetes

Mariana G. Rosca, Edwin J. Vazquez, Qun Chen, Janos Kerner, Timothy S. Kern, Charles L. Hoppel
Journal: Diabetes
Diabetes 2012;61(8):2074–2083
DOI: https://doi.org/10.2337/db11-1437
Published: 17 July 2012
View article titled, Oxidation of Fatty Acids Is the Source of Increased Mitochondrial Reactive Oxygen Species Production in Kidney Cortical Tubules in Early Diabetes
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Journal Articles

Sulfasalazine Blocks the Development of Tactile Allodynia in Diabetic Rats

Liliana N. Berti-Mattera, Timothy S. Kern, Ruth E. Siegel, Ina Nemet, Rochanda Mitchell
Journal: Diabetes
Diabetes 2008;57(10):2801–2808
DOI: https://doi.org/10.2337/db07-1274
Published: 01 October 2008
View article titled, Sulfasalazine Blocks the Development of Tactile Allodynia in Diabetic Rats
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Journal Articles

5-Lipoxygenase, but Not 12/15-Lipoxygenase, Contributes to Degeneration of Retinal Capillaries in a Mouse Model of Diabetic Retinopathy

Rose A. Gubitosi-Klug, Ramaprasad Talahalli, Yunpeng Du, Jerry L. Nadler, Timothy S. Kern
Journal: Diabetes
Diabetes 2008;57(5):1387–1393
DOI: https://doi.org/10.2337/db07-1217
Published: 01 May 2008
View article titled, 5-Lipoxygenase, but Not 12/15-Lipoxygenase, Contributes to Degeneration of Retinal Capillaries in a Mouse Model of Diabetic Retinopathy
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Includes: Supplementary data
Journal Articles

Ischemic Vascular Damage Can Be Repaired by Healthy, but Not Diabetic, Endothelial Progenitor Cells

Sergio Caballero, Nilanjana Sengupta, Aqeela Afzal, Kyung-Hee Chang, Sergio Li Calzi, Dennis L. Guberski, Timothy S. Kern, Maria B. Grant
Journal: Diabetes
Diabetes 2007;56(4):960–967
DOI: https://doi.org/10.2337/db06-1254
Published: 01 April 2007
View article titled, Ischemic Vascular Damage Can Be Repaired by Healthy, but Not Diabetic, Endothelial Progenitor Cells
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Journal Articles

Topical Administration of Nepafenac Inhibits Diabetes-Induced Retinal Microvascular Disease and Underlying Abnormalities of Retinal Metabolism and Physiology

Timothy S. Kern, Casey M. Miller, Yunpeng Du, Ling Zheng, Susanne Mohr, Sherry L. Ball, M. Kim, Jeffrey A. Jamison, David P. Bingaman
Journal: Diabetes
Diabetes 2007;56(2):373–379
DOI: https://doi.org/10.2337/db05-1621
Published: 01 February 2007
View article titled, Topical Administration of Nepafenac Inhibits Diabetes-Induced Retinal Microvascular Disease and Underlying Abnormalities of Retinal Metabolism and Physiology
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Journal Articles

Salicylate-Based Anti-Inflammatory Drugs Inhibit the Early Lesion of Diabetic Retinopathy

Ling Zheng, Scott J. Howell, Denise A. Hatala, Kun Huang, Timothy S. Kern
Journal: Diabetes
Diabetes 2007;56(2):337–345
DOI: https://doi.org/10.2337/db06-0789
Published: 01 February 2007
View article titled, Salicylate-Based Anti-Inflammatory Drugs Inhibit the Early Lesion of Diabetic Retinopathy
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Journal Articles

Reduction of Diabetes-Induced Oxidative Stress, Fibrotic Cytokine Expression, and Renal Dysfunction in Protein Kinase Cβ–Null Mice

Yuzuru Ohshiro, Ronald C. Ma, Yutaka Yasuda, Junko Hiraoka-Yamamoto, Allen C. Clermont, Keiji Isshiki, Kunimasa Yagi, Emi Arikawa, Timothy S. Kern, George L. King
Journal: Diabetes
Diabetes 2006;55(11):3112–3120
DOI: https://doi.org/10.2337/db06-0895
Published: 01 November 2006
View article titled, Reduction of Diabetes-Induced Oxidative Stress, Fibrotic Cytokine Expression, and Renal Dysfunction in Protein Kinase Cβ–Null Mice
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Journal Articles

Paradoxical Effects of Green Tea (Camellia Sinensis) and Antioxidant Vitamins in Diabetic Rats: Improved Retinopathy and Renal Mitochondrial Defects but Deterioration of Collagen Matrix Glycoxidation and Cross-Linking

Georgian T. Mustata, Mariana Rosca, Klaus M. Biemel, Oliver Reihl, Mark A. Smith, Ashwini Viswanathan, Christopher Strauch, Yunpeng Du, Jie Tang, Timothy S. Kern, Markus O. Lederer, Michael Brownlee, Miriam F. Weiss, Vincent M. Monnier
Journal: Diabetes
Diabetes 2005;54(2):517–526
DOI: https://doi.org/10.2337/diabetes.54.2.517
Published: 01 February 2005
View article titled, Paradoxical Effects of Green Tea (Camellia Sinensis) and Antioxidant Vitamins in Diabetic Rats: <span class="subtitle">Improved Retinopathy and Renal Mitochondrial Defects but Deterioration of Collagen Matrix Glycoxidation and Cross-Linking</span>
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Journal Articles

Poly(ADP-Ribose) Polymerase Is Involved in the Development of Diabetic Retinopathy via Regulation of Nuclear Factor-κB

Ling Zheng, Csaba Szabó, Timothy S. Kern
Journal: Diabetes
Diabetes 2004;53(11):2960–2967
DOI: https://doi.org/10.2337/diabetes.53.11.2960
Published: 01 November 2004
View article titled, Poly(ADP-Ribose) Polymerase Is Involved in the Development of Diabetic Retinopathy via Regulation of Nuclear Factor-κB
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Journal Articles

Regulation of the Early Subnormal Retinal Oxygenation Response in Experimental Diabetes by Inducible Nitric Oxide Synthase

Bruce A. Berkowitz, Hongmei Luan, Rita R. Gupta, Daniel Pacheco, Andres Seidner, Robin Roberts, Jessica Liggett, Deborah L. Knoerzer, Jane R. Connor, Yunpeng Du, Timothy S. Kern, Yasuki Ito
Journal: Diabetes
Diabetes 2004;53(1):173–178
DOI: https://doi.org/10.2337/diabetes.53.1.173
Published: 01 January 2004
View article titled, Regulation of the Early Subnormal Retinal Oxygenation Response in Experimental Diabetes by Inducible Nitric Oxide Synthase
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Journal Articles

Activation of Nuclear Factor-κB Induced by Diabetes and High Glucose Regulates a Proapoptotic Program in Retinal Pericytes

Giulio Romeo, Wei-Hua Liu, Veronica Asnaghi, Timothy S. Kern, Mara Lorenzi
Journal: Diabetes
Diabetes 2002;51(7):2241–2248
DOI: https://doi.org/10.2337/diabetes.51.7.2241
Published: 01 July 2002
View article titled, Activation of Nuclear Factor-κB Induced by Diabetes and High Glucose Regulates a Proapoptotic Program in Retinal Pericytes
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Journal Articles

Caspase Activation in Retinas of Diabetic and Galactosemic Mice and Diabetic Patients

Susanne Mohr, Xia Xi, Jie Tang, Timothy S. Kern
Journal: Diabetes
Diabetes 2002;51(4):1172–1179
DOI: https://doi.org/10.2337/diabetes.51.4.1172
Published: 01 April 2002
View article titled, Caspase Activation in Retinas of Diabetic and Galactosemic Mice and Diabetic Patients
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Journal Articles

Abnormalities of Retinal Metabolism in Diabetes and Experimental Galactosemia: VII. Effect of Long-Term Administration of Antioxidants on the Development of Retinopathy

Renu A. Kowluru, Jie Tang, Timothy S. Kern
Journal: Diabetes
Diabetes 2001;50(8):1938–1942
DOI: https://doi.org/10.2337/diabetes.50.8.1938
Published: 01 August 2001
View article titled, Abnormalities of Retinal Metabolism in Diabetes and Experimental Galactosemia: <span class="subtitle">VII. Effect of Long-Term Administration of Antioxidants on the Development of Retinopathy</span>
Open the PDF for Abnormalities of Retinal Metabolism in Diabetes and Experimental Galactosemia: <span class="subtitle">VII. Effect of Long-Term Administration of Antioxidants on the Development of Retinopathy</span> in another window
Journal Articles

Pharmacological Inhibition of Diabetic Retinopathy: Aminoguanidine and Aspirin

Timothy S. Kern, Ronald L. Engerman
Journal: Diabetes
Diabetes 2001;50(7):1636–1642
DOI: https://doi.org/10.2337/diabetes.50.7.1636
Published: 01 July 2001
View article titled, Pharmacological Inhibition of Diabetic Retinopathy: <span class="subtitle">Aminoguanidine and Aspirin</span>
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Journal Articles

Abnormalities of Retinal Metabolism in Diabetes or Experimental Galactosemia. III. Effects of Antioxidants

Renu A Kowluru, Timothy S Kern, Ronald L Engerman, Donald Armstrong
Journal: Diabetes
Diabetes 1996;45(9):1233–1237
DOI: https://doi.org/10.2337/diab.45.9.1233
Published: 01 September 1996
View article titled, Abnormalities of Retinal Metabolism in Diabetes or Experimental Galactosemia. III. Effects of Antioxidants
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Journal Articles

Evidence of a Glycemic Threshold for the Formation of Pentosidine in Diabetic Dog Lens but Not in Collagen

Ramanakoppa H Nagaraj, Timothy S Kern, David R Sell, John Fogarty, Ronald L Engerman, Vincent M Monnier
Journal: Diabetes
Diabetes 1996;45(5):587–594
DOI: https://doi.org/10.2337/diab.45.5.587
Published: 01 May 1996
View article titled, Evidence of a Glycemic Threshold for the Formation of Pentosidine in Diabetic Dog Lens but Not in Collagen
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