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Timothy S Kern
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Journal Articles

Mechanical Regulation of Retinal Vascular Inflammation and Degeneration in Diabetes

Sathishkumar Chandrakumar, Irene Santiago Tierno, Mahesh Agarwal, Emma M. Lessieur, Yunpeng Du, Jie Tang, Jianying Kiser, Xiao Yang, Anthony Rodriguez, Timothy S. Kern, Kaustabh Ghosh
Journal: Diabetes
Diabetes 2024;73(2):280–291
https://doi.org/10.2337/db23-0584
Published: 21 November 2023
View articletitled, Mechanical Regulation of Retinal Vascular Inflammation and Degeneration in Diabetes
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Journal Articles

Subendothelial Matrix Stiffening by Lysyl Oxidase Enhances RAGE-Mediated Retinal Endothelial Activation in Diabetes

Sathishkumar Chandrakumar, Irene Santiago Tierno, Mahesh Agarwal, Nikolaos Matisioudis, Timothy S. Kern, Kaustabh Ghosh
Journal: Diabetes
Diabetes 2023;72(7):973–985
https://doi.org/10.2337/db22-0761
Published: 14 April 2023
View articletitled, Subendothelial Matrix Stiffening by Lysyl Oxidase Enhances RAGE-Mediated Retinal Endothelial Activation in Diabetes
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Journal Articles

Photobiomodulation Inhibits Long-term Structural and Functional Lesions of Diabetic Retinopathy

Yan Cheng, Yunpeng Du, Haitao Liu, Jie Tang, Alex Veenstra, Timothy S. Kern
Journal: Diabetes
Diabetes 2018;67(2):291–298
https://doi.org/10.2337/db17-0803
Published: 21 November 2017
View articletitled, Photobiomodulation Inhibits Long-term Structural and Functional Lesions of Diabetic Retinopathy
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Includes: Supplementary data
Journal Articles

CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy

Jose-Andres C. Portillo, Yalitza Lopez Corcino, Yanling Miao, Jie Tang, Nader Sheibani, Timothy S. Kern, George R. Dubyak, Carlos S. Subauste
Journal: Diabetes
Diabetes 2017;66(2):483–493
https://doi.org/10.2337/db16-0051
Published: 29 July 2016
View articletitled, CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy
Open the PDF for CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy in another window
Includes: Supplementary data
Journal Articles

Marrow-Derived Cells Regulate the Development of Early Diabetic Retinopathy and Tactile Allodynia in Mice

Guangyuan Li, Alexander A. Veenstra, Ramaprasad R. Talahalli, Xiaoqi Wang, Rose A. Gubitosi-Klug, Nader Sheibani, Timothy S. Kern
Journal: Diabetes
Diabetes 2012;61(12):3294–3303
https://doi.org/10.2337/db11-1249
Published: 15 November 2012
View articletitled, Marrow-Derived Cells Regulate the Development of Early Diabetic Retinopathy and Tactile Allodynia in Mice
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Includes: Supplementary data
Journal Articles

Oxidation of Fatty Acids Is the Source of Increased Mitochondrial Reactive Oxygen Species Production in Kidney Cortical Tubules in Early Diabetes

Mariana G. Rosca, Edwin J. Vazquez, Qun Chen, Janos Kerner, Timothy S. Kern, Charles L. Hoppel
Journal: Diabetes
Diabetes 2012;61(8):2074–2083
https://doi.org/10.2337/db11-1437
Published: 17 July 2012
View articletitled, Oxidation of Fatty Acids Is the Source of Increased Mitochondrial Reactive Oxygen Species Production in Kidney Cortical Tubules in Early Diabetes
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Journal Articles

Sulfasalazine Blocks the Development of Tactile Allodynia in Diabetic Rats

Liliana N. Berti-Mattera, Timothy S. Kern, Ruth E. Siegel, Ina Nemet, Rochanda Mitchell
Journal: Diabetes
Diabetes 2008;57(10):2801–2808
https://doi.org/10.2337/db07-1274
Published: 01 October 2008
View articletitled, Sulfasalazine Blocks the Development of Tactile Allodynia in Diabetic Rats
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Journal Articles

5-Lipoxygenase, but Not 12/15-Lipoxygenase, Contributes to Degeneration of Retinal Capillaries in a Mouse Model of Diabetic Retinopathy

Rose A. Gubitosi-Klug, Ramaprasad Talahalli, Yunpeng Du, Jerry L. Nadler, Timothy S. Kern
Journal: Diabetes
Diabetes 2008;57(5):1387–1393
https://doi.org/10.2337/db07-1217
Published: 01 May 2008
View articletitled, 5-Lipoxygenase, but Not 12/15-Lipoxygenase, Contributes to Degeneration of Retinal Capillaries in a Mouse Model of Diabetic Retinopathy
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Includes: Supplementary data
Journal Articles

Ischemic Vascular Damage Can Be Repaired by Healthy, but Not Diabetic, Endothelial Progenitor Cells

Sergio Caballero, Nilanjana Sengupta, Aqeela Afzal, Kyung-Hee Chang, Sergio Li Calzi, Dennis L. Guberski, Timothy S. Kern, Maria B. Grant
Journal: Diabetes
Diabetes 2007;56(4):960–967
https://doi.org/10.2337/db06-1254
Published: 01 April 2007
View articletitled, Ischemic Vascular Damage Can Be Repaired by Healthy, but Not Diabetic, Endothelial Progenitor Cells
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Journal Articles

Topical Administration of Nepafenac Inhibits Diabetes-Induced Retinal Microvascular Disease and Underlying Abnormalities of Retinal Metabolism and Physiology

Timothy S. Kern, Casey M. Miller, Yunpeng Du, Ling Zheng, Susanne Mohr, Sherry L. Ball, M. Kim, Jeffrey A. Jamison, David P. Bingaman
Journal: Diabetes
Diabetes 2007;56(2):373–379
https://doi.org/10.2337/db05-1621
Published: 01 February 2007
View articletitled, Topical Administration of Nepafenac Inhibits Diabetes-Induced Retinal Microvascular Disease and Underlying Abnormalities of Retinal Metabolism and Physiology
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Journal Articles

Salicylate-Based Anti-Inflammatory Drugs Inhibit the Early Lesion of Diabetic Retinopathy

Ling Zheng, Scott J. Howell, Denise A. Hatala, Kun Huang, Timothy S. Kern
Journal: Diabetes
Diabetes 2007;56(2):337–345
https://doi.org/10.2337/db06-0789
Published: 01 February 2007
View articletitled, Salicylate-Based Anti-Inflammatory Drugs Inhibit the Early Lesion of Diabetic Retinopathy
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Journal Articles

Reduction of Diabetes-Induced Oxidative Stress, Fibrotic Cytokine Expression, and Renal Dysfunction in Protein Kinase Cβ–Null Mice

Yuzuru Ohshiro, Ronald C. Ma, Yutaka Yasuda, Junko Hiraoka-Yamamoto, Allen C. Clermont, Keiji Isshiki, Kunimasa Yagi, Emi Arikawa, Timothy S. Kern, George L. King
Journal: Diabetes
Diabetes 2006;55(11):3112–3120
https://doi.org/10.2337/db06-0895
Published: 01 November 2006
View articletitled, Reduction of Diabetes-Induced Oxidative Stress, Fibrotic Cytokine Expression, and Renal Dysfunction in Protein Kinase Cβ–Null Mice
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Journal Articles

Paradoxical Effects of Green Tea (Camellia Sinensis) and Antioxidant Vitamins in Diabetic Rats: Improved Retinopathy and Renal Mitochondrial Defects but Deterioration of Collagen Matrix Glycoxidation and Cross-Linking

Georgian T. Mustata, Mariana Rosca, Klaus M. Biemel, Oliver Reihl, Mark A. Smith, Ashwini Viswanathan, Christopher Strauch, Yunpeng Du, Jie Tang, Timothy S. Kern, Markus O. Lederer, Michael Brownlee, Miriam F. Weiss, Vincent M. Monnier
Journal: Diabetes
Diabetes 2005;54(2):517–526
https://doi.org/10.2337/diabetes.54.2.517
Published: 01 February 2005
View articletitled, Paradoxical Effects of Green Tea (Camellia Sinensis) and Antioxidant Vitamins in Diabetic Rats: Improved Retinopathy and Renal Mitochondrial Defects but Deterioration of Collagen Matrix Glycoxidation and Cross-Linking
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Journal Articles

Poly(ADP-Ribose) Polymerase Is Involved in the Development of Diabetic Retinopathy via Regulation of Nuclear Factor-κB

Ling Zheng, Csaba Szabó, Timothy S. Kern
Journal: Diabetes
Diabetes 2004;53(11):2960–2967
https://doi.org/10.2337/diabetes.53.11.2960
Published: 01 November 2004
View articletitled, Poly(ADP-Ribose) Polymerase Is Involved in the Development of Diabetic Retinopathy via Regulation of Nuclear Factor-κB
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Journal Articles

Regulation of the Early Subnormal Retinal Oxygenation Response in Experimental Diabetes by Inducible Nitric Oxide Synthase

Bruce A. Berkowitz, Hongmei Luan, Rita R. Gupta, Daniel Pacheco, Andres Seidner, Robin Roberts, Jessica Liggett, Deborah L. Knoerzer, Jane R. Connor, Yunpeng Du, Timothy S. Kern, Yasuki Ito
Journal: Diabetes
Diabetes 2004;53(1):173–178
https://doi.org/10.2337/diabetes.53.1.173
Published: 01 January 2004
View articletitled, Regulation of the Early Subnormal Retinal Oxygenation Response in Experimental Diabetes by Inducible Nitric Oxide Synthase
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Journal Articles

Activation of Nuclear Factor-κB Induced by Diabetes and High Glucose Regulates a Proapoptotic Program in Retinal Pericytes

Giulio Romeo, Wei-Hua Liu, Veronica Asnaghi, Timothy S. Kern, Mara Lorenzi
Journal: Diabetes
Diabetes 2002;51(7):2241–2248
https://doi.org/10.2337/diabetes.51.7.2241
Published: 01 July 2002
View articletitled, Activation of Nuclear Factor-κB Induced by Diabetes and High Glucose Regulates a Proapoptotic Program in Retinal Pericytes
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Journal Articles

Caspase Activation in Retinas of Diabetic and Galactosemic Mice and Diabetic Patients

Susanne Mohr, Xia Xi, Jie Tang, Timothy S. Kern
Journal: Diabetes
Diabetes 2002;51(4):1172–1179
https://doi.org/10.2337/diabetes.51.4.1172
Published: 01 April 2002
View articletitled, Caspase Activation in Retinas of Diabetic and Galactosemic Mice and Diabetic Patients
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Journal Articles

Abnormalities of Retinal Metabolism in Diabetes and Experimental Galactosemia: VII. Effect of Long-Term Administration of Antioxidants on the Development of Retinopathy

Renu A. Kowluru, Jie Tang, Timothy S. Kern
Journal: Diabetes
Diabetes 2001;50(8):1938–1942
https://doi.org/10.2337/diabetes.50.8.1938
Published: 01 August 2001
View articletitled, Abnormalities of Retinal Metabolism in Diabetes and Experimental Galactosemia: VII. Effect of Long-Term Administration of Antioxidants on the Development of Retinopathy
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Journal Articles

Pharmacological Inhibition of Diabetic Retinopathy: Aminoguanidine and Aspirin

Timothy S. Kern, Ronald L. Engerman
Journal: Diabetes
Diabetes 2001;50(7):1636–1642
https://doi.org/10.2337/diabetes.50.7.1636
Published: 01 July 2001
View articletitled, Pharmacological Inhibition of Diabetic Retinopathy: Aminoguanidine and Aspirin
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Journal Articles

Abnormalities of Retinal Metabolism in Diabetes or Experimental Galactosemia. III. Effects of Antioxidants

Renu A Kowluru, Timothy S Kern, Ronald L Engerman, Donald Armstrong
Journal: Diabetes
Diabetes 1996;45(9):1233–1237
https://doi.org/10.2337/diab.45.9.1233
Published: 01 September 1996
View articletitled, Abnormalities of Retinal Metabolism in Diabetes or Experimental Galactosemia. III. Effects of Antioxidants
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