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Meeting Abstracts

155-OR: Genetic Variation and Time to Progression in TN10 (Teplizumab)

DOMINIKA A. MICHALEK, SUNA ONENGUT-GUMUSCU, WEI-MIN CHEN, TODD M. BRUSKO, ANDREA STECK, PETER GOTTLIEB, RICHARD A. ORAM, JEFFREY KRISCHER, HEMANG M. PARIKH, MARIA J. REDONDO, KEVAN C. HEROLD, STEPHEN S. RICH

Diabetes 2024;73(Supplement_1):155-OR

https://doi.org/10.2337/db24-155-OR

Published: 14 June 2024

View article titled, 155-OR: Genetic Variation and Time to Progression in TN10 (Teplizumab)

Meeting Abstracts

1441-P: Low Morning Cortisol in Early Life Associated with Increased Risk of Islet Autoimmunity

KENDRA VEHIK, KRISTIAN F. LYNCH, HEMANG M. PARIKH, ÅKE LERNMARK, MARIAN REWERS, RICHARD MCINDOE, JORMA TOPPARI, ANETTE-GABRIELE ZIEGLER, BEENA AKOLKAR, WILLIAM HAGOPIAN, TODD M. BRUSKO, JEFFREY KRISCHER, ROSWITH L. ROTH, SUZANNE B. JOHNSON, TEDDY STUDY GROUP

Diabetes 2024;73(Supplement_1):1441-P

https://doi.org/10.2337/db24-1441-P

Published: 14 June 2024

View article titled, 1441-P: Low Morning Cortisol in Early Life Associated with Increased Risk of Islet Autoimmunity

Meeting Abstracts

1318-P: Postprandial C-Peptide (pCP) in Provider-Diagnosed Pediatric Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D)

MARIA J. REDONDO, KYLIE K. HARRALL, SARAH M. BIRD, MUSTAFA TOSUR, SERIFE UYSAL, ALEJANDRO F. SILLER, HORACIO J. VELASQUEZ, ANDREW MUIR, KENDRA VEHIK, TODD M. BRUSKO, MARK A. ATKINSON, DANA DABELEA, WILLIAM HAGOPIAN, RICHARD A. ORAM

Diabetes 2024;73(Supplement_1):1318-P

https://doi.org/10.2337/db24-1318-P

Published: 14 June 2024

View article titled, 1318-P: Postprandial C-Peptide (pCP) in Provider-Diagnosed Pediatric Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D)

Meeting Abstracts

1997-LB: Curation of an AI-Ready Dataset Using Domain-Informed Features Derived from Type 1 Diabetes TrialNet Studies

ERIN M. TALLON, MELANIE R. SHAPIRO, AMEY SHRIKRISHNA WAGHMODE, RYAN MERRITT, CLIVE WASSERFALL, RHONDA BACHER, BRENT LOCKEE, CRAIG VANDERVELDEN, KELSEY PANFIL, WAYNE V. MOORE, MARK A. ATKINSON, TODD M. BRUSKO, MARK A. CLEMENTS

Diabetes 2024;73(Supplement_1):1997-LB

https://doi.org/10.2337/db24-1997-LB

Published: 14 June 2024

View article titled, 1997-LB: Curation of an AI-Ready Dataset Using Domain-Informed Features Derived from Type 1 Diabetes TrialNet Studies

Journal Articles

Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability

Puchong Thirawatananond, Matthew E. Brown, Lindsey K. Sachs, Juan M. Arnoletti, Wen-I Yeh, Amanda L. Posgai, Melanie R. Shapiro, Yi-Guang Chen, Todd M. Brusko

Diabetes 2023;72(11):1629–1640

https://doi.org/10.2337/db23-0307

Published: 25 August 2023

View article titled, Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability

Meeting Abstracts

1298-P: Independent Associations of GAD65, IA2, and ZnT8 Autoantibody (Ab) Positivity with C-Peptide (CPep) in a Diverse Cohort of Youth with Diabetes (DM)

MARIA J. REDONDO, KYLIE K. HARRALL, DEBORAH H. GLUECK, MUSTAFA TOSUR, SERIFE UYSAL, ANDREW MUIR, KENDRA VEHIK, TODD M. BRUSKO, MARK A. ATKINSON, RICHARD A. ORAM, DANA DABELEA, WILLIAM HAGOPIAN, DISCOVER STUDY GROUP

Diabetes 2023;72(Supplement_1):1298-P

https://doi.org/10.2337/db23-1298-P

Published: 20 June 2023

View article titled, 1298-P: Independent Associations of GAD65, IA2, and ZnT8 Autoantibody (Ab) Positivity with C-Peptide (CPep) in a Diverse Cohort of Youth with Diabetes (DM)

Meeting Abstracts

189-OR: Immune-Profiling of Pancreatic Tissue Affected by Immune Checkpoint Inhibitor–Induced Diabetes (CPI-D)

ZOE QUANDT, ARABELLA YOUNG, GRAHAM BARLOW, SHEN DONG, JENNIFER SMITH, IRINA KUSMARTSEVA, TODD M. BRUSKO, STEWART COOPER, MARK S. ANDERSON

Diabetes 2022;71(Supplement_1):189-OR

https://doi.org/10.2337/db22-189-OR

Published: 01 June 2022

View article titled, 189-OR: Immune-Profiling of Pancreatic Tissue Affected by Immune Checkpoint Inhibitor–Induced Diabetes (CPI-D)

Meeting Abstracts

192-LB: Human CD4+CD25+CD226- Regulatory T Cells Demonstrate High Purity and Lineage Stability following In Vitro Expansion for Adoptive Cell Therapy

MATTHEW E. BROWN, SEIF R. HANBALI, LUZ MARINA GOMEZ RODRIGUEZ, JUAN M. ARNOLETTI, EMMA B. CARPENTER, TODD M. BRUSKO

Diabetes 2021;70(Supplement_1):192-LB

https://doi.org/10.2337/db21-192-LB

Published: 01 June 2021

View article titled, 192-LB: Human CD4+CD25+CD226- Regulatory T Cells Demonstrate High Purity and Lineage Stability following In Vitro Expansion for Adoptive Cell Therapy

Journal Articles

Low-Dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report

Andrea Lin, Jasmine A. Mack, Brittany Bruggeman, Laura M. Jacobsen, Amanda L. Posgai, Clive H. Wasserfall, Todd M. Brusko, Mark A. Atkinson, Stephen E. Gitelman, Peter A. Gottlieb, Matthew J. Gurka, Clayton E. Mathews, Desmond A. Schatz, Michael J. Haller

Diabetes 2021;70(5):1123–1129

https://doi.org/10.2337/db20-1103

Published: 25 February 2021

View article titled, Low-Dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report

Journal Articles

Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size

James J. Ross, Clive H. Wasserfall, Rhonda Bacher, Daniel J. Perry, Kieran McGrail, Amanda L. Posgai, Xiaoru Dong, Andrew Muir, Xia Li, Martha Campbell-Thompson, Todd M. Brusko, Desmond A. Schatz, Michael J. Haller, Mark A. Atkinson

Diabetes 2021;70(4):944–954

https://doi.org/10.2337/db20-0995

Published: 13 January 2021

View article titled, Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size

Journal Articles

Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis

MacKenzie D. Williams, Rhonda Bacher, Daniel J. Perry, C. Ramsey Grace, Kieran M. McGrail, Amanda L. Posgai, Andrew Muir, Srikar Chamala, Michael J. Haller, Desmond A. Schatz, Todd M. Brusko, Mark A. Atkinson, Clive H. Wasserfall

Diabetes 2021;70(4):932–943

https://doi.org/10.2337/db20-0937

Published: 08 January 2021

View article titled, Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis

Journal Articles

Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis

Melanie R. Shapiro, Clive H. Wasserfall, Sean M. McGrail, Amanda L. Posgai, Rhonda Bacher, Andrew Muir, Michael J. Haller, Desmond A. Schatz, Johnna D. Wesley, Matthias von Herrath, William A. Hagopian, Cate Speake, Mark A. Atkinson, Todd M. Brusko

Diabetes 2020;69(3):413–423

https://doi.org/10.2337/db19-0942

Published: 11 December 2020

View article titled, Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis

Includes: Supplementary data

Meeting Abstracts

1663-P: Gene Editing of the Human T-Cell Receptor Locus Enables Optimized In Vitro Testing of Autoreactive T-Cell Function in Type 1 Diabetes

LEEANA D. PETERS, AMANDA L. POSGAI, TODD M. BRUSKO

Diabetes 2020;69(Supplement_1):1663-P

https://doi.org/10.2337/db20-1663-P

Published: 01 June 2020

View article titled, 1663-P: Gene Editing of the Human T-Cell Receptor Locus Enables Optimized In Vitro Testing of Autoreactive T-Cell Function in Type 1 Diabetes

Meeting Abstracts

253-OR: Circulating Neutrophil Numbers Increase with Age, but Are Not a Biomarker of T1D Risk

ANDREA LIN, DANIEL J. PERRY, DESMOND SCHATZ, TODD M. BRUSKO, MARK A. ATKINSON, MICHAEL J. HALLER, CLAYTON E. MATHEWS

Diabetes 2020;69(Supplement_1):253-OR

https://doi.org/10.2337/db20-253-OR

Published: 01 June 2020

View article titled, 253-OR: Circulating Neutrophil Numbers Increase with Age, but Are Not a Biomarker of T1D Risk

Journal Articles

Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances

Simi Ahmed, Karen Cerosaletti, Eddie James, S. Alice Long, Stuart Mannering, Cate Speake, Maki Nakayama, Timothy Tree, Bart O. Roep, Kevan C. Herold, Todd M. Brusko

Diabetes 2019;68(7):1366–1379

https://doi.org/10.2337/db19-0119

Published: 13 June 2019

View article titled, Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances

Includes: Supplementary data

Meeting Abstracts

164-OR: Efficacy of New-Onset Type 1 Diabetes (T1D) Intervention Trials: Variation in 1-Year Outcomes

MICHAEL J. HALLER, MADISON N. GRECO, DESMOND SCHATZ, MARK A. ATKINSON, TODD M. BRUSKO, CLAYTON E. MATHEWS, LAURA M. JACOBSEN, KEVAN C. HEROLD, STEPHEN E. GITELMAN, JEFFREY KRISCHER, BRIAN N. BUNDY

Diabetes 2019;68(Supplement_1):164-OR

https://doi.org/10.2337/db19-164-OR

Published: 01 June 2019

View article titled, 164-OR: Efficacy of New-Onset Type 1 Diabetes (T1D) Intervention Trials: Variation in 1-Year Outcomes

Meeting Abstracts

SH2B3 (lnk) Regulates Type 1 Diabetes Immune Phenotypes

ANA CAMARGO, DANIEL J. PERRY, TODD M. BRUSKO, MARK A. WALLET

Diabetes 2018;67(Supplement_1):224-LB

https://doi.org/10.2337/db18-224-LB

Published: 01 July 2018

View article titled, SH2B3 (lnk) Regulates Type 1 Diabetes Immune Phenotypes

Meeting Abstracts

Insulin-Like Growth-Factor Axis Collectively Identifies Pre–Type 1 Diabetes

MELANIE SHAPIRO, CLIVE WASSERFALL, ANDREW R. SCHULTZ, SEAN M. MCGRAIL, MICHAEL J. HALLER, DESMOND SCHATZ, MARK A. ATKINSON, TODD M. BRUSKO

Diabetes 2018;67(Supplement_1):1967-P

https://doi.org/10.2337/db18-1967-P

Published: 01 July 2018

View article titled, Insulin-Like Growth-Factor Axis Collectively Identifies Pre–Type 1 Diabetes

Meeting Abstracts

Exocrine Pancreatic Function as a Novel Biomarker in Pre-T1D

JAMES J. ROSS, CLIVE WASSERFALL, DANIEL J. PERRY, KIERAN M. MCGRAIL, AMANDA L. POSGAI, TODD M. BRUSKO, DESMOND SCHATZ, MICHAEL J. HALLER, MARK A. ATKINSON

Diabetes 2018;67(Supplement_1):1543-P

https://doi.org/10.2337/db18-1543-P

Published: 01 July 2018

View article titled, Exocrine Pancreatic Function as a Novel Biomarker in Pre-T1D

Meeting Abstracts

Costimulatory Molecules CD226 and TIGIT Impact CD8+ T-Cell Activity and Function during Type 1 Diabetes

WEN-I YEH, HOWARD SEAY, CLAYTON E. MATHEWS, TODD M. BRUSKO

Diabetes 2018;67(Supplement_1):96-OR

https://doi.org/10.2337/db18-96-OR

Published: 01 July 2018

View article titled, Costimulatory Molecules CD226 and TIGIT Impact CD8+ T-Cell Activity and Function during Type 1 Diabetes

NARROW

155-OR: Genetic Variation and Time to Progression in TN10 (Teplizumab)

1441-P: Low Morning Cortisol in Early Life Associated with Increased Risk of Islet Autoimmunity

1318-P: Postprandial C-Peptide (pCP) in Provider-Diagnosed Pediatric Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D)

1997-LB: Curation of an AI-Ready Dataset Using Domain-Informed Features Derived from Type 1 Diabetes TrialNet Studies

Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability

1298-P: Independent Associations of GAD65, IA2, and ZnT8 Autoantibody (Ab) Positivity with C-Peptide (CPep) in a Diverse Cohort of Youth with Diabetes (DM)

189-OR: Immune-Profiling of Pancreatic Tissue Affected by Immune Checkpoint Inhibitor–Induced Diabetes (CPI-D)

192-LB: Human CD4+CD25+CD226- Regulatory T Cells Demonstrate High Purity and Lineage Stability following In Vitro Expansion for Adoptive Cell Therapy

Low-Dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report

Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size

Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis

Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis

1663-P: Gene Editing of the Human T-Cell Receptor Locus Enables Optimized In Vitro Testing of Autoreactive T-Cell Function in Type 1 Diabetes

253-OR: Circulating Neutrophil Numbers Increase with Age, but Are Not a Biomarker of T1D Risk

Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances

164-OR: Efficacy of New-Onset Type 1 Diabetes (T1D) Intervention Trials: Variation in 1-Year Outcomes

SH2B3 (lnk) Regulates Type 1 Diabetes Immune Phenotypes

Insulin-Like Growth-Factor Axis Collectively Identifies Pre–Type 1 Diabetes

Exocrine Pancreatic Function as a Novel Biomarker in Pre-T1D

Costimulatory Molecules CD226 and TIGIT Impact CD8+ T-Cell Activity and Function during Type 1 Diabetes

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