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Meeting Abstracts

1489-P: GAD65_247-266 Is a Major Th1 Epitope in Japanese Patients with Acute-Onset Type 1 Diabetes

DAISUKE CHUJO, KUMIKO AJIMA, MAYA MATSUSHITA, CHIHARU TSUTSUMI, FUMITAKA HASEDA, AKIHISA IMAGAWA, TOSHIAKI HANAFUSA, HIROSHI KAJIO, MASAYUKI SHIMODA, KAZUYUKI TOBE

Diabetes 2024;73(Supplement_1):1489-P

https://doi.org/10.2337/db24-1489-P

Published: 14 June 2024

View articletitled, 1489-P: GAD65247-266 Is a Major Th1 Epitope in Japanese Patients with Acute-Onset Type 1 Diabetes

Journal Articles

Genome-Wide Association Study Confirming a Strong Effect of HLA and Identifying Variants in CSAD/lnc-ITGB7-1 on Chromosome 12q13.13 Associated With Susceptibility to Fulminant Type 1 Diabetes

Yumiko Kawabata, Nao Nishida, Takuya Awata, Eiji Kawasaki, Akihisa Imagawa, Akira Shimada, Haruhiko Osawa, Shoichiro Tanaka, Kazuma Takahashi, Masao Nagata, Hisafumi Yasuda, Yasuko Uchigata, Hiroshi Kajio, Hideichi Makino, Kazuki Yasuda, Tetsuro Kobayashi, Toshiaki Hanafusa, Katsushi Tokunaga, Hiroshi Ikegami

Diabetes 2019;68(3):665–675

https://doi.org/10.2337/db18-0314

Published: 14 December 2018

View articletitled, Genome-Wide Association Study Confirming a Strong Effect of HLA and Identifying Variants in CSAD/lnc-ITGB7-1 on Chromosome 12q13.13 Associated With Susceptibility to Fulminant Type 1 Diabetes

Includes: Supplementary data

Meeting Abstracts

Distinct Phenotypes of Islet Antigen-Specific CD4⁺ T Cells among the Three Subtypes of Type 1 Diabetes

DAISUKE CHUJO, AKITSU KAWABE, NOBUYUKI TAKAHASHI, MAYA MATSUSHITA, CHIHARU TSUTSUMI, FUMITAKA HASEDA, AKIHISA IMAGAWA, TOSHIAKI HANAFUSA, KUNIMASA YAGI, MASAYUKI SHIMODA, KOHJIRO UEKI, HIROSHI KAJIO

Diabetes 2018;67(Supplement_1):100-OR

https://doi.org/10.2337/db18-100-OR

Published: 01 July 2018

View articletitled, Distinct Phenotypes of Islet Antigen-Specific CD4+ T Cells among the Three Subtypes of Type 1 Diabetes

Journal Articles

Hepatocyte Nuclear Factor-1α Modulates Pancreatic β-Cell Growth by Regulating the Expression of Insulin-Like Growth Factor-1 in INS-1 Cells

Qin Yang, Kazuya Yamagata, Kenji Fukui, Yang Cao, Takao Nammo, Hiromi Iwahashi, Haiyan Wang, Itaru Matsumura, Toshiaki Hanafusa, Richard Bucala, Claes B. Wollheim, Jun-ichiro Miyagawa, Yuji Matsuzawa

Diabetes 2002;51(6):1785–1792

https://doi.org/10.2337/diabetes.51.6.1785

Published: 01 June 2002

View articletitled, Hepatocyte Nuclear Factor-1α Modulates Pancreatic β-Cell Growth by Regulating the Expression of Insulin-Like Growth Factor-1 in INS-1 Cells

Journal Articles

Thyroid Hormone Receptor Interacting Protein 3 (Trip3) Is a Novel Coactivator of Hepatocyte Nuclear Factor-4α

Hiromi Iwahashi, Kazuya Yamagata, Issei Yoshiuchi, Jungo Terasaki, Qin Yang, Kenji Fukui, Arisa Ihara, Qian Zhu, Takeshi Asakura, Yang Cao, Akihisa Imagawa, Mitsuyoshi Namba, Toshiaki Hanafusa, Jun-ichiro Miyagawa, Yuji Matsuzawa

Diabetes 2002;51(4):910–914

https://doi.org/10.2337/diabetes.51.4.910

Published: 01 April 2002

View articletitled, Thyroid Hormone Receptor Interacting Protein 3 (Trip3) Is a Novel Coactivator of Hepatocyte Nuclear Factor-4α

Journal Articles

Overexpression of Dominant-Negative Mutant Hepatocyte Nuclear Factor-1α in Pancreatic β-Cells Causes Abnormal Islet Architecture With Decreased Expression of E-Cadherin, Reduced β-cell Proliferation, and Diabetes

Kazuya Yamagata, Takao Nammo, Makoto Moriwaki, Arisa Ihara, Katsumi Iizuka, Qin Yang, Tomomi Satoh, Ming Li, Rikako Uenaka, Kohei Okita, Hiromi Iwahashi, Qian Zhu, Yang Cao, Akihisa Imagawa, Yoshihiro Tochino, Toshiaki Hanafusa, Jun-ichiro Miyagawa, Yuji Matsuzawa

Diabetes 2002;51(1):114–123

https://doi.org/10.2337/diabetes.51.1.114

Published: 01 January 2002

View articletitled, Overexpression of Dominant-Negative Mutant Hepatocyte Nuclear Factor-1α in Pancreatic β-Cells Causes Abnormal Islet Architecture With Decreased Expression of E-Cadherin, Reduced β-cell Proliferation, and Diabetes

Journal Articles

Pancreatic Biopsy as a Procedure for Detecting In Situ Autoimmune Phenomena in Type 1 Diabetes: Close Correlation Between Serological Markers and Histological Evidence of Cellular Autoimmunity

Akihisa Imagawa, Toshiaki Hanafusa, Shinji Tamura, Makoto Moriwaki, Naoto Itoh, Koji Yamamoto, Hiromi Iwahashi, Kazuya Yamagata, Masako Waguri, Takao Nanmo, Sae Uno, Hiromu Nakajima, Mitsuyoshi Namba, Sumio Kawata, Jun-ichiro Miyagawa, Yuji Matsuzawa

Diabetes 2001;50(6):1269–1273

https://doi.org/10.2337/diabetes.50.6.1269

Published: 01 June 2001

View articletitled, Pancreatic Biopsy as a Procedure for Detecting In Situ Autoimmune Phenomena in Type 1 Diabetes: Close Correlation Between Serological Markers and Histological Evidence of Cellular Autoimmunity

Journal Articles

The Pro¹²→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General Population: Possible Involvement in Impairment of Insulin Secretion in Individuals With Type 2 Diabetes

Diabetes 2001;50(4):891–894

https://doi.org/10.2337/diabetes.50.4.891

Published: 01 April 2001

View articletitled, The Pro12→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General Population: Possible Involvement in Impairment of Insulin Secretion in Individuals With Type 2 Diabetes

Journal Articles

Mutation P291fsinsC in the Transcription Factor Hepatocyte Nuclear Factor-1α is Dominant Negative

Kazuya Yamagata, Qin Yang, Koji Yamamoto, Hiromi Iwahashi, Jun-ichiro Miyagawa, Kohei Okita, Issei Yoshiuchi, Jun-ichi Miyazaki, Tamio Noguchi, Hiromu Nakajima, Mitsuyoshi Namba, Toshiaki Hanafusa, Yuji Matsuzawa

Diabetes 1998;47(8):1231–1235

https://doi.org/10.2337/diab.47.8.1231

Published: 01 August 1998

View articletitled, Mutation P291fsinsC in the Transcription Factor Hepatocyte Nuclear Factor-1α is Dominant Negative

Journal Articles

Demonstration of Two Different Processes of β-Cell Regeneration in a New Diabetic Mouse Model Induced by Selective Perfusion of Alloxan

Masako Waguri, Koji Yamamoto, Jun-ichiro Miyagawa, Yoshihiro Tochino, Katsumi Yamamori, Yoshitaka Kajimoto, Hiromu Nakajima, Hirotaka Watada, Issei Yoshiuchi, Naoto Itoh, Akihisa Imagawa, Mitsuyoshi Namba, Masamichi Kuwajima, Yoshimitsu Yamasaki, Toshiaki Hanafusa, Yuji Matsuzawa

Diabetes 1997;46(8):1281–1290

https://doi.org/10.2337/diab.46.8.1281

Published: 01 August 1997

View articletitled, Demonstration of Two Different Processes of β-Cell Regeneration in a New Diabetic Mouse Model Induced by Selective Perfusion of Alloxan

Journal Articles

PDX-1 Induces Insulin and Glucokinase Gene Expressions in αTC1 Clone 6 Cells in the Presence of Betacellulin

Hirotaka Watada, Yoshitaka Kajimoto, Jun-ichiro Miyagawa, Toshiaki Hanafusa, Kazuyuki Hamaguchi, Taka-aki Matsuoka, Koji Yamamoto, Yuji Matsuzawa, Ryuzo Kawamori, Yoshimitsu Yamasaki

Diabetes 1996;45(12):1826–1831

https://doi.org/10.2337/diab.45.12.1826

Published: 01 December 1996

View articletitled, PDX-1 Induces Insulin and Glucokinase Gene Expressions in αTC1 Clone 6 Cells in the Presence of Betacellulin

Journal Articles

Induction of Insulitis by Adoptive Transfer With L3T4⁺ Lyt2⁻ T-Lymphocytes in T-Lymphocyte–Depleted NOD Mice

Toshiaki Hanafusa, Shigetaka Sugihara, Hiroko Fujino-Kurihara, Jun-Ichiro Miyagawa, Atsushi Miyazaki, Takayuki Yoshioka, Kentaro Yamada, Hiromu Nakajima, Hideki Asakawa, Norio Kono, Hiromi Fujiwara, Toshiyuki Hamaoka, Seiichiro Tarui

Diabetes 1988;37(2):204–208

https://doi.org/10.2337/diab.37.2.204

Published: 01 February 1988

View articletitled, Induction of Insulitis by Adoptive Transfer With L3T4+ Lyt2− T-Lymphocytes in T-Lymphocyte–Depleted NOD Mice

Journal Articles

Preventive and Therapeutic Effects of Large-Dose Nicotinamide Injections on Diabetes Associated with Insulitis: An Observation in Nonobese Diabetic (NOD) Mice

Kentaro Yamada, Kyohei Nonaka, Toshiaki Hanafusa, Atsushi Miyazaki, Hiroyuki Toyoshima, Seiichiro Tarui

Diabetes 1982;31(9):749–753

https://doi.org/10.2337/diab.31.9.749

Published: 01 September 1982

View articletitled, Preventive and Therapeutic Effects of Large-Dose Nicotinamide Injections on Diabetes Associated with Insulitis: An Observation in Nonobese Diabetic (NOD) Mice

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1489-P: GAD65_247-266 Is a Major Th1 Epitope in Japanese Patients with Acute-Onset Type 1 Diabetes

Genome-Wide Association Study Confirming a Strong Effect of HLA and Identifying Variants in CSAD/lnc-ITGB7-1 on Chromosome 12q13.13 Associated With Susceptibility to Fulminant Type 1 Diabetes

Distinct Phenotypes of Islet Antigen-Specific CD4⁺ T Cells among the Three Subtypes of Type 1 Diabetes

Hepatocyte Nuclear Factor-1α Modulates Pancreatic β-Cell Growth by Regulating the Expression of Insulin-Like Growth Factor-1 in INS-1 Cells

Thyroid Hormone Receptor Interacting Protein 3 (Trip3) Is a Novel Coactivator of Hepatocyte Nuclear Factor-4α

Overexpression of Dominant-Negative Mutant Hepatocyte Nuclear Factor-1α in Pancreatic β-Cells Causes Abnormal Islet Architecture With Decreased Expression of E-Cadherin, Reduced β-cell Proliferation, and Diabetes

Pancreatic Biopsy as a Procedure for Detecting In Situ Autoimmune Phenomena in Type 1 Diabetes: Close Correlation Between Serological Markers and Histological Evidence of Cellular Autoimmunity

The Pro¹²→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General Population: Possible Involvement in Impairment of Insulin Secretion in Individuals With Type 2 Diabetes

Mutation P291fsinsC in the Transcription Factor Hepatocyte Nuclear Factor-1α is Dominant Negative

Demonstration of Two Different Processes of β-Cell Regeneration in a New Diabetic Mouse Model Induced by Selective Perfusion of Alloxan

PDX-1 Induces Insulin and Glucokinase Gene Expressions in αTC1 Clone 6 Cells in the Presence of Betacellulin

Induction of Insulitis by Adoptive Transfer With L3T4⁺ Lyt2⁻ T-Lymphocytes in T-Lymphocyte–Depleted NOD Mice

Preventive and Therapeutic Effects of Large-Dose Nicotinamide Injections on Diabetes Associated with Insulitis: An Observation in Nonobese Diabetic (NOD) Mice

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