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Meeting Abstracts

493-P: Synchrotron Radiation Micro-CT Reveals Glomerular Loss without Glomerular or Renal Hypertrophy in Streptozotocin-Induced Type 1 Diabetic Mice

YUMI TAKIYAMA, TOSHIHIRO SERA, MASANORI NAKAMURA, RYOICHI BESSHO, TAKAO TAKIYAMA, TSUGUHITO OTA, MASAKAZU HANEDA

Diabetes 2019;68(Supplement_1):493-P

https://doi.org/10.2337/db19-493-P

Published: 01 June 2019

View article titled, 493-P: Synchrotron Radiation Micro-CT Reveals Glomerular Loss without Glomerular or Renal Hypertrophy in Streptozotocin-Induced Type 1 Diabetic Mice

Meeting Abstracts

492-P: A Novel Renoprotective Target of SGLT2 Inhibitor: HIF-1α Inhibition and AMPK Activation in Renal Proximal Tubular Epithelial Cells

RYOICHI BESSHO, YUMI TAKIYAMA, TAKAO TAKIYAMA, TSUGUHITO OTA

Diabetes 2019;68(Supplement_1):492-P

https://doi.org/10.2337/db19-492-P

Published: 01 June 2019

View article titled, 492-P: A Novel Renoprotective Target of SGLT2 Inhibitor: HIF-1α Inhibition and AMPK Activation in Renal Proximal Tubular Epithelial Cells

Meeting Abstracts

1865-P: Dual Chemokine Receptor CCR2/CCR5 Antagonist Cenicriviroc Ameliorates Lipotoxicity-Induced Insulin Resistance and NASH in Mice

TSUGUHITO OTA, GUANLIANG CHEN, MAYUMI NAGASHIMADA

Diabetes 2019;68(Supplement_1):1865-P

https://doi.org/10.2337/db19-1865-P

Published: 01 June 2019

View article titled, 1865-P: Dual Chemokine Receptor CCR2/CCR5 Antagonist Cenicriviroc Ameliorates Lipotoxicity-Induced Insulin Resistance and NASH in Mice

Meeting Abstracts

1948-P: Secretion of the Short-Form Gastric Inhibitory Polypeptide in Nondiabetic and Diabetic Subjects

YASUTAKA TAKEDA, YUKIHIRO FUJITA, TSUYOSHI YANAGIMACHI, NOBUHIRO MARUYAMA, RYOICHI BESSHO, HIDEMITSU SAKAGAMI, MASAKAZU HANEDA, TSUGUHITO OTA

Diabetes 2019;68(Supplement_1):1948-P

https://doi.org/10.2337/db19-1948-P

Published: 01 June 2019

View article titled, 1948-P: Secretion of the Short-Form Gastric Inhibitory Polypeptide in Nondiabetic and Diabetic Subjects

Meeting Abstracts

A Porcine Placental Extract Alleviates Lipotoxicity-Induced NASH by Polarizing M2 Macrophages and Attenuating Stellate Cell Activation in Mice

GUANLIANG CHEN, LIANG XU, NAOTO NAGATA, MAYUMI NAGASHIMADA, TSUGUHITO OTA

Diabetes 2018;67(Supplement_1):1839-P

https://doi.org/10.2337/db18-1839-P

Published: 01 July 2018

View article titled, A Porcine Placental Extract Alleviates Lipotoxicity-Induced NASH by Polarizing M2 Macrophages and Attenuating Stellate Cell Activation in Mice

Meeting Abstracts

Lactobacillus Pentosus Strain S-PT84 Attenuates Insulin Resistance and Steatohepatitis by Maintaining Gut Permeability and Polarizing M2 Macrophages

YURIKO SAKAI, MAYUMI NAGASHIMADA, TSUGUHITO OTA

Diabetes 2018;67(Supplement_1):1852-P

https://doi.org/10.2337/db18-1852-P

Published: 01 July 2018

View article titled, Lactobacillus Pentosus Strain S-PT84 Attenuates Insulin Resistance and Steatohepatitis by Maintaining Gut Permeability and Polarizing M2 Macrophages

Meeting Abstracts

Luseogliflozin Inhibits HIF-1α Expression in Renal Proximal Tubular Epithelial Cells

RYOICHI BESSHO, YUMI TAKIYAMA, TSUGUHITO OTA

Diabetes 2018;67(Supplement_1):90-OR

https://doi.org/10.2337/db18-90-OR

Published: 01 July 2018

View article titled, Luseogliflozin Inhibits HIF-1α Expression in Renal Proximal Tubular Epithelial Cells

Meeting Abstracts

Loss of Fractalkine-CX3CR1 Signaling Exacerbates Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance through M1 Dominant Shift in Macrophages

MAYUMI NAGASHIMADA, YINHUA NI, TSUGUHITO OTA

Diabetes 2018;67(Supplement_1):1989-P

https://doi.org/10.2337/db18-1989-P

Published: 01 July 2018

View article titled, Loss of Fractalkine-CX3CR1 Signaling Exacerbates Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance through M1 Dominant Shift in Macrophages

Journal Articles

Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice

Naoto Nagata, Liang Xu, Susumu Kohno, Yusuke Ushida, Yudai Aoki, Ryohei Umeda, Nobuo Fuke, Fen Zhuge, Yinhua Ni, Mayumi Nagashimada, Chiaki Takahashi, Hiroyuki Suganuma, Shuichi Kaneko, Tsuguhito Ota

Diabetes 2017;66(5):1222–1236

https://doi.org/10.2337/db16-0662

Published: 16 February 2017

View article titled, Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice

Includes: Supplementary data

Journal Articles

DPP-4 Inhibition by Linagliptin Attenuates Obesity-Related Inflammation and Insulin Resistance by Regulating M1/M2 Macrophage Polarization

Fen Zhuge, Yinhua Ni, Mayumi Nagashimada, Naoto Nagata, Liang Xu, Naofumi Mukaida, Shuichi Kaneko, Tsuguhito Ota

Diabetes 2016;65(10):2966–2979

https://doi.org/10.2337/db16-0317

Published: 21 July 2016

View article titled, DPP-4 Inhibition by Linagliptin Attenuates Obesity-Related Inflammation and Insulin Resistance by Regulating M1/M2 Macrophage Polarization

Includes: Supplementary data

Journal Articles

LECT2 Functions as a Hepatokine That Links Obesity to Skeletal Muscle Insulin Resistance

Diabetes 2014;63(5):1649–1664

https://doi.org/10.2337/db13-0728

Published: 12 April 2014

View article titled, LECT2 Functions as a Hepatokine That Links Obesity to Skeletal Muscle Insulin Resistance

Includes: Supplementary data

Journal Articles

Histidine Augments the Suppression of Hepatic Glucose Production by Central Insulin Action

Kumi Kimura, Yusuke Nakamura, Yuka Inaba, Michihiro Matsumoto, Yoshiaki Kido, Shun-ichiro Asahara, Tomokazu Matsuda, Hiroshi Watanabe, Akifumi Maeda, Fuyuhiko Inagaki, Chisato Mukai, Kiyoshi Takeda, Shizuo Akira, Tsuguhito Ota, Hajime Nakabayashi, Shuichi Kaneko, Masato Kasuga, Hiroshi Inoue

Diabetes 2013;62(7):2266–2277

https://doi.org/10.2337/db12-1701

Published: 14 June 2013

View article titled, Histidine Augments the Suppression of Hepatic Glucose Production by Central Insulin Action

Includes: Supplementary data

Journal Articles

Proteasome Dysfunction Mediates Obesity-Induced Endoplasmic Reticulum Stress and Insulin Resistance in the Liver

Diabetes 2013;62(3):811–824

https://doi.org/10.2337/db11-1652

Published: 14 February 2013

View article titled, Proteasome Dysfunction Mediates Obesity-Induced Endoplasmic Reticulum Stress and Insulin Resistance in the Liver

Includes: Supplementary data

Journal Articles

CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status

Hironori Kitade, Kazuki Sawamoto, Mayumi Nagashimada, Hiroshi Inoue, Yasuhiko Yamamoto, Yoshimichi Sai, Toshinari Takamura, Hiroshi Yamamoto, Ken-ichi Miyamoto, Henry N. Ginsberg, Naofumi Mukaida, Shuichi Kaneko, Tsuguhito Ota

Diabetes 2012;61(7):1680–1690

https://doi.org/10.2337/db11-1506

Published: 15 June 2012

View article titled, CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status

Includes: Supplementary data

Journal Articles

Endoplasmic Reticulum Stress Inhibits STAT3-Dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation

Kumi Kimura, Tomoko Yamada, Michihiro Matsumoto, Yoshiaki Kido, Tetsuya Hosooka, Shun-ichiro Asahara, Tomokazu Matsuda, Tsuguhito Ota, Hiroshi Watanabe, Yoshimichi Sai, Kenichi Miyamoto, Shuichi Kaneko, Masato Kasuga, Hiroshi Inoue

Diabetes 2012;61(1):61–73

https://doi.org/10.2337/db10-1684

Published: 12 December 2011

View article titled, Endoplasmic Reticulum Stress Inhibits STAT3-Dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation

Includes: Supplementary data

NARROW

493-P: Synchrotron Radiation Micro-CT Reveals Glomerular Loss without Glomerular or Renal Hypertrophy in Streptozotocin-Induced Type 1 Diabetic Mice

492-P: A Novel Renoprotective Target of SGLT2 Inhibitor: HIF-1α Inhibition and AMPK Activation in Renal Proximal Tubular Epithelial Cells

1865-P: Dual Chemokine Receptor CCR2/CCR5 Antagonist Cenicriviroc Ameliorates Lipotoxicity-Induced Insulin Resistance and NASH in Mice

1948-P: Secretion of the Short-Form Gastric Inhibitory Polypeptide in Nondiabetic and Diabetic Subjects

A Porcine Placental Extract Alleviates Lipotoxicity-Induced NASH by Polarizing M2 Macrophages and Attenuating Stellate Cell Activation in Mice

Lactobacillus Pentosus Strain S-PT84 Attenuates Insulin Resistance and Steatohepatitis by Maintaining Gut Permeability and Polarizing M2 Macrophages

Luseogliflozin Inhibits HIF-1α Expression in Renal Proximal Tubular Epithelial Cells

Loss of Fractalkine-CX3CR1 Signaling Exacerbates Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance through M1 Dominant Shift in Macrophages

Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice

DPP-4 Inhibition by Linagliptin Attenuates Obesity-Related Inflammation and Insulin Resistance by Regulating M1/M2 Macrophage Polarization

LECT2 Functions as a Hepatokine That Links Obesity to Skeletal Muscle Insulin Resistance

Histidine Augments the Suppression of Hepatic Glucose Production by Central Insulin Action

Proteasome Dysfunction Mediates Obesity-Induced Endoplasmic Reticulum Stress and Insulin Resistance in the Liver

CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status

Endoplasmic Reticulum Stress Inhibits STAT3-Dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation

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