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Varman Samuel
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Meeting Abstracts

1577-P: CIDEB Knockdown Promotes Increased Hepatic Mitochondrial Fat Oxidation and Reverses Hepatic Steatosis and Hepatic Insulin Resistance by the PKCε-Insulin Receptor Kinase Pathway

JIE ZHENG, ALI NASIRI, RAFAEL C. GASPAR, BRANDON T. HUBBARD, IKKI SAKUMA, XIAOXIAN MA, SUE MURRAY, MARK PERELIS, WILLIAM BARNES, VARMAN SAMUEL, KITT PETERSEN, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1577-P
https://doi.org/10.2337/db24-1577-P
Published: 14 June 2024
View article titled, 1577-P: CIDEB Knockdown Promotes Increased Hepatic Mitochondrial Fat Oxidation and Reverses Hepatic Steatosis and Hepatic Insulin Resistance by the PKCε-Insulin Receptor Kinase Pathway
Meeting Abstracts

1571-P: CIDEB and CGI-58 Regulate Liver Lipid Droplet Size with Cholesterol Content, Linking to Inflammation and Fibrosis in Metabolic Dysfunction–Associated Steatohepatitis

IKKI SAKUMA, RAFAEL C. GASPAR, ALI NASIRI, MARIO KAHN, JIE ZHENG, MATEUS GUERRA, DEAN YIMLAMAI, SUE MURRAY, MARK PERELIS, WILLIAM BARNES, DANIEL F. VATNER, KITT PETERSEN, VARMAN SAMUEL, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1571-P
https://doi.org/10.2337/db24-1571-P
Published: 14 June 2024
View article titled, 1571-P: CIDEB and CGI-58 Regulate Liver Lipid Droplet Size with Cholesterol Content, Linking to Inflammation and Fibrosis in Metabolic Dysfunction–Associated Steatohepatitis
Meeting Abstracts

292-OR: Coenzyme A Synthase Knockdown Alleviates Metabolic Dysfunction–Associated Steatohepatitis via Decreasing Cholesterol in Liver Lipid Droplets

IKKI SAKUMA, RAFAEL C. GASPAR, ALI NASIRI, MARIO KAHN, MATEUS GUERRA, DEAN YIMLAMAI, SUE MURRAY, MARK PERELIS, WILLIAM BARNES, DANIEL F. VATNER, KITT PETERSEN, VARMAN SAMUEL, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2024;73(Supplement_1):292-OR
https://doi.org/10.2337/db24-292-OR
Published: 14 June 2024
View article titled, 292-OR: Coenzyme A Synthase Knockdown Alleviates Metabolic Dysfunction–Associated Steatohepatitis via Decreasing Cholesterol in Liver Lipid Droplets
Meeting Abstracts

1569-P: Lysophosphatidic Acid Mediates Inflammation in Liver and White Adipose Tissue in a Rat Model of 1-acyl-sn-glycerol-3-phosphate Acyltransferase 2 Deficiency

IKKI SAKUMA, RAFAEL C. GASPAR, PANU LUUKKONEN, MARIO KAHN, SUE MURRAY, VARMAN SAMUEL, KITT PETERSEN, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1569-P
https://doi.org/10.2337/db23-1569-P
Published: 20 June 2023
View article titled, 1569-P: Lysophosphatidic Acid Mediates Inflammation in Liver and White Adipose Tissue in a Rat Model of 1-acyl-sn-glycerol-3-phosphate Acyltransferase 2 Deficiency
Meeting Abstracts

205-OR: Hepatic Protein Kinase C-e Is Necessary and Sufficient in Mediating Lipid-Induced Hepatic Insulin Resistance

KUN LYU, DONGYAN ZHANG, MARIO KAHN, MARCOS R.S. RODRIGUES, SANDRO HIRABARA, PANU LUUKKONEN, SEOHYUK LEE, SANJAY BHANOT, JESSE RINEHART, NIELS BLUME, MORTEN RASCH, MIREILLE J. SERLIE, JONATHAN BOGAN, GARY CLINE, VARMAN SAMUEL, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):205-OR
https://doi.org/10.2337/db20-205-OR
Published: 01 June 2020
View article titled, 205-OR: Hepatic Protein Kinase C-e Is Necessary and Sufficient in Mediating Lipid-Induced Hepatic Insulin Resistance
Meeting Abstracts

266-OR: Plasma Membrane sn-1,2 Diacylglycerol Mediates Lipid-Induced Hepatic Insulin Resistance

KUN LYU, YE ZHANG, DONGYAN ZHANG, MARIO KAHN, YUICHI NOZAKI, SANJAY BHANOT, JONATHAN BOGAN, GARY CLINE, VARMAN SAMUEL, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):266-OR
https://doi.org/10.2337/db19-266-OR
Published: 01 June 2019
View article titled, 266-OR: Plasma Membrane sn-1,2 Diacylglycerol Mediates Lipid-Induced Hepatic Insulin Resistance
Meeting Abstracts

1782-P: Mechanism of Lipid-Induced White Adipose Tissue Insulin Resistance

YE ZHANG, DONGYAN ZHANG, KUN LYU, JOONGYU D. SONG, XIRUO LI, RACHEL J. PERRY, VARMAN SAMUEL, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1782-P
https://doi.org/10.2337/db19-1782-P
Published: 01 June 2019
View article titled, 1782-P: Mechanism of Lipid-Induced White Adipose Tissue Insulin Resistance
Meeting Abstracts

283-LB: Dissociating Insulin Signaling and SREBP1c Action from the Lipogenic Drive Seen in Human and Murine Hepatic Insulin Resistance

DANIEL F. VATNER, KASPER W. TER HORST, LEIGH GOEDEKE, DONGYAN ZHANG, VARMAN SAMUEL, MIREILLE J. SERLIE, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):283-LB
https://doi.org/10.2337/db19-283-LB
Published: 01 June 2019
View article titled, 283-LB: Dissociating Insulin Signaling and SREBP1c Action from the Lipogenic Drive Seen in Human and Murine Hepatic Insulin Resistance
Meeting Abstracts

Membrane sn-1,2 Diacylglycerol Mediates Lipid-Induced Hepatic Insulin Resistance In Vivo

KUN LYU, DONGYAN ZHANG, YUICHI NOZAKI, YE ZHANG, SANJAY BHANOT, GARY CLINE, VARMAN SAMUEL, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2018;67(Supplement_1):243-LB
https://doi.org/10.2337/db18-243-LB
Published: 01 July 2018
View article titled, Membrane sn-1,2 Diacylglycerol Mediates Lipid-Induced Hepatic Insulin Resistance In Vivo
Meeting Abstracts

Targeting Ketohexokinase (KHK) with a Novel Antisense Oligonucleotide (ASO) Decreases De Novo Lipogenesis and Improves Insulin-Mediated Whole Body Glucose Metabolism

DONGQING LIU, JOHN A. STERPKA, DANIEL F. VATNER, MELANIE BELL, SUE MURRAY, SANJAY BHANOT, GARY CLINE, VARMAN SAMUEL
Journal: Diabetes
Diabetes 2018;67(Supplement_1):149-OR
https://doi.org/10.2337/db18-149-OR
Published: 01 July 2018
View article titled, Targeting Ketohexokinase (KHK) with a Novel Antisense Oligonucleotide (ASO) Decreases De Novo Lipogenesis and Improves Insulin-Mediated Whole Body Glucose Metabolism
Meeting Abstracts

Evidence against Pathway-Selective Hepatic Insulin Resistance in Mice

DANIEL F. VATNER, MAX C. PETERSEN, XIRUO LI, JILLIAN C. ROGERS, GARY CLINE, VARMAN SAMUEL, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1766-P
https://doi.org/10.2337/db18-1766-P
Published: 01 July 2018
View article titled, Evidence against Pathway-Selective Hepatic Insulin Resistance in Mice
Journal Articles

Muscle-Specific IRS-1 Ser→Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle

Katsutaro Morino, Susanne Neschen, Stefan Bilz, Saki Sono, Dimitrios Tsirigotis, Richard M. Reznick, Irene Moore, Yoshio Nagai, Varman Samuel, David Sebastian, Morris White, William Philbrick, Gerald I. Shulman
Journal: Diabetes
Diabetes 2008;57(10):2644–2651
https://doi.org/10.2337/db06-0454
Published: 01 October 2008
View article titled, Muscle-Specific IRS-1 Ser→Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle
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