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Meeting Abstracts

196-OR: The Long-Chain Fatty-Acid Receptor FFA4 Stimulates Insulin Secretion via Inhibition of Somatostatin Release from the Delta Cell

LAURA REININGER, MÉLANIE ETHIER, CAROLINE TREMBLAY, JULIEN GHISLAIN, MARK HUISING, VINCENT POITOUT, MARCUS FLISHER

Diabetes 2023;72(Supplement_1):196-OR

https://doi.org/10.2337/db23-196-OR

Published: 20 June 2023

View article titled, 196-OR: The Long-Chain Fatty-Acid Receptor FFA4 Stimulates Insulin Secretion via Inhibition of Somatostatin Release from the Delta Cell

Journal Articles

Single-Cell RNA Sequencing Reveals a Role for Reactive Oxygen Species and Peroxiredoxins in Fatty Acid–Induced Rat β-Cell Proliferation

Alexis Vivoli, Julien Ghislain, Ali Filali-Mouhim, Zuraya Elisa Angeles, Anne-Laure Castell, Robert Sladek, Vincent Poitout

Diabetes 2023;72(1):45–58

https://doi.org/10.2337/db22-0121

Published: 03 October 2022

View article titled, Single-Cell RNA Sequencing Reveals a Role for Reactive Oxygen Species and Peroxiredoxins in Fatty Acid–Induced Rat β-Cell Proliferation

Journal Articles

Very-Long-Chain Unsaturated Sphingolipids Mediate Oleate-Induced Rat β-Cell Proliferation

Anne-Laure Castell, Alexis Vivoli, Trevor S. Tippetts, Isabelle Robillard Frayne, Zuraya Elisa Angeles, Valentine S. Moullé, Scott A. Campbell, Matthieu Ruiz, Julien Ghislain, Christine Des Rosiers, William L. Holland, Scott A. Summers, Vincent Poitout

Diabetes 2022;71(6):1218–1232

https://doi.org/10.2337/db21-0640

Published: 14 March 2022

View article titled, Very-Long-Chain Unsaturated Sphingolipids Mediate Oleate-Induced Rat β-Cell Proliferation

Journal Articles

The Tetracycline-Controlled Transactivator (Tet-On/Off) System in β-Cells Reduces Insulin Expression and Secretion in Mice

Nathalie Jouvet, Khalil Bouyakdan, Scott A. Campbell, Cindy Baldwin, Shannon E. Townsend, Maureen A. Gannon, Vincent Poitout, Thierry Alquier, Jennifer L. Estall

Diabetes 2021;70(12):2850–2859

https://doi.org/10.2337/db21-0147

Published: 05 October 2021

View article titled, The Tetracycline-Controlled Transactivator (Tet-On/Off) System in β-Cells Reduces Insulin Expression and Secretion in Mice

Meeting Abstracts

180-OR: Single-Cell RNA Sequencing Reveals a Role for ROS Signaling in Nutrient-Induced ß-Cell Proliferation

ALEXIS VIVOLI, JULIEN GHISLAIN, ANNE-LAURE CASTELL, ALI FILALI, ROBERT M. SLADEK, VINCENT POITOUT

Diabetes 2021;70(Supplement_1):180-OR

https://doi.org/10.2337/db21-180-OR

Published: 01 June 2021

View article titled, 180-OR: Single-Cell RNA Sequencing Reveals a Role for ROS Signaling in Nutrient-Induced ß-Cell Proliferation

Journal Articles

HB-EGF Signaling Is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats

Hasna Maachi, Grace Fergusson, Melanie Ethier, Gabriel N. Brill, Liora S. Katz, Lee B. Honig, Mallikarjuna R. Metukuri, Donald K. Scott, Julien Ghislain, Vincent Poitout

Diabetes 2020;69(3):369–380

https://doi.org/10.2337/db19-0643

Published: 27 December 2020

View article titled, HB-EGF Signaling Is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats

Includes: Supplementary data

Meeting Abstracts

2068-P: Beta-Cell Compensation to Pubertal Insulin Resistance Is Compromised in High-Fat Fed Rats and Impairs Glucose Homeostasis Later in Life

ANNE-LAURE CASTELL, GRACE FERGUSSON, MÉLANIE ETHIER, CAROLINE TREMBLAY, JULIEN GHISLAIN, VINCENT POITOUT

Diabetes 2020;69(Supplement_1):2068-P

https://doi.org/10.2337/db20-2068-P

Published: 01 June 2020

View article titled, 2068-P: Beta-Cell Compensation to Pubertal Insulin Resistance Is Compromised in High-Fat Fed Rats and Impairs Glucose Homeostasis Later in Life

Meeting Abstracts

2098-P: Transcriptomic Changes Associated with Oleate-Induced ß-Cell Proliferation in Rat Islets

ALEXIS VIVOLI, ANNE-LAURE CASTELL, ALAIN PACIS, ROBERT M. SLADEK, JULIEN GHISLAIN, VINCENT POITOUT

Diabetes 2020;69(Supplement_1):2098-P

https://doi.org/10.2337/db20-2098-P

Published: 01 June 2020

View article titled, 2098-P: Transcriptomic Changes Associated with Oleate-Induced ß-Cell Proliferation in Rat Islets

Meeting Abstracts

2196-P: HB-EGF Signaling Is Required for Glucose-Induced Pancreatic ß-Cell Proliferation in Rats

HASNA MAACHI, DONALD SCOTT, JULIEN GHISLAIN, VINCENT POITOUT

Diabetes 2019;68(Supplement_1):2196-P

https://doi.org/10.2337/db19-2196-P

Published: 01 June 2019

View article titled, 2196-P: HB-EGF Signaling Is Required for Glucose-Induced Pancreatic ß-Cell Proliferation in Rats

Meeting Abstracts

2177-P: Role of De Novo Sphingolipid Metabolites in Oleate-Induced Pancreatic ß-Cell Proliferation in Rats

ANNE-LAURE CASTELL, ALEXIS VIVOLI, VALENTINE S. MOULLÉ, JULIEN GHISLAIN, VINCENT POITOUT

Diabetes 2019;68(Supplement_1):2177-P

https://doi.org/10.2337/db19-2177-P

Published: 01 June 2019

View article titled, 2177-P: Role of De Novo Sphingolipid Metabolites in Oleate-Induced Pancreatic ß-Cell Proliferation in Rats

Meeting Abstracts

200-OR: Role of Delta Cell Gpr120 in the Regulation of Islet Function and Glucose Control

MARINE L. CROZE, SABRINA GRANZIERA, KEVIN VIVOT, ANAIS SZPIGEL, JULIEN GHISLAIN, VINCENT POITOUT

Diabetes 2019;68(Supplement_1):200-OR

https://doi.org/10.2337/db19-200-OR

Published: 01 June 2019

View article titled, 200-OR: Role of Delta Cell Gpr120 in the Regulation of Islet Function and Glucose Control

Meeting Abstracts

2159-P: Beta-Cell Compensation to Pubertal Insulin Resistance Is Compromised in High-Fat Fed Rats and Impairs Glucose Homeostasis Later in Life

ANNE-LAURE CASTELL, MÉLANIE ETHIER, GRACE FERGUSSON, JULIEN GHISLAIN, VINCENT POITOUT

Diabetes 2019;68(Supplement_1):2159-P

https://doi.org/10.2337/db19-2159-P

Published: 01 June 2019

View article titled, 2159-P: Beta-Cell Compensation to Pubertal Insulin Resistance Is Compromised in High-Fat Fed Rats and Impairs Glucose Homeostasis Later in Life

Journal Articles

A Call for Improved Reporting of Human Islet Characteristics in Research Articles

Vincent Poitout, Leslie S. Satin, Steven E. Kahn, Doris A. Stoffers, Piero Marchetti, Maureen Gannon, C. Bruce Verchere, Kevan C. Herold, Martin G. Myers, Jr., Sally M. Marshall

Diabetes 2019;68(2):239–240

https://doi.org/10.2337/dbi18-0055

Published: 14 December 2018

View article titled, A Call for Improved Reporting of Human Islet Characteristics in Research Articles

Journal Articles

Fatty Acids and Insulin Secretion: From FFAR and Near?

Vincent Poitout

Diabetes 2018;67(10):1932–1934

https://doi.org/10.2337/dbi18-0027

Published: 12 September 2018

View article titled, Fatty Acids and Insulin Secretion: From FFAR and Near?

Journal Articles

Deletion of Protein Kinase D1 in Pancreatic β-Cells Impairs Insulin Secretion in High-Fat Diet–Fed Mice

Valérie Bergeron, Julien Ghislain, Kevin Vivot, Natalia Tamarina, Louis H. Philipson, Jens Fielitz, Vincent Poitout

Diabetes 2018;67(1):71–77

https://doi.org/10.2337/db17-0982

Published: 16 October 2017

View article titled, Deletion of Protein Kinase D1 in Pancreatic β-Cells Impairs Insulin Secretion in High-Fat Diet–Fed Mice

Includes: Supplementary data

Journal Articles

The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice

Ghislaine Fontés, Julien Ghislain, Isma Benterki, Bader Zarrouki, Dominique Trudel, Yves Berthiaume, Vincent Poitout

Diabetes 2015;64(12):4112–4122

https://doi.org/10.2337/db14-0810

Published: 17 August 2015

View article titled, The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice

Includes: Supplementary data

Journal Articles

Phenotypic Characterization of MIP-CreERT^1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone

Diabetes 2015;64(11):3798–3807

https://doi.org/10.2337/db15-0272

Published: 07 July 2015

View article titled, Phenotypic Characterization of MIP-CreERT<sup>1Lphi</sup> Mice With Transgene-Driven Islet Expression of Human Growth Hormone

Includes: Supplementary data

Journal Articles

Epidermal Growth Factor Receptor Signaling Promotes Pancreatic β-Cell Proliferation in Response to Nutrient Excess in Rats Through mTOR and FOXM1

Bader Zarrouki, Isma Benterki, Ghislaine Fontés, Marie-Line Peyot, Ondrej Seda, Marc Prentki, Vincent Poitout

Diabetes 2014;63(3):982–993

https://doi.org/10.2337/db13-0425

Published: 13 February 2014

View article titled, Epidermal Growth Factor Receptor Signaling Promotes Pancreatic β-Cell Proliferation in Response to Nutrient Excess in Rats Through mTOR and FOXM1

Includes: Supplementary data

Journal Articles

Npas4 Is a Novel Activity–Regulated Cytoprotective Factor in Pancreatic β-Cells

Paul V. Sabatini, Nicole A.J. Krentz, Bader Zarrouki, Clara Y. Westwell-Roper, Cuilan Nian, Ryan A. Uy, A.M. James Shapiro, Vincent Poitout, Francis C. Lynn

Diabetes 2013;62(8):2808–2820

https://doi.org/10.2337/db12-1527

Published: 17 July 2013

View article titled, Npas4 Is a Novel Activity–Regulated Cytoprotective Factor in Pancreatic β-Cells

Includes: Supplementary data

Journal Articles

Pioglitazone Acutely Reduces Energy Metabolism and Insulin Secretion in Rats

Julien Lamontagne, Élise Jalbert-Arsenault, Émilie Pepin, Marie-Line Peyot, Neil B. Ruderman, Christopher J. Nolan, Erik Joly, S.R. Murthy Madiraju, Vincent Poitout, Marc Prentki

Diabetes 2013;62(6):2122–2129

https://doi.org/10.2337/db12-0428

Published: 20 May 2013

View article titled, Pioglitazone Acutely Reduces Energy Metabolism and Insulin Secretion in Rats

Includes: Supplementary data

NARROW

196-OR: The Long-Chain Fatty-Acid Receptor FFA4 Stimulates Insulin Secretion via Inhibition of Somatostatin Release from the Delta Cell

Single-Cell RNA Sequencing Reveals a Role for Reactive Oxygen Species and Peroxiredoxins in Fatty Acid–Induced Rat β-Cell Proliferation

Very-Long-Chain Unsaturated Sphingolipids Mediate Oleate-Induced Rat β-Cell Proliferation

The Tetracycline-Controlled Transactivator (Tet-On/Off) System in β-Cells Reduces Insulin Expression and Secretion in Mice

180-OR: Single-Cell RNA Sequencing Reveals a Role for ROS Signaling in Nutrient-Induced ß-Cell Proliferation

HB-EGF Signaling Is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats

2068-P: Beta-Cell Compensation to Pubertal Insulin Resistance Is Compromised in High-Fat Fed Rats and Impairs Glucose Homeostasis Later in Life

2098-P: Transcriptomic Changes Associated with Oleate-Induced ß-Cell Proliferation in Rat Islets

2196-P: HB-EGF Signaling Is Required for Glucose-Induced Pancreatic ß-Cell Proliferation in Rats

2177-P: Role of De Novo Sphingolipid Metabolites in Oleate-Induced Pancreatic ß-Cell Proliferation in Rats

200-OR: Role of Delta Cell Gpr120 in the Regulation of Islet Function and Glucose Control

2159-P: Beta-Cell Compensation to Pubertal Insulin Resistance Is Compromised in High-Fat Fed Rats and Impairs Glucose Homeostasis Later in Life

A Call for Improved Reporting of Human Islet Characteristics in Research Articles

Fatty Acids and Insulin Secretion: From FFAR and Near?

Deletion of Protein Kinase D1 in Pancreatic β-Cells Impairs Insulin Secretion in High-Fat Diet–Fed Mice

The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice

Phenotypic Characterization of MIP-CreERT^1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone

Epidermal Growth Factor Receptor Signaling Promotes Pancreatic β-Cell Proliferation in Response to Nutrient Excess in Rats Through mTOR and FOXM1

Npas4 Is a Novel Activity–Regulated Cytoprotective Factor in Pancreatic β-Cells

Pioglitazone Acutely Reduces Energy Metabolism and Insulin Secretion in Rats

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