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Journal Articles

Metabolic Stress Levels Influence the Ability of Myelin Transcription Factors to Regulate β-Cell Identity and Survival

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Xin Tong, Mahircan Yagan, Ruiying Hu, Simone Nevills, Teri D. Doss, Roland W. Stein, Appakalai N. Balamurugan, Guoqiang Gu
Journal: Diabetes
Diabetes 2024;73(10):1662–1672
https://doi.org/10.2337/db23-0528
Published: 26 July 2024
View articletitled, Metabolic Stress Levels Influence the Ability of Myelin Transcription Factors to Regulate β-Cell Identity and Survival
Open the PDF for Metabolic Stress Levels Influence the Ability of Myelin Transcription Factors to Regulate β-Cell Identity and Survival in another window
Meeting Abstracts

1742-P: Loss of MAFB Compromises a-Cell Identity and Glucagon Secretion in Adult Human Islets

Free
KATIE C. COATE, XIN TONG, JIN-HUA LIU, REGINA JENKINS, RADHIKA ARAMANDLA, NANDITA DEY, SEUNG KIM, MARCELA BRISSOVA, ALVIN C. POWERS, ROLAND STEIN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1742-P
https://doi.org/10.2337/db23-1742-P
Published: 20 June 2023
View articletitled, 1742-P: Loss of MAFB Compromises a-Cell Identity and Glucagon Secretion in Adult Human Islets
Journal Articles

High-Fat Diet–Induced DeSUMOylation of E4BP4 Promotes Lipid Droplet Biogenesis and Liver Steatosis in Mice

Free
Sujuan Wang, Meichan Yang, Pei Li, Julian Sit, Audrey Wong, Kyle Rodrigues, Daniel Lank, Deqiang Zhang, Kezhong Zhang, Lei Yin, Xin Tong
Journal: Diabetes
Diabetes 2023;72(3):348–361
https://doi.org/10.2337/db22-0332
Published: 12 December 2022
View articletitled, High-Fat Diet–Induced DeSUMOylation of E4BP4 Promotes Lipid Droplet Biogenesis and Liver Steatosis in Mice
Open the PDF for High-Fat Diet–Induced DeSUMOylation of E4BP4 Promotes Lipid Droplet Biogenesis and Liver Steatosis in Mice in another window
Meeting Abstracts

369-OR: Defining the Role of RIPK3 in Beta Cells and the Mechanism of Its Activation by ER Stress

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LIU YANG, BINGYUAN YANG, XIN TONG, CHUNHUA DAI, ZIHAN TANG, WENBIAO CHEN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):369-OR
https://doi.org/10.2337/db22-369-OR
Published: 01 June 2022
View articletitled, 369-OR: Defining the Role of RIPK3 in Beta Cells and the Mechanism of Its Activation by ER Stress
Journal Articles

Lipid Droplets Protect Human β-Cells From Lipotoxicity-Induced Stress and Cell Identity Changes

Free
Xin Tong, Roland Stein
Journal: Diabetes
Diabetes 2021;70(11):2595–2607
https://doi.org/10.2337/db21-0261
Published: 25 August 2021
View articletitled, Lipid Droplets Protect Human β-Cells From Lipotoxicity-Induced Stress and Cell Identity Changes
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Journal Articles

Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health

Free
Xin Tong, Chunhua Dai, John T. Walker, Gopika G. Nair, Arion Kennedy, Rotonya M. Carr, Matthias Hebrok, Alvin C. Powers, Roland Stein
Journal: Diabetes
Diabetes 2020;69(3):342–354
https://doi.org/10.2337/db19-0281
Published: 13 December 2020
View articletitled, Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health
Open the PDF for Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health in another window
Includes: Supplementary data
Meeting Abstracts

2116-P: MAFA S64F Missense Mutation Causes Islet Beta-Cell Aging and Senescence

Free
JEEYEON CHA, EMILY M. WALKER, XIN TONG, MIN GUO, JIN HUA LIU, SOPHIA YU, DONATO IACOVAZZO, FRANCK MAUVAIS-JARVIS, SARAH E. FLANAGAN, MARTA KORBONITS, JOHN M. STAFFORD, ROLAND STEIN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):2116-P
https://doi.org/10.2337/db20-2116-P
Published: 01 June 2020
View articletitled, 2116-P: MAFA S64F Missense Mutation Causes Islet Beta-Cell Aging and Senescence
Meeting Abstracts

48-OR: Pancreatic ß Cell SERCA2 Deficiency Leads to Impaired Proinsulin Processing and Reduced ER to Golgi Protein Trafficking

Free
TATSUYOSHI KONO, HITOSHI IIDA, TIMOTHY S. JARVELA, CHIH-CHUN LEE, XIN TONG, PETER ARVAN, IRIS LINDBERG, CARMELLA EVANS-MOLINA
Journal: Diabetes
Diabetes 2020;69(Supplement_1):48-OR
https://doi.org/10.2337/db20-48-OR
Published: 01 June 2020
View articletitled, 48-OR: Pancreatic ß Cell SERCA2 Deficiency Leads to Impaired Proinsulin Processing and Reduced ER to Golgi Protein Trafficking
Meeting Abstracts

341-LB: Chronic ER Calcium Depletion Resulting from Sarcoendoplasmic Reticulum Ca2+ Atpase 2b (SERCA2b) Deficiency Leads to Impaired Proinsulin Processing in the Pancreatic ß Cell

Free
HITOSHI IIDA, TATSUYOSHI KONO, XIN TONG, IRIS LINDBERG, CARMELLA EVANS-MOLINA
Journal: Diabetes
Diabetes 2019;68(Supplement_1):341-LB
https://doi.org/10.2337/db19-341-LB
Published: 01 June 2019
View articletitled, 341-LB: Chronic ER Calcium Depletion Resulting from Sarcoendoplasmic Reticulum Ca2+ Atpase 2b (SERCA2b) Deficiency Leads to Impaired Proinsulin Processing in the Pancreatic ß Cell
Journal Articles

Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β-Cell

Free
Tatsuyoshi Kono, Xin Tong, Solaema Taleb, Robert N. Bone, Hitoshi Iida, Chih-Chun Lee, Paul Sohn, Patrick Gilon, Michael W. Roe, Carmella Evans-Molina
Journal: Diabetes
Diabetes 2018;67(11):2293–2304
https://doi.org/10.2337/db17-1351
Published: 21 August 2018
View articletitled, Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β-Cell
Open the PDF for Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β-Cell in another window
Includes: Supplementary data
Journal Articles

Erratum. DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver. Diabetes 2017;66: 2571–2582

Free
Xin Tong, Deqiang Zhang, Nicholas Charney, Ethan Jin, Kyle VanDommelon, Kenneth Stamper, Neil Gupta, Johnny Saldate, Lei Yin
Journal: Diabetes
Diabetes 2017;66(12):3144
https://doi.org/10.2337/db17-er12e
Published: 09 October 2017
View articletitled, Erratum. DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver. Diabetes 2017;66: 2571–2582
Open the PDF for Erratum. DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver. Diabetes 2017;66: 2571–2582 in another window
Journal Articles

DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver

Free
Xin Tong, Deqiang Zhang, Nicholas Charney, Ethan Jin, Kyle VanDommelen, Kenneth Stamper, Neil Gupta, Johnny Saldate, Lei Yin
Journal: Diabetes
Diabetes 2017;66(10):2571–2582
https://doi.org/10.2337/db16-1600
Published: 08 August 2017
View articletitled, DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver
Open the PDF for DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver in another window
Includes: Supplementary data
Journal Articles

SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity

Free
Xin Tong, Tatsuyoshi Kono, Emily K. Anderson-Baucum, Wataru Yamamoto, Patrick Gilon, Djamel Lebeche, Richard N. Day, Gary E. Shull, Carmella Evans-Molina
Journal: Diabetes
Diabetes 2016;65(10):3039–3052
https://doi.org/10.2337/db16-0084
Published: 03 August 2016
View articletitled, SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity
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Includes: Supplementary data