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Meeting Abstracts

793-P: Biased GLP-1 Analog Ecnoglutide (XW003) Has Improved Efficacy Relative to Unbiased Peptides

GUO WANJUN, HAIXIA ZOU, ZHIYI ZHU, YAO LI, JING NING, QING ZHENG, YAN LI, RUI ZHU, CATHERINE L. JONES, MARTIJN FENAUX, SUSAN XU, MOHAMMED K. JUNAIDI
Journal: Diabetes
Diabetes 2024;73(Supplement_1):793-P
https://doi.org/10.2337/db24-793-P
Published: 14 June 2024
View article titled, 793-P: Biased GLP-1 Analog Ecnoglutide (XW003) Has Improved Efficacy Relative to Unbiased Peptides
Meeting Abstracts

789-P: Discovery of a Novel, Long-Acting Amylin Receptor Agonist for Body Weight Control

YAN LI, HAIXIA ZOU, XINLE WU, RUI ZHU, RUIPENG WANG, SUJUAN HAO, ZHAOYING LI, YAXU WANG, JIANHUI DENG, HONGYANG WANG, FEI PENG, CATHERINE L. JONES, MARTIJN FENAUX
Journal: Diabetes
Diabetes 2024;73(Supplement_1):789-P
https://doi.org/10.2337/db24-789-P
Published: 14 June 2024
View article titled, 789-P: Discovery of a Novel, Long-Acting Amylin Receptor Agonist for Body Weight Control
Meeting Abstracts

788-P: Synergistic Body Weight Reduction of GLP-1 Analog Ecnoglutide and Amylin Analogs in Preclinical Animal Models

HAIXIA ZOU, XINLE WU, YAN LI, RUI ZHU, RUIPENG WANG, SUJUAN HAO, ZHAOYING LI, YAXU WANG, JIANHUI DENG, CATHERINE L. JONES, MARTIJN FENAUX
Journal: Diabetes
Diabetes 2024;73(Supplement_1):788-P
https://doi.org/10.2337/db24-788-P
Published: 14 June 2024
View article titled, 788-P: Synergistic Body Weight Reduction of GLP-1 Analog Ecnoglutide and Amylin Analogs in Preclinical Animal Models
Meeting Abstracts

1769-P: Single-Nucleus Multiomics Reveals Unique Molecular Signatures of ß-Cell Heterogeneity and Compensation in Human Obesity

HYUNKI KIM, YAN LI, HOUXIANG ZHU, ZIYOU REN, KHADIJA EL JELLAS, NAMRATA SHUKLA, MENGJIE CHEN, ROHIT KULKARNI
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1769-P
https://doi.org/10.2337/db23-1769-P
Published: 20 June 2023
View article titled, 1769-P: Single-Nucleus Multiomics Reveals Unique Molecular Signatures of ß-Cell Heterogeneity and Compensation in Human Obesity
Meeting Abstracts

872-P: Cardiovascular Benefits of Novel Diabetes Drugs by Baseline Cardiovascular Risk: A Meta-Regression Analysis of 17 Randomized Trials

JOSE M. RODRIGUEZ-VALADEZ, MYRIAM HUNINK, UMESH MASHARANI, JOSEPH YEBOAH, MEYEON PARK, LIHUA LI, ELLERIE WEBER, YAN LI, ASEM BERKALIEVA, WENDY MAX, KIRSTEN FLEISCHMANN, BART FERKET
Journal: Diabetes
Diabetes 2022;71(Supplement_1):872-P
https://doi.org/10.2337/db22-872-P
Published: 01 June 2022
View article titled, 872-P: Cardiovascular Benefits of Novel Diabetes Drugs by Baseline Cardiovascular Risk: A Meta-Regression Analysis of 17 Randomized Trials
Meeting Abstracts

871-P: Weight Change as Mediator for Cardiovascular Benefits of Novel Diabetes Medications: A Meta-Regression Analysis

JOSE M. RODRIGUEZ-VALADEZ, MYRIAM HUNINK, UMESH MASHARANI, JOSEPH YEBOAH, MEYEON PARK, LIHUA LI, ELLERIE WEBER, YAN LI, ASEM BERKALIEVA, WENDY MAX, KIRSTEN FLEISCHMANN, BART FERKET
Journal: Diabetes
Diabetes 2022;71(Supplement_1):871-P
https://doi.org/10.2337/db22-871-P
Published: 01 June 2022
View article titled, 871-P: Weight Change as Mediator for Cardiovascular Benefits of Novel Diabetes Medications: A Meta-Regression Analysis
Journal Articles

Hepatic p38 Activation Modulates Systemic Metabolism Through FGF21-Mediated Interorgan Communication

Wei Liu, Chao Sun, Ying Yan, Hongchao Cao, Zhoumin Niu, Siyi Shen, Shengnan Liu, Yuting Wu, Yan Li, Lijian Hui, Yuying Li, Lin Zhao, Cheng Hu, Qiurong Ding, Jingjing Jiang, Hao Ying
Journal: Diabetes
Diabetes 2022;71(1):60–72
https://doi.org/10.2337/db21-0240
Published: 21 October 2021
View article titled, Hepatic p38 Activation Modulates Systemic Metabolism Through FGF21-Mediated Interorgan Communication
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Journal Articles

Podocyte EGFR Inhibits Autophagy Through Upregulation of Rubicon in Type 2 Diabetic Nephropathy

Yan Li, Yu Pan, Shirong Cao, Kensuke Sasaki, Yinqiu Wang, Aolei Niu, Xiaofeng Fan, Suwan Wang, Ming-Zhi Zhang, Raymond C. Harris
Journal: Diabetes
Diabetes 2021;70(2):562–576
https://doi.org/10.2337/db20-0660
Published: 25 November 2020
View article titled, Podocyte EGFR Inhibits Autophagy Through Upregulation of Rubicon in Type 2 Diabetic Nephropathy
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Journal Articles

Erratum. Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts. Diabetes 2018;67:

Junlian Gu, Xiaoqing Yan, Xiaozhen Dai, Yuehui Wang, Qian Lin, Jian Xiao, Shanshan Zhou, Jian Zhang, Kai Wang, Jun Zeng, Ying Xin, Michelle T. Barati, Chi Zhang, Yang Bai, Yan Li, Paul N. Epstein, Kupper A. Wintergerst, Xiaokun Li, Yi Tan, Lu Cai
Journal: Diabetes
Diabetes 2020;69(2):267
https://doi.org/10.2337/db20-er02a
Published: 16 December 2019
View article titled, Erratum. Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts. Diabetes 2018;67:
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Meeting Abstracts

Comparing Diabetes Screening Strategies in China—An Agent-Based Modeling Approach

XIAOLEI XIE, BOWEN PANG, YAN LI
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1283-P
https://doi.org/10.2337/db18-1283-P
Published: 01 July 2018
View article titled, Comparing Diabetes Screening Strategies in China—An Agent-Based Modeling Approach
Meeting Abstracts

Metformin Ameliorates Renal Fibrosis in Mice with Unilateral Ureteral Obstruction and Inhibits TGF-ß1-Induced Upregulation of Cadherin-6 in Renal Proximal Tubule Epithelial Cells

DIEFEI LIANG, SHANYING LIU, ZIJIAO SONG, WEIWEN LIANG, RUIMING CHANG, YAN LI
Journal: Diabetes
Diabetes 2018;67(Supplement_1):2199-PUB
https://doi.org/10.2337/db18-2199-PUB
Published: 01 July 2018
View article titled, Metformin Ameliorates Renal Fibrosis in Mice with Unilateral Ureteral Obstruction and Inhibits TGF-ß1-Induced Upregulation of Cadherin-6 in Renal Proximal Tubule Epithelial Cells
Journal Articles

Inhibition of Epidermal Growth Factor Receptor Activation Is Associated With Improved Diabetic Nephropathy and Insulin Resistance in Type 2 Diabetes

Zhilian Li, Yan Li, Jessica M. Overstreet, Sungjin Chung, Aolei Niu, Xiaofeng Fan, Suwan Wang, Yinqiu Wang, Ming-Zhi Zhang, Raymond C. Harris
Journal: Diabetes
Diabetes 2018;67(9):1847–1857
https://doi.org/10.2337/db17-1513
Published: 29 June 2018
View article titled, Inhibition of Epidermal Growth Factor Receptor Activation Is Associated With Improved Diabetic Nephropathy and Insulin Resistance in Type 2 Diabetes
Open the PDF for Inhibition of Epidermal Growth Factor Receptor Activation Is Associated With Improved Diabetic Nephropathy and Insulin Resistance in Type 2 Diabetes in another window
Includes: Supplementary data
Journal Articles

Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts

Junlian Gu, Xiaoqing Yan, Xiaozhen Dai, Yuehui Wang, Qian Lin, Jian Xiao, Shanshan Zhou, Jian Zhang, Kai Wang, Jun Zeng, Ying Xin, Michelle T. Barati, Chi Zhang, Yang Bai, Yan Li, Paul N. Epstein, Kupper A. Wintergerst, Xiaokun Li, Yi Tan, Lu Cai
Journal: Diabetes
Diabetes 2018;67(3):507–517
https://doi.org/10.2337/db17-0219
Published: 27 October 2017
View article titled, Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts
Open the PDF for Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts in another window
Includes: Supplementary data
Journal Articles

Cationic Polystyrene Resolves Nonalcoholic Steatohepatitis, Obesity, and Metabolic Disorders by Promoting Eubiosis of Gut Microbiota and Decreasing Endotoxemia

Airu Zhu, Jingjing Chen, Pengfei Wu, Mei Luo, Yilan Zeng, Yong Liu, Han Zheng, Li Zhang, Zishou Chen, Qun Sun, Wenwen Li, Yixiang Duan, Danmei Su, Zhixiong Xiao, Zhongping Duan, Sujun Zheng, Li Bai, Xiaohui Zhang, Zhongyuan Ju, Yan Li, Richard Hu, Stephen J. Pandol, Yuan-Ping Han
Journal: Diabetes
Diabetes 2017;66(8):2137–2143
https://doi.org/10.2337/db17-0070
Published: 26 April 2017
View article titled, Cationic Polystyrene Resolves Nonalcoholic Steatohepatitis, Obesity, and Metabolic Disorders by Promoting Eubiosis of Gut Microbiota and Decreasing Endotoxemia
Open the PDF for Cationic Polystyrene Resolves Nonalcoholic Steatohepatitis, Obesity, and Metabolic Disorders by Promoting Eubiosis of Gut Microbiota and Decreasing Endotoxemia in another window
Includes: Supplementary data
Journal Articles

Glucocorticoids Transcriptionally Regulate miR-27b Expression Promoting Body Fat Accumulation Via Suppressing the Browning of White Adipose Tissue

Xiaocen Kong, Jing Yu, Jianhua Bi, Hanmei Qi, Wenjuan Di, Lin Wu, Long Wang, Juanmin Zha, Shan Lv, Feng Zhang, Yan Li, Fang Hu, Feng Liu, Hong Zhou, Juan Liu, Guoxian Ding
Journal: Diabetes
Diabetes 2015;64(2):393–404
https://doi.org/10.2337/db14-0395
Published: 02 September 2014
View article titled, Glucocorticoids Transcriptionally Regulate miR-27b Expression Promoting Body Fat Accumulation Via Suppressing the Browning of White Adipose Tissue
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Includes: Supplementary data
Journal Articles

Proinflammatory Effects of Advanced Lipoxidation End Products in Monocytes

Narkunarajaa Shanmugam, James L. Figarola, Yan Li, Piotr M. Swiderski, Samual Rahbar, Rama Natarajan
Journal: Diabetes
Diabetes 2008;57(4):879–888
https://doi.org/10.2337/db07-1204
Published: 01 April 2008
View article titled, Proinflammatory Effects of Advanced Lipoxidation End Products in Monocytes
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Includes: Supplementary data
Journal Articles

Inhibition of Superoxide Generation and Associated Nitrosative Damage Is Involved in Metallothionein Prevention of Diabetic Cardiomyopathy

Lu Cai, Jianxun Wang, Yan Li, Xuihua Sun, Lipeng Wang, Zhanxiang Zhou, Y. James Kang
Journal: Diabetes
Diabetes 2005;54(6):1829–1837
https://doi.org/10.2337/diabetes.54.6.1829
Published: 01 June 2005
View article titled, Inhibition of Superoxide Generation and Associated Nitrosative Damage Is Involved in Metallothionein Prevention of Diabetic Cardiomyopathy
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Journal Articles

Difference in Ischemic Regulation of Vascular Endothelial Growth Factor and Pigment Epithelium--Derived Factor in Brown Norway and Sprague Dawley Rats Contributing to Different Susceptibilities to Retinal Neovascularization

Guoquan Gao, Yan Li, James Fant, Craig E. Crosson, S. Patricia Becerra, Jian-xing Ma
Journal: Diabetes
Diabetes 2002;51(4):1218–1225
https://doi.org/10.2337/diabetes.51.4.1218
Published: 01 April 2002
View article titled, Difference in Ischemic Regulation of Vascular Endothelial Growth Factor and Pigment Epithelium--Derived Factor in Brown Norway and Sprague Dawley Rats Contributing to Different Susceptibilities to Retinal Neovascularization
Open the PDF for Difference in Ischemic Regulation of Vascular Endothelial Growth Factor and Pigment Epithelium--Derived Factor in Brown Norway and Sprague Dawley Rats Contributing to Different Susceptibilities to Retinal Neovascularization in another window