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Yi-Guang Chen
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Meeting Abstracts

92-OR: Defining Type 1 Diabetes Endtypes

AMINA BEDRAT, TARUN PANT, SHUANG JIA, MARK ROETHLE, NATHAN A. TRUCHAN, YI-GUANG CHEN, CHIEN-WEI LIN, MARTIN HESSNER
Journal: Diabetes
Diabetes 2024;73(Supplement_1):92-OR
https://doi.org/10.2337/db24-92-OR
Published: 14 June 2024
View articletitled, 92-OR: Defining Type 1 Diabetes Endtypes
Journal Articles

Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability

Puchong Thirawatananond, Matthew E. Brown, Lindsey K. Sachs, Juan M. Arnoletti, Wen-I Yeh, Amanda L. Posgai, Melanie R. Shapiro, Yi-Guang Chen, Todd M. Brusko
Journal: Diabetes
Diabetes 2023;72(11):1629–1640
https://doi.org/10.2337/db23-0307
Published: 25 August 2023
View articletitled, Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability
Open the PDF for Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability in another window
Meeting Abstracts

201-OR: Characterization of Type 1 Diabetes (T1D) Endotypes

AMINA BEDRAT, TARUN PANT, SHUANG JIA, MARK ROETHLE, NATHAN A. TRUCHAN, SUSANNE M. CABRERA, YI-GUANG CHEN, CHIEN-WEI LIN, MARTIN HESSNER
Journal: Diabetes
Diabetes 2023;72(Supplement_1):201-OR
https://doi.org/10.2337/db23-201-OR
Published: 20 June 2023
View articletitled, 201-OR: Characterization of Type 1 Diabetes (T1D) Endotypes
Meeting Abstracts

110-OR: MDA5-Dependent Responses Can Influence Spontaneous and Virus-Accelerated T1D Onset

SAMUEL I. BLUM, YI-GUANG CHEN, HUBERT M. TSE
Journal: Diabetes
Diabetes 2021;70(Supplement_1):110-OR
https://doi.org/10.2337/db21-110-OR
Published: 01 June 2021
View articletitled, 110-OR: MDA5-Dependent Responses Can Influence Spontaneous and Virus-Accelerated T1D Onset
Meeting Abstracts

291-OR: Deletion within the Helicase 1 Domain of MDA5 Dampens Immune Cell Activation and Delays Type 1 Diabetes

SAMUEL I. BLUM, YI-GUANG CHEN, HUBERT M. TSE
Journal: Diabetes
Diabetes 2020;69(Supplement_1):291-OR
https://doi.org/10.2337/db20-291-OR
Published: 01 June 2020
View articletitled, 291-OR: Deletion within the Helicase 1 Domain of MDA5 Dampens Immune Cell Activation and Delays Type 1 Diabetes
Meeting Abstracts

1726-P: MDA5, a Janus-Faced dsRNA Sensor in Coxsackievirus-Accelerated Autoimmune Diabetes

SAMUEL I. BLUM, YI-GUANG CHEN, HUBERT M. TSE
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1726-P
https://doi.org/10.2337/db19-1726-P
Published: 01 June 2019
View articletitled, 1726-P: MDA5, a Janus-Faced dsRNA Sensor in Coxsackievirus-Accelerated Autoimmune Diabetes
Meeting Abstracts

Investigating the Role of CD137 Ligand in the Pathogenesis of Type 1 Diabetes

BARDEES FODA, MATTHEW H. FORSBERG, ASHLEY E. CIECKO, KEVIN W. MUELLER, ARON GEURTS, YI-GUANG CHEN
Journal: Diabetes
Diabetes 2018;67(Supplement_1):317-OR
https://doi.org/10.2337/db18-317-OR
Published: 01 July 2018
View articletitled, Investigating the Role of CD137 Ligand in the Pathogenesis of Type 1 Diabetes
Journal Articles

Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development

Jeremy J. Racine, Isabel Stewart, Jeremy Ratiu, Greg Christianson, Emily Lowell, Kelsay Helm, Jennifer Allocco, Richard S. Maser, Yi-Guang Chen, Cathleen M. Lutz, Derry Roopenian, Jennifer Schloss, Teresa P. DiLorenzo, David V. Serreze
Journal: Diabetes
Diabetes 2018;67(5):923–935
https://doi.org/10.2337/db17-1467
Published: 22 February 2018
View articletitled, Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development
Open the PDF for Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development in another window
Includes: Supplementary data
Journal Articles

Interferon-γ Limits Diabetogenic CD8+ T-Cell Effector Responses in Type 1 Diabetes

John P. Driver, Jeremy J. Racine, Cheng Ye, Deanna J. Lamont, Brittney N. Newby, Caroline M. Leeth, Harold D. Chapman, Todd M. Brusko, Yi-Guang Chen, Clayton E. Mathews, David V. Serreze
Journal: Diabetes
Diabetes 2017;66(3):710–721
https://doi.org/10.2337/db16-0846
Published: 05 December 2016
View articletitled, Interferon-γ Limits Diabetogenic CD8+ T-Cell Effector Responses in Type 1 Diabetes
Open the PDF for Interferon-γ Limits Diabetogenic CD8+ T-Cell Effector Responses in Type 1 Diabetes in another window
Includes: Supplementary data
Journal Articles

Molecular Signatures Differentiate Immune States in Type 1 Diabetic Families

Yi-Guang Chen, Susanne M. Cabrera, Shuang Jia, Mary L. Kaldunski, Joanna Kramer, Sami Cheong, Rhonda Geoffrey, Mark F. Roethle, Jeffrey E. Woodliff, Carla J. Greenbaum, Xujing Wang, Martin J. Hessner
Journal: Diabetes
Diabetes 2014;63(11):3960–3973
https://doi.org/10.2337/db14-0214
Published: 13 October 2014
View articletitled, Molecular Signatures Differentiate Immune States in Type 1 Diabetic Families
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Includes: Supplementary data
Journal Articles

Gene Targeting in NOD Mouse Embryos Using Zinc-Finger Nucleases

Yi-Guang Chen, Matthew H. Forsberg, Shamim Khaja, Ashley E. Ciecko, Martin J. Hessner, Aron M. Geurts
Journal: Diabetes
Diabetes 2014;63(1):68–74
https://doi.org/10.2337/db13-0192
Published: 13 December 2013
View articletitled, Gene Targeting in NOD Mouse Embryos Using Zinc-Finger Nucleases
Open the PDF for Gene Targeting in NOD Mouse Embryos Using Zinc-Finger Nucleases in another window
Journal Articles

Unmasking Genes in a Type 1 Diabetes–Resistant Mouse Strain That Enhances Pathogenic CD8 T-Cell Responses

John P. Driver, Yi-Guang Chen, Weidong Zhang, Seblewongel Asrat, David V. Serreze
Journal: Diabetes
Diabetes 2011;60(4):1354–1359
https://doi.org/10.2337/db10-0885
Published: 22 March 2011
View articletitled, Unmasking Genes in a Type 1 Diabetes–Resistant Mouse Strain That Enhances Pathogenic CD8 T-Cell Responses
Open the PDF for Unmasking Genes in a Type 1 Diabetes–Resistant Mouse Strain That Enhances Pathogenic CD8 T-Cell Responses in another window
Includes: Supplementary data
Journal Articles

Invariant Natural Killer T-Cell Control of Type 1 Diabetes: A Dendritic Cell Genetic Decision of a Silver Bullet or Russian Roulette

John P. Driver, Felix Scheuplein, Yi-Guang Chen, Alexandra E. Grier, S. Brian Wilson, David V. Serreze
Journal: Diabetes
Diabetes 2010;59(2):423–432
https://doi.org/10.2337/db09-1116
Published: 10 November 2009
View articletitled, Invariant Natural Killer T-Cell Control of Type 1 Diabetes: A Dendritic Cell Genetic Decision of a Silver Bullet or Russian Roulette
Open the PDF for Invariant Natural Killer T-Cell Control of Type 1 Diabetes: A Dendritic Cell Genetic Decision of a Silver Bullet or Russian Roulette in another window
Includes: Supplementary data
Journal Articles

Idd9/11 Genetic Locus Regulates Diabetogenic Activity of CD4 T-Cells in Nonobese Diabetic (NOD) Mice

Yi-Guang Chen, Felix Scheuplein, Melissa A. Osborne, Shirng-Wern Tsaih, Harold D. Chapman, David V. Serreze
Journal: Diabetes
Diabetes 2008;57(12):3273–3280
https://doi.org/10.2337/db08-0767
Published: 01 December 2008
View articletitled, Idd9/11 Genetic Locus Regulates Diabetogenic Activity of CD4 T-Cells in Nonobese Diabetic (NOD) Mice
Open the PDF for Idd9/11 Genetic Locus Regulates Diabetogenic Activity of CD4 T-Cells in Nonobese Diabetic (NOD) Mice in another window
Journal Articles

Cellular Expression Requirements for Inhibition of Type 1 Diabetes by a Dominantly Protective Major Histocompatibility Complex Haplotype

Yi-Guang Chen, Pablo A. Silveira, Melissa A. Osborne, Harold D. Chapman, David V. Serreze
Journal: Diabetes
Diabetes 2007;56(2):424–430
https://doi.org/10.2337/db06-1303
Published: 01 February 2007
View articletitled, Cellular Expression Requirements for Inhibition of Type 1 Diabetes by a Dominantly Protective Major Histocompatibility Complex Haplotype
Open the PDF for Cellular Expression Requirements for Inhibition of Type 1 Diabetes by a Dominantly Protective Major Histocompatibility Complex Haplotype in another window
Journal Articles

Novel Leptin Receptor Mutation in NOD/LtJ Mice Suppresses Type 1 Diabetes Progression: II. Immunologic Analysis

Chul-Ho Lee, Yi-Guang Chen, Jing Chen, Peter C. Reifsnyder, David V. Serreze, Michael Clare-Salzler, Michelle Rodriguez, Clive Wasserfall, Mark A. Atkinson, Edward H. Leiter
Journal: Diabetes
Diabetes 2006;55(1):171–178
https://doi.org/10.2337/diabetes.55.01.06.db05-1129
Published: 01 January 2006
View articletitled, Novel Leptin Receptor Mutation in NOD/LtJ Mice Suppresses Type 1 Diabetes Progression: II. Immunologic Analysis
Open the PDF for Novel Leptin Receptor Mutation in NOD/LtJ Mice Suppresses Type 1 Diabetes Progression: II. Immunologic Analysis in another window