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Meeting Abstracts

266-LB: SGLT2 Inhibition Improved Endurance Performance of db/db Mice Accompanied by an Increased Endogenous AMPK Activator in Skeletal Muscles

SHINTARO NAKAMURA, YASUTAKA MIYACHI, HISASHI YOKOMIZO, HIROKO OTSUKA, RYUICHI SAKAMOTO, MASATOMO TAKAHASHI, YOSHIHIRO IZUMI, TAKASHI MIYAZAWA, TAKESHI BAMBA, YOSHIHIRO OGAWA

Diabetes 2023;72(Supplement_1):266-LB

https://doi.org/10.2337/db23-266-LB

Published: 20 June 2023

View article titled, 266-LB: SGLT2 Inhibition Improved Endurance Performance of db/db Mice Accompanied by an Increased Endogenous AMPK Activator in Skeletal Muscles

Journal Articles

Acyl-CoA Thioesterase 1 (ACOT1) Regulates PPARα to Couple Fatty Acid Flux With Oxidative Capacity During Fasting

Mallory P. Franklin, Aishwarya Sathyanarayan, Douglas G. Mashek

Diabetes 2017;66(8):2112–2123

https://doi.org/10.2337/db16-1519

Published: 12 June 2017

View article titled, Acyl-CoA Thioesterase 1 (ACOT1) Regulates PPARα to Couple Fatty Acid Flux With Oxidative Capacity During Fasting

Includes: Supplementary data

Journal Articles

Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion

Aida Martinez-Sanchez, Timothy J. Pullen, Pauline Chabosseau, Qifeng Zhang, Elizabeth Haythorne, Matthew C. Cane, Marie-Sophie Nguyen-Tu, Sophie R. Sayers, Guy A. Rutter

Diabetes 2016;65(5):1268–1282

https://doi.org/10.2337/db15-1240

Published: 09 February 2016

View article titled, Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion

Includes: Supplementary data

Journal Articles

Compartmentalized Acyl-CoA Metabolism in Skeletal Muscle Regulates Systemic Glucose Homeostasis

Lei O. Li, Trisha J. Grevengoed, David S. Paul, Olga Ilkayeva, Timothy R. Koves, Florencia Pascual, Christopher B. Newgard, Deborah M. Muoio, Rosalind A. Coleman

Diabetes 2015;64(1):23–35

https://doi.org/10.2337/db13-1070

Published: 28 July 2014

View article titled, Compartmentalized Acyl-CoA Metabolism in Skeletal Muscle Regulates Systemic Glucose Homeostasis

Includes: Supplementary data

Journal Articles

Fatty Acid Incubation of Myotubes From Humans With Type 2 Diabetes Leads to Enhanced Release of β-Oxidation Products Because of Impaired Fatty Acid Oxidation: Effects of Tetradecylthioacetic Acid and Eicosapentaenoic Acid

Andreas J. Wensaas, Arild C. Rustan, Marlene Just, Rolf K. Berge, Christian A. Drevon, Michael Gaster

Diabetes 2009;58(3):527–535

https://doi.org/10.2337/db08-1043

Published: 01 March 2009

View article titled, Fatty Acid Incubation of Myotubes From Humans With Type 2 Diabetes Leads to Enhanced Release of β-Oxidation Products Because of Impaired Fatty Acid Oxidation: <subtitle>Effects of Tetradecylthioacetic Acid and Eicosapentaenoic Acid</subtitle>

Includes: Supplementary data

Journal Articles

n-3 Fatty Acids Preserve Insulin Sensitivity In Vivo in a Peroxisome Proliferator–Activated Receptor-α–Dependent Manner

Susanne Neschen, Katsutaro Morino, Jianying Dong, Yanlin Wang-Fischer, Gary W. Cline, Anthony J. Romanelli, Jörg C. Rossbacher, Irene K. Moore, Werner Regittnig, David S. Munoz, Jung H. Kim, Gerald I. Shulman

Diabetes 2007;56(4):1034–1041

https://doi.org/10.2337/db06-1206

Published: 01 April 2007

View article titled, n-3 Fatty Acids Preserve Insulin Sensitivity In Vivo in a Peroxisome Proliferator–Activated Receptor-α–Dependent Manner

Includes: Supplementary data

Journal Articles

Paradoxical Changes in Muscle Gene Expression in Insulin-Resistant Subjects After Sustained Reduction in Plasma Free Fatty Acid Concentration

Mandeep Bajaj, Rafael Medina-Navarro, Swangjit Suraamornkul, Christian Meyer, Ralph A. DeFronzo, Lawrence J. Mandarino

Diabetes 2007;56(3):743–752

https://doi.org/10.2337/db06-0840

Published: 01 March 2007

View article titled, Paradoxical Changes in Muscle Gene Expression in Insulin-Resistant Subjects After Sustained Reduction in Plasma Free Fatty Acid Concentration

Journal Articles

Saturated, but Not Unsaturated, Fatty Acids Induce Apoptosis of Human Coronary Artery Endothelial Cells via Nuclear Factor-κB Activation

Katrin Staiger, Harald Staiger, Cora Weigert, Carina Haas, Hans-Ulrich Häring, Monika Kellerer

Diabetes 2006;55(11):3121–3126

https://doi.org/10.2337/db06-0188

Published: 01 November 2006

View article titled, Saturated, but Not Unsaturated, Fatty Acids Induce Apoptosis of Human Coronary Artery Endothelial Cells via Nuclear Factor-κB Activation

Journal Articles

Increased Malonyl-CoA Levels in Muscle From Obese and Type 2 Diabetic Subjects Lead to Decreased Fatty Acid Oxidation and Increased Lipogenesis; Thiazolidinedione Treatment Reverses These Defects

Gautam K. Bandyopadhyay, Joseph G. Yu, Jachelle Ofrecio, Jerrold M. Olefsky

Diabetes 2006;55(8):2277–2285

https://doi.org/10.2337/db06-0062

Published: 01 August 2006

View article titled, Increased Malonyl-CoA Levels in Muscle From Obese and Type 2 Diabetic Subjects Lead to Decreased Fatty Acid Oxidation and Increased Lipogenesis; Thiazolidinedione Treatment Reverses These Defects

Journal Articles

Saturated and cis/trans Unsaturated Acyl CoA Esters Differentially Regulate Wild-Type and Polymorphic β-Cell ATP-Sensitive K⁺ Channels

Michael J. Riedel, Peter E. Light

Diabetes 2005;54(7):2070–2079

https://doi.org/10.2337/diabetes.54.7.2070

Published: 01 July 2005

View article titled, Saturated and cis/trans Unsaturated Acyl CoA Esters Differentially Regulate Wild-Type and Polymorphic β-Cell ATP-Sensitive K+ Channels

Journal Articles

Adipocyte-Specific Overexpression of FOXC2 Prevents Diet-Induced Increases in Intramuscular Fatty Acyl CoA and Insulin Resistance

Jason K. Kim, Hyo-Jeong Kim, So-Young Park, Anna Cederberg, Rickard Westergren, Daniel Nilsson, Takamasa Higashimori, You-Ree Cho, Zhen-Xiang Liu, Jianying Dong, Gary W. Cline, Sven Enerback, Gerald I. Shulman

Diabetes 2005;54(6):1657–1663

https://doi.org/10.2337/diabetes.54.6.1657

Published: 01 June 2005

View article titled, Adipocyte-Specific Overexpression of FOXC2 Prevents Diet-Induced Increases in Intramuscular Fatty Acyl CoA and Insulin Resistance

Journal Articles

Metabolic Regulation of the Pancreatic Beta-Cell ATP-Sensitive K⁺ Channel: A Pas de Deux

Andrei Tarasov, Julien Dusonchet, Frances Ashcroft

Diabetes 2004;53(suppl_3):S113–S122

https://doi.org/10.2337/diabetes.53.suppl_3.S113

Published: 01 December 2004

View article titled, Metabolic Regulation of the Pancreatic Beta-Cell ATP-Sensitive K+ Channel: <subtitle>A Pas de Deux</subtitle>

Journal Articles

Differential Effects of Interleukin-6 and -10 on Skeletal Muscle and Liver Insulin Action In Vivo

Hyo-Jeong Kim, Takamasa Higashimori, So-Young Park, Hyejeong Choi, Jianying Dong, Yoon-Jung Kim, Hye-Lim Noh, You-Ree Cho, Gary Cline, Young-Bum Kim, Jason K. Kim

Diabetes 2004;53(4):1060–1067

https://doi.org/10.2337/diabetes.53.4.1060

Published: 01 April 2004

View article titled, Differential Effects of Interleukin-6 and -10 on Skeletal Muscle and Liver Insulin Action In Vivo

Journal Articles

A Role for the Malonyl-CoA/Long-Chain Acyl-CoA Pathway of Lipid Signaling in the Regulation of Insulin Secretion in Response to Both Fuel and Nonfuel Stimuli

Raphaël Roduit, Christopher Nolan, Cristina Alarcon, Patrick Moore, Annie Barbeau, Viviane Delghingaro-Augusto, Ewa Przybykowski, Johane Morin, Frédéric Massé, Bernard Massie, Neil Ruderman, Christopher Rhodes, Vincent Poitout, Marc Prentki

Diabetes 2004;53(4):1007–1019

https://doi.org/10.2337/diabetes.53.4.1007

Published: 01 April 2004

View article titled, A Role for the Malonyl-CoA/Long-Chain Acyl-CoA Pathway of Lipid Signaling in the Regulation of Insulin Secretion in Response to Both Fuel and Nonfuel Stimuli

Journal Articles

Differential Effects of Rosiglitazone on Skeletal Muscle and Liver Insulin Resistance in A-ZIP/F-1 Fatless Mice

Jason K. Kim, Jonathan J. Fillmore, Oksana Gavrilova, Lily Chao, Takamasa Higashimori, Hyejeong Choi, Hyo-Jeong Kim, Chunli Yu, Yan Chen, Xianqin Qu, Martin Haluzik, Marc L. Reitman, Gerald I. Shulman

Diabetes 2003;52(6):1311–1318

https://doi.org/10.2337/diabetes.52.6.1311

Published: 01 June 2003

View article titled, Differential Effects of Rosiglitazone on Skeletal Muscle and Liver Insulin Resistance in A-ZIP/F-1 Fatless Mice

Journal Articles

Errata

Diabetes 2003;52(1):223–224

https://doi.org/10.2337/diabetes.52.1.223

Published: 01 January 2003

View article titled, Errata

Journal Articles

The Ryanodine Receptor Calcium Channel of β-Cells: Molecular Regulation and Physiological Significance

Md. Shahidul Islam

Diabetes 2002;51(5):1299–1309

https://doi.org/10.2337/diabetes.51.5.1299

Published: 01 May 2002

View article titled, The Ryanodine Receptor Calcium Channel of β-Cells: <subtitle>Molecular Regulation and Physiological Significance</subtitle>

Journal Articles

Acyl-CoA Binding Protein Expression Is Fiber Type- Specific and Elevated in Muscles From the Obese Insulin-Resistant Zucker Rat

Jesper Franch, Jens Knudsen, Bronwyn A. Ellis, Preben K. Pedersen, Gregory J. Cooney, Jørgen Jensen

Diabetes 2002;51(2):449–454

https://doi.org/10.2337/diabetes.51.2.449

Published: 01 February 2002

View article titled, Acyl-CoA Binding Protein Expression Is Fiber Type- Specific and Elevated in Muscles From the Obese Insulin-Resistant Zucker Rat

Meeting Abstracts

Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance.

A L Thompson, G J Cooney

Diabetes 2000;49(11):1761–1765

https://doi.org/10.2337/diabetes.49.11.1761

Published: 01 November 2000

View article titled, Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance.

Journal Articles

Diet-Induced Muscle Insulin Resistance in Rats Is Ameliorated by Acute Dietary Lipid Withdrawal or a Single Bout of Exercise: Parallel Relationship Between Insulin Stimulation of Glucose Uptake and Suppression of Long-Chain Fatty Acyl-CoA

Nicholas D Oakes, Kim S Bell, Stuart M Furler, Souad Camilleri, Asish K Saha, Neil B Ruderman, Donald J Chisholm, Edward W Kraegen

Diabetes 1997;46(12):2022–2028

https://doi.org/10.2337/diab.46.12.2022

Published: 01 December 1997

View article titled, Diet-Induced Muscle Insulin Resistance in Rats Is Ameliorated by Acute Dietary Lipid Withdrawal or a Single Bout of Exercise: Parallel Relationship Between Insulin Stimulation of Glucose Uptake and Suppression of Long-Chain Fatty Acyl-CoA

NARROW

266-LB: SGLT2 Inhibition Improved Endurance Performance of db/db Mice Accompanied by an Increased Endogenous AMPK Activator in Skeletal Muscles

Acyl-CoA Thioesterase 1 (ACOT1) Regulates PPARα to Couple Fatty Acid Flux With Oxidative Capacity During Fasting

Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion

Compartmentalized Acyl-CoA Metabolism in Skeletal Muscle Regulates Systemic Glucose Homeostasis

Fatty Acid Incubation of Myotubes From Humans With Type 2 Diabetes Leads to Enhanced Release of β-Oxidation Products Because of Impaired Fatty Acid Oxidation: Effects of Tetradecylthioacetic Acid and Eicosapentaenoic Acid

n-3 Fatty Acids Preserve Insulin Sensitivity In Vivo in a Peroxisome Proliferator–Activated Receptor-α–Dependent Manner

Paradoxical Changes in Muscle Gene Expression in Insulin-Resistant Subjects After Sustained Reduction in Plasma Free Fatty Acid Concentration

Saturated, but Not Unsaturated, Fatty Acids Induce Apoptosis of Human Coronary Artery Endothelial Cells via Nuclear Factor-κB Activation

Increased Malonyl-CoA Levels in Muscle From Obese and Type 2 Diabetic Subjects Lead to Decreased Fatty Acid Oxidation and Increased Lipogenesis; Thiazolidinedione Treatment Reverses These Defects

Saturated and cis/trans Unsaturated Acyl CoA Esters Differentially Regulate Wild-Type and Polymorphic β-Cell ATP-Sensitive K⁺ Channels

Adipocyte-Specific Overexpression of FOXC2 Prevents Diet-Induced Increases in Intramuscular Fatty Acyl CoA and Insulin Resistance

Metabolic Regulation of the Pancreatic Beta-Cell ATP-Sensitive K⁺ Channel: A Pas de Deux

Differential Effects of Interleukin-6 and -10 on Skeletal Muscle and Liver Insulin Action In Vivo

A Role for the Malonyl-CoA/Long-Chain Acyl-CoA Pathway of Lipid Signaling in the Regulation of Insulin Secretion in Response to Both Fuel and Nonfuel Stimuli

Differential Effects of Rosiglitazone on Skeletal Muscle and Liver Insulin Resistance in A-ZIP/F-1 Fatless Mice

Errata

The Ryanodine Receptor Calcium Channel of β-Cells: Molecular Regulation and Physiological Significance

Acyl-CoA Binding Protein Expression Is Fiber Type- Specific and Elevated in Muscles From the Obese Insulin-Resistant Zucker Rat

Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance.

Diet-Induced Muscle Insulin Resistance in Rats Is Ameliorated by Acute Dietary Lipid Withdrawal or a Single Bout of Exercise: Parallel Relationship Between Insulin Stimulation of Glucose Uptake and Suppression of Long-Chain Fatty Acyl-CoA

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