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Meeting Abstracts

204-OR: The Chd4 Helicase Modulates ß-Cell Function In Vivo

REBECCA K. DAVIDSON, NOLAN CASEY, SUKRATI KANOJIA, JASON SPAETH
Journal: Diabetes
Diabetes 2022;71(Supplement_1):204-OR
https://doi.org/10.2337/db22-204-OR
Published: 01 June 2022
View article titled, 204-OR: The Chd4 Helicase Modulates ß-Cell Function In Vivo
Meeting Abstracts

1456-P: Molecular Architecture of AR Action in Insulin Secretion in Male Pancreatic ß-Cells

PAULA MOTA DE SA, MIRZA MUHAMMAD FAHD QADIR, MANUEL BLANDINO-ROSANO, JIA FAN, WEIWEI XU, ERNESTO BERNAL-MIZRACHI, FRANCK MAUVAIS-JARVIS
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1456-P
https://doi.org/10.2337/db22-1456-P
Published: 01 June 2022
View article titled, 1456-P: Molecular Architecture of AR Action in Insulin Secretion in Male Pancreatic ß-Cells
Meeting Abstracts

1243-P: The Chd4 Helicase Regulates Pdx1-Controlled Genes Involved in ß-Cell Function

REBECCA K. DAVIDSON, NOLAN CASEY, SUKRATI KANOJIA, JASON SPAETH
Journal: Diabetes
Diabetes 2021;70(Supplement_1):1243-P
https://doi.org/10.2337/db21-1243-P
Published: 01 June 2021
View article titled, 1243-P: The Chd4 Helicase Regulates Pdx1-Controlled Genes Involved in ß-Cell Function
Meeting Abstracts

110-OR: MDA5-Dependent Responses Can Influence Spontaneous and Virus-Accelerated T1D Onset

SAMUEL I. BLUM, YI-GUANG CHEN, HUBERT M. TSE
Journal: Diabetes
Diabetes 2021;70(Supplement_1):110-OR
https://doi.org/10.2337/db21-110-OR
Published: 01 June 2021
View article titled, 110-OR: MDA5-Dependent Responses Can Influence Spontaneous and Virus-Accelerated T1D Onset
Meeting Abstracts

2112-P: Sarco/Endoplasmic Reticulum ATPase (SERCA2) Deficiency in the Nonobese Diabetic (NOD) Mouse Accelerates Type 1 Diabetes Development

ROBERT N. BONE, CHRISTOPHER A. REISSAUS, TATSUYOSHI KONO, CARMELLA EVANS-MOLINA
Journal: Diabetes
Diabetes 2020;69(Supplement_1):2112-P
https://doi.org/10.2337/db20-2112-P
Published: 01 June 2020
View article titled, 2112-P: Sarco/Endoplasmic Reticulum ATPase (SERCA2) Deficiency in the Nonobese Diabetic (NOD) Mouse Accelerates Type 1 Diabetes Development
Journal Articles

The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function

Jason M. Spaeth, Jin-Hua Liu, Daniel Peters, Min Guo, Anna B. Osipovich, Fardin Mohammadi, Nilotpal Roy, Anil Bhushan, Mark A. Magnuson, Matthias Hebrok, Christopher V.E. Wright, Roland Stein
Journal: Diabetes
Diabetes 2019;68(9):1806–1818
https://doi.org/10.2337/db19-0349
Published: 14 June 2019
View article titled, The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function
Open the PDF for The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function in another window
Includes: Supplementary data
Meeting Abstracts

341-LB: Chronic ER Calcium Depletion Resulting from Sarcoendoplasmic Reticulum Ca2+ Atpase 2b (SERCA2b) Deficiency Leads to Impaired Proinsulin Processing in the Pancreatic ß Cell

HITOSHI IIDA, TATSUYOSHI KONO, XIN TONG, IRIS LINDBERG, CARMELLA EVANS-MOLINA
Journal: Diabetes
Diabetes 2019;68(Supplement_1):341-LB
https://doi.org/10.2337/db19-341-LB
Published: 01 June 2019
View article titled, 341-LB: Chronic ER Calcium Depletion Resulting from Sarcoendoplasmic Reticulum Ca2<sup>+</sup> Atpase 2b (SERCA2b) Deficiency Leads to Impaired Proinsulin Processing in the Pancreatic ß Cell
Meeting Abstracts

Reduced ß Cell SPCA1 Leads to Impaired Calcium Oscillations and Decreased Autophagy

ROBERT N. BONE, TATSUYOSHI KONO, CARMELLA EVANS-MOLINA
Journal: Diabetes
Diabetes 2018;67(Supplement_1):194-OR
https://doi.org/10.2337/db18-194-OR
Published: 01 July 2018
View article titled, Reduced ß Cell SPCA1 Leads to Impaired Calcium Oscillations and Decreased Autophagy
Meeting Abstracts

Exploring the Role of Calcium-Activated Potassium Channels in Alpha-Cell Function

MATTHEW DICKERSON, MOLLY K. ALTMAN, PRASANNA DADI, NICHOLAS C. VIERRA, DAVID JACOBSON
Journal: Diabetes
Diabetes 2018;67(Supplement_1):2172-P
https://doi.org/10.2337/db18-2172-P
Published: 01 July 2018
View article titled, Exploring the Role of Calcium-Activated Potassium Channels in Alpha-Cell Function
Journal Articles

Palmitate-Induced Vacuolar-Type H+-ATPase Inhibition Feeds Forward Into Insulin Resistance and Contractile Dysfunction

Yilin Liu, Laura K.M. Steinbusch, Miranda Nabben, Dimitris Kapsokalyvas, Marc van Zandvoort, Patrick Schönleitner, Gudrun Antoons, Peter J. Simons, Will A. Coumans, Amber Geomini, Dipanjan Chanda, Jan F.C. Glatz, Dietbert Neumann, Joost J.F.P. Luiken
Journal: Diabetes
Diabetes 2017;66(6):1521–1534
https://doi.org/10.2337/db16-0727
Published: 16 March 2017
View article titled, Palmitate-Induced Vacuolar-Type H<sup>+</sup>-ATPase Inhibition Feeds Forward Into Insulin Resistance and Contractile Dysfunction
Open the PDF for Palmitate-Induced Vacuolar-Type H<sup>+</sup>-ATPase Inhibition Feeds Forward Into Insulin Resistance and Contractile Dysfunction in another window
Includes: Supplementary data
Journal Articles

High-Fat Diet–Induced Mitochondrial Biogenesis Is Regulated by Mitochondrial-Derived Reactive Oxygen Species Activation of CaMKII

Swati S. Jain, Sabina Paglialunga, Chris Vigna, Alison Ludzki, Eric A. Herbst, James S. Lally, Patrick Schrauwen, Joris Hoeks, A. Russ Tupling, Arend Bonen, Graham P. Holloway
Journal: Diabetes
Diabetes 2014;63(6):1907–1913
https://doi.org/10.2337/db13-0816
Published: 15 May 2014
View article titled, High-Fat Diet–Induced Mitochondrial Biogenesis Is Regulated by Mitochondrial-Derived Reactive Oxygen Species Activation of CaMKII
Open the PDF for High-Fat Diet–Induced Mitochondrial Biogenesis Is Regulated by Mitochondrial-Derived Reactive Oxygen Species Activation of CaMKII in another window
Includes: Supplementary data
Journal Articles

Tempol Reduces Oxidative Stress, Improves Insulin Sensitivity, Decreases Renal Dopamine D1 Receptor Hyperphosphorylation, and Restores D1 Receptor–G-Protein Coupling and Function in Obese Zucker Rats

Anees Ahmad Banday, Aditi Marwaha, Lakshmi S. Tallam, Mustafa F. Lokhandwala
Journal: Diabetes
Diabetes 2005;54(7):2219–2226
https://doi.org/10.2337/diabetes.54.7.2219
Published: 01 July 2005
View article titled, Tempol Reduces Oxidative Stress, Improves Insulin Sensitivity, Decreases Renal Dopamine D1 Receptor Hyperphosphorylation, and Restores D1 Receptor–G-Protein Coupling and Function in Obese Zucker Rats
Open the PDF for Tempol Reduces Oxidative Stress, Improves Insulin Sensitivity, Decreases Renal Dopamine D1 Receptor Hyperphosphorylation, and Restores D1 Receptor–G-Protein Coupling and Function in Obese Zucker Rats in another window
Journal Articles

Cytokines Downregulate the Sarcoendoplasmic Reticulum Pump Ca2+ ATPase 2b and Deplete Endoplasmic Reticulum Ca2+, Leading to Induction of Endoplasmic Reticulum Stress in Pancreatic β-Cells

Alessandra K. Cardozo, Fernanda Ortis, Joachim Storling, Ying-Mei Feng, Joanne Rasschaert, Morten Tonnesen, Françoise Van Eylen, Thomas Mandrup-Poulsen, André Herchuelz, Décio L. Eizirik
Journal: Diabetes
Diabetes 2005;54(2):452–461
https://doi.org/10.2337/diabetes.54.2.452
Published: 01 February 2005
View article titled, Cytokines Downregulate the Sarcoendoplasmic Reticulum Pump Ca<sup>2+</sup> ATPase 2b and Deplete Endoplasmic Reticulum Ca<sup>2+</sup>, Leading to Induction of Endoplasmic Reticulum Stress in Pancreatic β-Cells
Open the PDF for Cytokines Downregulate the Sarcoendoplasmic Reticulum Pump Ca<sup>2+</sup> ATPase 2b and Deplete Endoplasmic Reticulum Ca<sup>2+</sup>, Leading to Induction of Endoplasmic Reticulum Stress in Pancreatic β-Cells in another window
Journal Articles

Islet Secretory Defect in Insulin Receptor Substrate 1 Null Mice Is Linked With Reduced Calcium Signaling and Expression of Sarco(endo)plasmic Reticulum Ca2+-ATPase (SERCA)-2b and -3

Rohit N. Kulkarni, Michael G. Roper, Gabriella Dahlgren, David Q. Shih, Lisa M. Kauri, Jennifer L. Peters, Markus Stoffel, Robert T. Kennedy
Journal: Diabetes
Diabetes 2004;53(6):1517–1525
https://doi.org/10.2337/diabetes.53.6.1517
Published: 01 June 2004
View article titled, Islet Secretory Defect in Insulin Receptor Substrate 1 Null Mice Is Linked With Reduced Calcium Signaling and Expression of Sarco(endo)plasmic Reticulum Ca<sup>2+</sup>-ATPase (SERCA)-2b and -3
Open the PDF for Islet Secretory Defect in Insulin Receptor Substrate 1 Null Mice Is Linked With Reduced Calcium Signaling and Expression of Sarco(endo)plasmic Reticulum Ca<sup>2+</sup>-ATPase (SERCA)-2b and -3 in another window
Journal Articles

Role for Plasma Membrane-Related Ca2+-ATPase-1 (ATP2C1) in Pancreatic β-Cell Ca2+ Homeostasis Revealed by RNA Silencing

Kathryn J. Mitchell, Takashi Tsuboi, Guy A. Rutter
Journal: Diabetes
Diabetes 2004;53(2):393–400
https://doi.org/10.2337/diabetes.53.2.393
Published: 01 February 2004
View article titled, Role for Plasma Membrane-Related Ca<sup>2+</sup>-ATPase-1 (ATP2C1) in Pancreatic β-Cell Ca<sup>2+</sup> Homeostasis Revealed by RNA Silencing
Open the PDF for Role for Plasma Membrane-Related Ca<sup>2+</sup>-ATPase-1 (ATP2C1) in Pancreatic β-Cell Ca<sup>2+</sup> Homeostasis Revealed by RNA Silencing in another window
Includes: Supplementary data
Journal Articles

Neuroprotective Effect of Docosahexaenoic Acid-Enriched Phospholipids in Experimental Diabetic Neuropathy

Thierry C. Coste, Alain Gerbi, Philippe Vague, Gérard Pieroni, Denis Raccah
Journal: Diabetes
Diabetes 2003;52(10):2578–2585
https://doi.org/10.2337/diabetes.52.10.2578
Published: 01 October 2003
View article titled, Neuroprotective Effect of Docosahexaenoic Acid-Enriched Phospholipids in Experimental Diabetic Neuropathy
Open the PDF for Neuroprotective Effect of Docosahexaenoic Acid-Enriched Phospholipids in Experimental Diabetic Neuropathy in another window
Journal Articles

Differential Effects of Diabetes on Rat Choroid Plexus Ion Transporter Expression

Richard D. Egleton, Christopher C. Campos, Jason D. Huber, Rachel C. Brown, Thomas P. Davis
Journal: Diabetes
Diabetes 2003;52(6):1496–1501
https://doi.org/10.2337/diabetes.52.6.1496
Published: 01 June 2003
View article titled, Differential Effects of Diabetes on Rat Choroid Plexus Ion Transporter Expression
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Journal Articles

Dissection of Metabolic, Vascular, and Nerve Conduction Interrelationships in Experimental Diabetic Neuropathy by Cyclooxygenase Inhibition and Acetyl-l-Carnitine Administration

Rodica Pop-Busui, Victor Marinescu, Carol Van Huysen, Fei Li, Kelli Sullivan, Douglas A. Greene, Dennis Larkin, Martin J. Stevens
Journal: Diabetes
Diabetes 2002;51(8):2619–2628
https://doi.org/10.2337/diabetes.51.8.2619
Published: 01 August 2002
View article titled, Dissection of Metabolic, Vascular, and Nerve Conduction Interrelationships in Experimental Diabetic Neuropathy by Cyclooxygenase Inhibition and Acetyl-<sc>l</sc>-Carnitine Administration
Open the PDF for Dissection of Metabolic, Vascular, and Nerve Conduction Interrelationships in Experimental Diabetic Neuropathy by Cyclooxygenase Inhibition and Acetyl-<sc>l</sc>-Carnitine Administration in another window
Journal Articles

Dynamic Imaging of Endoplasmic Reticulum Ca2+ Concentration in Insulin-Secreting MIN6 Cells Using Recombinant Targeted Cameleons: Roles of Sarco(endo)plasmic Reticulum Ca2+-ATPase (SERCA)-2 and Ryanodine Receptors

Aniko Varadi, Guy A. Rutter
Journal: Diabetes
Diabetes 2002;51(suppl_1):S190–S201
https://doi.org/10.2337/diabetes.51.2007.S190
Published: 01 February 2002
View article titled, Dynamic Imaging of Endoplasmic Reticulum Ca<sup>2+</sup> Concentration in Insulin-Secreting MIN6 Cells Using Recombinant Targeted Cameleons: <subtitle>Roles of Sarco(endo)plasmic Reticulum Ca<sup>2+</sup>-ATPase (SERCA)-2 and Ryanodine Receptors </subtitle>
Open the PDF for Dynamic Imaging of Endoplasmic Reticulum Ca<sup>2+</sup> Concentration in Insulin-Secreting MIN6 Cells Using Recombinant Targeted Cameleons: <subtitle>Roles of Sarco(endo)plasmic Reticulum Ca<sup>2+</sup>-ATPase (SERCA)-2 and Ryanodine Receptors </subtitle> in another window
Journal Articles

Effect of Antioxidant Treatment of Streptozotocin-Induced Diabetic Rats on Endoneurial Blood Flow, Motor Nerve Conduction Velocity, and Vascular Reactivity of Epineurial Arterioles of the Sciatic Nerve

Lawrence J. Coppey, Jill S. Gellett, Eric P. Davidson, Joyce A. Dunlap, Donald D. Lund, Mark A. Yorek
Journal: Diabetes
Diabetes 2001;50(8):1927–1937
https://doi.org/10.2337/diabetes.50.8.1927
Published: 01 August 2001
View article titled, Effect of Antioxidant Treatment of Streptozotocin-Induced Diabetic Rats on Endoneurial Blood Flow, Motor Nerve Conduction Velocity, and Vascular Reactivity of Epineurial Arterioles of the Sciatic Nerve
Open the PDF for Effect of Antioxidant Treatment of Streptozotocin-Induced Diabetic Rats on Endoneurial Blood Flow, Motor Nerve Conduction Velocity, and Vascular Reactivity of Epineurial Arterioles of the Sciatic Nerve in another window