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Meeting Abstracts

207-LB: Aldose Reductase Inhibition by AT-001 Limits Diastolic Dysfunction and Adverse Remodelling in Diabetic Cardiomyopathy

QUTUBA G. KARWI, KESHAV GOPAL, SEYED AMIRHOSSEIN TABATABAEI DAKHILI, CORY S. WAGG, LIYAN ZHANG, QIUYU SUN, CHRISTINA T. SAED, SAI PANIDARAPU, RICCARDO PERFETTI, RAVICHANDRAN RAMASAMY, JOHN R. USSHER, GARY LOPASCHUK
Journal: Diabetes
Diabetes 2022;71(Supplement_1):207-LB
https://doi.org/10.2337/db22-207-LB
Published: 01 June 2022
View article titled, 207-LB: Aldose Reductase Inhibition by AT-001 Limits Diastolic Dysfunction and Adverse Remodelling in Diabetic Cardiomyopathy
Meeting Abstracts

379-P: Aldose Reductase Inhibition by AT-001 Prevents Diabetic Cardiomyopathy via Reducing Myocardial Fatty Acid Oxidation Rates

KESHAV GOPAL, QUTUBA G. KARWI, SEYED AMIRHOSSEIN TABATABAEI DAKHILI, CORY S. WAGG, RICCARDO PERFETTI, RAVICHANDRAN RAMASAMY, JOHN R. USSHER, GARY LOPASCHUK
Journal: Diabetes
Diabetes 2021;70(Supplement_1):379-P
https://doi.org/10.2337/db21-379-P
Published: 01 June 2021
View article titled, 379-P: Aldose Reductase Inhibition by AT-001 Prevents Diabetic Cardiomyopathy via Reducing Myocardial Fatty Acid Oxidation Rates
Meeting Abstracts

462-P: AT-001, a Next Generation Aldose Reductase Inhibitor with Improved Selectivity and Specificity, Protects from Cellular Damage Associated with Hyperglycemia

RICCARDO PERFETTI, GAUTHAM YEPURI, NOSIRUDEEN A. QUADRI, RAVICHANDRAN RAMASAMY, AMEEN F. GHANNAM, SHOSHANA SHENDELMAN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):462-P
https://doi.org/10.2337/db20-462-P
Published: 01 June 2020
View article titled, 462-P: AT-001, a Next Generation Aldose Reductase Inhibitor with Improved Selectivity and Specificity, Protects from Cellular Damage Associated with Hyperglycemia
Meeting Abstracts

186-OR: Safety and Tolerability of the Next Generation Aldose Reductase Inhibitor (ARI) AT-001 Supports Initiation of the Pivotal Trial in Diabetic Cardiomyopathy (DbCM)

RICCARDO PERFETTI, FRANCESCA C. LAWSON, JULIO ROSENSTOCK, JAMES JANUZZI, JR., SHOSHANA SHENDELMAN, STELLA WANG, AMEEN F. GHANNAM
Journal: Diabetes
Diabetes 2020;69(Supplement_1):186-OR
https://doi.org/10.2337/db20-186-OR
Published: 01 June 2020
View article titled, 186-OR: Safety and Tolerability of the Next Generation Aldose Reductase Inhibitor (ARI) AT-001 Supports Initiation of the Pivotal Trial in Diabetic Cardiomyopathy (DbCM)
Meeting Abstracts

1080-P: Addressing the Safety Challenges of Aldose Reductase Inhibition: Development of AT-001 for Diabetic Cardiomyopathy, a Potent and Selective Next Generation Aldose Reductase Inhibitor

RICCARDO PERFETTI, GAUTHAM YEPURI, NOSIRUDEEN A. QUADRI, AMEEN F. GHANNAM, RAVICHANDRAN RAMASAMY, SHOSHANA SHENDELMAN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1080-P
https://doi.org/10.2337/db20-1080-P
Published: 01 June 2020
View article titled, 1080-P: Addressing the Safety Challenges of Aldose Reductase Inhibition: Development of AT-001 for Diabetic Cardiomyopathy, a Potent and Selective Next Generation Aldose Reductase Inhibitor
Meeting Abstracts

145-LB: Phase 1/2 Safety and Proof of Biological Activity Study of AT-001, an Aldose Reductase Inhibitor in Development for Diabetic Cardiomyopathy

SHOSHANA SHENDELMAN, RICCARDO PERFETTI
Journal: Diabetes
Diabetes 2019;68(Supplement_1):145-LB
https://doi.org/10.2337/db19-145-LB
Published: 01 June 2019
View article titled, 145-LB: Phase 1/2 Safety and Proof of Biological Activity Study of AT-001, an Aldose Reductase Inhibitor in Development for Diabetic Cardiomyopathy
Journal Articles

In This Issue of Diabetes

Journal: Diabetes
Diabetes 2018;67(9):1699–1700
https://doi.org/10.2337/db18-ti09
Published: 15 August 2018
View article titled, In This Issue of <em>Diabetes</em>
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Journal Articles

Human Aldose Reductase Expression Prevents Atherosclerosis Regression in Diabetic Mice

Chujun Yuan, Jiyuan Hu, Saj Parathath, Lisa Grauer, Courtney Blachford Cassella, Svetlana Bagdasarov, Ira J. Goldberg, Ravichandran Ramasamy, Edward A. Fisher
Journal: Diabetes
Diabetes 2018;67(9):1880–1891
https://doi.org/10.2337/db18-0156
Published: 11 June 2018
View article titled, Human Aldose Reductase Expression Prevents Atherosclerosis Regression in Diabetic Mice
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Includes: Supplementary data
Journal Articles

Activation of Aldose Reductase by Interaction With Tubulin and Involvement of This Mechanism in Diabetic Cataract Formation. Diabetes. 10 April 2014 [Epub ahead of print]. DOI: 10.2337/db13-1265

Juan F. Rivelli, Verónica S. Santander, Sofía O. Peretti, Noelia E. Monesterolo, Ayelen D. Nigra, Gabriela Previtali, Marina R. Amaiden, Carlos A. Arce, Emiliano Primo, Angela T. Lisa, Juan Pie, César H. Casale
Journal: Diabetes
Diabetes 2014;63(8):2896
https://doi.org/10.2337/db13-1265
Published: 17 July 2014
View article titled, Activation of Aldose Reductase by Interaction With Tubulin and Involvement of This Mechanism in Diabetic Cataract Formation. Diabetes. 10 April 2014 [Epub ahead of print]. DOI: 10.2337/db13-1265
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Journal Articles

Aldose Reductase Meets Histone Acetylation: A New Role for an Old Player

Julia V. Busik, Maria B. Grant
Journal: Diabetes
Diabetes 2014;63(2):402–404
https://doi.org/10.2337/db13-1696
Published: 16 January 2014
View article titled, Aldose Reductase Meets Histone Acetylation: A New Role for an Old Player
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Journal Articles

Aldose Reductase Drives Hyperacetylation of Egr-1 in Hyperglycemia and Consequent Upregulation of Proinflammatory and Prothrombotic Signals

Srinivasan Vedantham, Devi Thiagarajan, Radha Ananthakrishnan, Lingjie Wang, Rosa Rosario, Yu Shan Zou, Ira Goldberg, Shi Fang Yan, Ann Marie Schmidt, Ravichandran Ramasamy
Journal: Diabetes
Diabetes 2014;63(2):761–774
https://doi.org/10.2337/db13-0032
Published: 16 January 2014
View article titled, Aldose Reductase Drives Hyperacetylation of Egr-1 in Hyperglycemia and Consequent Upregulation of Proinflammatory and Prothrombotic Signals
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Includes: Supplementary data
Journal Articles

Chelation: A Fundamental Mechanism of Action of AGE Inhibitors, AGE Breakers, and Other Inhibitors of Diabetes Complications

Ryoji Nagai, David B. Murray, Thomas O. Metz, John W. Baynes
Journal: Diabetes
Diabetes 2012;61(3):549–559
https://doi.org/10.2337/db11-1120
Published: 13 February 2012
View article titled, Chelation: A Fundamental Mechanism of Action of AGE Inhibitors, AGE Breakers, and Other Inhibitors of Diabetes Complications
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Journal Articles

Reductive Metabolism of AGE Precursors: A Metabolic Route for Preventing AGE Accumulation in Cardiovascular Tissue

Shahid P. Baba, Oleg A. Barski, Yonis Ahmed, Timothy E. O'Toole, Daniel J. Conklin, Aruni Bhatnagar, Sanjay Srivastava
Journal: Diabetes
Diabetes 2009;58(11):2486–2497
https://doi.org/10.2337/db09-0375
Published: 03 August 2009
View article titled, Reductive Metabolism of AGE Precursors: A Metabolic Route for Preventing AGE Accumulation in Cardiovascular Tissue
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Includes: Supplementary data
Journal Articles

High-Fat Diet–Induced Neuropathy of Pre-Diabetes and Obesity : Effects of “Healthy” Diet and Aldose Reductase Inhibition

Irina G. Obrosova, Olga Ilnytska, Valeriy V. Lyzogubov, Ivan A. Pavlov, Nazar Mashtalir, Jerry L. Nadler, Viktor R. Drel
Journal: Diabetes
Diabetes 2007;56(10):2598–2608
https://doi.org/10.2337/db06-1176
Published: 01 October 2007
View article titled, High-Fat Diet–Induced Neuropathy of Pre-Diabetes and Obesity : <subtitle>Effects of “Healthy” Diet and Aldose Reductase Inhibition</subtitle>
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Journal Articles

Pathogenesis of Spinally Mediated Hyperalgesia in Diabetes

Khara M. Ramos, Yun Jiang, Camilla I. Svensson, Nigel A. Calcutt
Journal: Diabetes
Diabetes 2007;56(6):1569–1576
https://doi.org/10.2337/db06-1269
Published: 01 June 2007
View article titled, Pathogenesis of Spinally Mediated Hyperalgesia in Diabetes
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Journal Articles

A Selective Aldose Reductase Inhibitor of a New Structural Class Prevents or Reverses Early Retinal Abnormalities in Experimental Diabetic Retinopathy

Wei Sun, Peter J. Oates, James B. Coutcher, Chiara Gerhardinger, Mara Lorenzi
Journal: Diabetes
Diabetes 2006;55(10):2757–2762
https://doi.org/10.2337/db06-0138
Published: 01 October 2006
View article titled, A Selective Aldose Reductase Inhibitor of a New Structural Class Prevents or Reverses Early Retinal Abnormalities in Experimental Diabetic Retinopathy
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Journal Articles

Aldose Reductase–Deficient Mice Are Protected From Delayed Motor Nerve Conduction Velocity, Increased c-Jun NH2-Terminal Kinase Activation, Depletion of Reduced Glutathione, Increased Superoxide Accumulation, and DNA Damage

Eric C.M. Ho, Karen S.L. Lam, Yuk Shan Chen, Johnny C.W. Yip, Meena Arvindakshan, Shin-Ichiro Yamagishi, Soroku Yagihashi, Peter J. Oates, Craig A. Ellery, Stephen S.M. Chung, Sookja K. Chung
Journal: Diabetes
Diabetes 2006;55(7):1946–1953
https://doi.org/10.2337/db05-1497
Published: 01 July 2006
View article titled, Aldose Reductase–Deficient Mice Are Protected From Delayed Motor Nerve Conduction Velocity, Increased c-Jun NH<sub>2</sub>-Terminal Kinase Activation, Depletion of Reduced Glutathione, Increased Superoxide Accumulation, and DNA Damage
Open the PDF for Aldose Reductase–Deficient Mice Are Protected From Delayed Motor Nerve Conduction Velocity, Increased c-Jun NH<sub>2</sub>-Terminal Kinase Activation, Depletion of Reduced Glutathione, Increased Superoxide Accumulation, and DNA Damage in another window
Journal Articles

Aldose Reductase Pathway Inhibition Improved Vascular and C-Fiber Functions, Allowing for Pressure-Induced Vasodilation Restoration During Severe Diabetic Neuropathy

Claire Demiot, Maylis Tartas, Bérengère Fromy, Pierre Abraham, Jean Louis Saumet, Dominique Sigaudo-Roussel
Journal: Diabetes
Diabetes 2006;55(5):1478–1483
https://doi.org/10.2337/db05-1433
Published: 01 May 2006
View article titled, Aldose Reductase Pathway Inhibition Improved Vascular and C-Fiber Functions, Allowing for Pressure-Induced Vasodilation Restoration During Severe Diabetic Neuropathy
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Journal Articles

Contribution of Aldose Reductase to Diabetic Hyperproliferation of Vascular Smooth Muscle Cells

Sanjay Srivastava, Kota V. Ramana, Ravinder Tammali, Satish K. Srivastava, Aruni Bhatnagar
Journal: Diabetes
Diabetes 2006;55(4):901–910
https://doi.org/10.2337/diabetes.55.04.06.db05-0932
Published: 01 April 2006
View article titled, Contribution of Aldose Reductase to Diabetic Hyperproliferation of Vascular Smooth Muscle Cells
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Journal Articles

Aldose Reductase Deficiency Prevents Diabetes-Induced Blood-Retinal Barrier Breakdown, Apoptosis, and Glial Reactivation in the Retina of db/db Mice

Alvin K.H. Cheung, Maggie K.L. Fung, Amy C.Y. Lo, Terence T.L. Lam, Kwok Fai So, Stephen S.M. Chung, Sookja K. Chung
Journal: Diabetes
Diabetes 2005;54(11):3119–3125
https://doi.org/10.2337/diabetes.54.11.3119
Published: 01 November 2005
View article titled, Aldose Reductase Deficiency Prevents Diabetes-Induced Blood-Retinal Barrier Breakdown, Apoptosis, and Glial Reactivation in the Retina of <em>db/db</em> Mice
Open the PDF for Aldose Reductase Deficiency Prevents Diabetes-Induced Blood-Retinal Barrier Breakdown, Apoptosis, and Glial Reactivation in the Retina of <em>db/db</em> Mice in another window