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Journal Articles

Electrophysiological Characterization of Inducible Pluripotent Stem Cell–Derived Human β-Like Cells and an SLC30A8 Disease Model

Manon Jaffredo, Nicole A.J. Krentz, Benoite Champon, Claire E. Duff, Sameena Nawaz, Nicola Beer, Christian Honore, Anne Clark, Patrik Rorsman, Jochen Lang, Anna L. Gloyn, Matthieu Raoux, Benoit Hastoy
Journal: Diabetes
Diabetes 2024;73(8):1255–1265
https://doi.org/10.2337/db23-0776
Published: 22 May 2024
View article titled, Electrophysiological Characterization of Inducible Pluripotent Stem Cell–Derived Human β-Like Cells and an <em>SLC30A8</em> Disease Model
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Journal Articles

An E115A Missense Variant in CERS2 Is Associated With Increased Sleeping Energy Expenditure and Hepatic Insulin Resistance in American Indians

Sascha Heinitz, Michael Traurig, Jonathan Krakoff, Philipp Rabe, Claudia Stäubert, Sayuko Kobes, Robert L. Hanson, Michael Stumvoll, Matthias Blüher, Clifton Bogardus, Leslie Baier, Paolo Piaggi
Journal: Diabetes
Diabetes 2024;73(8):1361–1371
https://doi.org/10.2337/db23-0690
Published: 22 May 2024
View article titled, An E115A Missense Variant in <em>CERS2</em> Is Associated With Increased Sleeping Energy Expenditure and Hepatic Insulin Resistance in American Indians
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Journal Articles

Epistasis Between HLA-DRB1*16:02:01 and SLC16A11 T-C-G-T-T Reduces Odds for Type 2 Diabetes in Southwest American Indians

Robert C. Williams, Robert L. Hanson, Bjoern Peters, Kendall Kearns, William C. Knowler, Clifton Bogardus, Leslie J. Baier
Journal: Diabetes
Diabetes 2024;73(6):1002–1011
https://doi.org/10.2337/db23-0925
Published: 26 March 2024
View article titled, Epistasis Between <em>HLA-DRB1*16:02:01</em> and <em>SLC16A11 T-C-G-T-T</em> Reduces Odds for Type 2 Diabetes in Southwest American Indians
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Journal Articles

Human Genetic Variation at rs10071329 Correlates With Adiposity-Related Traits, Modulates PPARGC1B Expression, and Alters Brown Adipocyte Function

Mi Huang, Rashmi B. Prasad, Daniel E. Coral, Line Hjort, Daniel T.R. Minja, Hindrik Mulder, Paul W. Franks, Sebastian Kalamajski
Journal: Diabetes
Diabetes 2024;73(4):637–645
https://doi.org/10.2337/db23-0531
Published: 08 January 2024
View article titled, Human Genetic Variation at rs10071329 Correlates With Adiposity-Related Traits, Modulates <em>PPARGC1B</em> Expression, and Alters Brown Adipocyte Function
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Meeting Abstracts

1470-P: Novel Associations of Glycometabolic Traits in Ethnically Diverse Africans

MATTHEW HANSEN, DANIEL HARRIS, ALEXANDRE M. HARRIS, THOMAS B. NYAMBO, GURJA BELAY, SUNUNGUKO MPOLOKA, CHARLES BURANT, SARAH A. TISHKOFF
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1470-P
https://doi.org/10.2337/db23-1470-P
Published: 20 June 2023
View article titled, 1470-P: Novel Associations of Glycometabolic Traits in Ethnically Diverse Africans
Meeting Abstracts

299-OR: Molecular and Physiological Consequences of the Diabetes-Related PGC1A Gly482Ser Polymorphism

MARIA GALIPEAU, NATHALIE JOUVET, EMILIE COURTY, ROXANNE VANDENBEEK, NAVEEN P. KHAN, KHALIL BOUYAKDAN, CUILAN NIAN, CATERINA IORIO, DANIEL D. SCOTT, MAY FARAJ, MARLENE OEFFINGER, FRANCIS C. LYNN, ROBERT A. SCREATON, THIERRY ALQUIER, JENNIFER L. ESTALL
Journal: Diabetes
Diabetes 2022;71(Supplement_1):299-OR
https://doi.org/10.2337/db22-299-OR
Published: 01 June 2022
View article titled, 299-OR: Molecular and Physiological Consequences of the Diabetes-Related PGC1A Gly482Ser Polymorphism
Meeting Abstracts

12-OR: Preventing ß-Cell Death under Glucotoxic Conditions: The Role of ChREBPb

LIORA S. KATZ, GABRIEL BRILL, MARK A. HERMAN, ADOLFO GARCIA-OCANA, DONALD SCOTT
Journal: Diabetes
Diabetes 2022;71(Supplement_1):12-OR
https://doi.org/10.2337/db22-12-OR
Published: 01 June 2022
View article titled, 12-OR: Preventing ß-Cell Death under Glucotoxic Conditions: The Role of ChREBPb
Journal Articles

The Low-Expression Variant of FABP4 Is Associated With Cardiovascular Disease in Type 1 Diabetes

Emma H. Dahlström, Jani Saksi, Carol Forsblom, Nicoline Uglebjerg, Nina Mars, Lena M. Thorn, Valma Harjutsalo, Peter Rossing, Tarunveer S. Ahluwalia, Perttu J. Lindsberg, Niina Sandholm, Per-Henrik Groop
Journal: Diabetes
Diabetes 2021;70(10):2391–2401
https://doi.org/10.2337/db21-0056
Published: 09 July 2021
View article titled, The Low-Expression Variant of <em>FABP4</em> Is Associated With Cardiovascular Disease in Type 1 Diabetes
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Meeting Abstracts

28-OR: Identification of Ancestry-Specific Alleles in a Genome-Wide Association Study (GWAS) for Metformin (MET) Response in the Diabetes Prevention Program (DPP)

JOSEPHINE H. LI, JAMES A. PERRY, KATHLEEN A. JABLONSKI, LING CHEN, SHYLAJA SRINIVASAN, JENNIFER N. TODD, MAEGAN HARDEN, JOSEP M. MERCADER, PAUL W. FRANKS, ROBERT L. HANSON, STEVEN E. KAHN, WILLIAM C. KNOWLER, TONI I. POLLIN, JOSE C. FLOREZ, DPP RESEARCH GROUP
Journal: Diabetes
Diabetes 2021;70(Supplement_1):28-OR
https://doi.org/10.2337/db21-28-OR
Published: 01 June 2021
View article titled, 28-OR: Identification of Ancestry-Specific Alleles in a Genome-Wide Association Study (GWAS) for Metformin (MET) Response in the Diabetes Prevention Program (DPP)
Journal Articles

The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion

Gregor Sachse, Elizabeth Haythorne, Thomas Hill, Peter Proks, Russell Joynson, Raul Terrón-Expósito, Liz Bentley, Stephen J. Tucker, Roger D. Cox, Frances M. Ashcroft
Journal: Diabetes
Diabetes 2021;70(5):1145–1156
https://doi.org/10.2337/db20-0691
Published: 10 February 2021
View article titled, The <em>KCNJ11-E23K</em> Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion
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Journal Articles

Low-Frequency Genetic Variant in the Hepatic Glucokinase Gene Is Associated With Type 2 Diabetes and Insulin Resistance in Chinese Population

Yumin Ma, Yingying Luo, Siqian Gong, Xianghai Zhou, Yufeng Li, Wei Liu, Simin Zhang, Xiaoling Cai, Qian Ren, Lingli Zhou, Xiuying Zhang, Yanai Wang, Xiuting Huang, Xueying Gao, Mengdie Hu, Xueyao Han, Linong Ji
Journal: Diabetes
Diabetes 2021;70(3):809–816
https://doi.org/10.2337/db20-0564
Published: 09 December 2020
View article titled, Low-Frequency Genetic Variant in the Hepatic Glucokinase Gene Is Associated With Type 2 Diabetes and Insulin Resistance in Chinese Population
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Journal Articles

Association of the 1q25 Diabetes-Specific Coronary Heart Disease Locus With Alterations of the γ-Glutamyl Cycle and Increased Methylglyoxal Levels in Endothelial Cells

Caterina Pipino, Hetal Shah, Sabrina Prudente, Natalia Di Pietro, Lixia Zeng, Kyoungmin Park, Vincenzo Trischitta, Subramanian Pennathur, Assunta Pandolfi, Alessandro Doria
Journal: Diabetes
Diabetes 2020;69(10):2206–2216
https://doi.org/10.2337/db20-0475
Published: 10 July 2020
View article titled, Association of the 1q25 Diabetes-Specific Coronary Heart Disease Locus With Alterations of the γ-Glutamyl Cycle and Increased Methylglyoxal Levels in Endothelial Cells
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Meeting Abstracts

109-OR: Genetic Discrepancy of HLA Class I Alleles in Chinese Patients with Type 1 Diabetes at Different Onset Ages

ZIYU JIANG, WENQIAN REN, YINGXIN XIAN, JINHUA YAN, DAIZHI YANG, SIHUI LUO, XUEYING ZHENG, WEN XU, JIN-XIN BEI, LEIF GROOP, JIANPING WENG
Journal: Diabetes
Diabetes 2020;69(Supplement_1):109-OR
https://doi.org/10.2337/db20-109-OR
Published: 01 June 2020
View article titled, 109-OR: Genetic Discrepancy of HLA Class I Alleles in Chinese Patients with Type 1 Diabetes at Different Onset Ages
Journal Articles

Failed Genetic Protection: Type 1 Diabetes in the Presence of HLA-DQB1*06:02

Kimber M. Simmons, Angela M. Mitchell, Aimon A. Alkanani, Kristen A. McDaniel, Erin E. Baschal, Taylor Armstrong, Laura Pyle, Liping Yu, Aaron W. Michels
Journal: Diabetes
Diabetes 2020;69(8):1763–1769
https://doi.org/10.2337/db20-0038
Published: 21 May 2020
View article titled, Failed Genetic Protection: Type 1 Diabetes in the Presence of <em>HLA-DQB1*06:02</em>
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Journal Articles

Motifs of Three HLA-DQ Amino Acid Residues (α44, β57, β135) Capture Full Association With the Risk of Type 1 Diabetes in DQ2 and DQ8 Children

Lue Ping Zhao, George K. Papadopoulos, William W. Kwok, Antonis K. Moustakas, George P. Bondinas, Helena Elding Larsson, Johnny Ludvigsson, Claude Marcus, Ulf Samuelsson, Ruihan Wang, Chul-Woo Pyo, Wyatt C. Nelson, Daniel E. Geraghty, Åke Lernmark
Journal: Diabetes
Diabetes 2020;69(7):1573–1587
https://doi.org/10.2337/db20-0075
Published: 03 April 2020
View article titled, Motifs of Three HLA-DQ Amino Acid Residues (α44, β57, β135) Capture Full Association With the Risk of Type 1 Diabetes in DQ2 and DQ8 Children
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Journal Articles

Assessment of MTNR1B Type 2 Diabetes Genetic Risk Modification by Shift Work and Morningness-Eveningness Preference in the UK Biobank

Hassan S. Dashti, Céline Vetter, Jacqueline M. Lane, Matt C. Smith, Andrew R. Wood, Michael N. Weedon, Martin K. Rutter, Marta Garaulet, Frank A.J.L. Scheer, Richa Saxena
Journal: Diabetes
Diabetes 2020;69(2):259–266
https://doi.org/10.2337/db19-0606
Published: 22 November 2019
View article titled, Assessment of <em>MTNR1B</em> Type 2 Diabetes Genetic Risk Modification by Shift Work and Morningness-Eveningness Preference in the UK Biobank
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Includes: Supplementary data
Journal Articles

Longitudinal Pattern of First-Phase Insulin Response Is Associated With Genetic Variants Outside the Class II HLA Region in Children With Multiple Autoantibodies

Maarit K. Koskinen, Mari-Liis Mikk, Antti-Pekka Laine, Johanna Lempainen, Eliisa Löyttyniemi, Paula Vähäsalo, Anne Hekkala, Taina Härkönen, Minna Kiviniemi, Olli Simell, Mikael Knip, Riitta Veijola, Jorma Ilonen, Jorma Toppari
Journal: Diabetes
Diabetes 2020;69(1):12–19
https://doi.org/10.2337/db19-0329
Published: 07 October 2019
View article titled, Longitudinal Pattern of First-Phase Insulin Response Is Associated With Genetic Variants Outside the Class II HLA Region in Children With Multiple Autoantibodies
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Meeting Abstracts

25-OR: Investigating a Candidate Causal Allele in Type 2 Diabetes Susceptibility Gene PAM as a Cause of Neonatal Diabetes Mellitus

SHAHANA SENGUPTA, LORI L. BONNYCASTLE, BENOIT HASTOY, ANTJE GROTZ, MAHESH M. UMAPATHYSIVAM, ANNE RAIMONDO, AMY SWIFT, PETER S. CHINES, ANNE CLARK, HANNA HUOPIO, FRANCIS S. COLLINS, MARKKU LAAKSO, SR., ANNA L. GLOYN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):25-OR
https://doi.org/10.2337/db19-25-OR
Published: 01 June 2019
View article titled, 25-OR: Investigating a Candidate Causal Allele in Type 2 Diabetes Susceptibility Gene PAM as a Cause of Neonatal Diabetes Mellitus
Meeting Abstracts

1720-P: The rs10423928 GIP Receptor “A” Allele Contributes to an Improved ß-Cell Response in Prediabetes Patients

RENATE LUZÍA BARBOSA-YAÑEZ, ULRIKE DAMBECK, CAROLINE HONSEK, STEFAN KABISCH, ANDREAS F. PFEIFFER
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1720-P
https://doi.org/10.2337/db19-1720-P
Published: 01 June 2019
View article titled, 1720-P: The rs10423928 GIP Receptor “A” Allele Contributes to an Improved ß-Cell Response in Prediabetes Patients
Meeting Abstracts

1721-P: Effect of the TCF7L2 Variant rs7903146 T Allele on the Incretin Effect in Individuals with Normal Glucose Tolerance or Type 2 Diabetes

DAVID S. MATHIESEN, ASGER B. LUND, KATRINE BAGGE HANSEN, ANDERS JUNKER, THOMAS IDORN, MADS HORNUM, ANNA JONSSON, TORBEN HANSEN, TINA VILSBØLL, JONATAN I. BAGGER, FILIP K. KNOP
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1721-P
https://doi.org/10.2337/db19-1721-P
Published: 01 June 2019
View article titled, 1721-P: Effect of the TCF7L2 Variant rs7903146 T Allele on the Incretin Effect in Individuals with Normal Glucose Tolerance or Type 2 Diabetes