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Meeting Abstracts

1470-P: Novel Associations of Glycometabolic Traits in Ethnically Diverse Africans

MATTHEW HANSEN, DANIEL HARRIS, ALEXANDRE M. HARRIS, THOMAS B. NYAMBO, GURJA BELAY, SUNUNGUKO MPOLOKA, CHARLES BURANT, SARAH A. TISHKOFF

Diabetes 2023;72(Supplement_1):1470-P

https://doi.org/10.2337/db23-1470-P

Published: 20 June 2023

View article titled, 1470-P: Novel Associations of Glycometabolic Traits in Ethnically Diverse Africans

Meeting Abstracts

299-OR: Molecular and Physiological Consequences of the Diabetes-Related PGC1A Gly482Ser Polymorphism

MARIA GALIPEAU, NATHALIE JOUVET, EMILIE COURTY, ROXANNE VANDENBEEK, NAVEEN P. KHAN, KHALIL BOUYAKDAN, CUILAN NIAN, CATERINA IORIO, DANIEL D. SCOTT, MAY FARAJ, MARLENE OEFFINGER, FRANCIS C. LYNN, ROBERT A. SCREATON, THIERRY ALQUIER, JENNIFER L. ESTALL

Diabetes 2022;71(Supplement_1):299-OR

https://doi.org/10.2337/db22-299-OR

Published: 01 June 2022

View article titled, 299-OR: Molecular and Physiological Consequences of the Diabetes-Related PGC1A Gly482Ser Polymorphism

Meeting Abstracts

12-OR: Preventing ß-Cell Death under Glucotoxic Conditions: The Role of ChREBPb

LIORA S. KATZ, GABRIEL BRILL, MARK A. HERMAN, ADOLFO GARCIA-OCANA, DONALD SCOTT

Diabetes 2022;71(Supplement_1):12-OR

https://doi.org/10.2337/db22-12-OR

Published: 01 June 2022

View article titled, 12-OR: Preventing ß-Cell Death under Glucotoxic Conditions: The Role of ChREBPb

Journal Articles

The Low-Expression Variant of FABP4 Is Associated With Cardiovascular Disease in Type 1 Diabetes

Emma H. Dahlström, Jani Saksi, Carol Forsblom, Nicoline Uglebjerg, Nina Mars, Lena M. Thorn, Valma Harjutsalo, Peter Rossing, Tarunveer S. Ahluwalia, Perttu J. Lindsberg, Niina Sandholm, Per-Henrik Groop

Diabetes 2021;70(10):2391–2401

https://doi.org/10.2337/db21-0056

Published: 09 July 2021

View article titled, The Low-Expression Variant of FABP4 Is Associated With Cardiovascular Disease in Type 1 Diabetes

Meeting Abstracts

28-OR: Identification of Ancestry-Specific Alleles in a Genome-Wide Association Study (GWAS) for Metformin (MET) Response in the Diabetes Prevention Program (DPP)

JOSEPHINE H. LI, JAMES A. PERRY, KATHLEEN A. JABLONSKI, LING CHEN, SHYLAJA SRINIVASAN, JENNIFER N. TODD, MAEGAN HARDEN, JOSEP M. MERCADER, PAUL W. FRANKS, ROBERT L. HANSON, STEVEN E. KAHN, WILLIAM C. KNOWLER, TONI I. POLLIN, JOSE C. FLOREZ, DPP RESEARCH GROUP

Diabetes 2021;70(Supplement_1):28-OR

https://doi.org/10.2337/db21-28-OR

Published: 01 June 2021

View article titled, 28-OR: Identification of Ancestry-Specific Alleles in a Genome-Wide Association Study (GWAS) for Metformin (MET) Response in the Diabetes Prevention Program (DPP)

Journal Articles

The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion

Gregor Sachse, Elizabeth Haythorne, Thomas Hill, Peter Proks, Russell Joynson, Raul Terrón-Expósito, Liz Bentley, Stephen J. Tucker, Roger D. Cox, Frances M. Ashcroft

Diabetes 2021;70(5):1145–1156

https://doi.org/10.2337/db20-0691

Published: 10 February 2021

View article titled, The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion

Journal Articles

Low-Frequency Genetic Variant in the Hepatic Glucokinase Gene Is Associated With Type 2 Diabetes and Insulin Resistance in Chinese Population

Yumin Ma, Yingying Luo, Siqian Gong, Xianghai Zhou, Yufeng Li, Wei Liu, Simin Zhang, Xiaoling Cai, Qian Ren, Lingli Zhou, Xiuying Zhang, Yanai Wang, Xiuting Huang, Xueying Gao, Mengdie Hu, Xueyao Han, Linong Ji

Diabetes 2021;70(3):809–816

https://doi.org/10.2337/db20-0564

Published: 09 December 2020

View article titled, Low-Frequency Genetic Variant in the Hepatic Glucokinase Gene Is Associated With Type 2 Diabetes and Insulin Resistance in Chinese Population

Journal Articles

Association of the 1q25 Diabetes-Specific Coronary Heart Disease Locus With Alterations of the γ-Glutamyl Cycle and Increased Methylglyoxal Levels in Endothelial Cells

Caterina Pipino, Hetal Shah, Sabrina Prudente, Natalia Di Pietro, Lixia Zeng, Kyoungmin Park, Vincenzo Trischitta, Subramanian Pennathur, Assunta Pandolfi, Alessandro Doria

Diabetes 2020;69(10):2206–2216

https://doi.org/10.2337/db20-0475

Published: 10 July 2020

View article titled, Association of the 1q25 Diabetes-Specific Coronary Heart Disease Locus With Alterations of the γ-Glutamyl Cycle and Increased Methylglyoxal Levels in Endothelial Cells

Meeting Abstracts

109-OR: Genetic Discrepancy of HLA Class I Alleles in Chinese Patients with Type 1 Diabetes at Different Onset Ages

ZIYU JIANG, WENQIAN REN, YINGXIN XIAN, JINHUA YAN, DAIZHI YANG, SIHUI LUO, XUEYING ZHENG, WEN XU, JIN-XIN BEI, LEIF GROOP, JIANPING WENG

Diabetes 2020;69(Supplement_1):109-OR

https://doi.org/10.2337/db20-109-OR

Published: 01 June 2020

View article titled, 109-OR: Genetic Discrepancy of HLA Class I Alleles in Chinese Patients with Type 1 Diabetes at Different Onset Ages

Journal Articles

Failed Genetic Protection: Type 1 Diabetes in the Presence of HLA-DQB106:02*

Kimber M. Simmons, Angela M. Mitchell, Aimon A. Alkanani, Kristen A. McDaniel, Erin E. Baschal, Taylor Armstrong, Laura Pyle, Liping Yu, Aaron W. Michels

Diabetes 2020;69(8):1763–1769

https://doi.org/10.2337/db20-0038

Published: 21 May 2020

View article titled, Failed Genetic Protection: Type 1 Diabetes in the Presence of HLA-DQB1*06:02

Journal Articles

Motifs of Three HLA-DQ Amino Acid Residues (α44, β57, β135) Capture Full Association With the Risk of Type 1 Diabetes in DQ2 and DQ8 Children

Lue Ping Zhao, George K. Papadopoulos, William W. Kwok, Antonis K. Moustakas, George P. Bondinas, Helena Elding Larsson, Johnny Ludvigsson, Claude Marcus, Ulf Samuelsson, Ruihan Wang, Chul-Woo Pyo, Wyatt C. Nelson, Daniel E. Geraghty, Åke Lernmark

Diabetes 2020;69(7):1573–1587

https://doi.org/10.2337/db20-0075

Published: 03 April 2020

View article titled, Motifs of Three HLA-DQ Amino Acid Residues (α44, β57, β135) Capture Full Association With the Risk of Type 1 Diabetes in DQ2 and DQ8 Children

Journal Articles

Assessment of MTNR1B Type 2 Diabetes Genetic Risk Modification by Shift Work and Morningness-Eveningness Preference in the UK Biobank

Hassan S. Dashti, Céline Vetter, Jacqueline M. Lane, Matt C. Smith, Andrew R. Wood, Michael N. Weedon, Martin K. Rutter, Marta Garaulet, Frank A.J.L. Scheer, Richa Saxena

Diabetes 2020;69(2):259–266

https://doi.org/10.2337/db19-0606

Published: 22 November 2019

View article titled, Assessment of MTNR1B Type 2 Diabetes Genetic Risk Modification by Shift Work and Morningness-Eveningness Preference in the UK Biobank

Includes: Supplementary data

Journal Articles

Longitudinal Pattern of First-Phase Insulin Response Is Associated With Genetic Variants Outside the Class II HLA Region in Children With Multiple Autoantibodies

Maarit K. Koskinen, Mari-Liis Mikk, Antti-Pekka Laine, Johanna Lempainen, Eliisa Löyttyniemi, Paula Vähäsalo, Anne Hekkala, Taina Härkönen, Minna Kiviniemi, Olli Simell, Mikael Knip, Riitta Veijola, Jorma Ilonen, Jorma Toppari

Diabetes 2020;69(1):12–19

https://doi.org/10.2337/db19-0329

Published: 07 October 2019

View article titled, Longitudinal Pattern of First-Phase Insulin Response Is Associated With Genetic Variants Outside the Class II HLA Region in Children With Multiple Autoantibodies

Meeting Abstracts

1845-P: Divergent Effects on T2D of Alleles Associated with Increased Liver Fat Reflect Differential Impact on Hepatic Glucose and Lipid Output: An IMI DIRECT Study

ROBERT W. KOIVULA, IMI-DIRECT CONSORTIUM, PAUL W. FRANKS, TUE H. HANSEN, MARKKU LAAKSO, SR., EWAN PEARSON, FEMKE RUTTERS, FREDRIK KARPE, JEREMY W. TOMLINSON, ANUBHA MAHAJAN, MARK MCCARTHY

Diabetes 2019;68(Supplement_1):1845-P

https://doi.org/10.2337/db19-1845-P

Published: 01 June 2019

View article titled, 1845-P: Divergent Effects on T2D of Alleles Associated with Increased Liver Fat Reflect Differential Impact on Hepatic Glucose and Lipid Output: An IMI DIRECT Study

Meeting Abstracts

1570-P: The Haptoglobin 2 Allele Is Associated with Cardiac Autonomic Neuropathy in Both Type 1 Diabetes and Controls: The Retro HDLc Study

JINGHUI JU, ERIN L. TOMASZEWSKI, TREVOR J. ORCHARD, TINA COSTACOU

Diabetes 2019;68(Supplement_1):1570-P

https://doi.org/10.2337/db19-1570-P

Published: 01 June 2019

View article titled, 1570-P: The Haptoglobin 2 Allele Is Associated with Cardiac Autonomic Neuropathy in Both Type 1 Diabetes and Controls: The Retro HDLc Study

Meeting Abstracts

25-OR: Investigating a Candidate Causal Allele in Type 2 Diabetes Susceptibility Gene PAM as a Cause of Neonatal Diabetes Mellitus

SHAHANA SENGUPTA, LORI L. BONNYCASTLE, BENOIT HASTOY, ANTJE GROTZ, MAHESH M. UMAPATHYSIVAM, ANNE RAIMONDO, AMY SWIFT, PETER S. CHINES, ANNE CLARK, HANNA HUOPIO, FRANCIS S. COLLINS, MARKKU LAAKSO, SR., ANNA L. GLOYN

Diabetes 2019;68(Supplement_1):25-OR

https://doi.org/10.2337/db19-25-OR

Published: 01 June 2019

View article titled, 25-OR: Investigating a Candidate Causal Allele in Type 2 Diabetes Susceptibility Gene PAM as a Cause of Neonatal Diabetes Mellitus

Meeting Abstracts

1720-P: The rs10423928 GIP Receptor “A” Allele Contributes to an Improved ß-Cell Response in Prediabetes Patients

RENATE LUZÍA BARBOSA-YAÑEZ, ULRIKE DAMBECK, CAROLINE HONSEK, STEFAN KABISCH, ANDREAS F. PFEIFFER

Diabetes 2019;68(Supplement_1):1720-P

https://doi.org/10.2337/db19-1720-P

Published: 01 June 2019

View article titled, 1720-P: The rs10423928 GIP Receptor “A” Allele Contributes to an Improved ß-Cell Response in Prediabetes Patients

Meeting Abstracts

1721-P: Effect of the TCF7L2 Variant rs7903146 T Allele on the Incretin Effect in Individuals with Normal Glucose Tolerance or Type 2 Diabetes

DAVID S. MATHIESEN, ASGER B. LUND, KATRINE BAGGE HANSEN, ANDERS JUNKER, THOMAS IDORN, MADS HORNUM, ANNA JONSSON, TORBEN HANSEN, TINA VILSBØLL, JONATAN I. BAGGER, FILIP K. KNOP

Diabetes 2019;68(Supplement_1):1721-P

https://doi.org/10.2337/db19-1721-P

Published: 01 June 2019

View article titled, 1721-P: Effect of the TCF7L2 Variant rs7903146 T Allele on the Incretin Effect in Individuals with Normal Glucose Tolerance or Type 2 Diabetes

Journal Articles

Eleven Amino Acids of HLA-DRB1 and Fifteen Amino Acids of HLA-DRB3, 4, and 5 Include Potentially Causal Residues Responsible for the Risk of Childhood Type 1 Diabetes

Lue Ping Zhao, George K. Papadopoulos, William W. Kwok, Bryan Xu, Matthew Kong, Antonis K. Moustakas, George P. Bondinas, Annelie Carlsson, Helena Elding-Larsson, Johnny Ludvigsson, Claude Marcus, Martina Persson, Ulf Samuelsson, Ruihan Wang, Chul-Woo Pyo, Wyatt C. Nelson, Daniel E. Geraghty, Åke Lernmark

Diabetes 2019;68(8):1692–1704

https://doi.org/10.2337/db19-0273

Published: 24 May 2019

View article titled, Eleven Amino Acids of HLA-DRB1 and Fifteen Amino Acids of HLA-DRB3, 4, and 5 Include Potentially Causal Residues Responsible for the Risk of Childhood Type 1 Diabetes

Includes: Multimedia, Supplementary data

Journal Articles

ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations

Diabetes 2019;68(3):502–514

https://doi.org/10.2337/db18-0418

Published: 09 January 2019

View article titled, ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations

Includes: Supplementary data

NARROW

1470-P: Novel Associations of Glycometabolic Traits in Ethnically Diverse Africans

299-OR: Molecular and Physiological Consequences of the Diabetes-Related PGC1A Gly482Ser Polymorphism

12-OR: Preventing ß-Cell Death under Glucotoxic Conditions: The Role of ChREBPb

The Low-Expression Variant of FABP4 Is Associated With Cardiovascular Disease in Type 1 Diabetes

28-OR: Identification of Ancestry-Specific Alleles in a Genome-Wide Association Study (GWAS) for Metformin (MET) Response in the Diabetes Prevention Program (DPP)

The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion

Low-Frequency Genetic Variant in the Hepatic Glucokinase Gene Is Associated With Type 2 Diabetes and Insulin Resistance in Chinese Population

Association of the 1q25 Diabetes-Specific Coronary Heart Disease Locus With Alterations of the γ-Glutamyl Cycle and Increased Methylglyoxal Levels in Endothelial Cells

109-OR: Genetic Discrepancy of HLA Class I Alleles in Chinese Patients with Type 1 Diabetes at Different Onset Ages

Failed Genetic Protection: Type 1 Diabetes in the Presence of HLA-DQB106:02*

Motifs of Three HLA-DQ Amino Acid Residues (α44, β57, β135) Capture Full Association With the Risk of Type 1 Diabetes in DQ2 and DQ8 Children

Assessment of MTNR1B Type 2 Diabetes Genetic Risk Modification by Shift Work and Morningness-Eveningness Preference in the UK Biobank

Longitudinal Pattern of First-Phase Insulin Response Is Associated With Genetic Variants Outside the Class II HLA Region in Children With Multiple Autoantibodies

1845-P: Divergent Effects on T2D of Alleles Associated with Increased Liver Fat Reflect Differential Impact on Hepatic Glucose and Lipid Output: An IMI DIRECT Study

1570-P: The Haptoglobin 2 Allele Is Associated with Cardiac Autonomic Neuropathy in Both Type 1 Diabetes and Controls: The Retro HDLc Study

25-OR: Investigating a Candidate Causal Allele in Type 2 Diabetes Susceptibility Gene PAM as a Cause of Neonatal Diabetes Mellitus

1720-P: The rs10423928 GIP Receptor “A” Allele Contributes to an Improved ß-Cell Response in Prediabetes Patients

1721-P: Effect of the TCF7L2 Variant rs7903146 T Allele on the Incretin Effect in Individuals with Normal Glucose Tolerance or Type 2 Diabetes

Eleven Amino Acids of HLA-DRB1 and Fifteen Amino Acids of HLA-DRB3, 4, and 5 Include Potentially Causal Residues Responsible for the Risk of Childhood Type 1 Diabetes

ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations

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