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Journal Articles

A Novel Model of Diabetic Complications: Adipocyte Mitochondrial Dysfunction Triggers Massive β-Cell Hyperplasia

Christine M. Kusminski, Alexandra L. Ghaben, Thomas S. Morley, Ricardo J. Samms, Andrew C. Adams, Yu An, Joshua A. Johnson, Nolwenn Joffin, Toshiharu Onodera, Clair Crewe, William L. Holland, Ruth Gordillo, Philipp E. Scherer
Journal: Diabetes
Diabetes 2020;69(3):313–330
https://doi.org/10.2337/db19-0327
Published: 27 December 2020
View article titled, A Novel Model of Diabetic Complications: Adipocyte Mitochondrial Dysfunction Triggers Massive β-Cell Hyperplasia
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Includes: Supplementary data
Journal Articles

CCL21 Expression in β-Cells Induces Antigen-Expressing Stromal Cell Networks in the Pancreas and Prevents Autoimmune Diabetes in Mice

Freddy E. Gonzalez Badillo, Flavia Zisi Tegou, Maria M. Abreu, Riccardo Masina, Divya Sha, Mejdi Najjar, Shane H. Wright, Allison L. Bayer, Éva Korpos, Alberto Pugliese, R. Damaris Molano, Alice A. Tomei
Journal: Diabetes
Diabetes 2019;68(10):1990–2003
https://doi.org/10.2337/db19-0239
Published: 01 August 2019
View article titled, CCL21 Expression in β-Cells Induces Antigen-Expressing Stromal Cell Networks in the Pancreas and Prevents Autoimmune Diabetes in Mice
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Includes: Supplementary data
Meeting Abstracts

327-LB: Transgenic Overexpression of MicroRNA-30d Impairs Glucose Homeostasis by Regulating Beta-Cell Proliferation and Dedifferentiation

XIAOQING TANG
Journal: Diabetes
Diabetes 2019;68(Supplement_1):327-LB
https://doi.org/10.2337/db19-327-LB
Published: 01 June 2019
View article titled, 327-LB: Transgenic Overexpression of MicroRNA-30d Impairs Glucose Homeostasis by Regulating Beta-Cell Proliferation and Dedifferentiation
Meeting Abstracts

2005-P: Transgenic Overexpression of Human Chimeric Intestinal Alkaline Phosphatase (IAP) Improves Plasma Lipid Profile and Attenuates Western Diet (WD)-Induced Atherosclerosis in LDLR-/- Mice

SIDDHARTHA S. GHOSH, JING WANG, PAUL J. YANNIE, YASHNOOR K. SANDHU, SHOBHA GHOSH
Journal: Diabetes
Diabetes 2019;68(Supplement_1):2005-P
https://doi.org/10.2337/db19-2005-P
Published: 01 June 2019
View article titled, 2005-P: Transgenic Overexpression of Human Chimeric Intestinal Alkaline Phosphatase (IAP) Improves Plasma Lipid Profile and Attenuates Western Diet (WD)-Induced Atherosclerosis in LDLR-/- Mice
Meeting Abstracts

30-LB: Diabetes Complications Including Nephropathy, Neuropathy, and Retinopathy Can Now Be Studied in a New Spontaneous Autoimmune Diabetes Transgenic Model

SHAHNAWAZ IMAM, JUAN C. JAUME, MARIA A. ALFONSO-JAUME
Journal: Diabetes
Diabetes 2019;68(Supplement_1):30-LB
https://doi.org/10.2337/db19-30-LB
Published: 01 June 2019
View article titled, 30-LB: Diabetes Complications Including Nephropathy, Neuropathy, and Retinopathy Can Now Be Studied in a New Spontaneous Autoimmune Diabetes Transgenic Model
Meeting Abstracts

Ileum-Specific Transgenic Expression of Human Chimeric Intestinal Alkaline Phosphatase (IAP) Attenuates Western Diet (WD)–Induced Barrier Dysfunction and Glucose Intolerance

HONGLIANG HE, SIDDHARTHA S. GHOSH, PAUL J. YANNIE, II, JING WANG, SHOBHA GHOSH
Journal: Diabetes
Diabetes 2018;67(Supplement_1):151-OR
https://doi.org/10.2337/db18-151-OR
Published: 01 July 2018
View article titled, Ileum-Specific Transgenic Expression of Human Chimeric Intestinal Alkaline Phosphatase (IAP) Attenuates Western Diet (WD)–Induced Barrier Dysfunction and Glucose Intolerance
Journal Articles

Nrf2-Mediated Antioxidant Defense and Peroxiredoxin 6 Are Linked to Biosynthesis of Palmitic Acid Ester of 9-Hydroxystearic Acid

Ondrej Kuda, Marie Brezinova, Jan Silhavy, Vladimir Landa, Vaclav Zidek, Chandra Dodia, Franziska Kreuchwig, Marek Vrbacky, Laurence Balas, Thierry Durand, Norbert Hübner, Aron B. Fisher, Jan Kopecky, Michal Pravenec
Journal: Diabetes
Diabetes 2018;67(6):1190–1199
https://doi.org/10.2337/db17-1087
Published: 16 March 2018
View article titled, Nrf2-Mediated Antioxidant Defense and Peroxiredoxin 6 Are Linked to Biosynthesis of Palmitic Acid Ester of 9-Hydroxystearic Acid
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Includes: Supplementary data
Journal Articles

Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation

Andrew T. Templin, Tanya Samarasekera, Daniel T. Meier, Meghan F. Hogan, Mahnaz Mellati, Michael T. Crow, Richard N. Kitsis, Sakeneh Zraika, Rebecca L. Hull, Steven E. Kahn
Journal: Diabetes
Diabetes 2017;66(10):2636–2645
https://doi.org/10.2337/db16-1352
Published: 20 July 2017
View article titled, Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation
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Journal Articles

A SNP in the Immunoregulatory Molecule CTLA-4 Controls mRNA Splicing In Vivo but Does Not Alter Diabetes Susceptibility in the NOD Mouse

Fabian Jakubczik, Ken Jones, Jennifer Nichols, William Mansfield, Anne Cooke, Nick Holmes
Journal: Diabetes
Diabetes 2016;65(1):120–128
https://doi.org/10.2337/db15-1175
Published: 08 October 2015
View article titled, A SNP in the Immunoregulatory Molecule CTLA-4 Controls mRNA Splicing In Vivo but Does Not Alter Diabetes Susceptibility in the NOD Mouse
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Journal Articles

Centroacinar Cells Are Progenitors That Contribute to Endocrine Pancreas Regeneration

Fabien Delaspre, Rebecca L. Beer, Meritxell Rovira, Wei Huang, Guangliang Wang, Stephen Gee, Maria del Carmen Vitery, Sarah J. Wheelan, Michael J. Parsons
Journal: Diabetes
Diabetes 2015;64(10):3499–3509
https://doi.org/10.2337/db15-0153
Published: 07 July 2015
View article titled, Centroacinar Cells Are Progenitors That Contribute to Endocrine Pancreas Regeneration
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Includes: Supplementary data
Journal Articles

The Baf60c/Deptor Pathway Links Skeletal Muscle Inflammation to Glucose Homeostasis in Obesity

Zhuo-Xian Meng, Lin Wang, Yuanyuan Xiao, Jiandie D. Lin
Journal: Diabetes
Diabetes 2014;63(5):1533–1545
https://doi.org/10.2337/db13-1061
Published: 12 April 2014
View article titled, The Baf60c/Deptor Pathway Links Skeletal Muscle Inflammation to Glucose Homeostasis in Obesity
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Includes: Supplementary data
Journal Articles

Permanent Neonatal Diabetes in INSC94Y Transgenic Pigs

Simone Renner, Christina Braun-Reichhart, Andreas Blutke, Nadja Herbach, Daniela Emrich, Elisabeth Streckel, Annegret Wünsch, Barbara Kessler, Mayuko Kurome, Andrea Bähr, Nikolai Klymiuk, Stefan Krebs, Oliver Puk, Hiroshi Nagashima, Jochen Graw, Helmut Blum, Ruediger Wanke, Eckhard Wolf
Journal: Diabetes
Diabetes 2013;62(5):1505–1511
https://doi.org/10.2337/db12-1065
Published: 16 April 2013
View article titled, Permanent Neonatal Diabetes in <em>INS</em><sup>C94Y</sup> Transgenic Pigs
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Journal Articles

PTPN22 Silencing in the NOD Model Indicates the Type 1 Diabetes–Associated Allele Is Not a Loss-of-Function Variant

Peilin Zheng, Stephan Kissler
Journal: Diabetes
Diabetes 2013;62(3):896–904
https://doi.org/10.2337/db12-0929
Published: 14 February 2013
View article titled, <em>PTPN22</em> Silencing in the NOD Model Indicates the Type 1 Diabetes–Associated Allele Is Not a Loss-of-Function Variant
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Journal Articles

Nutrient Excess Stimulates β-Cell Neogenesis in Zebrafish

Lisette A. Maddison, Wenbiao Chen
Journal: Diabetes
Diabetes 2012;61(10):2517–2524
https://doi.org/10.2337/db11-1841
Published: 13 September 2012
View article titled, Nutrient Excess Stimulates β-Cell Neogenesis in Zebrafish
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Includes: Supplementary data
Journal Articles

Changing Metabolic Signatures of Amino Acids and Lipids During the Prediabetic Period in a Pig Model With Impaired Incretin Function and Reduced β-Cell Mass

Simone Renner, Werner Römisch-Margl, Cornelia Prehn, Stefan Krebs, Jerzy Adamski, Burkhard Göke, Helmut Blum, Karsten Suhre, Adelbert A. Roscher, Eckhard Wolf
Journal: Diabetes
Diabetes 2012;61(8):2166–2175
https://doi.org/10.2337/db11-1133
Published: 17 July 2012
View article titled, Changing Metabolic Signatures of Amino Acids and Lipids During the Prediabetic Period in a Pig Model With Impaired Incretin Function and Reduced β-Cell Mass
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Includes: Supplementary data
Journal Articles

How to Kill Two Birds With One Transgenic Pig

Reid A. Aikin
Journal: Diabetes
Diabetes 2012;61(6):1348–1349
https://doi.org/10.2337/db12-0201
Published: 14 May 2012
View article titled, How to Kill Two Birds With One Transgenic Pig
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Journal Articles

Xenografted Islet Cell Clusters From INSLEA29Y Transgenic Pigs Rescue Diabetes and Prevent Immune Rejection in Humanized Mice

Nikolai Klymiuk, Lelia van Buerck, Andrea Bähr, Monika Offers, Barbara Kessler, Annegret Wuensch, Mayuko Kurome, Michael Thormann, Katharina Lochner, Hiroshi Nagashima, Nadja Herbach, Rüdiger Wanke, Jochen Seissler, Eckhard Wolf
Journal: Diabetes
Diabetes 2012;61(6):1527–1532
https://doi.org/10.2337/db11-1325
Published: 14 May 2012
View article titled, Xenografted Islet Cell Clusters From <em>INS</em>LEA29Y Transgenic Pigs Rescue Diabetes and Prevent Immune Rejection in Humanized Mice
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Includes: Supplementary data
Journal Articles

Prevention of Autoimmune Diabetes by Ectopic Pancreatic β-Cell Expression of Interleukin-35

Maria Bettini, Ashley H. Castellaw, Greig P. Lennon, Amanda R. Burton, Dario A.A. Vignali
Journal: Diabetes
Diabetes 2012;61(6):1519–1526
https://doi.org/10.2337/db11-0784
Published: 14 May 2012
View article titled, Prevention of Autoimmune Diabetes by Ectopic Pancreatic β-Cell Expression of Interleukin-35
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Includes: Supplementary data
Journal Articles

APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice

Yi Wang, Kenneth K.Y. Cheng, Karen S.L. Lam, Donghai Wu, Yu Wang, Yu Huang, Paul M. Vanhoutte, Gary Sweeney, Yiming Li, Aimin Xu
Journal: Diabetes
Diabetes 2011;60(11):3044–3054
https://doi.org/10.2337/db11-0666
Published: 17 October 2011
View article titled, APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice
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Includes: Supplementary data
Journal Articles

In Vivo Misfolding of Proinsulin Below the Threshold of Frank Diabetes

Israel Hodish, Afaf Absood, Leanza Liu, Ming Liu, Leena Haataja, Dennis Larkin, Ahmed Al-Khafaji, Anthony Zaki, Peter Arvan
Journal: Diabetes
Diabetes 2011;60(8):2092–2101
https://doi.org/10.2337/db10-1671
Published: 18 July 2011
View article titled, In Vivo Misfolding of Proinsulin Below the Threshold of Frank Diabetes
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