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Journal Articles

Blocking hemopexin with specific antibodies: a new strategy for treating diabetic retinopathy

Patricia Bogdanov, Anna Duarri, David Sabater, Anna Salas, Helena Isla-Magrané, Hugo Ramos, Jordi Huerta, Marta Valeri, José García-Arumí, Rafael Simó, Cristina Hernández

Diabetes db230027

https://doi.org/10.2337/db23-0027

Published: 18 September 2023

View article titled, Blocking hemopexin with specific antibodies: a new strategy for treating diabetic retinopathy

Journal Articles

Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism

Sean M. Peterson, Christine A. Juliana, Cameron F. Hu, Jinghua Chai, Carson Holliday, Kara Y. Chan, Ana G. Lujan Hernandez, Zoe Challocombe, Linya Wang, Zhen Han, Nikhil Haas, Ryan Stafford, Fumiko Axelrod, Tom Z. Yuan, Diva D. De León, Aaron K. Sato

Diabetes 2023;72(9):1320–1329

https://doi.org/10.2337/db22-1039

Published: 26 June 2023

View article titled, Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism

Meeting Abstracts

299-OR: A Combinatorial Approach with Monoclonal Antibodies to SerpinB13 and CD3 Is Therapeutically Superior to Single Antibody Use in Autoimmune Diabetes

BARBARA SZEPIETOWSKA, SVETLANA V. AVDULOV, YURY KRYVALAP, JAN CZYZYK

Diabetes 2023;72(Supplement_1):299-OR

https://doi.org/10.2337/db23-299-OR

Published: 20 June 2023

View article titled, 299-OR: A Combinatorial Approach with Monoclonal Antibodies to SerpinB13 and CD3 Is Therapeutically Superior to Single Antibody Use in Autoimmune Diabetes

Meeting Abstracts

205-OR: Automated Multiplex Antibody Detection by Agglutination PCR (ADAP) Compared with Gold Standard Radiobinding Assays of Autoantibodies in Type 1 Diabetes

ALEXANDER LIND, ANITA RAMELIUS, EVA FREYHULT, FELIPE DE JESUS CORTEZ, RASMUS BENNET, HELENA E. LARSSON, DAVID SEFTEL, JASON TSAI, ÅKE LERNMARK

Diabetes 2023;72(Supplement_1):205-OR

https://doi.org/10.2337/db23-205-OR

Published: 20 June 2023

View article titled, 205-OR: Automated Multiplex Antibody Detection by Agglutination PCR (ADAP) Compared with Gold Standard Radiobinding Assays of Autoantibodies in Type 1 Diabetes

Meeting Abstracts

1490-P: Levels of Specific Antibodies (Ab) for Sars Cov2 after Vaccination and Its Relationship with Clinical and Metabolic Variables in People with Type 2 Diabetes vs. Controls without Diabetes

MARIA L. POMARES, GABRIELA CUZZIOL, CLAUDIO E. LOPEZ, SANDRA KREMER SENDROS, DAMIAN POMARES, MARIANA OJEDA, VICTOR WOLFFENBUTTEL CARLOTO, RINA M. TEJADA, GONZALO A. OJEDA, ANTONELA FIGUERERO, CAROLINA GOMEZ MARTIN, SILVIA GORBAN DE LAPERTOSA

Diabetes 2023;72(Supplement_1):1490-P

https://doi.org/10.2337/db23-1490-P

Published: 20 June 2023

View article titled, 1490-P: Levels of Specific Antibodies (Ab) for Sars Cov2 after Vaccination and Its Relationship with Clinical and Metabolic Variables in People with Type 2 Diabetes vs. Controls without Diabetes

Meeting Abstracts

1042-P: Qualitative Study—Provider Awareness and Attitudes towards Type 1 Diabetes Antibody Screening

EMMA L. OSPELT, HOLLY HARDISON, NICOLE RIOLES, NUDRAT NOOR, GRACE NELSON, CAROL J. LEVY, ALEXIS M. MCKEE, ZOLTAN ANTAL, JENISE C. WONG, KATHRYN OBRYNBA, OSAGIE EBEKOZIEN

Diabetes 2023;72(Supplement_1):1042-P

https://doi.org/10.2337/db23-1042-P

Published: 20 June 2023

View article titled, 1042-P: Qualitative Study—Provider Awareness and Attitudes towards Type 1 Diabetes Antibody Screening

Meeting Abstracts

240-OR: Islet Allotransplantation into Prevascularized Sernova Cell Pouch—Early Results from the University of Chicago

MATEUSZ OGLEDZINSKI, SARAH GONDEK, WILLIAM LIN, KAMILA MILEJCZYK, BRADEN JUENGEL, LISA POTTER, PIOTR J. BACHUL, LINDSAY BASTO, LAURENCIA PEREA, LINGJIA WANG, MARTIN TIBUDAN, ROLF BARTH, JOHN FUNG, PIOTR WITKOWSKI

Diabetes 2023;72(Supplement_1):240-OR

https://doi.org/10.2337/db23-240-OR

Published: 20 June 2023

View article titled, 240-OR: Islet Allotransplantation into Prevascularized Sernova Cell Pouch—Early Results from the University of Chicago

Meeting Abstracts

1440-P: Single Islet Antigen 2 Antibody–Positive (IA2A Ab+) Children Exhibit Significant Metabolic Abnormalities and 5-Year Type 1 Diabetes (T1D) Risk

EMILY K. SIMS, DAVID D. CUTHBERTSON, EMANUELE BOSI, CARMELLA EVANS-MOLINA, MARIA J. REDONDO, BRANDON M. NATHAN, HEBA M. ISMAIL, LAURA M. JACOBSEN, JAY SOSENKO

Diabetes 2023;72(Supplement_1):1440-P

https://doi.org/10.2337/db23-1440-P

Published: 20 June 2023

View article titled, 1440-P: Single Islet Antigen 2 Antibody–Positive (IA2A Ab+) Children Exhibit Significant Metabolic Abnormalities and 5-Year Type 1 Diabetes (T1D) Risk

Meeting Abstracts

1180-P: Impact of Diabetes Exposure In Utero on Mesenchymal Stem Cell Phenotype and Metabolic Function

WAI HAN LEE, DAKOTA REDLING, OLIVIA BROOKS, APRIL M. TEAGUE, SHAONING JIANG, JEANIE B. TRYGGESTAD

Diabetes 2023;72(Supplement_1):1180-P

https://doi.org/10.2337/db23-1180-P

Published: 20 June 2023

View article titled, 1180-P: Impact of Diabetes Exposure In Utero on Mesenchymal Stem Cell Phenotype and Metabolic Function

Meeting Abstracts

284-OR: An Alternative Downstream Translational Start Site in PPARG Produces a Novel Protein That Rescues Loss-of-Function Mutations in Humans

KAREN MENDEZ LARA, XIAOMI DU, KIMBERLY GLASS, RUBEN HERNANDEZ, CAMILA DE ARRUDA SALDANHA, SVEN HEINZ, AMIT R. MAJITHIA

Diabetes 2023;72(Supplement_1):284-OR

https://doi.org/10.2337/db23-284-OR

Published: 20 June 2023

View article titled, 284-OR: An Alternative Downstream Translational Start Site in PPARG Produces a Novel Protein That Rescues Loss-of-Function Mutations in Humans

Meeting Abstracts

1549-P: scEMC10 Promotes Glucose Intolerance via the Inhibition of PKA-Mediated Insulin Secretion

JIARONG DAI, SHAN LIU, KUANGYANG CHEN, SHUOSHUO JIN, YAHAO WANG, LIJIAO CHEN, XUANCHUN WANG

Diabetes 2023;72(Supplement_1):1549-P

https://doi.org/10.2337/db23-1549-P

Published: 20 June 2023

View article titled, 1549-P: scEMC10 Promotes Glucose Intolerance via the Inhibition of PKA-Mediated Insulin Secretion

Journal Articles

Perilipin 1 Antibodies in Patients With Acquired Generalized Lipodystrophy

David B. Savage

Diabetes 2023;72(1):16–18

https://doi.org/10.2337/dbi22-0022

Published: 14 December 2022

View article titled, Perilipin 1 Antibodies in Patients With Acquired Generalized Lipodystrophy

Journal Articles

Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for In Vivo β-Cell Imaging and Islet-Specific Therapies

Zheng Guo, Devi Kasinathan, Chengfeng Merriman, Maki Nakayama, Hua Li, Huilin Li, Cheng Xu, G. William Wong, Liping Yu, Maria L. Golson, Dax Fu

Diabetes 2023;72(2):184–195

https://doi.org/10.2337/db22-0477

Published: 30 November 2022

View article titled, Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for In Vivo β-Cell Imaging and Islet-Specific Therapies

Journal Articles

Antibody-Mediated Targeting of a Hybrid Insulin Peptide Toward Neonatal Thymic Langerin-Positive Cells Enhances T-Cell Central Tolerance and Delays Autoimmune Diabetes

Yong Lin, Jelena Perovanovic, Yuelin Kong, Botond Z. Igyarto, Sandra Zurawski, Dean Tantin, Gerard Zurawski, Maria Bettini, Matthew L. Bettini

Diabetes 2022;71(8):1735–1745

https://doi.org/10.2337/db21-1069

Published: 21 August 2022

View article titled, Antibody-Mediated Targeting of a Hybrid Insulin Peptide Toward Neonatal Thymic Langerin-Positive Cells Enhances T-Cell Central Tolerance and Delays Autoimmune Diabetes

Journal Articles

Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity

Mei-Ling Yang, Sean E. Connolly, Renelle J. Gee, TuKiet T. Lam, Jean Kanyo, Jian Peng, Perrin Guyer, Farooq Syed, Hubert M. Tse, Steven G. Clarke, Catherine F. Clarke, Eddie A. James, Cate Speake, Carmella Evans-Molina, Peter Arvan, Kevan C. Herold, Li Wen, Mark J. Mamula

Diabetes 2022;71(9):1979–1993

https://doi.org/10.2337/db21-0989

Published: 22 June 2022

View article titled, Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity

Journal Articles

Autoantibodies to Perilipin-1 Define a Subset of Acquired Generalized Lipodystrophy

Diabetes 2023;72(1):59–70

https://doi.org/10.2337/db21-1172

Published: 16 June 2022

View article titled, Autoantibodies to Perilipin-1 Define a Subset of Acquired Generalized Lipodystrophy

Meeting Abstracts

1122-P: Subgroup Analysis to Evaluate Individuals at Risk for Incident Diabetes

RYOMA ITO, MAKOTO DAIMON, SATORU MIZUSHIRI, SHOMA ONO, YUKI NISHIYA, AYUMI TAMURA, MASAYA MURABAYASHI, AYA KAMBA

Diabetes 2022;71(Supplement_1):1122-P

https://doi.org/10.2337/db22-1122-P

Published: 01 June 2022

View article titled, 1122-P: Subgroup Analysis to Evaluate Individuals at Risk for Incident Diabetes

Meeting Abstracts

93-LB: A Randomized Clinical Trial of Safety, Pharmacokinetics, and Pharmacodynamics of Weekly Dosing Supagutide in Healthy Chinese Subjects

ANRAN MA, YUE ZHOU, YAN-RU LOU, YIJING LIAO, ANNA SHAO, ZHIHONG WANG, YAOJING JIANG, QIAOLI CUI, YING ZHAO, JIA LI, GERALD J. PRUD’HOMME, DALONG ZHU, QINGHUA WANG

Diabetes 2022;71(Supplement_1):93-LB

https://doi.org/10.2337/db22-93-LB

Published: 01 June 2022

View article titled, 93-LB: A Randomized Clinical Trial of Safety, Pharmacokinetics, and Pharmacodynamics of Weekly Dosing Supagutide in Healthy Chinese Subjects

Meeting Abstracts

1389-P: Asprosin-Neutralizing Antibodies as a Treatment for Binge Eating

JERNEY HARMS, BING FENG, JACOB VIDRINE, PINGWEN XU, YANLIN HE

Diabetes 2022;71(Supplement_1):1389-P

https://doi.org/10.2337/db22-1389-P

Published: 01 June 2022

View article titled, 1389-P: Asprosin-Neutralizing Antibodies as a Treatment for Binge Eating

Meeting Abstracts

1250-P: Identifying Pediatric A-ß+ Ketosis-Prone Diabetes (KPD)

ELIZABETH A. KUBOTA-MISHRA, XIAOFAN C. HUANG, CHARLES G. MINARD, MARCELA ASTUDILLO, AHMAD K. REFAEY, GRACIELA MONTES, STEPHANIE SISLEY, ASHOK BALASUBRAMANYAM, MARIA J. REDONDO, MUSTAFA TOSUR, RADIANT STUDY GROUP

Diabetes 2022;71(Supplement_1):1250-P

https://doi.org/10.2337/db22-1250-P

Published: 01 June 2022

View article titled, 1250-P: Identifying Pediatric A-ß+ Ketosis-Prone Diabetes (KPD)

NARROW

Blocking hemopexin with specific antibodies: a new strategy for treating diabetic retinopathy

Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism

299-OR: A Combinatorial Approach with Monoclonal Antibodies to SerpinB13 and CD3 Is Therapeutically Superior to Single Antibody Use in Autoimmune Diabetes

205-OR: Automated Multiplex Antibody Detection by Agglutination PCR (ADAP) Compared with Gold Standard Radiobinding Assays of Autoantibodies in Type 1 Diabetes

1490-P: Levels of Specific Antibodies (Ab) for Sars Cov2 after Vaccination and Its Relationship with Clinical and Metabolic Variables in People with Type 2 Diabetes vs. Controls without Diabetes

1042-P: Qualitative Study—Provider Awareness and Attitudes towards Type 1 Diabetes Antibody Screening

240-OR: Islet Allotransplantation into Prevascularized Sernova Cell Pouch—Early Results from the University of Chicago

1440-P: Single Islet Antigen 2 Antibody–Positive (IA2A Ab+) Children Exhibit Significant Metabolic Abnormalities and 5-Year Type 1 Diabetes (T1D) Risk

1180-P: Impact of Diabetes Exposure In Utero on Mesenchymal Stem Cell Phenotype and Metabolic Function

284-OR: An Alternative Downstream Translational Start Site in PPARG Produces a Novel Protein That Rescues Loss-of-Function Mutations in Humans

1549-P: scEMC10 Promotes Glucose Intolerance via the Inhibition of PKA-Mediated Insulin Secretion

Perilipin 1 Antibodies in Patients With Acquired Generalized Lipodystrophy

Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for In Vivo β-Cell Imaging and Islet-Specific Therapies

Antibody-Mediated Targeting of a Hybrid Insulin Peptide Toward Neonatal Thymic Langerin-Positive Cells Enhances T-Cell Central Tolerance and Delays Autoimmune Diabetes

Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity

Autoantibodies to Perilipin-1 Define a Subset of Acquired Generalized Lipodystrophy

1122-P: Subgroup Analysis to Evaluate Individuals at Risk for Incident Diabetes

93-LB: A Randomized Clinical Trial of Safety, Pharmacokinetics, and Pharmacodynamics of Weekly Dosing Supagutide in Healthy Chinese Subjects

1389-P: Asprosin-Neutralizing Antibodies as a Treatment for Binge Eating

1250-P: Identifying Pediatric A-ß+ Ketosis-Prone Diabetes (KPD)

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