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Journal Articles

Immunotherapy With Low-Dose IL-2/CD25 Prevents β-Cell Dysfunction and Dysglycemia in Prediabetic NOD Mice

Farhan M. Qureshi, Julia K. Panzer, Janika Põder, Thomas R. Malek, Alejandro Caicedo
Journal: Diabetes
Diabetes 2023;72(6):769–780
DOI: https://doi.org/10.2337/db22-0482
Published: 20 March 2023
View article titled, Immunotherapy With Low-Dose IL-2/CD25 Prevents β-Cell Dysfunction and Dysglycemia in Prediabetic NOD Mice
Click here to open pdf in another window PDF for Immunotherapy With Low-Dose IL-2/CD25 Prevents β-Cell Dysfunction and Dysglycemia in Prediabetic NOD Mice
Journal Articles

Antibody-Mediated Targeting of a Hybrid Insulin Peptide Toward Neonatal Thymic Langerin-Positive Cells Enhances T-Cell Central Tolerance and Delays Autoimmune Diabetes

Yong Lin, Jelena Perovanovic, Yuelin Kong, Botond Z. Igyarto, Sandra Zurawski, Dean Tantin, Gerard Zurawski, Maria Bettini, Matthew L. Bettini
Journal: Diabetes
Diabetes 2022;71(8):1735–1745
DOI: https://doi.org/10.2337/db21-1069
Published: 21 August 2022
View article titled, Antibody-Mediated Targeting of a Hybrid Insulin Peptide Toward Neonatal Thymic Langerin-Positive Cells Enhances T-Cell Central Tolerance and Delays Autoimmune Diabetes
Click here to open pdf in another window PDF for Antibody-Mediated Targeting of a Hybrid Insulin Peptide Toward Neonatal Thymic Langerin-Positive Cells Enhances T-Cell Central Tolerance and Delays Autoimmune Diabetes
Journal Articles

Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells

Sherman S. Leung, Danielle J. Borg, Domenica A. McCarthy, Tamar E. Boursalian, Justen Cracraft, Aowen Zhuang, Amelia K. Fotheringham, Nicole Flemming, Thomas Watkins, John J. Miles, Per-Henrik Groop, Jean L. Scheijen, Casper G. Schalkwijk, Raymond J. Steptoe, Kristen J. Radford, Mikael Knip, Josephine M. Forbes
Journal: Diabetes
Diabetes 2022;71(9):1994–2008
DOI: https://doi.org/10.2337/db22-0177
Published: 17 June 2022
View article titled, Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells
Click here to open pdf in another window PDF for Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells
Journal Articles

Persistent IL-2 Receptor Signaling by IL-2/CD25 Fusion Protein Controls Diabetes in NOD Mice by Multiple Mechanisms

Natasha C. Ward, Jen Bon Lui, Rosmely Hernandez, Liping Yu, Mary Struthers, Jenny Xie, Alicia Santos Savio, Connor J. Dwyer, Sunnie Hsiung, Aixin Yu, Thomas R. Malek
Journal: Diabetes
Diabetes 2020;69(11):2400–2413
DOI: https://doi.org/10.2337/db20-0186
Published: 25 August 2020
View article titled, Persistent IL-2 Receptor Signaling by IL-2/CD25 Fusion Protein Controls Diabetes in NOD Mice by Multiple Mechanisms
Click here to open pdf in another window PDF for Persistent IL-2 Receptor Signaling by IL-2/CD25 Fusion Protein Controls Diabetes in NOD Mice by Multiple Mechanisms
Journal Articles

Low-Dose Interleukin-2 Combined With Rapamycin Led to an Expansion of CD4+CD25+FOXP3+ Regulatory T Cells and Prolonged Human Islet Allograft Survival in Humanized Mice

Min Hu, Wayne J. Hawthorne, Leigh Nicholson, Heather Burns, Yi Wen Qian, David Liuwantara, Elvira Jimenez Vera, Yi Vee Chew, Lindy Williams, Shounan Yi, Karen Keung, Debbie Watson, Natasha Rogers, Stephen I. Alexander, Philip J. O’Connell
Journal: Diabetes
Diabetes 2020;69(8):1735–1748
DOI: https://doi.org/10.2337/db19-0525
Published: 07 May 2020
View article titled, Low-Dose Interleukin-2 Combined With Rapamycin Led to an Expansion of CD4<sup>+</sup>CD25<sup>+</sup>FOXP3<sup>+</sup> Regulatory T Cells and Prolonged Human Islet Allograft Survival in Humanized Mice
Click here to open pdf in another window PDF for Low-Dose Interleukin-2 Combined With Rapamycin Led to an Expansion of CD4<sup>+</sup>CD25<sup>+</sup>FOXP3<sup>+</sup> Regulatory T Cells and Prolonged Human Islet Allograft Survival in Humanized Mice
Journal Articles

Microencapsulated G3C Hybridoma Cell Graft Delays the Onset of Spontaneous Diabetes in NOD Mice by an Expansion of Gitr+ Treg Cells

Luigi Cari, Pia Montanucci, Giuseppe Basta, Maria G. Petrillo, Erika Ricci, Teresa Pescara, Alessia Greco, Sabrina Cipriani, Jun Shimizu, Graziella Migliorati, Giuseppe Nocentini, Riccardo Calafiore, Carlo Riccardi
Journal: Diabetes
Diabetes 2020;69(5):965–980
DOI: https://doi.org/10.2337/db19-0087
Published: 13 March 2020
View article titled, Microencapsulated G3C Hybridoma Cell Graft Delays the Onset of Spontaneous Diabetes in NOD Mice by an Expansion of Gitr<sup>+</sup> Treg Cells
Click here to open pdf in another window PDF for Microencapsulated G3C Hybridoma Cell Graft Delays the Onset of Spontaneous Diabetes in NOD Mice by an Expansion of Gitr<sup>+</sup> Treg Cells
Includes: Supplementary data
Journal Articles

Islet-Derived eATP Fuels Autoreactive CD8+ T Cells and Facilitates the Onset of Type 1 Diabetes

Sara Tezza, Moufida Ben Nasr, Francesca D’Addio, Andrea Vergani, Vera Usuelli, Simonetta Falzoni, Roberto Bassi, Sergio Dellepiane, Carmen Fotino, Chiara Rossi, Anna Maestroni, Anna Solini, Domenico Corradi, Elisa Giani, Chiara Mameli, Federico Bertuzzi, Marcus G. Pezzolesi, Clive H. Wasserfall, Mark A. Atkinson, Ernst-Martin Füchtbauer, Camillo Ricordi, Franco Folli, Francesco Di Virgilio, Antonello Pileggi, Sirano Dhe-Paganon, Gian Vincenzo Zuccotti, Paolo Fiorina
Journal: Diabetes
Diabetes 2018;67(10):2038–2053
DOI: https://doi.org/10.2337/db17-1227
Published: 31 July 2018
View article titled, Islet-Derived eATP Fuels Autoreactive CD8<sup>+</sup> T Cells and Facilitates the Onset of Type 1 Diabetes
Click here to open pdf in another window PDF for Islet-Derived eATP Fuels Autoreactive CD8<sup>+</sup> T Cells and Facilitates the Onset of Type 1 Diabetes
Journal Articles

A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes

Anne M. Pesenacker, Adele Y. Wang, Amrit Singh, Jana Gillies, Youngwoong Kim, Ciriaco A. Piccirillo, Duc Nguyen, W. Nicholas Haining, Scott J. Tebbutt, Constadina Panagiotopoulos, Megan K. Levings
Journal: Diabetes
Diabetes 2016;65(4):1031–1039
DOI: https://doi.org/10.2337/db15-0572
Published: 19 January 2016
View article titled, A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes
Click here to open pdf in another window PDF for A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes
Includes: Supplementary data
Journal Articles

Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes

Jennie H.M. Yang, Antony J. Cutler, Ricardo C. Ferreira, James L. Reading, Nicholas J. Cooper, Chris Wallace, Pamela Clarke, Deborah J. Smyth, Christopher S. Boyce, Guo-Jian Gao, John A. Todd, Linda S. Wicker, Timothy I.M. Tree
Journal: Diabetes
Diabetes 2015;64(11):3891–3902
DOI: https://doi.org/10.2337/db15-0516
Published: 29 July 2015
View article titled, Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes
Click here to open pdf in another window PDF for Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes
Includes: Supplementary data
Journal Articles

Reactivated CD4+Tm Cells of T1D Patients and Siblings Display an Exaggerated Effector Phenotype With Heightened Sensitivity to Activation-Induced Cell Death

Michael Lei Bian, Oscar Haigh, David Munster, Mark Harris, Andrew Cotterill, John J. Miles, Slavica Vuckovic
Journal: Diabetes
Diabetes 2015;64(6):2161–2171
DOI: https://doi.org/10.2337/db14-1151
Published: 31 December 2014
View article titled, Reactivated CD4<sup>+</sup>Tm Cells of T1D Patients and Siblings Display an Exaggerated Effector Phenotype With Heightened Sensitivity to Activation-Induced Cell Death
Click here to open pdf in another window PDF for Reactivated CD4<sup>+</sup>Tm Cells of T1D Patients and Siblings Display an Exaggerated Effector Phenotype With Heightened Sensitivity to Activation-Induced Cell Death
Includes: Supplementary data
Journal Articles

Activation of Islet Autoreactive Naïve T Cells in Infants Is Influenced by Homeostatic Mechanisms and Antigen-Presenting Capacity

Anne-Kristin Heninger, Paolo Monti, Carmen Wilhelm, Petra Schwaiger, Denise Kuehn, Anette-G. Ziegler, Ezio Bonifacio
Journal: Diabetes
Diabetes 2013;62(6):2059–2066
DOI: https://doi.org/10.2337/db12-0942
Published: 17 May 2013
View article titled, Activation of Islet Autoreactive Naïve T Cells in Infants Is Influenced by Homeostatic Mechanisms and Antigen-Presenting Capacity
Click here to open pdf in another window PDF for Activation of Islet Autoreactive Naïve T Cells in Infants Is Influenced by Homeostatic Mechanisms and Antigen-Presenting Capacity
Includes: Supplementary data
Journal Articles

Immune Regulatory Properties of Allogeneic Adipose-Derived Mesenchymal Stem Cells in the Treatment of Experimental Autoimmune Diabetes

Ênio J. Bassi, Pedro M.M. Moraes-Vieira, Carla S.R. Moreira-Sá, Danilo C. Almeida, Leonardo M. Vieira, Cláudia S. Cunha, Meire I. Hiyane, Alexandre S. Basso, Alvaro Pacheco-Silva, Niels O.S. Câmara
Journal: Diabetes
Diabetes 2012;61(10):2534–2545
DOI: https://doi.org/10.2337/db11-0844
Published: 13 September 2012
View article titled, Immune Regulatory Properties of Allogeneic Adipose-Derived Mesenchymal Stem Cells in the Treatment of Experimental Autoimmune Diabetes
Click here to open pdf in another window PDF for Immune Regulatory Properties of Allogeneic Adipose-Derived Mesenchymal Stem Cells in the Treatment of Experimental Autoimmune Diabetes
Includes: Supplementary data
Journal Articles

The Novel Therapeutic Effect of Phosphoinositide 3-Kinase-γ Inhibitor AS605240 in Autoimmune Diabetes

Jamil Azzi, Robert F. Moore, Wassim Elyaman, Marwan Mounayar, Najib El Haddad, Sunmi Yang, Mollie Jurewicz, Ayumi Takakura, Alessandra Petrelli, Paolo Fiorina, Thomas Ruckle, Reza Abdi
Journal: Diabetes
Diabetes 2012;61(6):1509–1518
DOI: https://doi.org/10.2337/db11-0134
Published: 14 May 2012
View article titled, The Novel Therapeutic Effect of Phosphoinositide 3-Kinase-γ Inhibitor AS605240 in Autoimmune Diabetes
Click here to open pdf in another window PDF for The Novel Therapeutic Effect of Phosphoinositide 3-Kinase-γ Inhibitor AS605240 in Autoimmune Diabetes
Includes: Supplementary data
Journal Articles

Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice

Shounan Yi, Ming Ji, Jingjing Wu, Xiaoqian Ma, Peta Phillips, Wayne J. Hawthorne, Philip J. O’Connell
Journal: Diabetes
Diabetes 2012;61(5):1180–1191
DOI: https://doi.org/10.2337/db11-1306
Published: 13 April 2012
View article titled, Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice
Click here to open pdf in another window PDF for Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice
Includes: Supplementary data
Journal Articles

Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients With Type 1 Diabetes

Alessandra Ferraro, Carlo Socci, Angela Stabilini, Andrea Valle, Paolo Monti, Lorenzo Piemonti, Rita Nano, Sven Olek, Paola Maffi, Marina Scavini, Antonio Secchi, Carlo Staudacher, Ezio Bonifacio, Manuela Battaglia
Journal: Diabetes
Diabetes 2011;60(11):2903–2913
DOI: https://doi.org/10.2337/db11-0090
Published: 17 October 2011
View article titled, Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients With Type 1 Diabetes
Click here to open pdf in another window PDF for Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients With Type 1 Diabetes
Includes: Supplementary data
Journal Articles

Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy

Kathrin Eller, Alexander Kirsch, Anna M. Wolf, Sieghart Sopper, Andrea Tagwerker, Ursula Stanzl, Dominik Wolf, Wolfgang Patsch, Alexander R. Rosenkranz, Philipp Eller
Journal: Diabetes
Diabetes 2011;60(11):2954–2962
DOI: https://doi.org/10.2337/db11-0358
Published: 17 October 2011
View article titled, Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy
Click here to open pdf in another window PDF for Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy
Journal Articles

Genetic Analysis of Adult-Onset Autoimmune Diabetes

Joanna M.M. Howson, Silke Rosinger, Deborah J. Smyth, Bernhard O. Boehm, the ADBW-END Study Group, John A. Todd
Journal: Diabetes
Diabetes 2011;60(10):2645–2653
DOI: https://doi.org/10.2337/db11-0364
Published: 16 September 2011
View article titled, Genetic Analysis of Adult-Onset Autoimmune Diabetes
Click here to open pdf in another window PDF for Genetic Analysis of Adult-Onset Autoimmune Diabetes
Includes: Supplementary data
Journal Articles

Defective Differentiation of Regulatory FoxP3+ T Cells by Small-Intestinal Dendritic Cells in Patients With Type 1 Diabetes

Ester Badami, Chiara Sorini, Margherita Coccia, Vera Usuelli, Laura Molteni, Andrea Mario Bolla, Marina Scavini, Alberto Mariani, Cecile King, Emanuele Bosi, Marika Falcone
Journal: Diabetes
Diabetes 2011;60(8):2120–2124
DOI: https://doi.org/10.2337/db10-1201
Published: 18 July 2011
View article titled, Defective Differentiation of Regulatory FoxP3<sup>+</sup> T Cells by Small-Intestinal Dendritic Cells in Patients With Type 1 Diabetes
Click here to open pdf in another window PDF for Defective Differentiation of Regulatory FoxP3<sup>+</sup> T Cells by Small-Intestinal Dendritic Cells in Patients With Type 1 Diabetes
Includes: Supplementary data
Journal Articles

The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function

Kay D. Gerold, Peilin Zheng, Daniel B. Rainbow, Alma Zernecke, Linda S. Wicker, Stephan Kissler
Journal: Diabetes
Diabetes 2011;60(7):1955–1963
DOI: https://doi.org/10.2337/db11-0130
Published: 20 June 2011
View article titled, The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function
Click here to open pdf in another window PDF for The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function
Includes: Supplementary data
Journal Articles

Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects

S. Alice Long, Karen Cerosaletti, Paul L. Bollyky, Megan Tatum, Heather Shilling, Sheng Zhang, Zhong-Yin Zhang, Catherine Pihoker, Srinath Sanda, Carla Greenbaum, Jane H. Buckner
Journal: Diabetes
Diabetes 2010;59(2):407–415
DOI: https://doi.org/10.2337/db09-0694
Published: 29 October 2009
View article titled, Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4<sup>+</sup>CD25<sup>+</sup> Regulatory T-Cells of Type 1 Diabetic Subjects
Click here to open pdf in another window PDF for Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4<sup>+</sup>CD25<sup>+</sup> Regulatory T-Cells of Type 1 Diabetic Subjects
Includes: Supplementary data