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Meeting Abstracts

38-OR: Insulin Prevents Palmitate-Induced Stress Kinase Activation, Autophagy, and Apoptosis in Human Cardiac Progenitor Cells

ISABELLA CALDERONI, ROSSELLA DORIA, CRISTINA CACCIOPPOLI, VALENTINA ANNAMARIA GENCHI, GIUSEPPE PALMA, GIUSEPPE SANTARPINO, ALDO D. MILANO, ANNA LEONARDINI, ANNALISA NATALICCHIO, SEBASTIO PERRINI, ANGELO CIGNARELLI, FRANCESCO GIORGINO, LUIGI LAVIOLA

Diabetes 2023;72(Supplement_1):38-OR

https://doi.org/10.2337/db23-38-OR

Published: 20 June 2023

View article titled, 38-OR: Insulin Prevents Palmitate-Induced Stress Kinase Activation, Autophagy, and Apoptosis in Human Cardiac Progenitor Cells

Meeting Abstracts

288-LB: CHIP Haplodeficiency Exacerbates Experimental Type 1 Diabetes via the Regulation of DNA Damage Response and Apoptosis

AE-RANG HWANG HWANG

Diabetes 2023;72(Supplement_1):288-LB

https://doi.org/10.2337/db23-288-LB

Published: 20 June 2023

View article titled, 288-LB: CHIP Haplodeficiency Exacerbates Experimental Type 1 Diabetes via the Regulation of DNA Damage Response and Apoptosis

Journal Articles

FGF13-Sensitive Alteration of Parkin Safeguards Mitochondrial Homeostasis in Endothelium of Diabetic Nephropathy

Jia Sun, Xueqiang Guan, Chao Niu, Peng Chen, Yuankuan Li, Xuejiao Wang, Lan Luo, Mengxue Liu, Yanni Shou, Xiaozhong Huang, Yan Cai, Junjie Zhu, Junfu Fan, Xiaokun Li, Litai Jin, Weitao Cong

Diabetes 2023;72(1):97–111

https://doi.org/10.2337/db22-0231

Published: 18 October 2022

View article titled, FGF13-Sensitive Alteration of Parkin Safeguards Mitochondrial Homeostasis in Endothelium of Diabetic Nephropathy

Journal Articles

Critical Role for Macrophages in the Developmental Programming of Pancreatic β-Cell Area in Offspring of Hypertensive Pregnancies

Kate M. Root, Brian Akhaphong, Melissa A. Cedars, Alexa M. Molin, Margaretta E. Huchthausen, Connor F. Laule, Ronald R. Regal, Emilyn U. Alejandro, Jean F. Regal

Diabetes 2022;71(12):2597–2611

https://doi.org/10.2337/db22-0404

Published: 20 September 2022

View article titled, Critical Role for Macrophages in the Developmental Programming of Pancreatic β-Cell Area in Offspring of Hypertensive Pregnancies

Meeting Abstracts

245-LB: An Ankyrin-B–Mediated Protein Chaperone Mechanism Modulates Pancreatic ß-Cell Susceptibility to Proteotoxicity-Induced ER Stress and Apoptosis

JOYCE TZENG, HANS-EWALD HOHMEIER, DAMARIS LORENZO

Diabetes 2022;71(Supplement_1):245-LB

https://doi.org/10.2337/db22-245-LB

Published: 01 June 2022

View article titled, 245-LB: An Ankyrin-B–Mediated Protein Chaperone Mechanism Modulates Pancreatic ß-Cell Susceptibility to Proteotoxicity-Induced ER Stress and Apoptosis

Journal Articles

Imeglimin to the Rescue: Enhanced CHOP/GADD34/eIF2α Signaling Axis Promotes β-Cell Survival

Seokwon Jo, Emilyn U. Alejandro

Diabetes 2022;71(3):376–378

https://doi.org/10.2337/dbi21-0035

Published: 23 February 2022

View article titled, Imeglimin to the Rescue: Enhanced CHOP/GADD34/eIF2α Signaling Axis Promotes β-Cell Survival

Journal Articles

Lactate Is a Key Mediator That Links Obesity to Insulin Resistance via Modulating Cytokine Production From Adipose Tissue

Yijun Lin, Meijuan Bai, Shuo Wang, Lingling Chen, Zixuan Li, Chenchen Li, Peijuan Cao, Yan Chen

Diabetes 2022;71(4):637–652

https://doi.org/10.2337/db21-0535

Published: 19 January 2022

View article titled, Lactate Is a Key Mediator That Links Obesity to Insulin Resistance via Modulating Cytokine Production From Adipose Tissue

Journal Articles

Diabetes: Concepts of β-Cell Organ Dysfunction and Failure Would Lead to Earlier Diagnoses and Prevention

M. Arthur Charles, R. David Leslie

Diabetes 2021;70(11):2444–2456

https://doi.org/10.2337/dbi21-0012

Published: 22 October 2021

View article titled, Diabetes: Concepts of β-Cell Organ Dysfunction and Failure Would Lead to Earlier Diagnoses and Prevention

Journal Articles

Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway

Jinghe Li, Ryota Inoue, Yu Togashi, Tomoko Okuyama, Aoi Satoh, Mayu Kyohara, Kuniyuki Nishiyama, Takahiro Tsuno, Daisuke Miyashita, Tatsuya Kin, A.M. James Shapiro, Resilind Su Ern Chew, Adrian Kee Keong Teo, Seiichi Oyadomari, Yasuo Terauchi, Jun Shirakawa

Diabetes 2022;71(3):424–439

https://doi.org/10.2337/db21-0123

Published: 29 September 2021

View article titled, Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway

Journal Articles

Hepatocytic Activating Transcription Factor 3 Protects Against Steatohepatitis via Hepatocyte Nuclear Factor 4α

Yanyong Xu, Shuwei Hu, Kavita Jadhav, Yingdong Zhu, Xiaoli Pan, Fathima Cassim Bawa, Liya Yin, Yanqiao Zhang

Diabetes 2021;70(11):2506–2517

https://doi.org/10.2337/db21-0181

Published: 02 September 2021

View article titled, Hepatocytic Activating Transcription Factor 3 Protects Against Steatohepatitis via Hepatocyte Nuclear Factor 4α

Journal Articles

Pinch Loss Ameliorates Obesity, Glucose Intolerance, and Fatty Liver by Modulating Adipocyte Apoptosis in Mice

Huanqing Gao, Yiming Zhong, Zhen Ding, Sixiong Lin, Xiaoting Hou, Wanze Tang, Xiaoqian Zhou, Xuenong Zou, Jie Shao, Fan Yang, Xiaochun Bai, Chuanju Liu, Huiling Cao, Guozhi Xiao

Diabetes 2021;70(11):2492–2505

https://doi.org/10.2337/db21-0392

Published: 11 August 2021

View article titled, Pinch Loss Ameliorates Obesity, Glucose Intolerance, and Fatty Liver by Modulating Adipocyte Apoptosis in Mice

Journal Articles

The Attenuation of Diabetic Nephropathy by Annexin A1 via Regulation of Lipid Metabolism Through the AMPK/PPARα/CPT1b Pathway

Liang Wu, Changjie Liu, Dong-Yuan Chang, Rui Zhan, Mingming Zhao, Sin Man Lam, Guanghou Shui, Ming-Hui Zhao, Lemin Zheng, Min Chen

Diabetes 2021;70(10):2192–2203

https://doi.org/10.2337/db21-0050

Published: 08 June 2021

View article titled, The Attenuation of Diabetic Nephropathy by Annexin A1 via Regulation of Lipid Metabolism Through the AMPK/PPARα/CPT1b Pathway

Meeting Abstracts

416-P: Palmitic Acid-Induced Schwann Cells Apoptosis and Oxidative Stress in Diabetes Peripheral Neuropathy

JINGWEN FAN, LIXIN GUO

Diabetes 2021;70(Supplement_1):416-P

https://doi.org/10.2337/db21-416-P

Published: 01 June 2021

View article titled, 416-P: Palmitic Acid-Induced Schwann Cells Apoptosis and Oxidative Stress in Diabetes Peripheral Neuropathy

Meeting Abstracts

1169-P: PNPLA3 148M Is More Susceptible to PA-Induced Endoplasmic Reticulum Stress-Associated Apoptosis in HepG2 Cells

HUA LIANG

Diabetes 2021;70(Supplement_1):1169-P

https://doi.org/10.2337/db21-1169-P

Published: 01 June 2021

View article titled, 1169-P: PNPLA3 148M Is More Susceptible to PA-Induced Endoplasmic Reticulum Stress-Associated Apoptosis in HepG2 Cells

Meeting Abstracts

1208-P: Caloric Restriction Modified Factors Regulating Lipid Storage and Apoptosis in Inguinal but Not Epididymal Adipose Tissue of 24-Month-Old Male Rats

PALLAVI VARSHNEY, MICHAEL W. SCHLEH, CHEEHOON AHN, AMY ZHENG, EDWARD B. ARIAS, GREGORY D. CARTEE, JEFFREY F. HOROWITZ

Diabetes 2021;70(Supplement_1):1208-P

https://doi.org/10.2337/db21-1208-P

Published: 01 June 2021

View article titled, 1208-P: Caloric Restriction Modified Factors Regulating Lipid Storage and Apoptosis in Inguinal but Not Epididymal Adipose Tissue of 24-Month-Old Male Rats

Meeting Abstracts

1241-P: Inhibition of MiR-146a-5p Prevents Mitochondrial Dysfunction and ß-Cell Apoptosis, and Improves Insulin Secretion

PREETHI KRISHNAN, FAROOQ SYED, STACI A. WEAVER, CHIH-CHUN LEE, CARMELLA EVANS-MOLINA

Diabetes 2021;70(Supplement_1):1241-P

https://doi.org/10.2337/db21-1241-P

Published: 01 June 2021

View article titled, 1241-P: Inhibition of MiR-146a-5p Prevents Mitochondrial Dysfunction and ß-Cell Apoptosis, and Improves Insulin Secretion

Journal Articles

SKAP2, a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients

Tina Fløyel, Kira Meyerovich, Michala C. Prause, Simranjeet Kaur, Caroline Frørup, Henrik B. Mortensen, Lotte B. Nielsen, Flemming Pociot, Alessandra K. Cardozo, Joachim Størling

Diabetes 2021;70(2):464–476

https://doi.org/10.2337/db20-0092

Published: 17 November 2020

View article titled, <em>SKAP2</em>, a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients

Journal Articles

Dapagliflozin Suppresses ER Stress and Improves Subclinical Myocardial Function in Diabetes: From Bedside to Bench

Jhih-Yuan Shih, Yu-Wen Lin, Sudeshna Fisch, Juei-Tang Cheng, Nai-Wen Kang, Chon-Seng Hong, Zhih-Cherng Chen, Wei-Ting Chang

Diabetes 2021;70(1):262–267

https://doi.org/10.2337/db20-0840

Published: 28 October 2020

View article titled, Dapagliflozin Suppresses ER Stress and Improves Subclinical Myocardial Function in Diabetes: From Bedside to Bench

Journal Articles

Protection of Pancreatic Islets Using Theranostic Silencing Nanoparticles in a Baboon Model of Islet Transplantation

Thomas Pomposelli, Ping Wang, Kazuhiro Takeuchi, Katsunori Miyake, Yuichi Ariyoshi, Hironosuke Watanabe, Xiaojuan Chen, Akira Shimizu, Neil Robertson, Kazuhiko Yamada, Anna Moore

Diabetes 2020;69(11):2414–2422

https://doi.org/10.2337/db20-0517

Published: 27 August 2020

View article titled, Protection of Pancreatic Islets Using Theranostic Silencing Nanoparticles in a Baboon Model of Islet Transplantation

Meeting Abstracts

1723-P: Transcription Factor Foxo1 Mediates TGF-ß1-Induced Apoptosis in Primary Hepatocytes

WEIQI AI, WANG LIAO, QUAN PAN, WANBAO YANG, ZHENG SHEN, SHAODONG GUO, SR., YUNMEI CHEN

Diabetes 2020;69(Supplement_1):1723-P

https://doi.org/10.2337/db20-1723-P

Published: 01 June 2020

View article titled, 1723-P: Transcription Factor Foxo1 Mediates TGF-ß1-Induced Apoptosis in Primary Hepatocytes

NARROW

38-OR: Insulin Prevents Palmitate-Induced Stress Kinase Activation, Autophagy, and Apoptosis in Human Cardiac Progenitor Cells

288-LB: CHIP Haplodeficiency Exacerbates Experimental Type 1 Diabetes via the Regulation of DNA Damage Response and Apoptosis

FGF13-Sensitive Alteration of Parkin Safeguards Mitochondrial Homeostasis in Endothelium of Diabetic Nephropathy

Critical Role for Macrophages in the Developmental Programming of Pancreatic β-Cell Area in Offspring of Hypertensive Pregnancies

245-LB: An Ankyrin-B–Mediated Protein Chaperone Mechanism Modulates Pancreatic ß-Cell Susceptibility to Proteotoxicity-Induced ER Stress and Apoptosis

Imeglimin to the Rescue: Enhanced CHOP/GADD34/eIF2α Signaling Axis Promotes β-Cell Survival

Lactate Is a Key Mediator That Links Obesity to Insulin Resistance via Modulating Cytokine Production From Adipose Tissue

Diabetes: Concepts of β-Cell Organ Dysfunction and Failure Would Lead to Earlier Diagnoses and Prevention

Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway

Hepatocytic Activating Transcription Factor 3 Protects Against Steatohepatitis via Hepatocyte Nuclear Factor 4α

Pinch Loss Ameliorates Obesity, Glucose Intolerance, and Fatty Liver by Modulating Adipocyte Apoptosis in Mice

The Attenuation of Diabetic Nephropathy by Annexin A1 via Regulation of Lipid Metabolism Through the AMPK/PPARα/CPT1b Pathway

416-P: Palmitic Acid-Induced Schwann Cells Apoptosis and Oxidative Stress in Diabetes Peripheral Neuropathy

1169-P: PNPLA3 148M Is More Susceptible to PA-Induced Endoplasmic Reticulum Stress-Associated Apoptosis in HepG2 Cells

1208-P: Caloric Restriction Modified Factors Regulating Lipid Storage and Apoptosis in Inguinal but Not Epididymal Adipose Tissue of 24-Month-Old Male Rats

1241-P: Inhibition of MiR-146a-5p Prevents Mitochondrial Dysfunction and ß-Cell Apoptosis, and Improves Insulin Secretion

SKAP2, a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients

Dapagliflozin Suppresses ER Stress and Improves Subclinical Myocardial Function in Diabetes: From Bedside to Bench

Protection of Pancreatic Islets Using Theranostic Silencing Nanoparticles in a Baboon Model of Islet Transplantation

1723-P: Transcription Factor Foxo1 Mediates TGF-ß1-Induced Apoptosis in Primary Hepatocytes

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