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Journal Articles

Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for In Vivo β-Cell Imaging and Islet-Specific Therapies

Zheng Guo, Devi Kasinathan, Chengfeng Merriman, Maki Nakayama, Hua Li, Huilin Li, Cheng Xu, G. William Wong, Liping Yu, Maria L. Golson, Dax Fu
Journal: Diabetes
Diabetes 2023;72(2):184–195
DOI: https://doi.org/10.2337/db22-0477
Published: 30 November 2022
View article titled, Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for In Vivo β-Cell Imaging and Islet-Specific Therapies
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Journal Articles

Islet Autoantibody Levels Differentiate Progression Trajectories in Individuals With Presymptomatic Type 1 Diabetes

Bum Chul Kwon, Peter Achenbach, Vibha Anand, Brigitte I. Frohnert, William Hagopian, Jianying Hu, Eileen Koski, Åke Lernmark, Olivia Lou, Frank Martin, Kenney Ng, Jorma Toppari, Riitta Veijola
Journal: Diabetes
Diabetes 2022;71(12):2632–2641
DOI: https://doi.org/10.2337/db22-0360
Published: 16 September 2022
View article titled, Islet Autoantibody Levels Differentiate Progression Trajectories in Individuals With Presymptomatic Type 1 Diabetes
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Journal Articles

Characterization and Clinical Association of Autoantibodies Against Perilipin 1 in Patients With Acquired Generalized Lipodystrophy

Fernando Corvillo, Brent S. Abel, Alberto López-Lera, Giovanni Ceccarini, Silvia Magno, Ferruccio Santini, David Araújo-Vilar, Rebecca J. Brown, Pilar Nozal, Margarita López-Trascasa
Journal: Diabetes
Diabetes 2023;72(1):71–84
DOI: https://doi.org/10.2337/db21-1086
Published: 30 June 2022
View article titled, Characterization and Clinical Association of Autoantibodies Against Perilipin 1 in Patients With Acquired Generalized Lipodystrophy
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Journal Articles

Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity

Mei-Ling Yang, Sean E. Connolly, Renelle J. Gee, TuKiet T. Lam, Jean Kanyo, Jian Peng, Perrin Guyer, Farooq Syed, Hubert M. Tse, Steven G. Clarke, Catherine F. Clarke, Eddie A. James, Cate Speake, Carmella Evans-Molina, Peter Arvan, Kevan C. Herold, Li Wen, Mark J. Mamula
Journal: Diabetes
Diabetes 2022;71(9):1979–1993
DOI: https://doi.org/10.2337/db21-0989
Published: 22 June 2022
View article titled, Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity
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Journal Articles

Changes in the Coexpression of Innate Immunity Genes During Persistent Islet Autoimmunity Are Associated With Progression of Islet Autoimmunity: Diabetes Autoimmunity Study in the Young (DAISY)

Patrick M. Carry, Kathleen Waugh, Lauren A. Vanderlinden, Randi K. Johnson, Teresa Buckner, Marian Rewers, Andrea K. Steck, Ivana Yang, Tasha E. Fingerlin, Katerina Kechris, Jill M. Norris
Journal: Diabetes
Diabetes 2022;71(9):2048–2057
DOI: https://doi.org/10.2337/db21-1111
Published: 20 June 2022
View article titled, Changes in the Coexpression of Innate Immunity Genes During Persistent Islet Autoimmunity Are Associated With Progression of Islet Autoimmunity: Diabetes Autoimmunity Study in the Young (DAISY)
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Journal Articles

Autoantibodies to Perilipin-1 Define a Subset of Acquired Generalized Lipodystrophy

Caleigh Mandel-Brehm, Sara E. Vazquez, Christopher Liverman, Mickie Cheng, Zoe Quandt, Andrew F. Kung, Audrey Parent, Brenda Miao, Emmanuel Disse, Christine Cugnet-Anceau, Stéphane Dalle, Elizaveta Orlova, Elena Frolova, Diana Alba, Aaron Michels, Bergithe E. Oftedal, Michail S. Lionakis, Eystein S. Husebye, Anil K. Agarwal, Xilong Li, Chengsong Zhu, Quan Li, Elif Oral, Rebecca Brown, Mark S. Anderson, Abhimanyu Garg, Joseph L. DeRisi
Journal: Diabetes
Diabetes 2023;72(1):59–70
DOI: https://doi.org/10.2337/db21-1172
Published: 16 June 2022
View article titled, Autoantibodies to Perilipin-1 Define a Subset of Acquired Generalized Lipodystrophy
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Meeting Abstracts

204-LB: An Unusual Case of Autoantibody-Negative Ketosis-Prone Diabetes (KPD) Secondary to Marked Insulin Resistance

MARCO INFANTE, PASQUALE DIPERNA, MARINA PASSERI, ROSANNA MONETTA, FRANCO PAPOLA, FRANCESCO BRANCATI, MASSIMILIANO CAPRIO, ANDREA FABBRI
Journal: Diabetes
Diabetes 2022;71(Supplement_1):204-LB
DOI: https://doi.org/10.2337/db22-204-LB
Published: 01 June 2022
View article titled, 204-LB: An Unusual Case of Autoantibody-Negative Ketosis-Prone Diabetes (KPD) Secondary to Marked Insulin Resistance
Meeting Abstracts

1255-P: IA-2A Autoantibody Titers Predict Subsequent Divergence between Nonprogressors (NP) and Progressors (P) to Type 1 Diabetes with Similar Degree of Initial Metabolic Abnormality

EMILY K. SIMS, DAVID D. CUTHBERTSON, LAURA M. JACOBSEN, HEBA M. ISMAIL, BRANDON M. NATHAN, MARIA J. REDONDO, JAY SOSENKO
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1255-P
DOI: https://doi.org/10.2337/db22-1255-P
Published: 01 June 2022
View article titled, 1255-P: IA-2A Autoantibody Titers Predict Subsequent Divergence between Nonprogressors (NP) and Progressors (P) to Type 1 Diabetes with Similar Degree of Initial Metabolic Abnormality
Meeting Abstracts

1221-P: Clinical Significance of Autoantibody Measurement for Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 in the Plasma

HIROKI YAMAGATA, SHUNICHIRO ONISHI, TOMOHIKO YOSHIDA, TAKAKI HIWASA, MINORU TAKEMOTO
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1221-P
DOI: https://doi.org/10.2337/db22-1221-P
Published: 01 June 2022
View article titled, 1221-P: Clinical Significance of Autoantibody Measurement for Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 in the Plasma
Meeting Abstracts

350-OR: The Oral Disposition Index (ODI) Predicts Type 1 Diabetes (T1D) in Autoantibody-Positive (Ab+) Individuals

HEBA M. ISMAIL, DAVID D. CUTHBERTSON, MARIA J. REDONDO, LAURA M. JACOBSEN, MARK A. ATKINSON, JAY SOSENKO, DIABETES PREVENTION TRIAL TYPE 1, TYPE 1 DIABETES TRIALNET
Journal: Diabetes
Diabetes 2022;71(Supplement_1):350-OR
DOI: https://doi.org/10.2337/db22-350-OR
Published: 01 June 2022
View article titled, 350-OR: The Oral Disposition Index (ODI) Predicts Type 1 Diabetes (T1D) in Autoantibody-Positive (Ab+) Individuals
Meeting Abstracts

34-OR: SARS-CoV-2 Infection Is Not Associated with Presence of Islet Autoantibodies in Children: Autoimmunity Screening for Kids (ASK)

CRISTY GENO RASMUSSEN, XIAOFAN JIA, HANAN SHORROSH, LIPING YU, BRIGITTE I. FROHNERT, KIMBER M. SIMMONS, ANDREA STECK, LAURA PYLE, MARIAN REWERS
Journal: Diabetes
Diabetes 2022;71(Supplement_1):34-OR
DOI: https://doi.org/10.2337/db22-34-OR
Published: 01 June 2022
View article titled, 34-OR: SARS-CoV-2 Infection Is Not Associated with Presence of Islet Autoantibodies in Children: Autoimmunity Screening for Kids (ASK)
Meeting Abstracts

1258-P: Islet Autoantibody Levels Differentiate Progression Trajectories in Individuals with Presymptomatic Type 1 Diabetes

BUM CHUL KWON, PETER ACHENBACH, VIBHA ANAND, WILLIAM HAGOPIAN, JIANYING HU, EILEEN KOSKI, ÅKE LERNMARK, KENNEY NG, JORMA TOPPARI, RIITTA VEIJOLA, BRIGITTE I. FROHNERT, T1DI STUDY GROUP
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1258-P
DOI: https://doi.org/10.2337/db22-1258-P
Published: 01 June 2022
View article titled, 1258-P: Islet Autoantibody Levels Differentiate Progression Trajectories in Individuals with Presymptomatic Type 1 Diabetes
Meeting Abstracts

1251-P: Aß Classification Defines Four Distinct Forms of Diabetes in Children

MUSTAFA TOSUR, SAIMA DEEN, SERIFE UYSAL, MARCELA ASTUDILLO, FAROOK JAHOOR, WILLIAM HAGOPIAN, RICHARD A. ORAM, MARIA J. REDONDO, ASHOK BALASUBRAMANYAM
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1251-P
DOI: https://doi.org/10.2337/db22-1251-P
Published: 01 June 2022
View article titled, 1251-P: Aß Classification Defines Four Distinct Forms of Diabetes in Children
Meeting Abstracts

1250-P: Identifying Pediatric A-ß+ Ketosis-Prone Diabetes (KPD)

ELIZABETH A. KUBOTA-MISHRA, XIAOFAN C. HUANG, CHARLES G. MINARD, MARCELA ASTUDILLO, AHMAD K. REFAEY, GRACIELA MONTES, STEPHANIE SISLEY, ASHOK BALASUBRAMANYAM, MARIA J. REDONDO, MUSTAFA TOSUR, RADIANT STUDY GROUP
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1250-P
DOI: https://doi.org/10.2337/db22-1250-P
Published: 01 June 2022
View article titled, 1250-P: Identifying Pediatric A-ß+ Ketosis-Prone Diabetes (KPD)
Meeting Abstracts

1187-P: Distinct Islet Autoantibody Profiles in Hispanic Youth at Type 1 Diabetes Onset

KIMBER M. SIMMONS, TIMOTHY B. VIGERS, LAURA PYLE, ERIN M. YOUNGKIN, ERIN E. BASCHAL, KRISTEN MCDANIEL, LIPING YU, AARON W. MICHELS
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1187-P
DOI: https://doi.org/10.2337/db22-1187-P
Published: 01 June 2022
View article titled, 1187-P: Distinct Islet Autoantibody Profiles in Hispanic Youth at Type 1 Diabetes Onset
Meeting Abstracts

186-OR: Novel Autoantibodies to Deamidated IA2 Extracellular Domain in Type 1 Diabetes

XIAOFAN JIA, DONGMEI MIAO, CAIGUO ZHANG, AARON W. MICHELS, LIPING YU, JANET M. WENZLAU
Journal: Diabetes
Diabetes 2022;71(Supplement_1):186-OR
DOI: https://doi.org/10.2337/db22-186-OR
Published: 01 June 2022
View article titled, 186-OR: Novel Autoantibodies to Deamidated IA2 Extracellular Domain in Type 1 Diabetes
Meeting Abstracts

154-LB: Population-Based Optimization of Metabolic Monitoring for Autoantibody-Positive Individuals at Risk for Type 1 Diabetes

COLIN OROURKE, CATE SPEAKE, ALYSSA YLESCUPIDEZ, CHRISTINE BENDER, SANDRA LORD
Journal: Diabetes
Diabetes 2022;71(Supplement_1):154-LB
DOI: https://doi.org/10.2337/db22-154-LB
Published: 01 June 2022
View article titled, 154-LB: Population-Based Optimization of Metabolic Monitoring for Autoantibody-Positive Individuals at Risk for Type 1 Diabetes
Journal Articles

Islet Autoimmunity Is Highly Prevalent and Associated With Diminished β-Cell Function in Patients With Type 2 Diabetes in the GRADE Study

Barbara Brooks-Worrell, Christiane S. Hampe, Erica G. Hattery, Brenda Palomino, Sahar Z. Zangeneh, Kristina Utzschneider, Steven E. Kahn, Mary E. Larkin, Mary L. Johnson, Kieren J. Mather, Naji Younes, Neda Rasouli, Cyrus Desouza, Robert M. Cohen, Jean Y. Park, Hermes J. Florez, Willy Marcos Valencia, GRADE β-cell Ancillary Study Network, Ali Shojaie, Jerry P. Palmer, Ashok Balasubramanyam
Journal: Diabetes
Diabetes 2022;71(6):1261–1271
DOI: https://doi.org/10.2337/db21-0590
Published: 21 January 2022
View article titled, Islet Autoimmunity Is Highly Prevalent and Associated With Diminished β-Cell Function in Patients With Type 2 Diabetes in the GRADE Study
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Journal Articles

Cytotoxicity-Related Gene Expression and Chromatin Accessibility Define a Subset of CD4+ T Cells That Mark Progression to Type 1 Diabetes

Naiara G. Bediaga, Alexandra L. Garnham, Gaetano Naselli, Esther Bandala-Sanchez, Natalie L. Stone, Joanna Cobb, Jessica E. Harbison, John M. Wentworth, Annette-G. Ziegler, Jennifer J. Couper, Gordon K. Smyth, Leonard C. Harrison
Journal: Diabetes
Diabetes 2022;71(3):566–577
DOI: https://doi.org/10.2337/db21-0612
Published: 18 January 2022
View article titled, Cytotoxicity-Related Gene Expression and Chromatin Accessibility Define a Subset of CD4<sup>+</sup> T Cells That Mark Progression to Type 1 Diabetes
Click here to open pdf in another window PDF for Cytotoxicity-Related Gene Expression and Chromatin Accessibility Define a Subset of CD4<sup>+</sup> T Cells That Mark Progression to Type 1 Diabetes
Journal Articles

Seroreactivity Against Tyrosine Phosphatase PTPRN Links Type 2 Diabetes and Colorectal Cancer and Identifies a Potential Diagnostic and Therapeutic Target

María Garranzo-Asensio, Guillermo Solís-Fernández, Ana Montero-Calle, José Manuel García-Martínez, Maria Carmen Fiuza, Pilar Pallares, Nuria Palacios-Garcia, Custodia García-Jiménez, Ana Guzman-Aranguez, Rodrigo Barderas
Journal: Diabetes
Diabetes 2022;71(3):497–510
DOI: https://doi.org/10.2337/db20-1206
Published: 18 January 2022
View article titled, Seroreactivity Against Tyrosine Phosphatase PTPRN Links Type 2 Diabetes and Colorectal Cancer and Identifies a Potential Diagnostic and Therapeutic Target
Click here to open pdf in another window PDF for Seroreactivity Against Tyrosine Phosphatase PTPRN Links Type 2 Diabetes and Colorectal Cancer and Identifies a Potential Diagnostic and Therapeutic Target