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Journal Articles

In This Issue of Diabetes

Max Bingham, PhD
Journal: Diabetes
Diabetes 2024;73(4):529–530
https://doi.org/10.2337/db24-ti04
Published: 20 March 2024
View article titled, In This Issue of <em>Diabetes</em>
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Journal Articles

Cell-Surface ZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice

Devi Kasinathan, Zheng Guo, Dylan C. Sarver, G. William Wong, Shumei Yun, Aaron W. Michels, Liping Yu, Chandan Sona, Matthew N. Poy, Maria L. Golson, Dax Fu
Journal: Diabetes
Diabetes 2024;73(5):806–818
https://doi.org/10.2337/db23-0568
Published: 22 February 2024
View article titled, Cell-Surface ZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice
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Journal Articles

Excess Salt Intake Activates IL-21–Dominant Autoimmune Diabetogenesis via a Salt-Regulated Ste20-Related Proline/Alanine-Rich Kinase in CD4 T Cells

Jing-Jie Ciou, Ming-Wei Chien, Chao-Yuan Hsu, Yu-Wen Liu, Jia-Ling Dong, Shin-Ying Tsai, Sung-Sen Yang, Shih-Hua Lin, B. Lin-Ju Yen, Shin-Huei Fu, Huey-Kang Sytwu
Journal: Diabetes
Diabetes 2024;73(4):592–603
https://doi.org/10.2337/db23-0599
Published: 19 January 2024
View article titled, Excess Salt Intake Activates IL-21–Dominant Autoimmune Diabetogenesis via a Salt-Regulated Ste20-Related Proline/Alanine-Rich Kinase in CD4 T Cells
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Journal Articles

Reversal of Experimental Autoimmune Diabetes With an sCD39/Anti-CD3 Treatment

Carmen Fotino, R. Damaris Molano, Moufida Ben Nasr, Oliver Umland, Christopher A. Fraker, Ulisse Ulissi, Hari Baskar Balasubramanian, Maria Elena Lunati, Vera Usuelli, Andy Joe Seelam, Salma Ayman Khalefa, Christian La Sala, Jennifer Gimeno, Armando J. Mendez, Camillo Ricordi, Allison L. Bayer, Paolo Fiorina, Antonello Pileggi
Journal: Diabetes
Diabetes 2023;72(11):1641–1651
https://doi.org/10.2337/db23-0178
Published: 25 August 2023
View article titled, Reversal of Experimental Autoimmune Diabetes With an sCD39/Anti-CD3 Treatment
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Meeting Abstracts

1808-PUB: Effective and Durable Stem-Cell-Enabled Therapy of Autoimmune T1DM in Rodents and Dogs Provides the Scientific Basis for the First-in-Human Trial Using I.P. Administered “Neo-Islets,” 3-D Organoids of Allogeneic Islet, and Mesenchymal Stromal Cells—The Omentum Becomes the New Endocrine Pancreas without the Need for Antirejection Drugs

ANNA GOOCH, CHRISTOF WESTENFELDER
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1808-PUB
https://doi.org/10.2337/db23-1808-PUB
Published: 23 June 2023
View article titled, 1808-PUB: Effective and Durable Stem-Cell-Enabled Therapy of Autoimmune T1DM in Rodents and Dogs Provides the Scientific Basis for the First-in-Human Trial Using I.P. Administered “Neo-Islets,” 3-D Organoids of Allogeneic Islet, and Mesenchymal Stromal Cells—The Omentum Becomes the New Endocrine Pancreas without the Need for Antirejection Drugs
Meeting Abstracts

1332-P: Comparison of Clinical Characteristics of People Living with Latent Autoimmune Diabetes of the Adult (LADA) and Type 1 Diabetes (T1D) in the Canadian BETTER Registry

MOHAMAD ISSA, ANNE-SOPHIE BRAZEAU, SARAH HAAG, AMÉLIE ROY-FLEMING, VIRGINIE MESSIER, NADINE TALEB
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1332-P
https://doi.org/10.2337/db23-1332-P
Published: 20 June 2023
View article titled, 1332-P: Comparison of Clinical Characteristics of People Living with Latent Autoimmune Diabetes of the Adult (LADA) and Type 1 Diabetes (T1D) in the Canadian BETTER Registry
Meeting Abstracts

299-OR: A Combinatorial Approach with Monoclonal Antibodies to SerpinB13 and CD3 Is Therapeutically Superior to Single Antibody Use in Autoimmune Diabetes

BARBARA SZEPIETOWSKA, SVETLANA V. AVDULOV, YURY KRYVALAP, JAN CZYZYK
Journal: Diabetes
Diabetes 2023;72(Supplement_1):299-OR
https://doi.org/10.2337/db23-299-OR
Published: 20 June 2023
View article titled, 299-OR: A Combinatorial Approach with Monoclonal Antibodies to SerpinB13 and CD3 Is Therapeutically Superior to Single Antibody Use in Autoimmune Diabetes
Meeting Abstracts

227-LB: Kynurenine Pathway Is Associated with Preservation of Beta-Cell Function in Autoimmune Diabetes

ERNESTO MADDALONI, AMALIA GASTALDELLI, LUCA NAVARINI, ROCCO AMENDOLARA, SIMONA FENIZIA, SAMANTHA PEZZICA, MARTA TESI, LUCA D'ONOFRIO, EMANUELE BOSI, FRANCESCO DOTTA, PIERO MARCHETTI, RAFFAELLA BUZZETTI
Journal: Diabetes
Diabetes 2023;72(Supplement_1):227-LB
https://doi.org/10.2337/db23-227-LB
Published: 20 June 2023
View article titled, 227-LB: Kynurenine Pathway Is Associated with Preservation of Beta-Cell Function in Autoimmune Diabetes
Meeting Abstracts

18-OR: Implementation of a Hybrid Screening and Monitoring Model in Colorado—Autoimmunity Screening for Kids (ASK)

CRISTY GENO RASMUSSEN, KIMBERLY A. BAUTISTA, RACHEL KARBAN, RUTH BEDOY, DANIEL FELIPE-MORALES, MARIAN REWERS
Journal: Diabetes
Diabetes 2023;72(Supplement_1):18-OR
https://doi.org/10.2337/db23-18-OR
Published: 20 June 2023
View article titled, 18-OR: Implementation of a Hybrid Screening and Monitoring Model in Colorado—Autoimmunity Screening for Kids (ASK)
Meeting Abstracts

981-P: Transition from Standard Time to Daylight Saving Time and Vice Versa—Effects on FGM Metrics in Patients with Autoimmune Diabetes

LUDOVICO DI GIOIA, SERGIO DI MOLFETTA, FIORELLA GIORDANO, MARIANGELA CAPORUSSO, GIAN PIO SORICE, ANGELO CIGNARELLI, ANNALISA NATALICCHIO, LUIGI LAVIOLA, FRANCESCO GIORGINO
Journal: Diabetes
Diabetes 2023;72(Supplement_1):981-P
https://doi.org/10.2337/db23-981-P
Published: 20 June 2023
View article titled, 981-P: Transition from Standard Time to Daylight Saving Time and Vice Versa—Effects on FGM Metrics in Patients with Autoimmune Diabetes
Journal Articles

Protective Renalase Deficiency in β-Cells Shapes Immune Metabolism and Function in Autoimmune Diabetes

Kevin Bode, Tara MacDonald, Taylor Stewart, Bryhan Mendez, Erica P. Cai, Noelle Morrow, Yu-Chi Lee, Peng Yi, Stephan Kissler
Journal: Diabetes
Diabetes 2023;72(8):1127–1143
https://doi.org/10.2337/db23-0030
Published: 22 May 2023
View article titled, Protective <em>Renalase</em> Deficiency in β-Cells Shapes Immune Metabolism and Function in Autoimmune Diabetes
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Journal Articles

An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes

Alan G. Derr, Adediwura Arowosegbe, Basanthi Satish, Sambra D. Redick, Natasha Qaisar, Zhiru Guo, Emma Vanderleeden, Melanie I. Trombly, Christina E. Baer, David M. Harlan, Dale L. Greiner, Manuel Garber, Jennifer P. Wang
Journal: Diabetes
Diabetes 2023;72(2):261–274
https://doi.org/10.2337/db22-0521
Published: 08 November 2022
View article titled, An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes
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Journal Articles

Hypothesis: Induction of Autoimmunity in Type 1 Diabetes—A Lipid Focus

Barbara E. Corkey, Laurie E. Kilpatrick, Carmella Evans-Molina
Journal: Diabetes
Diabetes 2022;71(10):2067–2074
https://doi.org/10.2337/db22-0240
Published: 12 September 2022
View article titled, Hypothesis: Induction of Autoimmunity in Type 1 Diabetes—A Lipid Focus
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Journal Articles

Antibody-Mediated Targeting of a Hybrid Insulin Peptide Toward Neonatal Thymic Langerin-Positive Cells Enhances T-Cell Central Tolerance and Delays Autoimmune Diabetes

Yong Lin, Jelena Perovanovic, Yuelin Kong, Botond Z. Igyarto, Sandra Zurawski, Dean Tantin, Gerard Zurawski, Maria Bettini, Matthew L. Bettini
Journal: Diabetes
Diabetes 2022;71(8):1735–1745
https://doi.org/10.2337/db21-1069
Published: 21 August 2022
View article titled, Antibody-Mediated Targeting of a Hybrid Insulin Peptide Toward Neonatal Thymic Langerin-Positive Cells Enhances T-Cell Central Tolerance and Delays Autoimmune Diabetes
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Journal Articles

The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events?

Roberto Mallone, Clémentine Halliez, Jinxiu Rui, Kevan C. Herold
Journal: Diabetes
Diabetes 2022;71(8):1603–1610
https://doi.org/10.2337/dbi21-0036
Published: 21 August 2022
View article titled, The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events?
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Journal Articles

Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity

Mei-Ling Yang, Sean E. Connolly, Renelle J. Gee, TuKiet T. Lam, Jean Kanyo, Jian Peng, Perrin Guyer, Farooq Syed, Hubert M. Tse, Steven G. Clarke, Catherine F. Clarke, Eddie A. James, Cate Speake, Carmella Evans-Molina, Peter Arvan, Kevan C. Herold, Li Wen, Mark J. Mamula
Journal: Diabetes
Diabetes 2022;71(9):1979–1993
https://doi.org/10.2337/db21-0989
Published: 22 June 2022
View article titled, Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity
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Journal Articles

Changes in the Coexpression of Innate Immunity Genes During Persistent Islet Autoimmunity Are Associated With Progression of Islet Autoimmunity: Diabetes Autoimmunity Study in the Young (DAISY)

Patrick M. Carry, Kathleen Waugh, Lauren A. Vanderlinden, Randi K. Johnson, Teresa Buckner, Marian Rewers, Andrea K. Steck, Ivana Yang, Tasha E. Fingerlin, Katerina Kechris, Jill M. Norris
Journal: Diabetes
Diabetes 2022;71(9):2048–2057
https://doi.org/10.2337/db21-1111
Published: 20 June 2022
View article titled, Changes in the Coexpression of Innate Immunity Genes During Persistent Islet Autoimmunity Are Associated With Progression of Islet Autoimmunity: Diabetes Autoimmunity Study in the Young (DAISY)
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Meeting Abstracts

1443-P: Real-Time In Vivo Analysis of Beta-Cell Autophagy in Autoimmune Diabetes

OLHA MELNYK, CHARANYA MURALIDHARAN, MICHELLE M. MARTINEZ IRIZARRY, JUSTIN CROWDER, AMELIA K. LINNEMANN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1443-P
https://doi.org/10.2337/db22-1443-P
Published: 01 June 2022
View article titled, 1443-P: Real-Time In Vivo Analysis of Beta-Cell Autophagy in Autoimmune Diabetes
Meeting Abstracts

294-OR: The Type 1 Diabetes Protective Variant of Tyrosine Kinase 2 (TYK2) Protects ß-Cells from Autoimmunity

AYMEE RODRIGUEZ TAMAYO, MOLLIE HUBER, EDWARD J. BUTFILOSKI, CLAYTON E. MATHEWS
Journal: Diabetes
Diabetes 2022;71(Supplement_1):294-OR
https://doi.org/10.2337/db22-294-OR
Published: 01 June 2022
View article titled, 294-OR: The Type 1 Diabetes Protective Variant of Tyrosine Kinase 2 (TYK2) Protects ß-Cells from Autoimmunity
Meeting Abstracts

351-OR: Investigation of Novel Vitamin D Metabolites and Risk of Islet Autoimmunity and Progression to Type 1 Diabetes

SOOJEONG KIM, NICOLE L. ZWICK, PATRICK M. CARRY, BRIAN C. DEFELICE, RANDI K. JOHNSON, FRAN DONG, TERESA BUCKNER, LAUREN A. VANDERLINDEN, BRIGITTE I. FROHNERT, KATERINA KECHRIS, OLIVER FIEHN, MARIAN REWERS, JILL M. NORRIS
Journal: Diabetes
Diabetes 2022;71(Supplement_1):351-OR
https://doi.org/10.2337/db22-351-OR
Published: 01 June 2022
View article titled, 351-OR: Investigation of Novel Vitamin D Metabolites and Risk of Islet Autoimmunity and Progression to Type 1 Diabetes