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Journal Articles

The Role of TRAPγ/SSR3 in Preproinsulin Translocation Into the Endoplasmic Reticulum

Xiaoxi Xu, Yumeng Huang, Xin Li, Peter Arvan, Ming Liu

Diabetes 2022;71(3):440–452

DOI: https://doi.org/10.2337/db21-0638

Published: 02 December 2021

View article titled, The Role of TRAPγ/SSR3 in Preproinsulin Translocation Into the Endoplasmic Reticulum

Meeting Abstracts

1252-P: Alteration of Alternative Splicing of RYR2 Modulates Insulin Biosynthesis in Pancreatic ß-Cells

MAI MAKINO, ASAKO ITAYA-HIRONAKA, AKIYO YAMAUCHI, SUMIYO SAKURAMOTO-TSUCHIDA, YOSHINORI TAKEDA, TOMOKO UCHIYAMA, SHIN TAKASAWA

Diabetes 2021;70(Supplement_1):1252-P

DOI: https://doi.org/10.2337/db21-1252-P

Published: 01 June 2021

View article titled, 1252-P: Alteration of Alternative Splicing of RYR2 Modulates Insulin Biosynthesis in Pancreatic ß-Cells

Meeting Abstracts

703-P: Exercise-Stimulated Resolvin Biosynthesis in Adipose Tissue Is Abrogated by Obesity-Induced Adrenergic Dysfunction

JASON HELLMANN, WILL LYNCH, ERNESTO P. CALDERIN, BRIAN SANSBURY, MATTHEW SPITE, ARUNI BHATNAGAR, BRADFORD HILL

Diabetes 2020;69(Supplement_1):703-P

DOI: https://doi.org/10.2337/db20-703-P

Published: 01 June 2020

View article titled, 703-P: Exercise-Stimulated Resolvin Biosynthesis in Adipose Tissue Is Abrogated by Obesity-Induced Adrenergic Dysfunction

Journal Articles

Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca²⁺ Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response

Xiaodun Yang, Sarah M. Graff, Cody N. Heiser, Kung-Hsien Ho, Bob Chen, Alan J. Simmons, Austin N. Southard-Smith, Gregory David, David A. Jacobson, Irina Kaverina, Christopher V.E. Wright, Ken S. Lau, Guoqiang Gu

Diabetes 2020;69(6):1219–1231

DOI: https://doi.org/10.2337/db19-0721

Published: 03 April 2020

View article titled, Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca2+ Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response

Meeting Abstracts

1783-P: Translocon-Associated Protein Alpha (TRAPα) Is Required for Insulin Biosynthesis in ß Cells

XIN LL

Diabetes 2019;68(Supplement_1):1783-P

DOI: https://doi.org/10.2337/db19-1783-P

Published: 01 June 2019

View article titled, 1783-P: Translocon-Associated Protein Alpha (TRAPα) Is Required for Insulin Biosynthesis in ß Cells

Meeting Abstracts

1859-P: Autophagy Promotes Gluconeogenesis in Hepatocytes through Forkhead/winged Helix Transcription Factor (FoxO1) Biosynthesis by Supporting Intracellular Amino Acids Turnover

ZHENG SHEN, QUAN PAN, WANBAO YANG, YUNMEI CHEN, XIAOPENG LI, WEIQI AI, SHAODONG GUO, SR.

Diabetes 2019;68(Supplement_1):1859-P

DOI: https://doi.org/10.2337/db19-1859-P

Published: 01 June 2019

View article titled, 1859-P: Autophagy Promotes Gluconeogenesis in Hepatocytes through Forkhead/winged Helix Transcription Factor (FoxO1) Biosynthesis by Supporting Intracellular Amino Acids Turnover

Meeting Abstracts

266-LB: Evidence for a Hexosamine Biosynthesis Pathway-Mediated Sp1 Cholesterolgenic Response Being an Early Etiological Factor of Insulin Resistance

BRIAN A. GRICE, JACOB D. COVERT, ALEC M. KREILACH, MATTHEW THORNBURG, LIXUAN TACKETT, DON MCCLAIN, JEFFREY S. ELMENDORF

Diabetes 2019;68(Supplement_1):266-LB

DOI: https://doi.org/10.2337/db19-266-LB

Published: 01 June 2019

View article titled, 266-LB: Evidence for a Hexosamine Biosynthesis Pathway-Mediated Sp1 Cholesterolgenic Response Being an Early Etiological Factor of Insulin Resistance

Journal Articles

Pseudotime Ordering of Single Human β-Cells Reveals States of Insulin Production and Unfolded Protein Response

Yurong Xin, Giselle Dominguez Gutierrez, Haruka Okamoto, Jinrang Kim, Ann-Hwee Lee, Christina Adler, Min Ni, George D. Yancopoulos, Andrew J. Murphy, Jesper Gromada

Diabetes 2018;67(9):1783–1794

DOI: https://doi.org/10.2337/db18-0365

Published: 27 June 2018

View article titled, Pseudotime Ordering of Single Human β-Cells Reveals States of Insulin Production and Unfolded Protein Response

Includes: Supplementary data

Journal Articles

Nrf2-Mediated Antioxidant Defense and Peroxiredoxin 6 Are Linked to Biosynthesis of Palmitic Acid Ester of 9-Hydroxystearic Acid

Ondrej Kuda, Marie Brezinova, Jan Silhavy, Vladimir Landa, Vaclav Zidek, Chandra Dodia, Franziska Kreuchwig, Marek Vrbacky, Laurence Balas, Thierry Durand, Norbert Hübner, Aron B. Fisher, Jan Kopecky, Michal Pravenec

Diabetes 2018;67(6):1190–1199

DOI: https://doi.org/10.2337/db17-1087

Published: 16 March 2018

View article titled, Nrf2-Mediated Antioxidant Defense and Peroxiredoxin 6 Are Linked to Biosynthesis of Palmitic Acid Ester of 9-Hydroxystearic Acid

Includes: Supplementary data

Journal Articles

Functional and Metabolomic Consequences of K_ATP Channel Inactivation in Human Islets

Changhong Li, Amanda M. Ackermann, Kara E. Boodhansingh, Tricia R. Bhatti, Chengyang Liu, Jonathan Schug, Nicolai Doliba, Bing Han, Karen E. Cosgrove, Indraneel Banerjee, Franz M. Matschinsky, Itzhak Nissim, Klaus H. Kaestner, Ali Naji, N. Scott Adzick, Mark J. Dunne, Charles A. Stanley, Diva D. De León

Diabetes 2017;66(7):1901–1913

DOI: https://doi.org/10.2337/db17-0029

Published: 25 April 2017

View article titled, Functional and Metabolomic Consequences of KATP Channel Inactivation in Human Islets

Includes: Supplementary data

Journal Articles

Erratum. Impaired Cardiolipin Biosynthesis Prevents Hepatic Steatosis and Diet-Induced Obesity. Diabetes 2016;65: 3289–3300

Laura K. Cole, Edgard M. Mejia, Marilyne Vandel, Genevieve C. Sparagna, Steven M. Claypool, Laura Dyck-Chan, Julianne Klein, Grant M. Hatch

Diabetes 2017;66(1):231

DOI: https://doi.org/10.2337/db17-er01a

Published: 17 November 2016

View article titled, Erratum. Impaired Cardiolipin Biosynthesis Prevents Hepatic Steatosis and Diet-Induced Obesity. Diabetes 2016;65: 3289–3300

Journal Articles

Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function

Cristina Alarcon, Brandon B. Boland, Yuji Uchizono, Patrick C. Moore, Bryan Peterson, Suryalekha Rajan, Olivia S. Rhodes, Andrew B. Noske, Leena Haataja, Peter Arvan, Bradly J. Marsh, Jotham Austin, Christopher J. Rhodes

Diabetes 2016;65(2):438–450

DOI: https://doi.org/10.2337/db15-0792

Published: 28 August 2015

View article titled, Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function

Includes: Multimedia, Supplementary data

Journal Articles

Wound Inflammation in Diabetic ob/ob Mice : Functional Coupling of Prostaglandin Biosynthesis to Cyclooxygenase-1 Activity in Diabetes-Impaired Wound Healing

Heiko Kämpfer, Ronald Schmidt, Gerd Geisslinger, Josef Pfeilschifter, Stefan Frank

Diabetes 2005;54(5):1543–1551

DOI: https://doi.org/10.2337/diabetes.54.5.1543

Published: 01 May 2005

View article titled, Wound Inflammation in Diabetic ob/ob Mice : Functional Coupling of Prostaglandin Biosynthesis to Cyclooxygenase-1 Activity in Diabetes-Impaired Wound Healing

Journal Articles

Insulin Does Not Mediate Glucose Stimulation of Proinsulin Biosynthesis

Gil Leibowitz, Andrei I. Oprescu, Gökhan Üçkaya, David J. Gross, Erol Cerasi, Nurit Kaiser

Diabetes 2003;52(4):998–1003

DOI: https://doi.org/10.2337/diabetes.52.4.998

Published: 01 April 2003

View article titled, Insulin Does Not Mediate Glucose Stimulation of Proinsulin Biosynthesis

Journal Articles

Succinate Is a Preferential Metabolic Stimulus-Coupling Signal for Glucose-Induced Proinsulin Biosynthesis Translation

Cristina Alarcon, Barton Wicksteed, Marc Prentki, Barbara E. Corkey, Christopher J. Rhodes

Diabetes 2002;51(8):2496–2504

DOI: https://doi.org/10.2337/diabetes.51.8.2496

Published: 01 August 2002

View article titled, Succinate Is a Preferential Metabolic Stimulus-Coupling Signal for Glucose-Induced Proinsulin Biosynthesis Translation

Journal Articles

Glycerol-Stimulated Proinsulin Biosynthesis in Isolated Pancreatic Rat Islets via Adenoviral-Induced Expression of Glycerol Kinase Is Mediated via Mitochondrial Metabolism

Robert H. Skelly, Barton Wicksteed, Peter A. Antinozzi, Christopher J. Rhodes

Diabetes 2001;50(8):1791–1798

DOI: https://doi.org/10.2337/diabetes.50.8.1791

Published: 01 August 2001

View article titled, Glycerol-Stimulated Proinsulin Biosynthesis in Isolated Pancreatic Rat Islets via Adenoviral-Induced Expression of Glycerol Kinase Is Mediated via Mitochondrial Metabolism

Meeting Abstracts

Naturally occurring amino acid substitutions at Arg1174 in the human insulin receptor result in differential effects on receptor biosynthesis and hybrid formation, leading to discordant clinical phenotypes.

H Rau, M Kocova, S O'Rahilly, J P Whitehead

Diabetes 2000;49(7):1264–1268

DOI: https://doi.org/10.2337/diabetes.49.7.1264

Published: 01 July 2000

View article titled, Naturally occurring amino acid substitutions at Arg1174 in the human insulin receptor result in differential effects on receptor biosynthesis and hybrid formation, leading to discordant clinical phenotypes.

Journal Articles

Glucose-Regulated Translational Control of Proinsulin Biosynthesis With That of the Proinsulin Endopeptidases PG2 and PC3 in the Insulin-Producing MIN6 Cell Line

Robert H Skelly, George T Schuppin, Hisamitsu Ishihara, Yoshitomo Oka, Christopher J Rhodes

Diabetes 1996;45(1):37–43

DOI: https://doi.org/10.2337/diab.45.1.37

Published: 01 January 1996

View article titled, Glucose-Regulated Translational Control of Proinsulin Biosynthesis With That of the Proinsulin Endopeptidases PG2 and PC3 in the Insulin-Producing MIN6 Cell Line

Journal Articles

Glycosylation of Asn³⁹⁷ or Asn⁴¹⁸ is Required for Normal Insulin Receptor Biosynthesis and Processing

William Bastian, Jian Zhu, Barbara Way, Dean Lockwood, James Livingston

Diabetes 1993;42(7):966–974

DOI: https://doi.org/10.2337/diab.42.7.966

Published: 01 July 1993

View article titled, Glycosylation of Asn397 or Asn418 is Required for Normal Insulin Receptor Biosynthesis and Processing

Journal Articles

Lack of Islet Amyloid Polypeptide Regulation of Insulin Biosynthesis or Secretion in Normal Rat Islets

Shinya Nagamatsu, Raymond J Carroll, Gerold M Grodsky, Donald F Steiner

Diabetes 1990;39(7):871–877

DOI: https://doi.org/10.2337/diab.39.7.871

Published: 01 July 1990

View article titled, Lack of Islet Amyloid Polypeptide Regulation of Insulin Biosynthesis or Secretion in Normal Rat Islets

NARROW

The Role of TRAPγ/SSR3 in Preproinsulin Translocation Into the Endoplasmic Reticulum

1252-P: Alteration of Alternative Splicing of RYR2 Modulates Insulin Biosynthesis in Pancreatic ß-Cells

703-P: Exercise-Stimulated Resolvin Biosynthesis in Adipose Tissue Is Abrogated by Obesity-Induced Adrenergic Dysfunction

Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca²⁺ Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response

1783-P: Translocon-Associated Protein Alpha (TRAPα) Is Required for Insulin Biosynthesis in ß Cells

1859-P: Autophagy Promotes Gluconeogenesis in Hepatocytes through Forkhead/winged Helix Transcription Factor (FoxO1) Biosynthesis by Supporting Intracellular Amino Acids Turnover

266-LB: Evidence for a Hexosamine Biosynthesis Pathway-Mediated Sp1 Cholesterolgenic Response Being an Early Etiological Factor of Insulin Resistance

Pseudotime Ordering of Single Human β-Cells Reveals States of Insulin Production and Unfolded Protein Response

Nrf2-Mediated Antioxidant Defense and Peroxiredoxin 6 Are Linked to Biosynthesis of Palmitic Acid Ester of 9-Hydroxystearic Acid

Functional and Metabolomic Consequences of K_ATP Channel Inactivation in Human Islets

Erratum. Impaired Cardiolipin Biosynthesis Prevents Hepatic Steatosis and Diet-Induced Obesity. Diabetes 2016;65: 3289–3300

Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function

Wound Inflammation in Diabetic ob/ob Mice : Functional Coupling of Prostaglandin Biosynthesis to Cyclooxygenase-1 Activity in Diabetes-Impaired Wound Healing

Insulin Does Not Mediate Glucose Stimulation of Proinsulin Biosynthesis

Succinate Is a Preferential Metabolic Stimulus-Coupling Signal for Glucose-Induced Proinsulin Biosynthesis Translation

Glycerol-Stimulated Proinsulin Biosynthesis in Isolated Pancreatic Rat Islets via Adenoviral-Induced Expression of Glycerol Kinase Is Mediated via Mitochondrial Metabolism

Naturally occurring amino acid substitutions at Arg1174 in the human insulin receptor result in differential effects on receptor biosynthesis and hybrid formation, leading to discordant clinical phenotypes.

Glucose-Regulated Translational Control of Proinsulin Biosynthesis With That of the Proinsulin Endopeptidases PG2 and PC3 in the Insulin-Producing MIN6 Cell Line

Glycosylation of Asn³⁹⁷ or Asn⁴¹⁸ is Required for Normal Insulin Receptor Biosynthesis and Processing

Lack of Islet Amyloid Polypeptide Regulation of Insulin Biosynthesis or Secretion in Normal Rat Islets

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