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Meeting Abstracts

1777-P: Three-Dimensional Imaging Reveals Pancreatic Islet Fast Calcium Wave Origin Formation

YI YU

Diabetes 2023;72(Supplement_1):1777-P

https://doi.org/10.2337/db23-1777-P

Published: 20 June 2023

View article titled, 1777-P: Three-Dimensional Imaging Reveals Pancreatic Islet Fast Calcium Wave Origin Formation

Meeting Abstracts

1650-P: Characterizing the Mechanism of Action of the Lipokine 12,13-diHOME

JARED I. SENFELD, MATTHEW LYNES, SEAN KODANI, KIN SING STEPHEN LEE, YU-HUA TSENG

Diabetes 2023;72(Supplement_1):1650-P

https://doi.org/10.2337/db23-1650-P

Published: 20 June 2023

View article titled, 1650-P: Characterizing the Mechanism of Action of the Lipokine 12,13-diHOME

Meeting Abstracts

1558-P: The Mitochondrial Calcium Uniporter Regulates Hepatic Mitochondrial Oxidation and Intracellular Redox In Vivo

TRACI E. LAMOIA, BRANDON T. HUBBARD, MATEUS GUERRA, RUSSELL GOODMAN, MICHAEL H. NATHANSON, GERALD I. SHULMAN

Diabetes 2023;72(Supplement_1):1558-P

https://doi.org/10.2337/db23-1558-P

Published: 20 June 2023

View article titled, 1558-P: The Mitochondrial Calcium Uniporter Regulates Hepatic Mitochondrial Oxidation and Intracellular Redox In Vivo

Meeting Abstracts

1512-P: The Novel Roles of Intracellular Calcium and Phosphoinositides in Insulin Signaling and Metabolic Disease

JIN-WOOK LEE, YUNJAE JUNG, SEUNG-SOON IM, DAE HO LEE, HWA-YONG LEE, IN SUN HONG, OK-HEE KIM, BYUNG-CHUL OH

Diabetes 2023;72(Supplement_1):1512-P

https://doi.org/10.2337/db23-1512-P

Published: 20 June 2023

View article titled, 1512-P: The Novel Roles of Intracellular Calcium and Phosphoinositides in Insulin Signaling and Metabolic Disease

Meeting Abstracts

1767-P: “Leader” ß-Cells within the Pancreatic Islet Are a Functionally Stable Subpopulation In Vitro and In Vivo

LUIS F. DELGADILLO SILVA, GUY A. RUTTER, PAULINE L. CHABOSSEAU, AUDREY PROVENCHER-GIRARD, ALEXANDRE PRAT, LIVIA LOPEZ NORIEGA

Diabetes 2023;72(Supplement_1):1767-P

https://doi.org/10.2337/db23-1767-P

Published: 20 June 2023

View article titled, 1767-P: “Leader” ß-Cells within the Pancreatic Islet Are a Functionally Stable Subpopulation In Vitro and In Vivo

Meeting Abstracts

1487-PUB: Fostering the Health Literacy of Younger Generations

SHIZUKA KANEKO, KAZUKO KAMIYA

Diabetes 2022;71(Supplement_1):1487-PUB

https://doi.org/10.2337/db22-1487-PUB

Published: 01 June 2022

View article titled, 1487-PUB: Fostering the Health Literacy of Younger Generations

Meeting Abstracts

219-LB: The Mitochondrial Calcium Uniporter Regulates Hepatic Lipid Accumulation and Mitochondrial Oxidation

TRACI E. LAMOIA, BRANDON T. HUBBARD, MATEUS GUERRA, RUSSELL GOODMAN, MICHAEL H. NATHANSON, VAMSI MOOTHA, GERALD I. SHULMAN

Diabetes 2022;71(Supplement_1):219-LB

https://doi.org/10.2337/db22-219-LB

Published: 01 June 2022

View article titled, 219-LB: The Mitochondrial Calcium Uniporter Regulates Hepatic Lipid Accumulation and Mitochondrial Oxidation

Meeting Abstracts

1454-P: A Transcriptomic Signature of Pancreatic Islet Leader Beta Cells

PAULINE L. CHABOSSEAU, SU WERN FIONA YONG, LIVIA LOPEZ, ISABELLE LECLERC, YUSUF ALI, AIDA MARTINEZ-SANCHEZ, GUY A. RUTTER

Diabetes 2022;71(Supplement_1):1454-P

https://doi.org/10.2337/db22-1454-P

Published: 01 June 2022

View article titled, 1454-P: A Transcriptomic Signature of Pancreatic Islet Leader Beta Cells

Meeting Abstracts

314-OR: Synaptotagmin-9 Regulates Early Phase Insulin Secretion by Regulating Tomosyn-1

MD MOSTAFIZUR RAHMAN, HAIFA ALSHARIF, SUSHANT BHATNAGAR

Diabetes 2022;71(Supplement_1):314-OR

https://doi.org/10.2337/db22-314-OR

Published: 01 June 2022

View article titled, 314-OR: Synaptotagmin-9 Regulates Early Phase Insulin Secretion by Regulating Tomosyn-1

Journal Articles

Cavβ3 Regulates Ca²⁺ Signaling and Insulin Expression in Pancreatic β-Cells in a Cell-Autonomous Manner

Alexander Becker, Barbara Wardas, Houssein Salah, Maryam Amini, Claudia Fecher-Trost, Qiao Sen, Damian Martus, Andreas Beck, Stephan E. Philipp, Veit Flockerzi, Anouar Belkacemi

Diabetes 2021;70(11):2532–2544

https://doi.org/10.2337/db21-0078

Published: 23 August 2021

View article titled, Cavβ3 Regulates Ca<sup>2+</sup> Signaling and Insulin Expression in Pancreatic β-Cells in a Cell-Autonomous Manner

Meeting Abstracts

288-OR: Role of Endoplasmic Reticulum (ER) Calcium in ß-Cell Senescence and Type 1 Diabetes Pathophysiology

STACI A. WEAVER, TATSUYOSHI KONO, FAROOQ SYED, ROBERT N. BONE, CARMELLA EVANS-MOLINA

Diabetes 2021;70(Supplement_1):288-OR

https://doi.org/10.2337/db21-288-OR

Published: 01 June 2021

View article titled, 288-OR: Role of Endoplasmic Reticulum (ER) Calcium in ß-Cell Senescence and Type 1 Diabetes Pathophysiology

Meeting Abstracts

1243-P: The Chd4 Helicase Regulates Pdx1-Controlled Genes Involved in ß-Cell Function

REBECCA K. DAVIDSON, NOLAN CASEY, SUKRATI KANOJIA, JASON SPAETH

Diabetes 2021;70(Supplement_1):1243-P

https://doi.org/10.2337/db21-1243-P

Published: 01 June 2021

View article titled, 1243-P: The Chd4 Helicase Regulates Pdx1-Controlled Genes Involved in ß-Cell Function

Meeting Abstracts

1248-P: Histone Deacetylase Inhibition Improves Store-Operated Calcium Entry and Glucose-Stimulated Insulin Secretion in Cytokine-Stressed Pancreatic ß-Cells

CHIH-CHUN LEE, TATSUYOSHI KONO, STACI A. WEAVER, PAUL SOHN, CARMELLA EVANS-MOLINA

Diabetes 2021;70(Supplement_1):1248-P

https://doi.org/10.2337/db21-1248-P

Published: 01 June 2021

View article titled, 1248-P: Histone Deacetylase Inhibition Improves Store-Operated Calcium Entry and Glucose-Stimulated Insulin Secretion in Cytokine-Stressed Pancreatic ß-Cells

Meeting Abstracts

1854-P: Kcnh6 Improves Glucose Metabolism by Inhibiting Oxidative Stress

JING LU, LIN ZHANG, TING-TING SHI

Diabetes 2020;69(Supplement_1):1854-P

https://doi.org/10.2337/db20-1854-P

Published: 01 June 2020

View article titled, 1854-P: Kcnh6 Improves Glucose Metabolism by Inhibiting Oxidative Stress

Meeting Abstracts

1789-P: Inactivation of Acyl-Protein Thioesterase 1, a Major Mediator of Palmitoylation Cycling, Promotes Insulin Secretion and ß-Cell Failure

GUIFANG DONG, XIAOCHAO WEI, LI YIN, CHU FENG, SANGEETA ADAK, ZEENAT A. SHYR, QIANG ZHANG, SHUNTARO MORIKAWA, RIE ASADA, FUMIHIKO URANO, MARIA S. REMEDI, CLAY F. SEMENKOVICH

Diabetes 2020;69(Supplement_1):1789-P

https://doi.org/10.2337/db20-1789-P

Published: 01 June 2020

View article titled, 1789-P: Inactivation of Acyl-Protein Thioesterase 1, a Major Mediator of Palmitoylation Cycling, Promotes Insulin Secretion and ß-Cell Failure

Meeting Abstracts

2074-P: Histone Deacetylase Inhibitors Improve Store-Operated Calcium Entry and Glucose-Stimulated Insulin Secretion in Cytokine-Stressed Pancreatic ß-Cells

CHIH-CHUN LEE, TATSUYOSHI KONO, STACI A. WEAVER, PAUL SOHN, CARMELLA EVANS-MOLINA

Diabetes 2020;69(Supplement_1):2074-P

https://doi.org/10.2337/db20-2074-P

Published: 01 June 2020

View article titled, 2074-P: Histone Deacetylase Inhibitors Improve Store-Operated Calcium Entry and Glucose-Stimulated Insulin Secretion in Cytokine-Stressed Pancreatic ß-Cells

Meeting Abstracts

224-LB: Role of the Mitochondrial Calcium Uniporter in the Regulation of Hepatic Mitochondrial Metabolism and Gluconeogenesis

TRACI E. LAMOIA, JI EUN LEE, MATEUS GUERRA, RUSSELL GOODMAN, GERALD I. SHULMAN

Diabetes 2020;69(Supplement_1):224-LB

https://doi.org/10.2337/db20-224-LB

Published: 01 June 2020

View article titled, 224-LB: Role of the Mitochondrial Calcium Uniporter in the Regulation of Hepatic Mitochondrial Metabolism and Gluconeogenesis

Journal Articles

A Phenotypic Screen Identifies Calcium Overload as a Key Mechanism of β-Cell Glucolipotoxicity

Jennifer Vogel, Jianning Yin, Liansheng Su, Sharon X. Wang, Richard Zessis, Sena Fowler, Chun-Hao Chiu, Aaron C. Wilson, Amy Chen, Frederic Zecri, Gordon Turner, Thomas M. Smith, Brian DeChristopher, Heming Xing, Deborah M. Rothman, Xinming Cai, Alina Berdichevsky

Diabetes 2020;69(5):1032–1041

https://doi.org/10.2337/db19-0813

Published: 20 February 2020

View article titled, A Phenotypic Screen Identifies Calcium Overload as a Key Mechanism of β-Cell Glucolipotoxicity

Includes: Supplementary data

Journal Articles

Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue

Peng Gao, Yanli Jiang, Hao Wu, Fang Sun, Yaohong Li, Hongbo He, Bin Wang, Zongshi Lu, Yingru Hu, Xiao Wei, Yuanting Cui, Chengkang He, Lijuan Wang, Hongting Zheng, Gangyi Yang, Daoyan Liu, Zhencheng Yan, Zhiming Zhu

Diabetes 2020;69(2):165–180

https://doi.org/10.2337/db19-0526

Published: 11 November 2019

View article titled, Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue

Includes: Supplementary data

Meeting Abstracts

341-LB: Chronic ER Calcium Depletion Resulting from Sarcoendoplasmic Reticulum Ca2⁺ Atpase 2b (SERCA2b) Deficiency Leads to Impaired Proinsulin Processing in the Pancreatic ß Cell

HITOSHI IIDA, TATSUYOSHI KONO, XIN TONG, IRIS LINDBERG, CARMELLA EVANS-MOLINA

Diabetes 2019;68(Supplement_1):341-LB

https://doi.org/10.2337/db19-341-LB

Published: 01 June 2019

View article titled, 341-LB: Chronic ER Calcium Depletion Resulting from Sarcoendoplasmic Reticulum Ca2<sup>+</sup> Atpase 2b (SERCA2b) Deficiency Leads to Impaired Proinsulin Processing in the Pancreatic ß Cell

NARROW

1777-P: Three-Dimensional Imaging Reveals Pancreatic Islet Fast Calcium Wave Origin Formation

1650-P: Characterizing the Mechanism of Action of the Lipokine 12,13-diHOME

1558-P: The Mitochondrial Calcium Uniporter Regulates Hepatic Mitochondrial Oxidation and Intracellular Redox In Vivo

1512-P: The Novel Roles of Intracellular Calcium and Phosphoinositides in Insulin Signaling and Metabolic Disease

1767-P: “Leader” ß-Cells within the Pancreatic Islet Are a Functionally Stable Subpopulation In Vitro and In Vivo

1487-PUB: Fostering the Health Literacy of Younger Generations

219-LB: The Mitochondrial Calcium Uniporter Regulates Hepatic Lipid Accumulation and Mitochondrial Oxidation

1454-P: A Transcriptomic Signature of Pancreatic Islet Leader Beta Cells

314-OR: Synaptotagmin-9 Regulates Early Phase Insulin Secretion by Regulating Tomosyn-1

Cavβ3 Regulates Ca²⁺ Signaling and Insulin Expression in Pancreatic β-Cells in a Cell-Autonomous Manner

288-OR: Role of Endoplasmic Reticulum (ER) Calcium in ß-Cell Senescence and Type 1 Diabetes Pathophysiology

1243-P: The Chd4 Helicase Regulates Pdx1-Controlled Genes Involved in ß-Cell Function

1248-P: Histone Deacetylase Inhibition Improves Store-Operated Calcium Entry and Glucose-Stimulated Insulin Secretion in Cytokine-Stressed Pancreatic ß-Cells

1854-P: Kcnh6 Improves Glucose Metabolism by Inhibiting Oxidative Stress

1789-P: Inactivation of Acyl-Protein Thioesterase 1, a Major Mediator of Palmitoylation Cycling, Promotes Insulin Secretion and ß-Cell Failure

2074-P: Histone Deacetylase Inhibitors Improve Store-Operated Calcium Entry and Glucose-Stimulated Insulin Secretion in Cytokine-Stressed Pancreatic ß-Cells

224-LB: Role of the Mitochondrial Calcium Uniporter in the Regulation of Hepatic Mitochondrial Metabolism and Gluconeogenesis

A Phenotypic Screen Identifies Calcium Overload as a Key Mechanism of β-Cell Glucolipotoxicity

Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue

341-LB: Chronic ER Calcium Depletion Resulting from Sarcoendoplasmic Reticulum Ca2⁺ Atpase 2b (SERCA2b) Deficiency Leads to Impaired Proinsulin Processing in the Pancreatic ß Cell

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