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Journal Articles

From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes

Decio L. Eizirik, Florian Szymczak, Maria Inês Alvelos, Frank Martin

Diabetes 2021;70(9):1915–1925

DOI: https://doi.org/10.2337/dbi20-0046

Published: 07 September 2021

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Meeting Abstracts

1242-P: Defining the Nkx6.1 Interactome in Beta Cells Reveals a Novel Interaction with Pdx1

CONNOR C. LITTLEFIELD, NATHANAEL C. JENSEN, JONATHON T. HILL, JOHN C. PRICE, JEFFERY S. TESSEM

Diabetes 2021;70(Supplement_1):1242-P

DOI: https://doi.org/10.2337/db21-1242-P

Published: 01 June 2021

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Meeting Abstracts

1258-P: Il-1ß-Induced Transcription of Nf-kB Target Genes Is Repressed by Bet Bromodomain Inhibitors in Pancreatic ß-Cells

JOSHUA NORD, SARAH WYNIA-SMITH, BRIAN C. SMITH, RACHEL JONES LIPINSKI

Diabetes 2021;70(Supplement_1):1258-P

DOI: https://doi.org/10.2337/db21-1258-P

Published: 01 June 2021

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Journal Articles

PPA1 Regulates Systemic Insulin Sensitivity by Maintaining Adipocyte Mitochondria Function as a Novel PPARγ Target Gene

Ye Yin, Yangyang Wu, Xu Zhang, Yeting Zhu, Yue Sun, Jiani Yu, Yufei Gong, Peng Sun, Haiyan Lin, Xiao Han

Diabetes 2021;70(6):1278–1291

DOI: https://doi.org/10.2337/db20-0622

Published: 15 March 2021

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Journal Articles

SKAP2, a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients

Tina Fløyel, Kira Meyerovich, Michala C. Prause, Simranjeet Kaur, Caroline Frørup, Henrik B. Mortensen, Lotte B. Nielsen, Flemming Pociot, Alessandra K. Cardozo, Joachim Størling

Diabetes 2021;70(2):464–476

DOI: https://doi.org/10.2337/db20-0092

Published: 17 November 2020

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Meeting Abstracts

370-OR: Hepatic FGF21 Expression Is Under the Regulation of the Canonical Wnt Signaling Pathway

YASAMAN BADAKHSHI, WEIJUAN SHAO, LILI TIAN, TIANRU JIN

Diabetes 2020;69(Supplement_1):370-OR

DOI: https://doi.org/10.2337/db20-370-OR

Published: 01 June 2020

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Meeting Abstracts

2049-P: The Chd4 Helicase of the Nucleosome Remodeling and Deacetylase Complex Modulates Pdx1 Target Gene Expression In Vitro

REBECCA K. DAVIDSON, NOLAN CASEY, JASON SPAETH

Diabetes 2020;69(Supplement_1):2049-P

DOI: https://doi.org/10.2337/db20-2049-P

Published: 01 June 2020

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Journal Articles

Systematic Genetic Study of Youth With Diabetes in a Single Country Reveals the Prevalence of Diabetes Subtypes, Novel Candidate Genes, and Response to Precision Therapy

Ingrida Stankute, Rasa Verkauskiene, Jean-Louis Blouin, Philippe Klee, Rimante Dobrovolskiene, Evalda Danyte, Mirjam Dirlewanger, Federico Santoni, Dovile Razanskaite-Virbickiene, Dale Marciulionyte, Edita Jasinskiene, Giedre Mockeviciene, Valerie M. Schwitzgebel

Diabetes 2020;69(5):1065–1071

DOI: https://doi.org/10.2337/db19-0974

Published: 21 February 2020

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Includes: Supplementary data

Journal Articles

RNF20 Functions as a Transcriptional Coactivator for PPARγ by Promoting NCoR1 Degradation in Adipocytes

Yong Geun Jeon, Jae Ho Lee, Yul Ji, Jee Hyung Sohn, Dabin Lee, Dong Wook Kim, Seul Gi Yoon, Kyung Cheul Shin, Jeu Park, Je Kyung Seong, Je-Yoel Cho, Sung Sik Choe, Jae Bum Kim

Diabetes 2020;69(1):20–34

DOI: https://doi.org/10.2337/db19-0508

Published: 11 October 2019

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Includes: Supplementary data

Journal Articles

CACNB2 Is a Novel Susceptibility Gene for Diabetic Retinopathy in Type 1 Diabetes

Nadja Vuori, Niina Sandholm, Anmol Kumar, Kustaa Hietala, Anna Syreeni, Carol Forsblom, Kati Juuti-Uusitalo, Heli Skottman, Minako Imamura, Shiro Maeda, Paula A. Summanen, Markku Lehto, Per-Henrik Groop

Diabetes 2019;68(11):2165–2174

DOI: https://doi.org/10.2337/db19-0130

Published: 22 August 2019

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Includes: Supplementary data

Meeting Abstracts

1699-P: Identification of HNF1A Target Gene SNPs Associated with the Age of Onset of HNF1A MODY

AGNIESZKA LUDWIG-SLOMCZYNSKA, MICHAL SEWERYN, PRZEMYSłAW KAPUSTA, JAN SKUPIEN, BEATA M. KIEC-WILK, JULITA MACHLOWSKA, JR., MACIEJ MALECKI, PAWEL P. WOLKOW, TOMASZ KLUPA, NEMO COLLABORATORS

Diabetes 2019;68(Supplement_1):1699-P

DOI: https://doi.org/10.2337/db19-1699-P

Published: 01 June 2019

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Meeting Abstracts

1692-P: miR17 Overexpression or Deleting Its Target Gene Txnip Ameliorates Neural Tube Defect Formation in Diabetic Embryopathy

PENGHUA YANG, PEIXIN YANG

Diabetes 2019;68(Supplement_1):1692-P

DOI: https://doi.org/10.2337/db19-1692-P

Published: 01 June 2019

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Meeting Abstracts

1722-P: Colocalization of TOPMed Whole Genome Sequencing Analysis and Tissue-Specific eQTL Signals Detects Target Genes for Type 2 Diabetes Risk

MINDY D. SZETO, HEATHER M. HIGHLAND, ALISA MANNING, TOPMED DIABETES WORKING GROUP

Diabetes 2019;68(Supplement_1):1722-P

DOI: https://doi.org/10.2337/db19-1722-P

Published: 01 June 2019

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Journal Articles

In This Issue of Diabetes

Diabetes 2019;68(3):469–470

DOI: https://doi.org/10.2337/db19-ti03

Published: 13 February 2019

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Meeting Abstracts

KIAA2022, a Candidate Gene for Syndromic Diabetes

CAROLINE STEKELENBURG, JEAN-LOUIS BLOUIN, FRED SANTONI, ELIZABETH A. O'HARE, NORANN A. ZAGHLOUL, VALERIE SCHWITZGEBEL

Diabetes 2018;67(Supplement_1):1358-P

DOI: https://doi.org/10.2337/db18-1358-P

Published: 01 July 2018

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Journal Articles

Nrf2-Mediated Antioxidant Defense and Peroxiredoxin 6 Are Linked to Biosynthesis of Palmitic Acid Ester of 9-Hydroxystearic Acid

Ondrej Kuda, Marie Brezinova, Jan Silhavy, Vladimir Landa, Vaclav Zidek, Chandra Dodia, Franziska Kreuchwig, Marek Vrbacky, Laurence Balas, Thierry Durand, Norbert Hübner, Aron B. Fisher, Jan Kopecky, Michal Pravenec

Diabetes 2018;67(6):1190–1199

DOI: https://doi.org/10.2337/db17-1087

Published: 16 March 2018

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Includes: Supplementary data

Journal Articles

New Tricks for Nrf2: Therapeutic Targeting to Restore BK-β1 Expression?

Sarah J. Chapple, Giovanni E. Mann

Diabetes 2017;66(10):2538–2540

DOI: https://doi.org/10.2337/dbi17-0024

Published: 13 September 2017

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Journal Articles

TGF-β Contributes to Impaired Exercise Response by Suppression of Mitochondrial Key Regulators in Skeletal Muscle

Anja Böhm, Christoph Hoffmann, Martin Irmler, Patrick Schneeweiss, Günter Schnauder, Corinna Sailer, Vera Schmid, Jens Hudemann, Jürgen Machann, Fritz Schick, Johannes Beckers, Martin Hrabě de Angelis, Harald Staiger, Andreas Fritsche, Norbert Stefan, Andreas M. Nieß, Hans-Ulrich Häring, Cora Weigert

Diabetes 2016;65(10):2849–2861

DOI: https://doi.org/10.2337/db15-1723

Published: 29 June 2016

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Includes: Supplementary data

Journal Articles

TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells

Laura Marroqui, Reinaldo Sousa Dos Santos, Tina Fløyel, Fabio A. Grieco, Izortze Santin, Anne Op de beeck, Lorella Marselli, Piero Marchetti, Flemming Pociot, Decio L. Eizirik

Diabetes 2015;64(11):3808–3817

DOI: https://doi.org/10.2337/db15-0362

Published: 03 August 2015

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Includes: Supplementary data

Journal Articles

ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling

Salmaan Ahmed Khan, Aishwarya Sathyanarayan, Mara T. Mashek, Kuok Teong Ong, Edith E. Wollaston-Hayden, Douglas G. Mashek

Diabetes 2015;64(2):418–426

DOI: https://doi.org/10.2337/db14-0325

Published: 13 January 2015

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NARROW

From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes

1242-P: Defining the Nkx6.1 Interactome in Beta Cells Reveals a Novel Interaction with Pdx1

1258-P: Il-1ß-Induced Transcription of Nf-kB Target Genes Is Repressed by Bet Bromodomain Inhibitors in Pancreatic ß-Cells

PPA1 Regulates Systemic Insulin Sensitivity by Maintaining Adipocyte Mitochondria Function as a Novel PPARγ Target Gene

SKAP2, a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients

370-OR: Hepatic FGF21 Expression Is Under the Regulation of the Canonical Wnt Signaling Pathway

2049-P: The Chd4 Helicase of the Nucleosome Remodeling and Deacetylase Complex Modulates Pdx1 Target Gene Expression In Vitro

Systematic Genetic Study of Youth With Diabetes in a Single Country Reveals the Prevalence of Diabetes Subtypes, Novel Candidate Genes, and Response to Precision Therapy

RNF20 Functions as a Transcriptional Coactivator for PPARγ by Promoting NCoR1 Degradation in Adipocytes

CACNB2 Is a Novel Susceptibility Gene for Diabetic Retinopathy in Type 1 Diabetes

1699-P: Identification of HNF1A Target Gene SNPs Associated with the Age of Onset of HNF1A MODY

1692-P: miR17 Overexpression or Deleting Its Target Gene Txnip Ameliorates Neural Tube Defect Formation in Diabetic Embryopathy

1722-P: Colocalization of TOPMed Whole Genome Sequencing Analysis and Tissue-Specific eQTL Signals Detects Target Genes for Type 2 Diabetes Risk

In This Issue of Diabetes

KIAA2022, a Candidate Gene for Syndromic Diabetes

Nrf2-Mediated Antioxidant Defense and Peroxiredoxin 6 Are Linked to Biosynthesis of Palmitic Acid Ester of 9-Hydroxystearic Acid

New Tricks for Nrf2: Therapeutic Targeting to Restore BK-β1 Expression?

TGF-β Contributes to Impaired Exercise Response by Suppression of Mitochondrial Key Regulators in Skeletal Muscle

TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells

ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling

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