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Journal Articles

Roflumilast-Mediated Phosphodiesterase 4D Inhibition Reverses Diabetes-Associated Cardiac Dysfunction and Remodeling: Effects Beyond Glucose Lowering

Rui Xu, Jing Fu, Yuting Hu, Xiaoyan Yang, Xiang Tao, Long Chen, Kai Huang, Qin Fu
Journal: Diabetes
Diabetes 2022;71(8):1660–1678
https://doi.org/10.2337/db21-0898
Published: 21 August 2022
View article titled, Roflumilast-Mediated Phosphodiesterase 4D Inhibition Reverses Diabetes-Associated Cardiac Dysfunction and Remodeling: Effects Beyond Glucose Lowering
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Journal Articles

Diabetes-Induced Cellular Senescence and Senescence-Associated Secretory Phenotype Impair Cardiac Regeneration and Function Independently of Age

Fabiola Marino, Mariangela Scalise, Nadia Salerno, Luca Salerno, Claudia Molinaro, Donato Cappetta, Michele Torella, Marta Greco, Daniela Foti, Ferdinando C. Sasso, Pasquale Mastroroberto, Antonella De Angelis, Georgina M. Ellison-Hughes, Maurilio Sampaolesi, Marcello Rota, Francesco Rossi, Konrad Urbanek, Bernardo Nadal-Ginard, Daniele Torella, Eleonora Cianflone
Journal: Diabetes
Diabetes 2022;71(5):1081–1098
https://doi.org/10.2337/db21-0536
Published: 02 February 2022
View article titled, Diabetes-Induced Cellular Senescence and Senescence-Associated Secretory Phenotype Impair Cardiac Regeneration and Function Independently of Age
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Journal Articles

Methazolamide Attenuates the Development of Diabetic Cardiomyopathy by Promoting β-Catenin Degradation in Type 1 Diabetic Mice

Xiaoqing Chen, Yilang Li, Xun Yuan, Wenchang Yuan, Conglin Li, Yue Zeng, Yuling Lian, Xiaoxia Qiu, Yuan Qin, Guiping Zhang, Xiawen Liu, Chengfeng Luo, Jian-Dong Luo, Ning Hou
Journal: Diabetes
Diabetes 2022;71(4):795–811
https://doi.org/10.2337/db21-0506
Published: 18 January 2022
View article titled, Methazolamide Attenuates the Development of Diabetic Cardiomyopathy by Promoting β-Catenin Degradation in Type 1 Diabetic Mice
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Journal Articles

MG53 E3 Ligase–Dead Mutant Protects Diabetic Hearts From Acute Ischemic/Reperfusion Injury and Ameliorates Diet-Induced Cardiometabolic Damage

Han Feng, Hao Shen, Matthew J. Robeson, Yue-Han Wu, Hong-Kun Wu, Geng-Jia Chen, Shuo Zhang, Peng Xie, Li Jin, Yanyun He, Yingfan Wang, Fengxiang Lv, Xinli Hu, Yan Zhang, Rui-Ping Xiao
Journal: Diabetes
Diabetes 2022;71(2):298–314
https://doi.org/10.2337/db21-0322
Published: 29 November 2021
View article titled, MG53 E3 Ligase–Dead Mutant Protects Diabetic Hearts From Acute Ischemic/Reperfusion Injury and Ameliorates Diet-Induced Cardiometabolic Damage
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Journal Articles

Activation of HIF1α Rescues the Hypoxic Response and Reverses Metabolic Dysfunction in the Diabetic Heart

Maria da Luz Sousa Fialho, Ujang Purnama, Kaitlyn M.J.H. Dennis, Claudia N. Montes Aparicio, Marcos Castro-Guarda, Emmanuelle Massourides, Damian J. Tyler, Carolyn A. Carr, Lisa C. Heather
Journal: Diabetes
Diabetes 2021;70(11):2518–2531
https://doi.org/10.2337/db21-0398
Published: 15 September 2021
View article titled, Activation of HIF1α Rescues the Hypoxic Response and Reverses Metabolic Dysfunction in the Diabetic Heart
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Meeting Abstracts

9-LB: Effects of Hyperglycemia-Induced Stress in a Human Cardiomyocyte Cell Line

HIRAL WAGHELA, VIKRAM THAKUR, MUNMUN CHATTOPADHYAY
Journal: Diabetes
Diabetes 2021;70(Supplement_1):9-LB
https://doi.org/10.2337/db21-9-LB
Published: 01 June 2021
View article titled, 9-LB: Effects of Hyperglycemia-Induced Stress in a Human Cardiomyocyte Cell Line
Meeting Abstracts

378-P: Upregulation of Regenerating Gene IV and Hepatocyte Growth Factor in Cardiomyocytes by Intermittent Hypoxia and Its MicroRNA-Mediated Mechanism

SHIN TAKASAWA, ASAKO ITAYA-HIRONAKA, AKIYO YAMAUCHI, MAI MAKINO, SUMIYO SAKURAMOTO-TSUCHIDA, TOMOKO UCHIYAMA, YOSHINORI TAKEDA, YOJI KYOTANI, HIROYO OTA
Journal: Diabetes
Diabetes 2021;70(Supplement_1):378-P
https://doi.org/10.2337/db21-378-P
Published: 01 June 2021
View article titled, 378-P: Upregulation of Regenerating Gene IV and Hepatocyte Growth Factor in Cardiomyocytes by Intermittent Hypoxia and Its MicroRNA-Mediated Mechanism
Journal Articles

Ncor2/PPARα-Dependent Upregulation of MCUb in the Type 2 Diabetic Heart Impacts Cardiac Metabolic Flexibility and Function

Federico Cividini, Brian T. Scott, Jorge Suarez, Darren E. Casteel, Sven Heinz, Anzhi Dai, Tanja Diemer, Jorge A. Suarez, Christopher W. Benner, Majid Ghassemian, Wolfgang H. Dillmann
Journal: Diabetes
Diabetes 2021;70(3):665–679
https://doi.org/10.2337/db20-0779
Published: 10 December 2020
View article titled, Ncor2/PPARα-Dependent Upregulation of MCUb in the Type 2 Diabetic Heart Impacts Cardiac Metabolic Flexibility and Function
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Journal Articles

Dapagliflozin Suppresses ER Stress and Improves Subclinical Myocardial Function in Diabetes: From Bedside to Bench

Jhih-Yuan Shih, Yu-Wen Lin, Sudeshna Fisch, Juei-Tang Cheng, Nai-Wen Kang, Chon-Seng Hong, Zhih-Cherng Chen, Wei-Ting Chang
Journal: Diabetes
Diabetes 2021;70(1):262–267
https://doi.org/10.2337/db20-0840
Published: 28 October 2020
View article titled, Dapagliflozin Suppresses ER Stress and Improves Subclinical Myocardial Function in Diabetes: From Bedside to Bench
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Journal Articles

Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice

Huimei Zang, Weiwei Wu, Lei Qi, Wenbin Tan, Prakash Nagarkatti, Mitzi Nagarkatti, Xuejun Wang, Taixing Cui
Journal: Diabetes
Diabetes 2020;69(12):2720–2734
https://doi.org/10.2337/db19-1176
Published: 18 September 2020
View article titled, Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice
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Meeting Abstracts

464-P: Linagliptin Directly Enhances Cardiac Contractile Recovery through Nitric Oxide Mediated Endothelial–Cardiomyocyte Communication

VEERA GANESH YERRA, SRI NAGARJUN BATCHU, YOUAN LIU, THOMAS KLEIN, ANDREW ADVANI
Journal: Diabetes
Diabetes 2020;69(Supplement_1):464-P
https://doi.org/10.2337/db20-464-P
Published: 01 June 2020
View article titled, 464-P: Linagliptin Directly Enhances Cardiac Contractile Recovery through Nitric Oxide Mediated Endothelial–Cardiomyocyte Communication
Meeting Abstracts

493-P: Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Uremic Serum and Restored by Empagliflozin

RIO JUNI, RUSHD AL-SHAMA, DIEDERIK KUSTER, JOLANDA VAN DER VELDEN, MARC VERVLOET, WALTER PAULUS, ETTO C. ERINGA, PIETER KOOLWIJK, VICTOR W. VAN HINSBERGH
Journal: Diabetes
Diabetes 2020;69(Supplement_1):493-P
https://doi.org/10.2337/db20-493-P
Published: 01 June 2020
View article titled, 493-P: Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Uremic Serum and Restored by Empagliflozin
Meeting Abstracts

1884-P: Cardiomyocyte-Specific PKA Inhibition Ameliorates Cardiac Dysfunction Induced by Obesity

XIONGWEN CHEN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1884-P
https://doi.org/10.2337/db20-1884-P
Published: 01 June 2020
View article titled, 1884-P: Cardiomyocyte-Specific PKA Inhibition Ameliorates Cardiac Dysfunction Induced by Obesity
Journal Articles

Maintaining Myocardial Glucose Utilization in Diabetic Cardiomyopathy Accelerates Mitochondrial Dysfunction

Adam R. Wende, John C. Schell, Chae-Myeong Ha, Mark E. Pepin, Oleh Khalimonchuk, Hansjörg Schwertz, Renata O. Pereira, Manoja K. Brahma, Joseph Tuinei, Ariel Contreras-Ferrat, Li Wang, Chase A. Andrizzi, Curtis D. Olsen, Wayne E. Bradley, Louis J. Dell’Italia, Wolfgang H. Dillmann, Sheldon E. Litwin, E. Dale Abel
Journal: Diabetes
Diabetes 2020;69(10):2094–2111
https://doi.org/10.2337/db19-1057
Published: 04 May 2020
View article titled, Maintaining Myocardial Glucose Utilization in Diabetic Cardiomyopathy Accelerates Mitochondrial Dysfunction
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Meeting Abstracts

451-P: SGLT2 Inhibitor Protects Cardiomyocytes against Palmitate-Induced Lipotoxicity by Increasing Activation of AMPK and Lipid Oxidations

HAN BYEOL LEE, SUNGE CHOI, YUP KANG, TAE HO KIM, NAMI LEE, HYUN UK MOON, SEUNG JIN HAN, DAE JUNG KIM, KWANWOO LEE
Journal: Diabetes
Diabetes 2019;68(Supplement_1):451-P
https://doi.org/10.2337/db19-451-P
Published: 01 June 2019
View article titled, 451-P: SGLT2 Inhibitor Protects Cardiomyocytes against Palmitate-Induced Lipotoxicity by Increasing Activation of AMPK and Lipid Oxidations
Meeting Abstracts

267-OR: Cardiomyocyte Insulin Resistance Manifests on High-Glucose Fibroblast-Derived Extracellular Matrix

STEPHAN NIEUWOUDT, XINMING WANG, SUBHADIP SENAPATI, PAUL PARK, SAM SENYO
Journal: Diabetes
Diabetes 2019;68(Supplement_1):267-OR
https://doi.org/10.2337/db19-267-OR
Published: 01 June 2019
View article titled, 267-OR: Cardiomyocyte Insulin Resistance Manifests on High-Glucose Fibroblast-Derived Extracellular Matrix
Meeting Abstracts

449-P: Pulsed Electromagnetic Field Attenuates Cardiomyocyte Damages Induced by Ischemia in Hyperglycemic H9c2 Cells

ILEANA TERRUZZI, PAMELA SENESI, FERNANDA VACANTE, LIVIO LUZI
Journal: Diabetes
Diabetes 2019;68(Supplement_1):449-P
https://doi.org/10.2337/db19-449-P
Published: 01 June 2019
View article titled, 449-P: Pulsed Electromagnetic Field Attenuates Cardiomyocyte Damages Induced by Ischemia in Hyperglycemic H9c2 Cells
Journal Articles

ADAMTS13 Deficiency Shortens the Life Span of Mice With Experimental Diabetes

Paola Cassis, Domenico Cerullo, Cristina Zanchi, Daniela Corna, Vincenzo Lionetti, Fabrizio Giordano, Rubina Novelli, Sara Conti, Valentina Casieri, Marco Matteucci, Monica Locatelli, Giulia Taraboletti, Sebastian Villa, Sara Gastoldi, Giuseppe Remuzzi, Ariela Benigni, Carlamaria Zoja
Journal: Diabetes
Diabetes 2018;67(10):2069–2083
https://doi.org/10.2337/db17-1508
Published: 05 July 2018
View article titled, ADAMTS13 Deficiency Shortens the Life Span of Mice With Experimental Diabetes
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Includes: Supplementary data
Meeting Abstracts

L-Carnitine and Resveratrol Action on Oxidative Response and Differentiation in H9c2 Rat Cardiomyocytes

ILEANA TERRUZZI, PAMELA SENESI, ANNA MONTESANO, FERNANDA VACANTE, LIVIO LUZI
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1243-P
https://doi.org/10.2337/db18-1243-P
Published: 01 July 2018
View article titled, L-Carnitine and Resveratrol Action on Oxidative Response and Differentiation in H9c2 Rat Cardiomyocytes
Journal Articles

Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts

Junlian Gu, Xiaoqing Yan, Xiaozhen Dai, Yuehui Wang, Qian Lin, Jian Xiao, Shanshan Zhou, Jian Zhang, Kai Wang, Jun Zeng, Ying Xin, Michelle T. Barati, Chi Zhang, Yang Bai, Yan Li, Paul N. Epstein, Kupper A. Wintergerst, Xiaokun Li, Yi Tan, Lu Cai
Journal: Diabetes
Diabetes 2018;67(3):507–517
https://doi.org/10.2337/db17-0219
Published: 27 October 2017
View article titled, Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts
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Includes: Supplementary data