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Journal Articles

Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and Insulin Signaling by Controlling FATP2 Localization and Activation of the DAG/PKCδ Axis

Kakali Ghoshal, James M. Luther, Suman B. Pakala, Sergei Chetyrkin, John R. Falck, Roy Zent, David H. Wasserman, Ambra Pozzi

Diabetes 2024;73(8):1229–1243

https://doi.org/10.2337/db23-0493

Published: 14 May 2024

View articletitled, Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and Insulin Signaling by Controlling FATP2 Localization and Activation of the DAG/PKCδ Axis

Journal Articles

Glucose Regulation of β-Cell K_ATP Channels: It Is Time for a New Model!

Matthew J. Merrins, Richard G. Kibbey

Diabetes 2024;73(6):856–863

https://doi.org/10.2337/dbi23-0032

Published: 19 April 2024

View articletitled, Glucose Regulation of β-Cell KATP Channels: It Is Time for a New Model!

Meeting Abstracts

229-LB: Quantification of GLP-1R Internalization and Recycling in Live ß Cells

SARAH M. GRAY, KYLE SLOOP, PETER RAVN, JONATHAN CAMPBELL, DAVID A. D’ALESSIO

Diabetes 2021;70(Supplement_1):229-LB

https://doi.org/10.2337/db21-229-LB

Published: 01 June 2021

View articletitled, 229-LB: Quantification of GLP-1R Internalization and Recycling in Live ß Cells

Meeting Abstracts

501-P: Lower Plasma Membrane Sn-1,2-Diacylglycerol Content and PKCepsilon/theta Activity Explain the Athlete’s Paradox

RAFAEL C. GASPAR, KUN LYU, BRANDON T. HUBBARD, BROOKS LEITNER, PANU LUUKKONEN, SANDRO HIRABARA, IKKI SAKUMA, ALI NASIRI, DONGYAN ZHANG, MARIO KAHN, GARY CLINE, JOSÉ R. PAULI, RACHEL J. PERRY, KITT PETERSEN, GERALD I. SHULMAN

Diabetes 2021;70(Supplement_1):501-P

https://doi.org/10.2337/db21-501-P

Published: 01 June 2021

View articletitled, 501-P: Lower Plasma Membrane Sn-1,2-Diacylglycerol Content and PKCepsilon/theta Activity Explain the Athlete’s Paradox

Meeting Abstracts

335-OR: Lipid-Induced Insulin Resistance in the Renal Cortex Is Associated with Plasma Membrane Sn-1,2-diacylglycerol Accumulation and PKCe Translocation

BRANDON T. HUBBARD, RAFAEL C. GASPAR, DONGYAN ZHANG, MARIO KAHN, ALI NASIRI, XIAN-MAN ZHANG, GARY CLINE, GERALD I. SHULMAN

Diabetes 2021;70(Supplement_1):335-OR

https://doi.org/10.2337/db21-335-OR

Published: 01 June 2021

View articletitled, 335-OR: Lipid-Induced Insulin Resistance in the Renal Cortex Is Associated with Plasma Membrane Sn-1,2-diacylglycerol Accumulation and PKCe Translocation

Journal Articles

Melanophilin Accelerates Insulin Granule Fusion without Predocking to the Plasma Membrane

Hao Wang, Kouichi Mizuno, Noriko Takahashi, Eri Kobayashi, Jun Shirakawa, Yasuo Terauchi, Haruo Kasai, Katsuhide Okunishi, Tetsuro Izumi

Diabetes 2020;69(12):2655–2666

https://doi.org/10.2337/db20-0069

Published: 29 November 2020

View articletitled, Melanophilin Accelerates Insulin Granule Fusion without Predocking to the Plasma Membrane

Meeting Abstracts

266-OR: Plasma Membrane sn-1,2 Diacylglycerol Mediates Lipid-Induced Hepatic Insulin Resistance

KUN LYU, YE ZHANG, DONGYAN ZHANG, MARIO KAHN, YUICHI NOZAKI, SANJAY BHANOT, JONATHAN BOGAN, GARY CLINE, VARMAN SAMUEL, GERALD I. SHULMAN

Diabetes 2019;68(Supplement_1):266-OR

https://doi.org/10.2337/db19-266-OR

Published: 01 June 2019

View articletitled, 266-OR: Plasma Membrane sn-1,2 Diacylglycerol Mediates Lipid-Induced Hepatic Insulin Resistance

Meeting Abstracts

Cdk2-Dependent Activation of ß-Cell Metabolism Is Eclipsed by Its Inhibitory Effect on Plasma Membrane Excitability and Insulin Secretion

SOPHIA SDAO, CHETAN POUDEL, KARA M. MORTENSEN, MATTHEW J. MERRINS

Diabetes 2018;67(Supplement_1):2140-P

https://doi.org/10.2337/db18-2140-P

Published: 01 July 2018

View articletitled, Cdk2-Dependent Activation of ß-Cell Metabolism Is Eclipsed by Its Inhibitory Effect on Plasma Membrane Excitability and Insulin Secretion

Journal Articles

Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis

Ida Alenkvist, Nikhil R. Gandasi, Sebastian Barg, Anders Tengholm

Diabetes 2017;66(10):2610–2622

https://doi.org/10.2337/db17-0050

Published: 05 July 2017

View articletitled, Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis

Journal Articles

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction

Jianyang Fu, Xiaoqing Dai, Gregory Plummer, Kunimasa Suzuki, Austin Bautista, John M. Githaka, Laura Senior, Mette Jensen, Dafna Greitzer-Antes, Jocelyn E. Manning Fox, Herbert Y. Gaisano, Christopher B. Newgard, Nicolas Touret, Patrick E. MacDonald

Diabetes 2017;66(7):1890–1900

https://doi.org/10.2337/db16-1170

Published: 15 June 2017

View articletitled, Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction

Includes: Supplementary data

Journal Articles

Vaspin Is an Adipokine Ameliorating ER Stress in Obesity as a Ligand for Cell-Surface GRP78/MTJ-1 Complex

Diabetes 2012;61(11):2823–2832

https://doi.org/10.2337/db12-0232

Published: 16 October 2012

View articletitled, Vaspin Is an Adipokine Ameliorating ER Stress in Obesity as a Ligand for Cell-Surface GRP78/MTJ-1 Complex

Includes: Supplementary data

Journal Articles

The Unconventional Role of Acid Sphingomyelinase in Regulation of Retinal Microangiopathy in Diabetic Human and Animal Models

Madalina Opreanu, Maria Tikhonenko, Svetlana Bozack, Todd A. Lydic, Gavin E. Reid, Kelly M. McSorley, Andrew Sochacki, Gloria I. Perez, Walter J. Esselman, Timothy Kern, Richard Kolesnick, Maria B. Grant, Julia V. Busik

Diabetes 2011;60(9):2370–2378

https://doi.org/10.2337/db10-0550

Published: 20 August 2011

View articletitled, The Unconventional Role of Acid Sphingomyelinase in Regulation of Retinal Microangiopathy in Diabetic Human and Animal Models

Includes: Supplementary data

Journal Articles

Brain GLP-1 Signaling Regulates Femoral Artery Blood Flow and Insulin Sensitivity Through Hypothalamic PKC-δ

Cendrine Cabou, Christelle Vachoux, Gérard Campistron, Daniel J. Drucker, Rémy Burcelin

Diabetes 2011;60(9):2245–2256

https://doi.org/10.2337/db11-0464

Published: 20 August 2011

View articletitled, Brain GLP-1 Signaling Regulates Femoral Artery Blood Flow and Insulin Sensitivity Through Hypothalamic PKC-δ

Includes: Supplementary data

Journal Articles

Phosphatidylinositol-4-Phosphate-5-Kinase α Deficiency Alters Dynamics of Glucose-Stimulated Insulin Release to Improve Glucohomeostasis and Decrease Obesity in Mice

Ping Huang, Oladapo Yeku, Haihong Zong, Phyllis Tsang, Wenjuan Su, Xiao Yu, Shuzhi Teng, Mary Osisami, Yasunori Kanaho, Jeffrey E. Pessin, Michael A. Frohman

Diabetes 2011;60(2):454–463

https://doi.org/10.2337/db10-0614

Published: 21 January 2011

View articletitled, Phosphatidylinositol-4-Phosphate-5-Kinase α Deficiency Alters Dynamics of Glucose-Stimulated Insulin Release to Improve Glucohomeostasis and Decrease Obesity in Mice

Includes: Multimedia, Supplementary data

Journal Articles

Gαo Represses Insulin Secretion by Reducing Vesicular Docking in Pancreatic β-Cells

Aizhen Zhao, Mica Ohara-Imaizumi, Marcella Brissova, Richard K.P. Benninger, Yanwen Xu, Yuhan Hao, Joel Abramowitz, Guylain Boulay, Alvin C. Powers, David Piston, Meisheng Jiang, Shinya Nagamatsu, Lutz Birnbaumer, Guoqiang Gu

Diabetes 2010;59(10):2522–2529

https://doi.org/10.2337/db09-1719

Published: 09 July 2010

View articletitled, Gαo Represses Insulin Secretion by Reducing Vesicular Docking in Pancreatic β-Cells

Includes: Supplementary data

Journal Articles

Nephrin Is Expressed on the Surface of Insulin Vesicles and Facilitates Glucose-Stimulated Insulin Release

Alessia Fornoni, Jongmin Jeon, Javier Varona Santos, Lorenzo Cobianchi, Alexandra Jauregui, Luca Inverardi, Slavena A. Mandic, Christina Bark, Kevin Johnson, George McNamara, Antonello Pileggi, R. Damaris Molano, Jochen Reiser, Karl Tryggvason, Dontscho Kerjaschki, Per-Olof Berggren, Peter Mundel, Camillo Ricordi

Diabetes 2010;59(1):190–199

https://doi.org/10.2337/db09-0655

Published: 15 October 2009

View articletitled, Nephrin Is Expressed on the Surface of Insulin Vesicles and Facilitates Glucose-Stimulated Insulin Release

Journal Articles

Insulin Granule Recruitment and Exocytosis Is Dependent on p110γ in Insulinoma and Human β-Cells

Gary M. Pigeau, Jelena Kolic, Brandon J. Ball, Michael B. Hoppa, Ying W. Wang, Thomas Rückle, Minna Woo, Jocelyn E. Manning Fox, Patrick E. MacDonald

Diabetes 2009;58(9):2084–2092

https://doi.org/10.2337/db08-1371

Published: 23 June 2009

View articletitled, Insulin Granule Recruitment and Exocytosis Is Dependent on p110γ in Insulinoma and Human β-Cells

Journal Articles

Munc18c Depletion Selectively Impairs the Sustained Phase of Insulin Release

Eunjin Oh, Debbie C. Thurmond

Diabetes 2009;58(5):1165–1174

https://doi.org/10.2337/db08-1059

Published: 02 February 2009

View articletitled, Munc18c Depletion Selectively Impairs the Sustained Phase of Insulin Release

Journal Articles

Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic β-Cells

Etsuko Hisanaga, Masahiro Nagasawa, Kohjiro Ueki, Rohit N. Kulkarni, Masatomo Mori, Itaru Kojima

Diabetes 2009;58(1):174–184

https://doi.org/10.2337/db08-0862

Published: 01 January 2009

View articletitled, Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic β-Cells

Includes: Supplementary data

Journal Articles

Rapid Turnover of Phosphatidylinositol-4,5-Bisphosphate in Insulin-Secreting Cells Mediated by Ca²⁺ and the ATP-to-ADP Ratio

Sophia Thore, Anne Wuttke, Anders Tengholm

Diabetes 2007;56(3):818–826

https://doi.org/10.2337/db06-0843

Published: 01 March 2007

View articletitled, Rapid Turnover of Phosphatidylinositol-4,5-Bisphosphate in Insulin-Secreting Cells Mediated by Ca2+ and the ATP-to-ADP Ratio

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Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and Insulin Signaling by Controlling FATP2 Localization and Activation of the DAG/PKCδ Axis

Glucose Regulation of β-Cell K_ATP Channels: It Is Time for a New Model!

229-LB: Quantification of GLP-1R Internalization and Recycling in Live ß Cells

501-P: Lower Plasma Membrane Sn-1,2-Diacylglycerol Content and PKCepsilon/theta Activity Explain the Athlete’s Paradox

335-OR: Lipid-Induced Insulin Resistance in the Renal Cortex Is Associated with Plasma Membrane Sn-1,2-diacylglycerol Accumulation and PKCe Translocation

Melanophilin Accelerates Insulin Granule Fusion without Predocking to the Plasma Membrane

266-OR: Plasma Membrane sn-1,2 Diacylglycerol Mediates Lipid-Induced Hepatic Insulin Resistance

Cdk2-Dependent Activation of ß-Cell Metabolism Is Eclipsed by Its Inhibitory Effect on Plasma Membrane Excitability and Insulin Secretion

Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction

Vaspin Is an Adipokine Ameliorating ER Stress in Obesity as a Ligand for Cell-Surface GRP78/MTJ-1 Complex

The Unconventional Role of Acid Sphingomyelinase in Regulation of Retinal Microangiopathy in Diabetic Human and Animal Models

Brain GLP-1 Signaling Regulates Femoral Artery Blood Flow and Insulin Sensitivity Through Hypothalamic PKC-δ

Phosphatidylinositol-4-Phosphate-5-Kinase α Deficiency Alters Dynamics of Glucose-Stimulated Insulin Release to Improve Glucohomeostasis and Decrease Obesity in Mice

Gαo Represses Insulin Secretion by Reducing Vesicular Docking in Pancreatic β-Cells

Nephrin Is Expressed on the Surface of Insulin Vesicles and Facilitates Glucose-Stimulated Insulin Release

Insulin Granule Recruitment and Exocytosis Is Dependent on p110γ in Insulinoma and Human β-Cells

Munc18c Depletion Selectively Impairs the Sustained Phase of Insulin Release

Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic β-Cells

Rapid Turnover of Phosphatidylinositol-4,5-Bisphosphate in Insulin-Secreting Cells Mediated by Ca²⁺ and the ATP-to-ADP Ratio

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