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Journal Articles

An E115A Missense Variant in CERS2 Is Associated With Increased Sleeping Energy Expenditure and Hepatic Insulin Resistance in American Indians

Sascha Heinitz, Michael Traurig, Jonathan Krakoff, Philipp Rabe, Claudia Stäubert, Sayuko Kobes, Robert L. Hanson, Michael Stumvoll, Matthias Blüher, Clifton Bogardus, Leslie Baier, Paolo Piaggi

Diabetes 2024;73(8):1361–1371

https://doi.org/10.2337/db23-0690

Published: 22 May 2024

View article titled, An E115A Missense Variant in <em>CERS2</em> Is Associated With Increased Sleeping Energy Expenditure and Hepatic Insulin Resistance in American Indians

Journal Articles

Ceramides as Risk Markers for Future Cardiovascular Events and All-Cause Mortality in Long-standing Type 1 Diabetes

Asger Wretlind, Viktor R. Curovic, Tommi Suvitaival, Simone Theilade, Nete Tofte, Signe A. Winther, Tina Vilsbøll, Henrik Vestergaard, Peter Rossing, Cristina Legido-Quigley

Diabetes 2023;72(10):1493–1501

https://doi.org/10.2337/db23-0052

Published: 21 July 2023

View article titled, Ceramides as Risk Markers for Future Cardiovascular Events and All-Cause Mortality in Long-standing Type 1 Diabetes

Meeting Abstracts

1173-P: Maternally Supplemented PQQ Targets Ceramide Metabolism in Offspring to Blunt Developmental Programming of NAFLD

ASHOK MANDALA, APRIL M. TEAGUE, RACHEL JANSSEN, NIKHIL PATIL, ADITYA D. JOSHI, JACOB E. FRIEDMAN, KAREN R. JONSCHER

Diabetes 2023;72(Supplement_1):1173-P

https://doi.org/10.2337/db23-1173-P

Published: 20 June 2023

View article titled, 1173-P: Maternally Supplemented PQQ Targets Ceramide Metabolism in Offspring to Blunt Developmental Programming of NAFLD

Meeting Abstracts

1638-P: Oxidized Lipids Cause Ceramide Accumulation and Insulin Resistance in Skeletal Muscle

KARIN ZEMSKI BERRY, BRYAN C. BERGMAN

Diabetes 2023;72(Supplement_1):1638-P

https://doi.org/10.2337/db23-1638-P

Published: 20 June 2023

View article titled, 1638-P: Oxidized Lipids Cause Ceramide Accumulation and Insulin Resistance in Skeletal Muscle

Meeting Abstracts

457-P: Ceramides and the Ceramide-Based Risk Scores CERT1 and CERT2 Are Elevated in Patients with the Metabolic Syndrome

THOMAS PLATTNER, CHRISTOPH H. SAELY, AXEL MUENDLEIN, ALEXANDER VONBANK, ARTHUR MADER, LUKAS SPRENGER, MAXIMILIAN MAECHLER, BARBARA LARCHER, HEINZ DREXEL, ANDREAS LEIHERER

Diabetes 2023;72(Supplement_1):457-P

https://doi.org/10.2337/db23-457-P

Published: 20 June 2023

View article titled, 457-P: Ceramides and the Ceramide-Based Risk Scores CERT1 and CERT2 Are Elevated in Patients with the Metabolic Syndrome

Meeting Abstracts

456-P: Ceramide- and Phosphatidylcholine-Based Coronary Event Risk Tests 1 and 2 (CERT1, CERT2) Predict Both Type 2 Diabetes and Chronic Kidney Disease

THOMAS PLATTNER, CHRISTOPH H. SAELY, AXEL MUENDLEIN, ALEXANDER VONBANK, ARTHUR MADER, LUKAS SPRENGER, MAXIMILIAN MAECHLER, BARBARA LARCHER, HEINZ DREXEL, ANDREAS LEIHERER

Diabetes 2023;72(Supplement_1):456-P

https://doi.org/10.2337/db23-456-P

Published: 20 June 2023

View article titled, 456-P: Ceramide- and Phosphatidylcholine-Based Coronary Event Risk Tests 1 and 2 (CERT1, CERT2) Predict Both Type 2 Diabetes and Chronic Kidney Disease

Meeting Abstracts

158-OR: Ceramides Predict the Development of Type 2 Diabetes

ANDREAS LEIHERER, AXEL MUENDLEIN, THOMAS PLATTNER, ALEXANDER VONBANK, ARTHUR MADER, LUKAS SPRENGER, MAXIMILIAN MAECHLER, BARBARA LARCHER, PETER FRAUNBERGER, HEINZ DREXEL, CHRISTOPH H. SAELY

Diabetes 2023;72(Supplement_1):158-OR

https://doi.org/10.2337/db23-158-OR

Published: 20 June 2023

View article titled, 158-OR: Ceramides Predict the Development of Type 2 Diabetes

Journal Articles

Placing a Hex on Glucose Uptake

Faith M. Bowman, Scott A. Summers, William L. Holland

Diabetes 2023;72(6):690–692

https://doi.org/10.2337/dbi22-0040

Published: 19 May 2023

View article titled, Placing a Hex on Glucose Uptake

Meeting Abstracts

1349-P: Bariatric Surgery Causes an Early Improvement in the Lipidomic Profile and a Decrease in Plasma Ceramides and Diacylglycerols in Patients with Type 2 Diabetes and NAFLD

SRILAXMI KALAVALAPALLI, DIANA BARB, RACHEL E. DILLARD, EDDISON GODINEZ, JEFFREY FRIEDMAN, NADA FANOUS, CURTIS O. WARREN, FERNANDO BRIL, ROMINA LOMONACO, ALI ZARRINPAR, KENNETH CUSI

Diabetes 2022;71(Supplement_1):1349-P

https://doi.org/10.2337/db22-1349-P

Published: 01 June 2022

View article titled, 1349-P: Bariatric Surgery Causes an Early Improvement in the Lipidomic Profile and a Decrease in Plasma Ceramides and Diacylglycerols in Patients with Type 2 Diabetes and NAFLD

Meeting Abstracts

209-OR: Ceramide-Based Lipid Profiles and the Prevalence of Type 2 Diabetes Differ between Patients with Coronary Artery Disease and Those with Peripheral Artery Disease

ANDREAS LEIHERER, AXEL MUENDLEIN, EVA MARIA BRANDTNER, CHRISTOPH H. SAELY, ALEXANDER VONBANK, ARTHUR MADER, LUKAS SPRENGER, MAXIMILIAN MAECHLER, BARBARA LARCHER, ANTTI JYLHA, MITJA LAAPERI, REIJO LAAKSONEN, WINFRIED MAERZ, PETER FRAUNBERGER, MARCUS KLEBER, HEINZ DREXEL

Diabetes 2022;71(Supplement_1):209-OR

https://doi.org/10.2337/db22-209-OR

Published: 01 June 2022

View article titled, 209-OR: Ceramide-Based Lipid Profiles and the Prevalence of Type 2 Diabetes Differ between Patients with Coronary Artery Disease and Those with Peripheral Artery Disease

Meeting Abstracts

12-OR: Preventing ß-Cell Death under Glucotoxic Conditions: The Role of ChREBPb

LIORA S. KATZ, GABRIEL BRILL, MARK A. HERMAN, ADOLFO GARCIA-OCANA, DONALD SCOTT

Diabetes 2022;71(Supplement_1):12-OR

https://doi.org/10.2337/db22-12-OR

Published: 01 June 2022

View article titled, 12-OR: Preventing ß-Cell Death under Glucotoxic Conditions: The Role of ChREBPb

Meeting Abstracts

370-OR: Proinflammatory Stress Activates Neutral Sphingomyelinase 2 Based Generation of Ceramide-Enriched ß-Cell Exosomes

JERRY XU, EMILY K. SIMS

Diabetes 2022;71(Supplement_1):370-OR

https://doi.org/10.2337/db22-370-OR

Published: 01 June 2022

View article titled, 370-OR: Proinflammatory Stress Activates Neutral Sphingomyelinase 2 Based Generation of Ceramide-Enriched ß-Cell Exosomes

Meeting Abstracts

164-LB: Association of Ceramide and Sphingolipid Species with Incident Prediabetes among Offspring of Parents with Type 2 Diabetes

NAWAJES MANDAL, JIM Y. WAN, FRANKIE B. STENTZ, SAMUEL DAGOGO-JACK

Diabetes 2022;71(Supplement_1):164-LB

https://doi.org/10.2337/db22-164-LB

Published: 01 June 2022

View article titled, 164-LB: Association of Ceramide and Sphingolipid Species with Incident Prediabetes among Offspring of Parents with Type 2 Diabetes

Journal Articles

Surplus Ceramides: An Added Twist in the Tale of TREM2 and Insulin Resistance

Kierstin L. Webster, Lev Becker

Diabetes 2021;70(9):1926–1928

https://doi.org/10.2337/dbi21-0017

Published: 07 September 2021

View article titled, Surplus Ceramides: An Added Twist in the Tale of TREM2 and Insulin Resistance

Meeting Abstracts

363-P: The Ceramide- and Phosphatidylcholine-Based Coronary Event Risk Test 2 (CERT2) and Cardiovascular Mortality in Men and Women with Type 2 Diabetes

ANDREAS LEIHERER, AXEL MUENDLEIN, CHRISTOPH H. SAELY, BARBARA LARCHER, ARTHUR MADER, MAXIMILIAN MAECHLER, LUKAS SPRENGER, BEATRIX MUTSCHLECHNER, REIJO LAAKSONEN, MITJA LAAPERI, ANTTI JYLHA, PETER FRAUNBERGER, HEINZ DREXEL

Diabetes 2021;70(Supplement_1):363-P

https://doi.org/10.2337/db21-363-P

Published: 01 June 2021

View article titled, 363-P: The Ceramide- and Phosphatidylcholine-Based Coronary Event Risk Test 2 (CERT2) and Cardiovascular Mortality in Men and Women with Type 2 Diabetes

Meeting Abstracts

39-OR: Pancreatic Beta Cell SERCA2 Deficiency Impacts ER-Golgi Vesicle Trafficking and Ceramide Metabolism

TATSUYOSHI KONO, HITOSHI IIDA, CHIH-CHUN LEE, PREETHI KRISHNAN, PETER ARVAN, IRIS LINDBERG, CARMELLA EVANS-MOLINA

Diabetes 2021;70(Supplement_1):39-OR

https://doi.org/10.2337/db21-39-OR

Published: 01 June 2021

View article titled, 39-OR: Pancreatic Beta Cell SERCA2 Deficiency Impacts ER-Golgi Vesicle Trafficking and Ceramide Metabolism

Meeting Abstracts

120-OR: Dapagliflozin Increases Adiponectin and Its Receptors, and Reduces Inflammation and Ceramide Synthesis Enzymes in the Obese Prediabetic Dog

MORVARID KABIR, RICHARD N. BERGMAN, V. SASHI GOPAUL, HSIUCHIUNG YANG, CATHRYN M. KOLKA

Diabetes 2021;70(Supplement_1):120-OR

https://doi.org/10.2337/db21-120-OR

Published: 01 June 2021

View article titled, 120-OR: Dapagliflozin Increases Adiponectin and Its Receptors, and Reduces Inflammation and Ceramide Synthesis Enzymes in the Obese Prediabetic Dog

Journal Articles

Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages

Diabetes 2021;70(9):2042–2057

https://doi.org/10.2337/db20-0572

Published: 24 February 2021

View article titled, Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages

Journal Articles

A Novel Model of Diabetic Complications: Adipocyte Mitochondrial Dysfunction Triggers Massive β-Cell Hyperplasia

Christine M. Kusminski, Alexandra L. Ghaben, Thomas S. Morley, Ricardo J. Samms, Andrew C. Adams, Yu An, Joshua A. Johnson, Nolwenn Joffin, Toshiharu Onodera, Clair Crewe, William L. Holland, Ruth Gordillo, Philipp E. Scherer

Diabetes 2020;69(3):313–330

https://doi.org/10.2337/db19-0327

Published: 27 December 2020

View article titled, A Novel Model of Diabetic Complications: Adipocyte Mitochondrial Dysfunction Triggers Massive β-Cell Hyperplasia

Includes: Supplementary data

Meeting Abstracts

7-OR: Comparison of Two Recent Ceramide-Based Coronary Risk Prediction Scores: CERT and CERT-2

ANDREAS LEIHERER, AXEL MUENDLEIN, CHRISTOPH H. SAELY, REIJO LAAKSONEN, MITJA LAAPERI, ALEXANDER VONBANK, PETER FRAUNBERGER, HEINZ DREXEL

Diabetes 2020;69(Supplement_1):7-OR

https://doi.org/10.2337/db20-7-OR

Published: 01 June 2020

View article titled, 7-OR: Comparison of Two Recent Ceramide-Based Coronary Risk Prediction Scores: CERT and CERT-2

NARROW

An E115A Missense Variant in CERS2 Is Associated With Increased Sleeping Energy Expenditure and Hepatic Insulin Resistance in American Indians

Ceramides as Risk Markers for Future Cardiovascular Events and All-Cause Mortality in Long-standing Type 1 Diabetes

1173-P: Maternally Supplemented PQQ Targets Ceramide Metabolism in Offspring to Blunt Developmental Programming of NAFLD

1638-P: Oxidized Lipids Cause Ceramide Accumulation and Insulin Resistance in Skeletal Muscle

457-P: Ceramides and the Ceramide-Based Risk Scores CERT1 and CERT2 Are Elevated in Patients with the Metabolic Syndrome

456-P: Ceramide- and Phosphatidylcholine-Based Coronary Event Risk Tests 1 and 2 (CERT1, CERT2) Predict Both Type 2 Diabetes and Chronic Kidney Disease

158-OR: Ceramides Predict the Development of Type 2 Diabetes

Placing a Hex on Glucose Uptake

1349-P: Bariatric Surgery Causes an Early Improvement in the Lipidomic Profile and a Decrease in Plasma Ceramides and Diacylglycerols in Patients with Type 2 Diabetes and NAFLD

209-OR: Ceramide-Based Lipid Profiles and the Prevalence of Type 2 Diabetes Differ between Patients with Coronary Artery Disease and Those with Peripheral Artery Disease

12-OR: Preventing ß-Cell Death under Glucotoxic Conditions: The Role of ChREBPb

370-OR: Proinflammatory Stress Activates Neutral Sphingomyelinase 2 Based Generation of Ceramide-Enriched ß-Cell Exosomes

164-LB: Association of Ceramide and Sphingolipid Species with Incident Prediabetes among Offspring of Parents with Type 2 Diabetes

Surplus Ceramides: An Added Twist in the Tale of TREM2 and Insulin Resistance

363-P: The Ceramide- and Phosphatidylcholine-Based Coronary Event Risk Test 2 (CERT2) and Cardiovascular Mortality in Men and Women with Type 2 Diabetes

39-OR: Pancreatic Beta Cell SERCA2 Deficiency Impacts ER-Golgi Vesicle Trafficking and Ceramide Metabolism

120-OR: Dapagliflozin Increases Adiponectin and Its Receptors, and Reduces Inflammation and Ceramide Synthesis Enzymes in the Obese Prediabetic Dog

Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages

A Novel Model of Diabetic Complications: Adipocyte Mitochondrial Dysfunction Triggers Massive β-Cell Hyperplasia

7-OR: Comparison of Two Recent Ceramide-Based Coronary Risk Prediction Scores: CERT and CERT-2

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