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Meeting Abstracts

83-LB: Pharmacokinetic and Pharmacodynamic Studies of Supaglutide in Rats and Monkeys

YIJING LIAO, ANRAN MA, ZHIHONG WANG, YUE ZHOU, LI ZHANG, LIN LIU, NA ZHANG, GERALD J. PRUD’HOMME, QINGHUA WANG

Diabetes 2022;71(Supplement_1):83-LB

DOI: https://doi.org/10.2337/db22-83-LB

Published: 01 June 2022

View article titled, 83-LB: Pharmacokinetic and Pharmacodynamic Studies of Supaglutide in Rats and Monkeys

Meeting Abstracts

940-P: 14C-Tirzepatide ADME Studies in Rat and Monkey

JENNIFER MARTIN, KENNETH CASSIDY, BORIS CZESKIS, JEFF ALBERTS, YANBIN LAO, JENNIFER GLUFF, ANDREA M. NIEDENTHAL

Diabetes 2020;69(Supplement_1):940-P

DOI: https://doi.org/10.2337/db20-940-P

Published: 01 June 2020

View article titled, 940-P: 14C-Tirzepatide ADME Studies in Rat and Monkey

Meeting Abstracts

2162-PUB: Diabetes Education for Technology Applications in Learning Study (DETAILS)

JENNIFER LEBLANC, NUHA ALI EL SAYED

Diabetes 2020;69(Supplement_1):2162-PUB

DOI: https://doi.org/10.2337/db20-2162-PUB

Published: 01 June 2020

View article titled, 2162-PUB: Diabetes Education for Technology Applications in Learning Study (DETAILS)

Journal Articles

The Effects of B1344, a Novel Fibroblast Growth Factor 21 Analog, on Nonalcoholic Steatohepatitis in Nonhuman Primates

Aoyuan Cui, Jian Li, Shaohui Ji, Fengguang Ma, Genbei Wang, Yaqian Xue, Zhengshuai Liu, Jing Gao, Jun Han, Ping Tai, Tony Wang, Jianxun Chen, Xiaohui Ma, Yu Li

Diabetes 2020;69(8):1611–1623

DOI: https://doi.org/10.2337/db20-0209

Published: 30 April 2020

View article titled, The Effects of B1344, a Novel Fibroblast Growth Factor 21 Analog, on Nonalcoholic Steatohepatitis in Nonhuman Primates

Meeting Abstracts

FFAR1 Agonism Restores Insulin Secretion in Rodents, Human Islets, and Diabetic Monkeys

JIANYING LIU, SEUNGHUN P. LEE, TONYA MARTIN, BRIAN RADY, SANATH MEEGALLA, HUI HUANG, MICHAEL P. WINTERS, LISA D. NORQUAY, JENSON QI, FUYONG DU, ANDREA R. NAWROCKI, MARK PLAYER, ALESSANDRO POCAI

Diabetes 2018;67(Supplement_1):609-P

DOI: https://doi.org/10.2337/db18-609-P

Published: 01 July 2018

View article titled, FFAR1 Agonism Restores Insulin Secretion in Rodents, Human Islets, and Diabetic Monkeys

Journal Articles

Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ_1–40/42 and Phospho-Tau May Abet Alzheimer Development

Mini Sajan, Barbara Hansen, Robert Ivey, III, Joshua Sajan, Csilla Ari, Shijie Song, Ursula Braun, Michael Leitges, Margaret Farese-Higgs, Robert V. Farese

Diabetes 2016;65(7):1892–1903

DOI: https://doi.org/10.2337/db15-1428

Published: 19 February 2016

View article titled, Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1–40/42 and Phospho-Tau May Abet Alzheimer Development

Includes: Supplementary data

Journal Articles

Resveratrol Prevents β-Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet

Jennifer L. Fiori, Yu-Kyong Shin, Wook Kim, Susan M. Krzysik-Walker, Isabel González-Mariscal, Olga D. Carlson, Mitesh Sanghvi, Ruin Moaddel, Kathleen Farhang, Shekhar K. Gadkaree, Maire E. Doyle, Kevin J. Pearson, Julie A. Mattison, Rafael de Cabo, Josephine M. Egan

Diabetes 2013;62(10):3500–3513

DOI: https://doi.org/10.2337/db13-0266

Published: 17 September 2013

View article titled, Resveratrol Prevents β-Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet

Includes: Supplementary data

Journal Articles

In This Issue of Diabetes

Diabetes 2013;62(10):3305–3306

DOI: https://doi.org/10.2337/db13-ti10

Published: 17 September 2013

View article titled, In This Issue of Diabetes

Journal Articles

Calorie Restriction Reduces the Influence of Glucoregulatory Dysfunction on Regional Brain Volume in Aged Rhesus Monkeys

Auriel A. Willette, Barbara B. Bendlin, Ricki J. Colman, Erik K. Kastman, Aaron S. Field, Andrew L. Alexander, Aadhavi Sridharan, David B. Allison, Rozalyn Anderson, Mary-Lou Voytko, Joseph W. Kemnitz, Richard H. Weindruch, Sterling C. Johnson

Diabetes 2012;61(5):1036–1042

DOI: https://doi.org/10.2337/db11-1187

Published: 13 April 2012

View article titled, Calorie Restriction Reduces the Influence of Glucoregulatory Dysfunction on Regional Brain Volume in Aged Rhesus Monkeys

Journal Articles

Ongoing β-Cell Turnover in Adult Nonhuman Primates Is Not Adaptively Increased in Streptozotocin-Induced Diabetes

Yoshifumi Saisho, Erica Manesso, Alexandra E. Butler, Ryan Galasso, Kylie Kavanagh, Mickey Flynn, Li Zhang, Paige Clark, Tatyana Gurlo, Gianna M. Toffolo, Claudio Cobelli, Janice D. Wagner, Peter C. Butler

Diabetes 2011;60(3):848–856

DOI: https://doi.org/10.2337/db09-1368

Published: 21 February 2011

View article titled, Ongoing β-Cell Turnover in Adult Nonhuman Primates Is Not Adaptively Increased in Streptozotocin-Induced Diabetes

Includes: Supplementary data

Journal Articles

Recovery of Endogenous β-Cell Function in Nonhuman Primates After Chemical Diabetes Induction and Islet Transplantation

Rita Bottino, Angela Criscimanna, Anna Casu, Jing He, Dirk J. Van der Windt, William A. Rudert, Carla Giordano, Massimo Trucco

Diabetes 2009;58(2):442–447

DOI: https://doi.org/10.2337/db08-1127

Published: 01 February 2009

View article titled, Recovery of Endogenous β-Cell Function in Nonhuman Primates After Chemical Diabetes Induction and Islet Transplantation

Journal Articles

Early-Life Stress and the Development of Obesity and Insulin Resistance in Juvenile Bonnet Macaques

Daniel Kaufman, Mary Ann Banerji, Igor Shorman, Eric L.P. Smith, Jeremy D. Coplan, Leonard A. Rosenblum, John G. Kral

Diabetes 2007;56(5):1382–1386

DOI: https://doi.org/10.2337/db06-1409

Published: 01 May 2007

View article titled, Early-Life Stress and the Development of Obesity and Insulin Resistance in Juvenile Bonnet Macaques

Journal Articles

Peptide YY_(3–36) Inhibits Morning, but Not Evening, Food Intake and Decreases Body Weight in Rhesus Macaques

Frank H. Koegler, Pablo J. Enriori, Sonja K. Billes, Diana L. Takahashi, Meghan S. Martin, Randall L. Clark, Anne E. Evans, Kevin L. Grove, Judy L. Cameron, Michael A. Cowley

Diabetes 2005;54(11):3198–3204

DOI: https://doi.org/10.2337/diabetes.54.11.3198

Published: 01 November 2005

View article titled, Peptide YY(3–36) Inhibits Morning, but Not Evening, Food Intake and Decreases Body Weight in Rhesus Macaques

Journal Articles

Neutrophils Are Associated With Capillary Closure in Spontaneously Diabetic Monkey Retinas

Sahng Y. Kim, Mary A. Johnson, D. Scott McLeod, Theresa Alexander, Barbara C. Hansen, Gerard A. Lutty

Diabetes 2005;54(5):1534–1542

DOI: https://doi.org/10.2337/diabetes.54.5.1534

Published: 01 May 2005

View article titled, Neutrophils Are Associated With Capillary Closure in Spontaneously Diabetic Monkey Retinas

Journal Articles

Skeletal Muscle Insulin Resistance in Obesity-Associated Type 2 Diabetes in Monkeys Is Linked to a Defect in Insulin Activation of Protein Kinase C-ζ/λ/ι

Mary L. Standaert, Heidi K. Ortmeyer, Mini P. Sajan, Yoshinori Kanoh, Gautam Bandyopadhyay, Barbara C. Hansen, Robert V. Farese

Diabetes 2002;51(10):2936–2943

DOI: https://doi.org/10.2337/diabetes.51.10.2936

Published: 01 October 2002

View article titled, Skeletal Muscle Insulin Resistance in Obesity-Associated Type 2 Diabetes in Monkeys Is Linked to a Defect in Insulin Activation of Protein Kinase C-ζ/λ/ι

Journal Articles

Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2 Diabetes in Rhesus Monkeys

Kikuko Hotta, Tohru Funahashi, Noni L. Bodkin, Heidi K. Ortmeyer, Yukio Arita, Barbara C. Hansen, Yuji Matsuzawa

Diabetes 2001;50(5):1126–1133

DOI: https://doi.org/10.2337/diabetes.50.5.1126

Published: 01 May 2001

View article titled, Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2 Diabetes in Rhesus Monkeys

Journal Articles

Processing of Proinsulin by Furin, PC2, and PC3 in (Co) Transfected COS (Monkey Kidney) Cells

Florence Vollenweider, Jocelyne Kaufmann, Jean-Claude Irminger, Philippe A Halban

Diabetes 1995;44(9):1075–1080

DOI: https://doi.org/10.2337/diab.44.9.1075

Published: 01 September 1995

View article titled, Processing of Proinsulin by Furin, PC2, and PC3 in (Co) Transfected COS (Monkey Kidney) Cells

Journal Articles

Primary Prevention of Diabetes Mellitus by Prevention of Obesity in Monkeys

Barbara C Hansen, Noni L Bodkin

Diabetes 1993;42(12):1809–1814

DOI: https://doi.org/10.2337/diab.42.12.1809

Published: 01 December 1993

View article titled, Primary Prevention of Diabetes Mellitus by Prevention of Obesity in Monkeys

Journal Articles

In Vivo Imaging of Insulin Receptors in Monkeys Using ¹⁸F-Labeled Insulin and Positron Emission Tomography

Richard C Eastman, Richard E Carson, Kenneth A Jacobson, Yechial Shai, Michael A Channing, Bonnie B Dunn, John D Bacher, Ervin Baas, Estelle Jones, Kenneth L Kirk, Maxine A Lesniak, Jesse Roth

Diabetes 1992;41(7):855–860

DOI: https://doi.org/10.2337/diab.41.7.855

Published: 01 July 1992

View article titled, In Vivo Imaging of Insulin Receptors in Monkeys Using 18F-Labeled Insulin and Positron Emission Tomography

Journal Articles

Mechanisms Involved in Degradation of Human Insulin by Cytosolic Fractions of Human, Monkey, and Rat Liver

Victor J Wroblewski, Michael Masnyk, Sunita S Khambatta, Gerald W Becker

Diabetes 1992;41(4):539–547

DOI: https://doi.org/10.2337/diab.41.4.539

Published: 01 April 1992

View article titled, Mechanisms Involved in Degradation of Human Insulin by Cytosolic Fractions of Human, Monkey, and Rat Liver

NARROW

83-LB: Pharmacokinetic and Pharmacodynamic Studies of Supaglutide in Rats and Monkeys

940-P: 14C-Tirzepatide ADME Studies in Rat and Monkey

2162-PUB: Diabetes Education for Technology Applications in Learning Study (DETAILS)

The Effects of B1344, a Novel Fibroblast Growth Factor 21 Analog, on Nonalcoholic Steatohepatitis in Nonhuman Primates

FFAR1 Agonism Restores Insulin Secretion in Rodents, Human Islets, and Diabetic Monkeys

Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ_1–40/42 and Phospho-Tau May Abet Alzheimer Development

Resveratrol Prevents β-Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet

In This Issue of Diabetes

Calorie Restriction Reduces the Influence of Glucoregulatory Dysfunction on Regional Brain Volume in Aged Rhesus Monkeys

Ongoing β-Cell Turnover in Adult Nonhuman Primates Is Not Adaptively Increased in Streptozotocin-Induced Diabetes

Recovery of Endogenous β-Cell Function in Nonhuman Primates After Chemical Diabetes Induction and Islet Transplantation

Early-Life Stress and the Development of Obesity and Insulin Resistance in Juvenile Bonnet Macaques

Peptide YY_(3–36) Inhibits Morning, but Not Evening, Food Intake and Decreases Body Weight in Rhesus Macaques

Neutrophils Are Associated With Capillary Closure in Spontaneously Diabetic Monkey Retinas

Skeletal Muscle Insulin Resistance in Obesity-Associated Type 2 Diabetes in Monkeys Is Linked to a Defect in Insulin Activation of Protein Kinase C-ζ/λ/ι

Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2 Diabetes in Rhesus Monkeys

Processing of Proinsulin by Furin, PC2, and PC3 in (Co) Transfected COS (Monkey Kidney) Cells

Primary Prevention of Diabetes Mellitus by Prevention of Obesity in Monkeys

In Vivo Imaging of Insulin Receptors in Monkeys Using ¹⁸F-Labeled Insulin and Positron Emission Tomography

Mechanisms Involved in Degradation of Human Insulin by Cytosolic Fractions of Human, Monkey, and Rat Liver

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