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Journal Articles

Adipocyte Glucocorticoid Receptor Deficiency Promotes Adipose Tissue Expandability and Improves the Metabolic Profile Under Corticosterone Exposure

Héloïse Dalle, Marie Garcia, Bénédicte Antoine, Vanessa Boehm, Thi Thu Huong Do, Marion Buyse, Tatiana Ledent, Antonin Lamazière, Christophe Magnan, Catherine Postic, Raphaël George Denis, Serge Luquet, Bruno Fève, Marthe Moldes
Journal: Diabetes
Diabetes 2019;68(2):305–317
DOI: https://doi.org/10.2337/db17-1577
Published: 19 November 2018
View article titled, Adipocyte Glucocorticoid Receptor Deficiency Promotes Adipose Tissue Expandability and Improves the Metabolic Profile Under Corticosterone Exposure
Click here to open pdf in another window PDF for Adipocyte Glucocorticoid Receptor Deficiency Promotes Adipose Tissue Expandability and Improves the Metabolic Profile Under Corticosterone Exposure
Includes: Supplementary data
Journal Articles

Adaptive β-Cell Neogenesis in the Adult Mouse in Response to Glucocorticoid-Induced Insulin Resistance

Emilie Courty, Adrien Besseiche, Thi Thu Huong Do, Alexandrine Liboz, Fatima Mohamed Aguid, Evans Quilichini, Melissa Buscato, Pierre Gourdy, Jean-François Gautier, Jean-Pierre Riveline, Cécile Haumaitre, Marion Buyse, Bruno Fève, Ghislaine Guillemain, Bertrand Blondeau
Journal: Diabetes
Diabetes 2019;68(1):95–108
DOI: https://doi.org/10.2337/db17-1314
Published: 16 October 2018
View article titled, Adaptive β-Cell Neogenesis in the Adult Mouse in Response to Glucocorticoid-Induced Insulin Resistance
Click here to open pdf in another window PDF for Adaptive β-Cell Neogenesis in the Adult Mouse in Response to Glucocorticoid-Induced Insulin Resistance
Includes: Supplementary data
Journal Articles

Recycling Between Cortisol and Cortisone in Human Splanchnic, Subcutaneous Adipose, and Skeletal Muscle Tissues In Vivo

Katherine A. Hughes, Konstantinos N. Manolopoulos, Javaid Iqbal, Nicholas L. Cruden, Roland H. Stimson, Rebecca M. Reynolds, David E. Newby, Ruth Andrew, Fredrik Karpe, Brian R. Walker
Journal: Diabetes
Diabetes 2012;61(6):1357–1364
DOI: https://doi.org/10.2337/db11-1345
Published: 14 May 2012
View article titled, Recycling Between Cortisol and Cortisone in Human Splanchnic, Subcutaneous Adipose, and Skeletal Muscle Tissues In Vivo
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Journal Articles

Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids

Özlem Gögebakan, Janin Andres, Katrin Biedasek, Knut Mai, Peter Kühnen, Heiko Krude, Frank Isken, Natalia Rudovich, Martin A. Osterhoff, Ulrich Kintscher, Michael Nauck, Andreas F.H. Pfeiffer, Joachim Spranger
Journal: Diabetes
Diabetes 2012;61(2):292–300
DOI: https://doi.org/10.2337/db10-0902
Published: 17 January 2012
View article titled, Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids
Click here to open pdf in another window PDF for Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids
Includes: Supplementary data
Journal Articles

Increased Whole-Body and Sustained Liver Cortisol Regeneration by 11β-Hydroxysteroid Dehydrogenase Type 1 in Obese Men With Type 2 Diabetes Provides a Target for Enzyme Inhibition

Roland H. Stimson, Ruth Andrew, Norma C. McAvoy, Dhiraj Tripathi, Peter C. Hayes, Brian R. Walker
Journal: Diabetes
Diabetes 2011;60(3):720–725
DOI: https://doi.org/10.2337/db10-0726
Published: 21 February 2011
View article titled, Increased Whole-Body and Sustained Liver Cortisol Regeneration by 11β-Hydroxysteroid Dehydrogenase Type 1 in Obese Men With Type 2 Diabetes Provides a Target for Enzyme Inhibition
Click here to open pdf in another window PDF for Increased Whole-Body and Sustained Liver Cortisol Regeneration by 11β-Hydroxysteroid Dehydrogenase Type 1 in Obese Men With Type 2 Diabetes Provides a Target for Enzyme Inhibition
Journal Articles

11β-Hydroxysteroid Dehydrogenase Type 1 Regulates Glucocorticoid-Induced Insulin Resistance in Skeletal Muscle

Stuart A. Morgan, Mark Sherlock, Laura L. Gathercole, Gareth G. Lavery, Carol Lenaghan, Iwona J. Bujalska, David Laber, Alice Yu, Gemma Convey, Rachel Mayers, Krisztina Hegyi, Jaswinder K. Sethi, Paul M. Stewart, David M. Smith, Jeremy W. Tomlinson
Journal: Diabetes
Diabetes 2009;58(11):2506–2515
DOI: https://doi.org/10.2337/db09-0525
Published: 12 August 2009
View article titled, 11β-Hydroxysteroid Dehydrogenase Type 1 Regulates Glucocorticoid-Induced Insulin Resistance in Skeletal Muscle
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Journal Articles

Cortisol Release From Adipose Tissue by 11β-Hydroxysteroid Dehydrogenase Type 1 in Humans

Roland H. Stimson, Jonas Andersson, Ruth Andrew, Doris N. Redhead, Fredrik Karpe, Peter C. Hayes, Tommy Olsson, Brian R. Walker
Journal: Diabetes
Diabetes 2009;58(1):46–53
DOI: https://doi.org/10.2337/db08-0969
Published: 01 January 2009
View article titled, Cortisol Release From Adipose Tissue by 11β-Hydroxysteroid Dehydrogenase Type 1 in Humans
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Journal Articles

Liver Is the Site of Splanchnic Cortisol Production in Obese Nondiabetic Humans

Rita Basu, Ananda Basu, Meagan Grudzien, Paul Jung, Peer Jacobson, Michael Johnson, Ravinder Singh, Michael Sarr, Robert A. Rizza
Journal: Diabetes
Diabetes 2009;58(1):39–45
DOI: https://doi.org/10.2337/db08-1079
Published: 01 January 2009
View article titled, Liver Is the Site of Splanchnic Cortisol Production in Obese Nondiabetic Humans
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Journal Articles

Impaired Glucose Tolerance and Insulin Resistance Are Associated With Increased Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Elevated Hepatic 5α-Reductase Activity

Jeremy W. Tomlinson, Joanne Finney, Christopher Gay, Beverly A. Hughes, Susan V. Hughes, Paul M. Stewart
Journal: Diabetes
Diabetes 2008;57(10):2652–2660
DOI: https://doi.org/10.2337/db08-0495
Published: 01 October 2008
View article titled, Impaired Glucose Tolerance and Insulin Resistance Are Associated With Increased Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Elevated Hepatic 5α-Reductase Activity
Click here to open pdf in another window PDF for Impaired Glucose Tolerance and Insulin Resistance Are Associated With Increased Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Elevated Hepatic 5α-Reductase Activity
Journal Articles

Reduced Glucocorticoid Production Rate, Decreased 5α-Reductase Activity, and Adipose Tissue Insulin Sensitization After Weight Loss

Jeremy W. Tomlinson, Joanne Finney, Beverly A. Hughes, Susan V. Hughes, Paul M. Stewart
Journal: Diabetes
Diabetes 2008;57(6):1536–1543
DOI: https://doi.org/10.2337/db08-0094
Published: 01 June 2008
View article titled, Reduced Glucocorticoid Production Rate, Decreased 5α-Reductase Activity, and Adipose Tissue Insulin Sensitization After Weight Loss
Click here to open pdf in another window PDF for Reduced Glucocorticoid Production Rate, Decreased 5α-Reductase Activity, and Adipose Tissue Insulin Sensitization After Weight Loss
Journal Articles

Effect of Nutrient Ingestion on Total-Body and Splanchnic Cortisol Production in Humans

Rita Basu, Ravinder Singh, Ananda Basu, C.M. Johnson, Robert A. Rizza
Journal: Diabetes
Diabetes 2006;55(3):667–674
DOI: https://doi.org/10.2337/diabetes.55.03.06.db05-1335
Published: 01 March 2006
View article titled, Effect of Nutrient Ingestion on Total-Body and Splanchnic Cortisol Production in Humans
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Journal Articles

Proopiomelanocortin-Deficient Mice Are Hypersensitive to the Adverse Metabolic Effects of Glucocorticoids

Anthony P. Coll, Benjamin G. Challis, Miguel López, Sarah Piper, Giles S.H. Yeo, Stephen O’Rahilly
Journal: Diabetes
Diabetes 2005;54(8):2269–2276
DOI: https://doi.org/10.2337/diabetes.54.8.2269
Published: 01 August 2005
View article titled, Proopiomelanocortin-Deficient Mice Are Hypersensitive to the Adverse Metabolic Effects of Glucocorticoids
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Journal Articles

The Contribution of Visceral Adipose Tissue to Splanchnic Cortisol Production in Healthy Humans

Ruth Andrew, Jukka Westerbacka, John Wahren, Hannele Yki-Järvinen, Brian R. Walker
Journal: Diabetes
Diabetes 2005;54(5):1364–1370
DOI: https://doi.org/10.2337/diabetes.54.5.1364
Published: 01 May 2005
View article titled, The Contribution of Visceral Adipose Tissue to Splanchnic Cortisol Production in Healthy Humans
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Journal Articles

Increased In Vivo Regeneration of Cortisol in Adipose Tissue in Human Obesity and Effects of the 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor Carbenoxolone

Thekkepat C. Sandeep, Ruth Andrew, Natalie Z.M. Homer, Robert C. Andrews, Ken Smith, Brian R. Walker
Journal: Diabetes
Diabetes 2005;54(3):872–879
DOI: https://doi.org/10.2337/diabetes.54.3.872
Published: 01 March 2005
View article titled, Increased In Vivo Regeneration of Cortisol in Adipose Tissue in Human Obesity and Effects of the 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor Carbenoxolone
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Journal Articles

Splanchnic Cortisol Production Occurs in Humans: Evidence for Conversion of Cortisone to Cortisol Via the 11-β Hydroxysteroid Dehydrogenase (11β-HSD) Type 1 Pathway

Rita Basu, Ravinder J. Singh, Ananda Basu, Elizabeth G. Chittilapilly, C. Michael Johnson, Gianna Toffolo, Claudio Cobelli, Robert A. Rizza
Journal: Diabetes
Diabetes 2004;53(8):2051–2059
DOI: https://doi.org/10.2337/diabetes.53.8.2051
Published: 01 August 2004
View article titled, Splanchnic Cortisol Production Occurs in Humans: <span class="subtitle">Evidence for Conversion of Cortisone to Cortisol Via the 11-β Hydroxysteroid Dehydrogenase (11β-HSD) Type 1 Pathway</span>
Click here to open pdf in another window PDF for Splanchnic Cortisol Production Occurs in Humans: <span class="subtitle">Evidence for Conversion of Cortisone to Cortisol Via the 11-β Hydroxysteroid Dehydrogenase (11β-HSD) Type 1 Pathway</span>
Journal Articles

Increased Glucocorticoid Receptor Expression in Human Skeletal Muscle Cells May Contribute to the Pathogenesis of the Metabolic Syndrome

Christopher B. Whorwood, Stephen J. Donovan, Daniel Flanagan, David I.W. Phillips, Christopher D. Byrne
Journal: Diabetes
Diabetes 2002;51(4):1066–1075
DOI: https://doi.org/10.2337/diabetes.51.4.1066
Published: 01 April 2002
View article titled, Increased Glucocorticoid Receptor Expression in Human Skeletal Muscle Cells May Contribute to the Pathogenesis of the Metabolic Syndrome
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Journal Articles

Abnormalities of Myocardial Depolarization in Overt, Subclinical and Prediabetes: A Vectorcardiographic Study

Emmanuel R Riff, M.D., Kenneth M Riff, BS
Journal: Diabetes
Diabetes 1974;23(7):572–578
DOI: https://doi.org/10.2337/diab.23.7.572
Published: 01 July 1974
View article titled, Abnormalities of Myocardial Depolarization in Overt, Subclinical and Prediabetes: A Vectorcardiographic Study
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Journal Articles

Capillary Blood Sugar Values in Children During the Oral Cortisone-Primed Glucose Tolerance Test

Harold S Cole, M.D., Joan H Bilder, M.D., Rosa Epel, M.D.
Journal: Diabetes
Diabetes 1971;20(9):615–621
DOI: https://doi.org/10.2337/diab.20.9.615
Published: 01 September 1971
View article titled, Capillary Blood Sugar Values in Children During the Oral Cortisone-Primed Glucose Tolerance Test
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Journal Articles

Levels of Plasma Insulin During Cortisone Glucose Tolerance Tests in “Nondiabetic” Relatives of Diabetic Patients: Implications of Diminished Insulin Secretory Reserve in Subclinical Diabetes

Juan A Rull, M.D., J W Conn, M.D., John C Floyd, Jr, M.D., Stefan S Fajans, M.D.
Journal: Diabetes
Diabetes 1970;19(1):1–10
DOI: https://doi.org/10.2337/diab.19.1.1
Published: 01 January 1970
View article titled, Levels of Plasma Insulin During Cortisone Glucose Tolerance Tests in “Nondiabetic” Relatives of Diabetic Patients: Implications of Diminished Insulin Secretory Reserve in Subclinical Diabetes
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Journal Articles

Beta Cell Structure in Latent and Chronic Diabetes of the Rabbit

Bruno W Folk, M.D., Sydney S Lazarus, M.D., Klaus F Wellman, M.D.
Journal: Diabetes
Diabetes 1965;14(12):792–804
DOI: https://doi.org/10.2337/diab.14.12.792
Published: 01 December 1965
View article titled, Beta Cell Structure in Latent and Chronic Diabetes of the Rabbit
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