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Journal Articles

Autoreactive T Cells and Cytokine Stress Drive β-Cell Senescence Entry and Accumulation in Type 1 Diabetes

Free
Jasmine Pipella, Roozbeh Akbari Motlagh, Nayara Rampazzo Morelli, Peter J. Thompson
Journal: Diabetes
Diabetes db241122
https://doi.org/10.2337/db24-1122
Published: 11 June 2025
View articletitled, Autoreactive T Cells and Cytokine Stress Drive β-Cell Senescence Entry and Accumulation in Type 1 Diabetes
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Journal Articles

Liraglutide Treatment Reverses Unconventional Cellular Defects in Induced Pluripotent Stem Cell–Derived β-Cells Harboring a Partially Functional WFS1 Variant

Free
Silvia Torchio, Gabriel Siracusano, Federica Cuozzo, Valentina Zamarian, Silvia Pellegrini, Fabio Manenti, Riccardo Bonfanti, Giulio Frontino, Valeria Sordi, Raniero Chimienti, Lorenzo Piemonti
Journal: Diabetes
Diabetes 2025;74(7):1273–1288
https://doi.org/10.2337/db24-0720
Published: 09 April 2025
View articletitled, Liraglutide Treatment Reverses Unconventional Cellular Defects in Induced Pluripotent Stem Cell–Derived β-Cells Harboring a Partially Functional WFS1 Variant
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Journal Articles

Reduced Function of the Adaptor SH2B3 Promotes T1D via Altered Cytokine-Regulated, T-Cell–Intrinsic Immune Tolerance

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Taylor K. Watson, Aaron B.I. Rosen, Travis Drow, Jacob A. Medjo, Matthew A. MacQuivey, Yan Ge, H. Denny Liggitt, Dane A. Grosvenor, Kimberly A. Dill-McFarland, Matthew C. Altman, Patrick J. Concannon, Jane H. Buckner, David J. Rawlings, Eric J. Allenspach
Journal: Diabetes
Diabetes 2025;74(6):943–955
https://doi.org/10.2337/db24-0655
Published: 06 March 2025
View articletitled, Reduced Function of the Adaptor SH2B3 Promotes T1D via Altered Cytokine-Regulated, T-Cell–Intrinsic Immune Tolerance
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Journal Articles

Extracellular Mitochondria Exacerbate Retinal Pigment Epithelium Degeneration in Diabetic Retinopathy

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Keiichi Nishikawa, Tomoaki Murakami, Miyo Yoshida, Noriko Terada, Kenji Ishihara, Yuki Mori, Shinji Ito, Akitaka Tsujikawa
Journal: Diabetes
Diabetes 2025;74(3):409–415
https://doi.org/10.2337/db24-0040
Published: 23 December 2024
View articletitled, Extracellular Mitochondria Exacerbate Retinal Pigment Epithelium Degeneration in Diabetic Retinopathy
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Journal Articles

Temporal Alterations in CD8+ T Cells During the Progression From Stage 1 to Stage 3 Type 1 Diabetes

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Anna-Mari Schroderus, Viola Pitkänen, Ilse Ekman, Daniella Stevens, Marja Rytkönen-Nissinen, Reeta Rintamäki, Jussi Pihlajamäki, Mikael Knip, Riitta Veijola, Jorma Toppari, Jorma Ilonen, Johanna Lempainen, Tuure Kinnunen
Journal: Diabetes
Diabetes 2024;73(10):1705–1715
https://doi.org/10.2337/db24-0159
Published: 05 July 2024
View articletitled, Temporal Alterations in CD8+ T Cells During the Progression From Stage 1 to Stage 3 Type 1 Diabetes
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Journal Articles

Regulation of STAT1 Signaling in Human Pancreatic β-Cells by the Lysine Deacetylase HDAC6: A New Therapeutic Opportunity in Type 1 Diabetes?

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Kaiyven Afi Leslie, Christiana Lekka, Sarah J. Richardson, Mark A. Russell, Noel G. Morgan
Journal: Diabetes
Diabetes 2024;73(9):1473–1485
https://doi.org/10.2337/db24-0008
Published: 13 June 2024
View articletitled, Regulation of STAT1 Signaling in Human Pancreatic β-Cells by the Lysine Deacetylase HDAC6: A New Therapeutic Opportunity in Type 1 Diabetes?
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Journal Articles

Elevated Cathepsin S Serum Levels in New-Onset Type 1 Diabetes and Autoantibody-Positive Siblings

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Caroline Frørup, Mathias Høj Jensen, Martin Haupt-Jorgensen, Karsten Buschard, Joachim Størling, Flemming Pociot, Tina Fløyel
Journal: Diabetes
Diabetes 2024;73(8):1278–1284
https://doi.org/10.2337/db23-0911
Published: 03 May 2024
View articletitled, Elevated Cathepsin S Serum Levels in New-Onset Type 1 Diabetes and Autoantibody-Positive Siblings
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Journal Articles

Immunometabolic Signatures of Circulating Monocytes in Humans With Obesity and Insulin Resistance

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Lisa Smeehuijzen, Anouk Gijbels, Joline P. Nugteren-Boogaard, Frank Vrieling, Mehdi Boutagouga Boudjadja, Inez Trouwborst, Kelly M. Jardon, Gabby B. Hul, Edith J.M. Feskens, Ellen E. Blaak, Gijs H. Goossens, Lydia A. Afman, Rinke Stienstra
Journal: Diabetes
Diabetes 2024;73(7):1112–1121
https://doi.org/10.2337/db23-0970
Published: 24 April 2024
View articletitled, Immunometabolic Signatures of Circulating Monocytes in Humans With Obesity and Insulin Resistance
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Journal Articles

Macrophage SHP2 Deficiency Alleviates Diabetic Nephropathy via Suppression of MAPK/NF-κB– Dependent Inflammation

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Xue Han, Jiajia Wei, Ruyi Zheng, Yu Tu, Mengyang Wang, Lingfeng Chen, Zheng Xu, Lei Zheng, Chao Zheng, Qiaojuan Shi, Huazhong Ying, Guang Liang
Journal: Diabetes
Diabetes 2024;73(5):780–796
https://doi.org/10.2337/db23-0700
Published: 23 February 2024
View articletitled, Macrophage SHP2 Deficiency Alleviates Diabetic Nephropathy via Suppression of MAPK/NF-κB– Dependent Inflammation
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Journal Articles

Multiomics Analyses With Stool-Type Stratification in Patient Cohorts and Blautia Identification as a Potential Bacterial Modulator in Type 2 Diabetes Mellitus

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Qian Guo, Zezheng Gao, Linhua Zhao, Han Wang, Zhen Luo, Doris Vandeputte, Lisha He, Mo Li, Sha Di, Yanwen Liu, Jiaheng Hou, Xiaoqing Jiang, Huaiqiu Zhu, Xiaolin Tong
Journal: Diabetes
Diabetes 2024;73(3):511–527
https://doi.org/10.2337/db23-0447
Published: 11 December 2023
View articletitled, Multiomics Analyses With Stool-Type Stratification in Patient Cohorts and Blautia Identification as a Potential Bacterial Modulator in Type 2 Diabetes Mellitus
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Journal Articles

PTPN2 Regulates Metabolic Flux to Affect β-Cell Susceptibility to Inflammatory Stress

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Yong Kyung Kim, Youngjung Rachel Kim, Kristen L. Wells, Dylan Sarbaugh, Michelle Guney, Chia-Feng Tsai, Tiffany Zee, Gerard Karsenty, Ernesto S. Nakayasu, Lori Sussel
Journal: Diabetes
Diabetes 2024;73(3):434–447
https://doi.org/10.2337/db23-0355
Published: 28 November 2023
View articletitled, PTPN2 Regulates Metabolic Flux to Affect β-Cell Susceptibility to Inflammatory Stress
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Journal Articles

Verapamil Prevents Decline of IGF-I in Subjects With Type 1 Diabetes and Promotes β-Cell IGF-I Signaling

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Guanlan Xu, Junqin Chen, Brian Lu, Praveen Sethupathy, Wei-Jun Qian, Anath Shalev
Journal: Diabetes
Diabetes 2023;72(10):1460–1469
https://doi.org/10.2337/db23-0256
Published: 26 July 2023
View articletitled, Verapamil Prevents Decline of IGF-I in Subjects With Type 1 Diabetes and Promotes β-Cell IGF-I Signaling
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Meeting Abstracts

252-LB: Dectin-2 Deficiency Promotes Proinflammatory Cytokine Release from Macrophages and Impairs Glucose-Stimulated Insulin Secretion

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MASAMICHI FUJITA, TAKASHI MIYAZAWA, KEIICHIRO UCHIDA, NAOHIRO UCHIDA, TOMOMI HATAYAMA, SHINTARO NAKAMURA, YUKINA TAKEICHI, YASUTAKA MIYACHI, YOSHIHIRO OGAWA
Journal: Diabetes
Diabetes 2023;72(Supplement_1):252-LB
https://doi.org/10.2337/db23-252-LB
Published: 20 June 2023
View articletitled, 252-LB: Dectin-2 Deficiency Promotes Proinflammatory Cytokine Release from Macrophages and Impairs Glucose-Stimulated Insulin Secretion
Meeting Abstracts

1725-P: The Role of miR-146a-5p on Cytokine-Induced ß-Cell Mitochondrial Dysfunction and Death

Free
PREETHI KRISHNAN, RENATO C.S. BRANCO, STACI A. WEAVER, CHIH-CHUN LEE, FAROOQ SYED, CARMELLA EVANS-MOLINA
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1725-P
https://doi.org/10.2337/db23-1725-P
Published: 20 June 2023
View articletitled, 1725-P: The Role of miR-146a-5p on Cytokine-Induced ß-Cell Mitochondrial Dysfunction and Death
Meeting Abstracts

230-LB: A Composite Capsule Strategy Support Longevity of Microencapsulated Pancreatic ß Cells

Free
TIAN QIN, ALEXANDRA M. SMINK, PAUL DE VOS
Journal: Diabetes
Diabetes 2023;72(Supplement_1):230-LB
https://doi.org/10.2337/db23-230-LB
Published: 20 June 2023
View articletitled, 230-LB: A Composite Capsule Strategy Support Longevity of Microencapsulated Pancreatic ß Cells
Meeting Abstracts

507-P: Trajectories of Inflammatory Proteins over Diabetic Wound Healing Course

Free
SARA PICKETT, SALINA MOON, GEORGIOS THEOCHARIDIS, ZAIPUL MD DOM, MONIKA NIEWCZAS, ARISTIDIS VEVES
Journal: Diabetes
Diabetes 2023;72(Supplement_1):507-P
https://doi.org/10.2337/db23-507-P
Published: 20 June 2023
View articletitled, 507-P: Trajectories of Inflammatory Proteins over Diabetic Wound Healing Course
Meeting Abstracts

1488-P: Reduced iPLA2b Expression in T-Lymphocytes Decreases Proinflammatory Eicosanoid Production and Cytokine Secretion Delaying Type 1 Diabetes Development in NOD Mice

Free
TAYLEUR WHITE, SASANKA RAMANADHAM, TERESA P. DILORENZO, CHARLES E. CHALFANT
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1488-P
https://doi.org/10.2337/db23-1488-P
Published: 20 June 2023
View articletitled, 1488-P: Reduced iPLA2b Expression in T-Lymphocytes Decreases Proinflammatory Eicosanoid Production and Cytokine Secretion Delaying Type 1 Diabetes Development in NOD Mice
Journal Articles

Topically Administered NOX4 Inhibitor, GLX7013114, Is Efficacious in Treating the Early Pathological Events of Diabetic Retinopathy

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Stavroula Dionysopoulou, Per Wikstrom, Claudio Bucolo, Giovanni Luca Romano, Vincenzo Micale, Richard Svensson, Dimitris Spyridakos, Niki Mastrodimou, Spiros Georgakis, Panayotis Verginis, Erik Walum, Kyriaki Thermos
Journal: Diabetes
Diabetes 2023;72(5):638–652
https://doi.org/10.2337/db22-0515
Published: 23 February 2023
View articletitled, Topically Administered NOX4 Inhibitor, GLX7013114, Is Efficacious in Treating the Early Pathological Events of Diabetic Retinopathy
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Journal Articles

Hypothesis: Induction of Autoimmunity in Type 1 Diabetes—A Lipid Focus

Free
Barbara E. Corkey, Laurie E. Kilpatrick, Carmella Evans-Molina
Journal: Diabetes
Diabetes 2022;71(10):2067–2074
https://doi.org/10.2337/db22-0240
Published: 12 September 2022
View articletitled, Hypothesis: Induction of Autoimmunity in Type 1 Diabetes—A Lipid Focus
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Journal Articles

Stem Cell Therapy Improves Human Islet Graft Survival in Mice via Regulation of Macrophages

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Wenyu Gou, Wei Hua, Lindsay Swaby, Wanxing Cui, Erica Green, Katherine A. Morgan, Charlie Strange, Hongjun Wang
Journal: Diabetes
Diabetes 2022;71(12):2642–2655
https://doi.org/10.2337/db22-0117
Published: 06 September 2022
View articletitled, Stem Cell Therapy Improves Human Islet Graft Survival in Mice via Regulation of Macrophages
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