1-20 of 75
cytosol
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Reduced Expression Level of Protein Phosphatase PPM1E Serves to Maintain Insulin Secretion in Type 2 Diabetes

Sevda Gheibi, Luis Rodrigo Cataldo, Alexander Hamilton, Mi Huang, Sebastian Kalamajski, Malin Fex, Hindrik Mulder
Journal: Diabetes
Diabetes 2023;72(4):455–466
https://doi.org/10.2337/db22-0472
Published: 20 January 2023
View article titled, Reduced Expression Level of Protein Phosphatase <em>PPM1E</em> Serves to Maintain Insulin Secretion in Type 2 Diabetes
Open the PDF for Reduced Expression Level of Protein Phosphatase <em>PPM1E</em> Serves to Maintain Insulin Secretion in Type 2 Diabetes in another window
Journal Articles

What Regulates Basal Insulin Secretion and Causes Hyperinsulinemia?

Barbara E. Corkey, Jude T. Deeney, Matthew J. Merrins
Journal: Diabetes
Diabetes 2021;70(10):2174–2182
https://doi.org/10.2337/dbi21-0009
Published: 27 September 2021
View article titled, What Regulates Basal Insulin Secretion and Causes Hyperinsulinemia?
Open the PDF for What Regulates Basal Insulin Secretion and Causes Hyperinsulinemia? in another window
Meeting Abstracts

1849-P: Fructose Induces Hepatic Steatosis via ME1-Mediated Cytosolic Redox Status

HAOWEN JIANG, JIA LI
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1849-P
https://doi.org/10.2337/db20-1849-P
Published: 01 June 2020
View article titled, 1849-P: Fructose Induces Hepatic Steatosis via ME1-Mediated Cytosolic Redox Status
Meeting Abstracts

1970-P: Mesenchymal Stromal Cells (MSCs) Upregulated with Both Mitochondrial and Cytosolic Antioxidants Improve Fatty Liver Disease in Diet-Induced Obesity (DIO) Mouse Model

SESHAGIRI RAO NANDULA, NABANITA KUNDU, SABYASACHI SEN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1970-P
https://doi.org/10.2337/db20-1970-P
Published: 01 June 2020
View article titled, 1970-P: Mesenchymal Stromal Cells (MSCs) Upregulated with Both Mitochondrial and Cytosolic Antioxidants Improve Fatty Liver Disease in Diet-Induced Obesity (DIO) Mouse Model
Journal Articles

A Phenotypic Screen Identifies Calcium Overload as a Key Mechanism of β-Cell Glucolipotoxicity

Jennifer Vogel, Jianning Yin, Liansheng Su, Sharon X. Wang, Richard Zessis, Sena Fowler, Chun-Hao Chiu, Aaron C. Wilson, Amy Chen, Frederic Zecri, Gordon Turner, Thomas M. Smith, Brian DeChristopher, Heming Xing, Deborah M. Rothman, Xinming Cai, Alina Berdichevsky
Journal: Diabetes
Diabetes 2020;69(5):1032–1041
https://doi.org/10.2337/db19-0813
Published: 20 February 2020
View article titled, A Phenotypic Screen Identifies Calcium Overload as a Key Mechanism of β-Cell Glucolipotoxicity
Open the PDF for A Phenotypic Screen Identifies Calcium Overload as a Key Mechanism of β-Cell Glucolipotoxicity in another window
Includes: Supplementary data
Journal Articles

The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism

Juli Bai, Feng Liu
Journal: Diabetes
Diabetes 2019;68(6):1099–1108
https://doi.org/10.2337/dbi18-0052
Published: 13 May 2019
View article titled, The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism
Open the PDF for The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism in another window
Meeting Abstracts

Glucose Oxidation Depletes Cytosolic Citrate and Glutamate in the Amplifying Pathways of Insulin Secretion

SOPHIE L. LEWANDOWSKI, MATTHEW J. MERRINS
Journal: Diabetes
Diabetes 2018;67(Supplement_1):2152-P
https://doi.org/10.2337/db18-2152-P
Published: 01 July 2018
View article titled, Glucose Oxidation Depletes Cytosolic Citrate and Glutamate in the Amplifying Pathways of Insulin Secretion
Journal Articles

Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn2+ Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart

Erkan Tuncay, Verda C. Bitirim, Aysegul Durak, Gaelle R.J. Carrat, Kathryn M. Taylor, Guy A. Rutter, Belma Turan
Journal: Diabetes
Diabetes 2017;66(5):1346–1358
https://doi.org/10.2337/db16-1099
Published: 23 February 2017
View article titled, Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn<sup>2+</sup> Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart
Open the PDF for Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn<sup>2+</sup> Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart in another window
Includes: Supplementary data
Journal Articles

SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity

Xin Tong, Tatsuyoshi Kono, Emily K. Anderson-Baucum, Wataru Yamamoto, Patrick Gilon, Djamel Lebeche, Richard N. Day, Gary E. Shull, Carmella Evans-Molina
Journal: Diabetes
Diabetes 2016;65(10):3039–3052
https://doi.org/10.2337/db16-0084
Published: 03 August 2016
View article titled, SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity
Open the PDF for SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity in another window
Includes: Supplementary data
Journal Articles

Alterations in β-Cell Calcium Dynamics and Efficacy Outweigh Islet Mass Adaptation in Compensation of Insulin Resistance and Prediabetes Onset

Chunguang Chen, Helena Chmelova, Christian M. Cohrs, Julie A. Chouinard, Stephan R. Jahn, Julia Stertmann, Ingo Uphues, Stephan Speier
Journal: Diabetes
Diabetes 2016;65(9):2676–2685
https://doi.org/10.2337/db15-1718
Published: 08 April 2016
View article titled, Alterations in β-Cell Calcium Dynamics and Efficacy Outweigh Islet Mass Adaptation in Compensation of Insulin Resistance and Prediabetes Onset
Open the PDF for Alterations in β-Cell Calcium Dynamics and Efficacy Outweigh Islet Mass Adaptation in Compensation of Insulin Resistance and Prediabetes Onset in another window
Includes: Supplementary data
Journal Articles

Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+ Stores

Alice Marmugi, Julia Parnis, Xi Chen, LeAnne Carmichael, Julie Hardy, Naila Mannan, Piero Marchetti, Lorenzo Piemonti, Domenico Bosco, Paul Johnson, James A.M. Shapiro, Céline Cruciani-Guglielmacci, Christophe Magnan, Mark Ibberson, Bernard Thorens, Héctor H. Valdivia, Guy A. Rutter, Isabelle Leclerc
Journal: Diabetes
Diabetes 2016;65(4):1009–1021
https://doi.org/10.2337/db15-1334
Published: 28 January 2016
View article titled, Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca<sup>2+</sup> Stores
Open the PDF for Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca<sup>2+</sup> Stores in another window
Includes: Supplementary data
Journal Articles

Induction of Cytosolic Phospholipase A2α Is Required for Adipose Neutrophil Infiltration and Hepatic Insulin Resistance Early in the Course of High-Fat Feeding

Nurit Hadad, Olga Burgazliev, Vered Elgazar-Carmon, Yulia Solomonov, Stephan Wueest, Flurin Item, Daniel Konrad, Assaf Rudich, Rachel Levy
Journal: Diabetes
Diabetes 2013;62(9):3053–3063
https://doi.org/10.2337/db12-1300
Published: 15 August 2013
View article titled, Induction of Cytosolic Phospholipase A<sub>2</sub>α Is Required for Adipose Neutrophil Infiltration and Hepatic Insulin Resistance Early in the Course of High-Fat Feeding
Open the PDF for Induction of Cytosolic Phospholipase A<sub>2</sub>α Is Required for Adipose Neutrophil Infiltration and Hepatic Insulin Resistance Early in the Course of High-Fat Feeding in another window
Includes: Supplementary data
Journal Articles

Metabolic Rescue of Obese Adipose-Derived Stem Cells by Lin28/Let7 Pathway

Laura M. Pérez, Aurora Bernal, Nuria San Martín, Margarita Lorenzo, Sonia Fernández-Veledo, Beatriz G. Gálvez
Journal: Diabetes
Diabetes 2013;62(7):2368–2379
https://doi.org/10.2337/db12-1220
Published: 14 June 2013
View article titled, Metabolic Rescue of Obese Adipose-Derived Stem Cells by Lin28/<em>Let7</em> Pathway
Open the PDF for Metabolic Rescue of Obese Adipose-Derived Stem Cells by Lin28/<em>Let7</em> Pathway in another window
Includes: Supplementary data
Journal Articles

Glucose-Induced Nuclear Shuttling of ChREBP Is Mediated by Sorcin and Ca2+ Ions in Pancreatic β-Cells

Nafeesa A. Noordeen, Gargi Meur, Guy A. Rutter, Isabelle Leclerc
Journal: Diabetes
Diabetes 2012;61(3):574–585
https://doi.org/10.2337/db10-1329
Published: 13 February 2012
View article titled, Glucose-Induced Nuclear Shuttling of ChREBP Is Mediated by Sorcin and Ca<sup>2+</sup> Ions in Pancreatic β-Cells
Open the PDF for Glucose-Induced Nuclear Shuttling of ChREBP Is Mediated by Sorcin and Ca<sup>2+</sup> Ions in Pancreatic β-Cells in another window
Includes: Multimedia, Supplementary data
Journal Articles

Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets: Role of Rac1–JNK1/2 Signaling Pathway in Mitochondrial Dysregulation in the Diabetic Islet

Ismail Syed, Chandrashekara N. Kyathanahalli, Bhavaani Jayaram, Sudha Govind, Christopher J. Rhodes, Renu A. Kowluru, Anjaneyulu Kowluru
Journal: Diabetes
Diabetes 2011;60(11):2843–2852
https://doi.org/10.2337/db11-0809
Published: 17 October 2011
View article titled, Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets: <subtitle>Role of Rac1–JNK1/2 Signaling Pathway in Mitochondrial Dysregulation in the Diabetic Islet</subtitle>
Open the PDF for Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets: <subtitle>Role of Rac1–JNK1/2 Signaling Pathway in Mitochondrial Dysregulation in the Diabetic Islet</subtitle> in another window
Journal Articles

The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes

Pontus Boström, Linda Andersson, Birgitte Vind, Liliana Håversen, Mikael Rutberg, Ylva Wickström, Erik Larsson, Per-Anders Jansson, Maria K. Svensson, Richard Brånemark, Charlotte Ling, Henning Beck-Nielsen, Jan Borén, Kurt Højlund, Sven-Olof Olofsson
Journal: Diabetes
Diabetes 2010;59(8):1870–1878
https://doi.org/10.2337/db09-1503
Published: 11 May 2010
View article titled, The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes
Open the PDF for The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes in another window
Includes: Multimedia, Supplementary data
Journal Articles

Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet–Induced Insulin Resistance

Clinton R. Bruce, Andrew J. Hoy, Nigel Turner, Matthew J. Watt, Tamara L. Allen, Kevin Carpenter, Gregory J. Cooney, Mark A. Febbraio, Edward W. Kraegen
Journal: Diabetes
Diabetes 2009;58(3):550–558
https://doi.org/10.2337/db08-1078
Published: 01 March 2009
View article titled, Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet–Induced Insulin Resistance
Open the PDF for Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet–Induced Insulin Resistance in another window
Includes: Supplementary data
Journal Articles

Role of Glyceraldehyde 3-Phosphate Dehydrogenase in the Development and Progression of Diabetic Retinopathy

Mamta Kanwar, Renu A. Kowluru
Journal: Diabetes
Diabetes 2009;58(1):227–234
https://doi.org/10.2337/db08-1025
Published: 01 January 2009
View article titled, Role of Glyceraldehyde 3-Phosphate Dehydrogenase in the Development and Progression of Diabetic Retinopathy
Open the PDF for Role of Glyceraldehyde 3-Phosphate Dehydrogenase in the Development and Progression of Diabetic Retinopathy in another window
Journal Articles

Inhibition of NADPH Oxidase Prevents Advanced Glycation End Product–Mediated Damage in Diabetic Nephropathy Through a Protein Kinase C-α–Dependent Pathway

Vicki Thallas-Bonke, Suzanne R. Thorpe, Melinda T. Coughlan, Kei Fukami, Felicia Y.T. Yap, Karly C. Sourris, Sally A. Penfold, Leon A. Bach, Mark E. Cooper, Josephine M. Forbes
Journal: Diabetes
Diabetes 2008;57(2):460–469
https://doi.org/10.2337/db07-1119
Published: 01 February 2008
View article titled, Inhibition of NADPH Oxidase Prevents Advanced Glycation End Product–Mediated Damage in Diabetic Nephropathy Through a Protein Kinase C-α–Dependent Pathway
Open the PDF for Inhibition of NADPH Oxidase Prevents Advanced Glycation End Product–Mediated Damage in Diabetic Nephropathy Through a Protein Kinase C-α–Dependent Pathway in another window
Journal Articles

Dominant-Negative α-Subunit of Farnesyl- and Geranyltransferase Inhibits Glucose-Stimulated, but Not KCl-Stimulated, Insulin Secretion in INS 832/13 Cells

Rajakrishnan Veluthakal, Hitchintan Kaur, Marc Goalstone, Anjaneyulu Kowluru
Journal: Diabetes
Diabetes 2007;56(1):204–210
https://doi.org/10.2337/db06-0668
Published: 01 January 2007
View article titled, Dominant-Negative α-Subunit of Farnesyl- and Geranyltransferase Inhibits Glucose-Stimulated, but Not KCl-Stimulated, Insulin Secretion in INS 832/13 Cells
Open the PDF for Dominant-Negative α-Subunit of Farnesyl- and Geranyltransferase Inhibits Glucose-Stimulated, but Not KCl-Stimulated, Insulin Secretion in INS 832/13 Cells in another window